Research Interest: Studying the human hematopoietic stem cells and their interaction with their microenvironment
Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Research Interest: Co-Director of the Rochester Genomics CenterDirector, Wilmot Cancer Institute Shared ResourcesDirector, Functional Genomics Resource
Research Interest: Molecular mechanisms of cancer stem cell interactions with tumor microenvironment in disease progression
Research Interest: The development of novel therapeutics for patients with chronic lymphocytic leukemia and lymphoma.
Research Interest: Malignant stem cell populations in myeloid neoplasms
Research Interest: Molecular and Cellular Mechanisms that Control Tissue Homeostasis and Somatic Stem Cells
Research Interest: The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Research Interest: Cardioprotection against ischemia-reperfusion (IR) injury. Role of Mitochondria and metabolism in ischemic preconditioning and anesthetic preconditioning.
Research Interest: Multiphoton Laser Scanning Microscopy, novel in vivo imaging and measurement techniques, tumor biology, angiogenesis
Research Interest: Activation induced cytidine deaminase (AID) impact on Follicular lymphoma (FL) tumors as a prognostic factor for Diffuse Large B-cell lymphoma (DLBCL)
Research Interest: The development and application of high-end flow cytometric assays to support the research programs of members of the URMC community
Research Interest: Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow
Research Interest: My laboratory studies cancer biology with an emphasis in developmental therapeutics and pancreatic cancer metastasis and dormancy
Research Interest: Development and implementation of mobile health interventions for smoking cessation among underserved populations (e.g., Latinos, people living with HIV, people living in low- and middle-income countries).
Research Interest: Newly diagnosed and relapsed Hodgkin lymphoma, mantle cell lymphoma, diffuse large B cell lymphoma ,and peripheral T cell lymphoma
Research Interest: Radiation Oncology
Community engagement and participatory research to address disparities in primary prevention using culturally and linguistic sensitive mobile intervention, particularly among under-represented minority (URM) populations
Research Interest: Tissue characterization, inverse problems, breast imaging, elastography, cardiovascular disease, molecular imaging, ultrasound, and MRI
Role of Mitochondria in regulation of cell fate in normal stem cells and cancer cells
Research Interest: Bioorganic chemistry, chemical biology, and biomolecular engineering and evolution
Research Interest: Development of novel therapies for patients with lymphoma
Research Interest: Role of inflammatory mediators in bone marrow microenvironmental dysfunction during hematologic malignancies
Research Interest: The Gerber lab studies tumor immunology with a focus on harnessing the immune system to recognize and kill cancerous cells utilizing an immunotherapeutic approach to enhance the efficacy of chemo/radiotherapies to control or even cure both primary and metastatic malignancies.
Research Interest: Biological markers of aging, supportivive care interventions, mechanisms of frailty and resilience
Research Interest: Role of cell-cell contact in regulating cellular function in both the normal and disease state
Research Interest: Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Community engagement and overall reduction of health disparities in deaf populations with a particular focus on the relationship between early childhood language experiences and subsequent health, cognitive, education, and overall quality of life outcomes across the lifespan and the phenomenon of language deprivation
Research Interest: Androgen Effects on Reproduction and Cancer
Understanding the roles of antioxidants in disease
Research Interest: The molecular biology and genetics of pancreatic and biliary tract cancers
Research Interest: Early origins research, linking in utero environment to later life health and educational attainment
Research Interest: Understanding clinical, psychological, and biological mechanisms of cognitive difficulties in cancer patients
Research Interest: Laparoscopic/minimally invasive urology (prostatectomy, nephrectomy), reconstructive urology, hematuria, genitourinary cancers, kidney stones, benign prostatic hypertrophy (BPH), urethral strictures, vasectomy, vasectomy reversal
Research Interest: Factors that lead to health disparities among sexual and gender minority populations, specifically disparities in cancer-related health outcomes and psychological distress
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Research Interest: Innate and adaptive immune responses and cancer immunotherapy
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Research Interest: Influence of environmental factors on the development and function of the immune system
Research Interest: Extracellular vesicles (Evs), Exosomes, for their roles in cancer development, progression and response to treatment in Urology cancers.
Research Interest: Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation
Translational cancer research and immunotherapy
Geriatric hematology, digital health technologies, behavioral and supportive care interventions, physical function, decision-making in AML, prognostic understanding, communication, end-of-life care
Director, Geriatric Hematology and Mobile Health Research
Director, Geriatric Oncology Research Observership Program
Cognition, cognitive interventions, GA and management interventions
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Research Interest: Developing methods to estimate gene regulatory networks from gene perturbation experiments
Research Interest: Cell Motility, and Quantitative light microscopy
Research Interest: Smoking Cessation in special populations, Technology/Web Assisted Risk Behavior Intervention and Dissemination of effective interventions to physician practices
Research Interest: Understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation.
Research Interest: Prostate and Bladder cancer
Research Interest: Understanding the role of cancer stem cells in the progression of brain tumors
Research Interest: Geriatric assessment and management interventions, symptomatic toxicities, tolerability, clinical trial design for older adults with cancer, caregiver research
Research Interest: Ovarian cancer biomarker research for the early detection and management of ovarian cancer
Research Interest: The regulation of cytokine responses of human and mouse T-cell subsets in infections asthma, allergy and autoimmunity
Hematology, Medical Oncology
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Research Interest: Neuro stem cell biology and medicine, developing pharmacological and cell based approaches to peripheral and spinal cord injury.
Research Interest: Defining neuro-inflammatory processes that contribute to pathology and disease progression in Alzheimer's disease, as well as late CNS effects following radiation exposure
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Behavioral medicine and outcomes management include tobacco use and smoking interventions, obesity prevention and exercise
Research Interest: Protective and regenerative strategies for salivary gland function and radiation therapies.
Research Interest: Cellular and Molecular events underlying the ontogeny of the hematopoietic system.
Research Interest: The use of nutritional supplementation and exercise to treat the symptoms and side effects of cancer and its related treatment
Research Interest: Genetic mechanisms in acute myeloid leukemia and myelodysplastic syndrome with focus on the zinc finger oncoprotein EVI1
Research Interest: Biostatistics and Computational Biology
Research Interest: Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants.
Research Interest: Polypharmacy, data science, informatics, implementation science
Research Interest: Urologic malignancies
Chronic illness, Palliative Care, Long-term childhood cancer survivors, Bereavement, Integrative medicine, Biofeedback, Chronic pain, Bioethics
Research Interest: Inflammatory bone loss as seen in rheumatoid arthritis, infections, tumor metastasis and wear debris induced osteolysis around prosthetic implants
Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Identification of relevant cutting-edge microscopy technologies for implementation at the University of Rochester. Application of quantitative imaging and analysis techniques to a variety of research projects.
Director, Center for Advanced Light Microscopy and Nanoscopy
Research Interest: Cancer epigenetics: the role of DNA methylation and chromatin in driving cancer phenotypes and as a target for therapeutic intervention
Mechanism and physiological importance of alternative polyadenylation; Integrator Complex and transcriptional control, development and application of next-generation sequencing technologies
Developing intravital imaging-based approaches to better understand the bone marrow microenvironment regulating the skeletal, hematopoietic, and malignant stem cells
Research Interest: Role of the estrogen receptor (ER) and androgen receptor (AR) in urological diseases, including prostate cancer, bladder cancer, benign prostatic hyperplasia (BPH) and male fertility.
Research Interest: RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.
Research Interest: Lymphoid Malignancy Research
Research Interest: Mechanisms of hematopoietic stem cells (HSC) and leukemia initiating cells (LIC) regulations