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Laura M. Calvi, M.D.
UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
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About Me

Dr. Calvi is the Leader of the Cancer Microenvironment Research Program at Wilmot Cancer Center. Dr. Calvi graduated from Union College, obtained her medical degree from Harvard Medi...
Dr. Calvi is the Leader of the Cancer Microenvironment Research Program at Wilmot Cancer Center. Dr. Calvi graduated from Union College, obtained her medical degree from Harvard Medical School, and then completed her residency in internal medicine at Massachusetts General Hospital, Harvard Medical School. Dr. Calvi then pursued fellowship training in endocrinology at MGH, where she trained in neuroendocrinology at the MGH Neuroendocrine Clinical Center and Pituitary Tumor Center. She then moved to Rochester to assume the position of Assistant Professor in the Department of Medicine, Division of Endocrinology, University of Rochester Medical Center. Together with Dr. Vates, Dr. Calvi has developed the University of Rochester Multidisciplinary Neuroendocrinology Clinic as a center of excellence for management of patients with pituitary tumors. Dr. Calvi currently leads her research program on the bone marrow microenvironment and holds several administrative and educational responsibilities within the University of Rochester.

Faculty Appointments

Professor - Department of Medicine, Endocrine/Metabolism (SMD)

SKAWA Foundation Professor in Endocrinology and Metabolism - Department of Medicine, Endocrine/Metabolism (SMD)

Vice Chair for Basic & Translational Science - Department of Medicine (SMD)

Professor - Cancer Center - Joint

Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint


Residency & Fellowship

Fellowship, Endocrinology, Diabetes and Metabolism, Massachusetts General Hospital. 1998 - 2000

Residency, Internal Medicine, Massachusetts General Hospital. 1996 - 1998

Internship, Internal Medicine, Massachusetts General Hospital. 1995 - 1996


MD | Children's Hospital Harvard Medical (USA). 1995


Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow

To survive throughout the life of an individual, hematopoietic stem cells (or HSC), which continuously give rise to all cellular blood components, must strictly regula...
Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow

To survive throughout the life of an individual, hematopoietic stem cells (or HSC), which continuously give rise to all cellular blood components, must strictly regulate their behavioral choices. These choices include self-renewal, differentiation, quiescence or death. This essential regulation of stem cells is thought to be determined at least in part by the environment, or niche, in which these cells reside. The bone forming cells, osteoblasts, have been known to support and expand HSC in vitro and co-transplantation of osteoblasts with HSC can increase engraftment rate. Work in our laboratory and others first identified osteoblastic cells as a regulatory component in the HSC niche through genetic means. A number of molecules have since been implicated in HSC-osteoblastic interaction. In fact, it has recently become evident that osteoblasts can both stimulate and limit HSC expansion, promote quiescence, coordinate HSC mobilization and, when destroyed or mutated, initiate hematopoietic dysfunction. Therefore, increasing evidence points to osteoblasts as key regulators of HSC behavior. While the HSC niche is still poorly understood, we and others have begun to demonstrate the therapeutic potential of its manipulation in animal models. Our laboratory has demonstrated that osteoblastic activation by Parathyroid Hormone (PTH) expands HSC, and improves recovery from myeloablation. Thus, the central hypothesis pursued by my laboratory is that osteoblastic cells play a central role in orchestrating microenvironmental control of the behavior of both benign and malignant HSC, and that they can be targeted for therapeutic benefit. My laboratory therefore uniquely uses techniques that bridge bone and stem cell biology to discover the regulatory components of the bone marrow microenvironment, with the long term goal of identifying targets for therapeutic manipulation.

Current areas of research include:
1) Molecular mechanisms of osteoblastic regulation of hematopoietic stem cells,

2) Role of osteoblasts in coordinating the actions of other bone marrow cellular components (osteoclasts, endothelial cells and adipocytes) for HSC regulation,

3) Regulation of malignant stem cells by bone microenvironmental factors,

4) Role of HSC niche components in response to toxic or irradiation injury,

5) Therapeutic targeting of the HSC niche to improve HSC expansion (in vivo and in vitro), response to toxic injury and malignant stem cell eradication.

Individuals working in the laboratory can expect to learn flow cytometric analysis, pharmacologic and immunohistochemical methods for studying microenvironmental interactions in several animal and in vitro models, and the necessary computational techniques for analyzing these data.

We are currently accepting applications for graduate students and post-doctoral fellow positions in Calvi Lab at the University of Rochester Medical Center. Individuals interested in conducting research on the physiology and stem cell biology within the bone marrow microenvironment are encouraged to apply. Interested candidates, please e-mail your CV and a cover letter detailing your scientific background and skills to Dr. Calvi ( )


Expansion of Hematopoietic Stem Cells

Issue date: July 19, 2016

Patent #: 9,394,520

Country: United States

Inventors: Laura M Calvi, Regis O'Keefe

Expansion of Hematopoietic Stem Cells

Issue date: February 05, 2020

Patent #: 2094839

Country: Europe

Inventors: Laura M Calvi, Regis O'Keefe

Expansion of Hematopoietic Stem Cells

Issue date: February 05, 2020

Patent #: FR2094839

Country: France

Inventors: Laura M Calvi, Regis O'Keefe

Expansion of Hematopoietic Stem Cells

Issue date: February 05, 2020

Patent #: DE2094839

Country: Germany

Inventors: Laura M Calvi, Regis O'Keefe

Expansion of Hematopoietic Stem Cells

Issue date: February 05, 2020

Patent #: GB2094839

Country: United Kingdom

Inventors: Laura M Calvi, Regis O'Keefe


Journal Articles

Interplay Between Skeletal and Hematopoietic Cells in the Bone Marrow Microenvironment in Homeostasis and Aging.

Quarato ER, Salama NA, Calvi LM

Current osteoporosis reports.. 2024 May 23 Epub 05/23/2024.

Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia.

Rodems BJ, Sharma S, Baker CD, Kaszuba CM, Ito T, Liesveld JL, Calvi LM, Becker MW, Jordan CT, Ashton JM, Bajaj J

bioRxiv : the preprint server for biology.. 2024 May 14 Epub 05/14/2024.

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia.

Kaszuba CM, Rodems BJ, Sharma S, Franco EI, Ashton JM, Calvi LM, Bajaj J

Journal of visualized experiments : JoVE.. 2023 November 10 (201)Epub 11/10/2023.

Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer.

Hughson AL, Hannon G, Salama NA, Vrooman TG, Stockwell CA, Mills BN, Garrett-Larsen J, Qiu H, Katerji R, Benoodt L, Johnston CJ, Murphy JD, Kruger E, Ye J, Gavras NW, Keeley DC, Qin SS, Lesch ML, Muhitch JB, Love TMT, Calvi LM, Lord EM, Luheshi N, Elyes J, Linehan DC, Gerber SA

bioRxiv : the preprint server for biology.. 2023 November 2 Epub 11/02/2023.

The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression.

Kfoury YS, Ji F, Jain E, Mazzola MC, Schiroli G, Papazian A, Mercier FE, Sykes DB, Kiem A, Randolph MA, Abdel-Wahab OI, Calvi LM, Sadreyev R, Scadden DT

Blood advances.. 2023 July 14 Epub 07/14/2023.

Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling.

Quarato ER, Salama NA, Li AJ, Smith CO, Zhang J, Kawano Y, McArthur M, Liesveld JL, Becker MW, Elliott MR, Eliseev RA, Calvi LM

Cell death & disease.. 2023 July 1414 (7):428. Epub 07/14/2023.

Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1.

Khazan N, Quarato ER, Singh NA, Snyder CWA, Moore T, Miller JP, Yasui M, Teramoto Y, Goto T, Reshi S, Hong J, Zhang N, Pandey D, Srivastava P, Morell A, Kawano H, Kawano Y, Conley T, Sahasrabudhe DM, Yano N, Miyamoto H, Aljitawi O, Liesveld J, Becker MW, Calvi LM, Zhovmer AS, Tabdanov ED, Dokholyan NV, Linehan DC, Hansen JN, Gerber SA, Sharon A, Khera MK, Jurutka PW, Rochel N, Kim KK, Rowswell-Turner RB, Singh RK, Moore RG

Cancers.. 2023 June 3015 (13)Epub 06/30/2023.

Mitochondrial Transfer to Host Cells from Ex Vivo Expanded Donor Hematopoietic Stem Cells.

Kawano H, Kawano Y, Yu C, LaMere MW, McArthur MJ, Becker MW, Ballinger SW, Gojo S, Eliseev RA, Calvi LM

Cells.. 2023 May 2512 (11)Epub 05/25/2023.

Myelodysplastic syndromes disable human CD271 VCAM1 CD146 niches supporting normal hematopoietic stem/progenitor cells.

Kawano Y, Kawano H, Ghoneim D, Fountaine TJ, Byun DK, LaMere MW, Mendler JH, Ho T, Salama NA, Myers JR, Hussein SE, Frisch BJ, Ashton JM, Azadniv M, Liesveld JL, Kfoury Y, Scadden DT, Becker MW, Calvi LM

bioRxiv : the preprint server for biology.. 2023 April 10 Epub 04/10/2023.

The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies.

Zhang H, Liesveld JL, Calvi LM, Lipe BC, Xing L, Becker MW, Schwarz EM, Yeh SA

Bone research.. 2023 March 1411 (1):15. Epub 03/14/2023.

GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity.

Ruffolo LI, Jackson KM, Kuhlers PC, Dale BS, Figueroa Guilliani NM, Ullman NA, Burchard PR, Qin SS, Juviler PG, Keilson JM, Morrison AB, Georger M, Jewell R, Calvi LM, Nywening TM, O'Dell MR, Hezel AF, De Las Casas L, Lesinski GB, Yeh JJ, Hernandez-Alejandro R, Belt BA, Linehan DC

Gut.. 2022 July 71 (7):1386-1398. Epub 08/19/2021.

CCR5 maintains macrophages in the bone marrow and drives hematopoietic failure in a mouse model of severe aplastic anemia.

Seyfried AN, McCabe A, Smith JNP, Calvi LM, MacNamara KC

Leukemia.. 2021 November 35 (11):3139-3151. Epub 03/20/2021.

Long-acting PGE2 and Lisinopril Mitigate H-ARS.

Saunders J, Niswander LM, McGrath KE, Koniski A, Catherman SC, Ture SK, Medhora M, Kingsley PD, Calvi LM, Williams JP, Morrell CN, Palis J

Radiation research.. 2021 September 1196 (3):284-296. Epub 1900 01 01.

Reduction of leukemic burden via bone-targeted nanoparticle delivery of an inhibitor of C-chemokine (C-C motif) ligand 3 (CCL3) signaling.

Ackun-Farmmer MA, Soto CA, Lesch ML, Byun D, Yang L, Calvi LM, Benoit DSW, Frisch BJ

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2021 April 35 (4):e21402. Epub 1900 01 01.

FGF-23: a novel actor in stem cell mobilization.

Calvi LM

Blood.. 2021 March 18137 (11):1434-1436. Epub 1900 01 01.

Improved in vivo Experimental Screening Identifies an Anabolic Analog of 1,25 Dihydroxyvitamin D3 With Minimal Bone Resorption Activity.

Calvi LM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 April 35 (4):621-622. Epub 01/06/2020.

Bone marrow mesenchymal stromal cells from acute myelogenous leukemia patients demonstrate adipogenic differentiation propensity with implications for leukemia cell support.

Azadniv M, Myers JR, McMurray HR, Guo N, Rock P, Coppage ML, Ashton J, Becker MW, Calvi LM, Liesveld JL

Leukemia.. 2020 February 34 (2):391-403. Epub 09/06/2019.

What is the role of the microenvironment in MDS?

Calvi LM, Li AJ, Becker MW

Best practice & research. Clinical haematology.. 2019 December 32 (4):101113. Epub 10/28/2019.

Acute and late effects of combined internal and external radiation exposures on the hematopoietic system.

Calvi LM, Frisch BJ, Kingsley PD, Koniski AD, Love TM, Williams JP, Palis J

International journal of radiation biology.. 2019 November 95 (11):1447-1461. Epub 07/30/2019.

Flaming and fanning: The Spectrum of inflammatory influences in myelodysplastic syndromes.

Banerjee T, Calvi LM, Becker MW, Liesveld JL

Blood reviews.. 2019 July 36 :57-69. Epub 04/18/2019.

A Novel Strategy for Repairing Multiple Myeloma Bone Lesions: Lessons From Murine Models.

Calvi LM, Hofbauer LC

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2019 May 34 (5):781-782. Epub 05/09/2019.

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B.

Frisch BJ, Hoffman CM, Latchney SE, LaMere MW, Myers J, Ashton J, Li AJ, Saunders J, Palis J, Perkins AS, McCabe A, Smith JN, McGrath KE, Rivera-Escalera F, McDavid A, Liesveld JL, Korshunov VA, Elliott MR, MacNamara KC, Becker MW, Calvi LM

JCI insight.. 2019 April 185 (10)Epub 04/18/2019.

Impact of aging on bone, marrow and their interactions.

Hoffman CM, Han J, Calvi LM

Bone.. 2019 February 119 :1-7. Epub 07/17/2018.

EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription.

Ayoub E, Wilson MP, McGrath KE, Li AJ, Frisch BJ, Palis J, Calvi LM, Zhang Y, Perkins AS

Nature communications.. 2018 October 129 (1):4239. Epub 10/12/2018.

The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers.

Staversky RJ, Byun DK, Georger MA, Zaffuto BJ, Goodman A, Becker MW, Calvi LM, Frisch BJ

Scientific reports.. 2018 October 28 (1):14691. Epub 10/02/2018.

The microenvironment in myelodysplastic syndromes: Niche-mediated disease initiation and progression.

Li AJ, Calvi LM

Experimental hematology.. 2017 November 55 :3-18. Epub 08/18/2017.

The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool.

Lawal RA, Zhou X, Batey K, Hoffman CM, Georger MA, Radtke F, Hilton MJ, Xing L, Frisch BJ, Calvi LM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 June 32 (6):1320-1331. Epub 03/09/2017.

PKK deficiency in B cells prevents lupus development in Sle lupus mice.

Oleksyn D, Zhao J, Vosoughi A, Zhao JC, Misra R, Pentland AP, Ryan D, Anolik J, Ritchlin C, Looney J, Anandarajah AP, Schwartz G, Calvi LM, Georger M, Mohan C, Sanz I, Chen L

Immunology letters.. 2017 May 185 :1-11. Epub 03/06/2017.

The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging.

Latchney SE, Calvi LM

Seminars in hematology.. 2017 January 54 (1):25-32. Epub 10/19/2016.

Geographic variation in cost of care for pituitary tumor surgery.

Lee CC, Kimmell KT, Lalonde A, Salzman P, Miller MC, Calvi LM, Manuylova E, Shafiq I, Edward Vates G

Pituitary.. 2016 October 19 (5):515-21. Epub 1900 01 01.

Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome.

Balderman SR, Li AJ, Hoffman CM, Frisch BJ, Goodman AN, LaMere MW, Georger MA, Evans AG, Liesveld JL, Becker MW, Calvi LM

Blood.. 2016 February 4127 (5):616-25. Epub 12/04/2015.

Late presentation of acromegaly in medically controlled prolactinoma patients.

Manuylova E, Calvi LM, Hastings C, Vates GE, Johnson MD, Cave WT, Shafiq I

Endocrinology, diabetes & metabolism case reports.. 2016 2016 Epub 10/17/2016.

The hematopoietic stem cell niche in homeostasis and disease.

Calvi LM, Link DC

Blood.. 2015 November 26126 (22):2443-51. Epub 10/14/2015.


Manuylova E, Calvi LM, Vates GE, Hastings C, Shafiq I

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.. 2015 August 21 (8):897-902. Epub 06/29/2015.

Impact of dietary supplements, obesity and treatment initiation on serum vitamin D levels in patients with lymphoma.

Hutchinson K, Jahangiri S, Calvi LM, Barr P, Friedberg JW, Kelly JL

Leukemia & lymphoma.. 2015 February 56 (2):508-11. Epub 07/15/2014.

Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis.

Evans AG, Calvi LM

Annals of the New York Academy of Sciences.. 2015 January 1335 (1):63-77. Epub 10/28/2014.

Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid Leukemia.

Sivagnanalingam U, Balys M, Eberhardt A, Wang N, Myers JR, Ashton JM, Becker MW, Calvi LM, Mendler JH

PloS one.. 2015 10 (7):e0132375. Epub 07/15/2015.

Biology of BM failure syndromes: role of microenvironment and niches.

Balderman SR, Calvi LM

Hematology. 2014 December 52014 (1):71-6. Epub 11/18/2014.

Minireview: complexity of hematopoietic stem cell regulation in the bone marrow microenvironment.

Hoffman CM, Calvi LM

Molecular endocrinology.. 2014 October 28 (10):1592-601. Epub 08/01/2014.

Cellular complexity of the bone marrow hematopoietic stem cell niche.

Calvi LM, Link DC

Calcified tissue international.. 2014 January 94 (1):112-24. Epub 10/08/2013.

Hematopoietic stem cell cultures and assays.

Frisch BJ, Calvi LM

Methods in molecular biology.. 2014 1130 :315-324. Epub 1900 01 01.

Osteoblasts as leukemia-initiating cells.

Frisch BJ, Calvi LM

BoneKEy reports. 2014 3 :572. Epub 09/03/2014.

Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B.

Li JY, Adams J, Calvi LM, Lane TF, Weitzmann MN, Pacifici R

Blood.. 2013 October 3122 (14):2346-57. Epub 08/16/2013.

Osteolineage cells and regulation of the hematopoietic stem cell.

Calvi LM

Best practice & research. Clinical haematology.. 2013 September 26 (3):249-52. Epub 10/16/2013.

Pituitary adenoma with mucin cells in a man with an unusual presentation of Carney complex.

Yeaney GA, Brathwaite JM, Dashnaw ML, Vates GE, Calvi LM

Endocrine pathology.. 2013 June 24 (2):106-9. Epub 1900 01 01.

PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis.

Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2013 March 28 (3):586-97. Epub 1900 01 01.

Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury.

Porter RL, Georger M, Bromberg O, McGrath KE, Frisch BJ, Becker MW, Calvi LM

Stem cells.. 2013 February 31 (2):372-83. Epub 1900 01 01.

Two cases of malignant struma ovarii with metastasis to pelvic bone.

Steinman RA, De Castro IO, Shrayyef M, Chengazi V, Giampoli E, Van Der Sloot P, Calvi LM, Wittlin SD, Hammes SR, Hou R

Gynecologic and obstetric investigation.. 2013 75 (2):139-44. Epub 02/06/2013.

PTH expands short-term murine hemopoietic stem cells through T cells.

Li JY, Adams J, Calvi LM, Lane TF, Dipaolo R, Weitzmann MN, Pacifici R

Blood.. 2012 November 22120 (22):4352-62. Epub 09/05/2012.

Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells.

Bromberg O, Frisch BJ, Weber JM, Porter RL, Civitelli R, Calvi LM

Blood.. 2012 July 12120 (2):303-13. Epub 05/17/2012.

Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells.

Calvi LM, Bromberg O, Rhee Y, Weber JM, Smith JN, Basil M, Frisch BJ, Bellido T

Blood.. 2012 March 15119 (11):2489-99. Epub 01/18/2012.

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia.

Frisch BJ, Ashton JM, Xing L, Becker MW, Jordan CT, Calvi LM

Blood.. 2012 January 12119 (2):540-50. Epub 09/28/2011.

Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury.

Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ

PloS one.. 2012 7 (7):e40602. Epub 07/11/2012.

The niche as a target for hematopoietic manipulation and regeneration.

Lawal RA, Calvi LM

Tissue engineering. Part B, Reviews.. 2011 December 17 (6):415-22. Epub 09/27/2011.

Agrin complicates the niche.

Calvi LM

Blood.. 2011 September 8118 (10):2641-2. Epub 1900 01 01.

Acute thyrotoxicosis secondary to destructive thyroiditis associated with cardiac catheterization contrast dye.

Calvi L, Daniels GH

Thyroid : official journal of the American Thyroid Association.. 2011 April 21 (4):443-9. Epub 1900 01 01.

Regulatory Interactions in the Bone Marrow Microenvironment.

Smith JN, Calvi LM

IBMS boneKEy. 2011 8 (2):96-111. Epub 1900 01 01.

A case-control study of ultraviolet radiation exposure, vitamin D, and lymphoma risk in adults.

Kelly JL, Friedberg JW, Calvi LM, van Wijngaarden E, Fisher SG

Cancer causes & control : CCC.. 2010 August 21 (8):1265-75. Epub 04/07/2010.

Notch signaling and the bone marrow hematopoietic stem cell niche.

Weber JM, Calvi LM

Bone.. 2010 February 46 (2):281-5. Epub 08/11/2009.

In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells.

Frisch BJ, Porter RL, Gigliotti BJ, Olm-Shipman AJ, Weber JM, O'Keefe RJ, Jordan CT, Calvi LM

Blood.. 2009 November 5114 (19):4054-63. Epub 09/02/2009.

Vitamin D and non-Hodgkin lymphoma risk in adults: a review.

Kelly JL, Friedberg JW, Calvi LM, van Wijngaarden E, Fisher SG

Cancer investigation.. 2009 November 27 (9):942-51. Epub 1900 01 01.

Key endothelial signals required for hematopoietic recovery.

Porter RL, Calvi LM

Cell stem cell.. 2009 March 64 (3):187-8. Epub 1900 01 01.

Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference.

Coleman RE, Guise TA, Lipton A, Roodman GD, Berenson JR, Body JJ, Boyce BF, Calvi LM, Hadji P, McCloskey EV, Saad F, Smith MR, Suva LJ, Taichman RS, Vessella RL, Weilbaecher KN

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2008 October 1514 (20):6387-95. Epub 1900 01 01.

Hematopoietic niche and bone meet.

Frisch BJ, Porter RL, Calvi LM

Current opinion in supportive and palliative care.. 2008 September 2 (3):211-7. Epub 1900 01 01.

When is it appropriate to order an ionized calcium?

Calvi LM, Bushinsky DA

Journal of the American Society of Nephrology : JASN.. 2008 July 19 (7):1257-60. Epub 01/23/2008.

Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging.

Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Calvi LM, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM

Arthritis and rheumatism.. 2008 July 58 (7):2019-29. Epub 1900 01 01.

Communications between bone cells and hematopoietic stem cells.

Porter RL, Calvi LM

Archives of biochemistry and biophysics.. 2008 May 15473 (2):193-200. Epub 04/07/2008.

Therapeutic targeting of a stem cell niche.

Adams GB, Martin RP, Alley IR, Chabner KT, Cohen KS, Calvi LM, Kronenberg HM, Scadden DT

Nature biotechnology.. 2007 February 25 (2):238-43. Epub 01/21/2007.

Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells.

Weber JM, Forsythe SR, Christianson CA, Frisch BJ, Gigliotti BJ, Jordan CT, Milner LA, Guzman ML, Calvi LM

Bone.. 2006 September 39 (3):485-93. Epub 05/02/2006.

Osteoblastic activation in the hematopoietic stem cell niche.

Calvi LM

Annals of the New York Academy of Sciences.. 2006 April 1068 :477-88. Epub 1900 01 01.

Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size.

Stier S, Ko Y, Forkert R, Lutz C, Neuhaus T, Grünewald E, Cheng T, Dombkowski D, Calvi LM, Rittling SR, Scadden DT

The Journal of experimental medicine.. 2005 June 6201 (11):1781-91. Epub 05/31/2005.

The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow.

Kuznetsov SA, Riminucci M, Ziran N, Tsutsui TW, Corsi A, Calvi L, Kronenberg HM, Schipani E, Robey PG, Bianco P

The Journal of cell biology.. 2004 December 20167 (6):1113-22. Epub 1900 01 01.

Constitutively active PTH/PTHrP receptor in odontoblasts alters odontoblast and ameloblast function and maturation.

Calvi LM, Shin HI, Knight MC, Weber JM, Young MF, Giovannetti A, Schipani E

Mechanisms of development.. 2004 April 121 (4):397-408. Epub 1900 01 01.

Osteoblastic cells regulate the haematopoietic stem cell niche.

Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, Milner LA, Kronenberg HM, Scadden DT

Nature.. 2003 October 23425 (6960):841-6. Epub 1900 01 01.

Collagenase cleavage of type I collagen is essential for both basal and parathyroid hormone (PTH)/PTH-related peptide receptor-induced osteoclast activation and has differential effects on discrete bone compartments.

Chiusaroli R, Maier A, Knight MC, Byrne M, Calvi LM, Baron R, Krane SM, Schipani E

Endocrinology.. 2003 September 144 (9):4106-16. Epub 1900 01 01.

Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.

Calvi LM, Sims NA, Hunzelman JL, Knight MC, Giovannetti A, Saxton JM, Kronenberg HM, Baron R, Schipani E

The Journal of clinical investigation.. 2001 February 107 (3):277-86. Epub 1900 01 01.

The PTH/PTHrP receptor in Jansen's metaphyseal chondrodysplasia.

Calvi LM, Schipani E

Journal of endocrinological investigation.. 2000 September 23 (8):545-54. Epub 1900 01 01.