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Gerber Lab

Welcome to the Gerber Laboratory

The Immune System and Cancer

Cancer cells

Immune cells (orange) and blood vessels (green) inside of the tumor

The immune system frequently protects us by destroying invading microorganisms such as viruses and bacteria, but is often ineffective in recognizing and combating cancer.  Interestingly, immune cells are very capable of finding and killing cancerous cells, but tumor cells are unique in that they can transform immune cells to elicit tumor-promoting functions and ultimately diminish the response to cancer.  The Gerber laboratory focuses on reversing this process and instead “re-activates” these immune cells to attack and eradicate the tumor.  This is accomplished by a new line of cancer treatment called immunotherapy (enhancing the body’s own immune system to fight cancer), which has resulted in remarkable anti-tumor responses.  Immunotherapy stands to redefine how clinicians treat tumors and may hold the key to eliminating cancer.

Tumor Microenvironment

tumor microenvironment

A major obstacle blocking the way for effective cancer therapy is the tumor microenvironment.  Within the tumor consists a multitude of various components ranging from cancer cells, fibroblasts, blood vessels, immune cells, nerves, bacteria, etc.  Cancerous cells “program” the components of the tumor microenvironment to promote the growth of the malignancy through the production and interaction of a very complex milieu of cancer-driving factors.  The Gerber lab focuses on understanding the complexities of the tumor microenvironment to identify what factors promote tumor growth and, from this data, develop therapies to counteract these molecules.  

Enhancing Cancer Radiotherapy by Targeting the Immune System

Cancer Cells in the crosshairsOne particular goal of the Gerber laboratory is to enhance the efficacy of radiotherapy.  We believe that improving this particular cancer treatment would benefit many cancer patients, as one half of all malignancies are treated with radiotherapy.  We accomplish this goal though a close collaboration with a fellow member of the Center, Edith Lord, who helped pioneer the concept that the immune system mediated many of the anti-tumor effects of existing cancer therapies, such as radiotherapy.  This work ushered in a paradigm shift in the field and suggests that radiotherapy, an effective cancer treatment modality, can be further enhanced by targeting and stimulating immune cells.  Using a state-of-the-art small animal radiation delivery system that recapitulates equipment used in clinical radiation oncology, we have demonstrated that immunotherapy can greatly impact the effectiveness of radiotherapy resulting in unprecedented tumor control and even cures in preclinical models.  We have also been fortunate to translate some of our findings into clinical trials and continue to take a “bench to bedside” approach to expedite the development of vital treatments for cancer patients.

Scott A. Gerber, Ph.D.

Scott A. Gerber, Ph.D.

Principal Investigator
Co-Director, Center for Tumor Immunology Research

Research Projects

pancreas image

Enhancing Specialized Radiotherapy with Immunotherapy to Treat Pancreatic Cancer


Crosstalk between the Nervous and Immune Systems within the Tumor

tumor cell death

Boosting Anti-tumor Immune Responses by Optimizing Immunogenic Cell Death

lymph node

Targeting the tumor draining lymph node to promote anti-tumor immunity

cancer cells

Decipher the Role of Granulocytes in Pancreatic Cancer

Selected Publications

Han BJ, Murphy JD, Qin S, Ye J, Uccello TP, Garrett-Larsen J, Belt BA, Prieto PA, Egilmez NK, Lord EM, Linehan DC, Mills BN, Gerber SA. Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma. Immunol Invest. 2020 Jun 4;:1-16. doi: 10.1080/08820139.2020.1765795. [Epub ahead of print] PubMed PMID: 32498585.

Ye J, Mills BN, Zhao T, Han BJ, Murphy JD, Patel AP, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA. Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer. Cancer Immunol Res. 2020 Jan;8(1):94-107. doi: 10.1158/2326-6066.CIR-19-0373. Epub 2019 Nov 12. PubMed PMID: 31719057; PubMed Central PMCID: PMC6946873.

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment.Mills BN, Connolly KA, Ye J, Murphy JD, Uccello TP, Han BJ, Zhao T, Drage MG, Murthy A, Qiu H, Patel A, Figueroa NM, Johnston CJ, Prieto PA, Egilmez NK, Belt BA, Lord EM, Linehan DC, Gerber SACell reports; Vol 29(2). 2019 Oct 08.

Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes. Connolly KA, Belt BA, Figueroa NM, Murthy A, Patel A, Kim M, Lord EM, Linehan DC, Gerber SA.  Oncotarget. 2016; 7(52):86522-86535. PMCID: PMC5349932

Total-Body Irradiation Exacerbates Dissemination of Cutaneous Candida Albicans Infection. Barlow ML, Cummings RJ, Pentland AP, Love TM, Haidaris CG, Ryan JL, Lord EM, Gerber SA. Radiation research. 2016; 186(5):436-446. PMCID:PMC5326582

Radiation therapy combined with Listeria monocytogenes-based cancer vaccine synergize to enhance tumor control in the B16 melanoma model. Lim JY, Brockstedt DG, Lord EM, Gerber SA. Oncoimmunology. 2014; 3:e29028. PMCID:PMC4106167

Radio-responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors. Gerber SA, Lim JY, Connolly KA, Sedlacek AL, Barlow ML, Murphy SP, Egilmez NK, Lord EM. International journal of cancer. 2014; 134(10):2383-92. PMCID: PMC3949198

IFN-γ mediates the antitumor effects of radiation therapy in a murine colon tumor. Gerber SA, Sedlacek AL, Cron KR, Murphy SP, Frelinger JG, Lord EM. The American journal of pathology. 2013; 182(6):2345-54. PMCID:PMC3668027

View All Publications

Contact Us

  Scott Gerber Laboratory
MRBX 2-11001
601 Elmwood Ave
Rochester, NY 14642