
Carla Casulo, M.D.
Contact
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About Me
Professional Background
Dr. Casulo completed Hematology and Oncology Fellowship at Memorial Sloan-Kettering Cancer Center in New York, New York. Dr. Casulo was honored as recipient of numerous awards, including the John W. Bracket Housestaff Teaching Award at Yale University School of Medicine, the Mortimer Latcher Fellowship Award from the Lymphoma Foundation, and the NIH John Calabresi K12 Career Development Award. Dr Casulo was recipient of The NIH Loan Repayment Award and was a Scholar in the Lymphoma Research Foundation Clinical Research Mentoring Program.
Dr. Casulo is an international expert and clinician-researcher in all forms of lymphoma, best known for her pivotal work in follicular lymphoma. She also has an expertise and passion for young adults with lymphoma and Hodgkin lymphoma. Dr. Casulo’s research focuses on identifying risk and individual prognosis to address patient's treatment needs and sequence of therapy using a precision approach. Dr. Casulo uses real world, large patient datasets and clinical trials to discover patterns of therapy, new treatments, and ways to improve survival for patients with lymphoma.
Dr. Casulo has presented her work and lectured on various lymphoma topics at numerous conferences, both nationally and internationally. She has been Chair of lymphoma sessions at The American Society of Hematology, The American Society of Clinical Oncology, and The International Conference on Malignant Lymphoma. She is a passionate mentor of students and trainees, and the recipient of numerous teaching and mentoring awards, including the University of Rochester School of Medicine and Dentistry Trainee Academic Mentoring Award in Clinical Programs.
Dr Casulo is a Steering Committee Member and Chair of the Women in Lymphoma Global Organization. She is certified by the American Board of Internal Medicine, in both Hematology and Medical Oncology.
Languages
English, Spanish
Faculty Appointments
Associate Professor - Department of Medicine, Hematology/Oncology (SMD)
Credentials
Residency & Fellowship
Fellowship, Hematology & Oncology, Memorial Sloan-Kettering Cancer Center. 2008 - 2011
Residency, Internal Medicine, Yale New Haven Hospital. 2005 - 2007
Internship, Internal Medicine, Yale New Haven Hospital. 2004 - 2005
Education
MD | SUNY Downstate Health Sciences University - College of Medicine. 2004
Awards
Nominee, Arthur W. Bauman Teaching Award. 2019
Selected among national competitors, AAMC Early Career Women Faculty Leadership Development Seminar. 2018
Nominee, Arthur W. Bauman Teaching Wardy. 2018
Arthur W. Bauman Teaching Award. 2017
Hematology/Oncology Training Program Teacher of the Year Award. 2016
ICARE Patient Centered Bronze Star Award. 2016
National Institute of Health Loan Repayment Award. 2016
Lymphoma Research Foundation Clinical Research Mentoring Program Recipient. 2015
American Society of Hematology Clinical Research Training Institute. 2014
SPORE Career Development Award in Lymphoma Research. 2013 - 2014
Abstract Achievement Award. 2011
Career Development Award (K12 Grant). 2010 - 2012
Competitively Selected. 2009
Latcher Fellowship Award. 2009 - 2010
John W Bracket House Staff Teaching Award. 2008
Intern of the Year. 2005
Golden Key National Honor Society. 1999
Thomas Hunter Honors Program. 1999
Cum Laude. 1999
Research
Clinical Trials
Lead Researcher: Carla Casulo
This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage I and II ...
Lead Researcher: Carla Casulo
This phase III trial compares the effects of nivolumab with chemo-immunotherapy versus chemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as ...
Lead Researcher: Carla Casulo
The overarching goals of this study are to measure levels of circulating tumor DNA (ctDNA) in patients with early stage diffuse large B cell lymphoma (DLBCL), to assess the change in ctDNA during treatment in order to prospectively identify markers o...
Lead Researcher: Carla Casulo
The purpose of this research study is to evaluate a new drug Pembrolizumab in combination with chemotherapy, for Relapsed/Refractory Hodgkin Lymphoma. The chemotherapy regimen is called "ICE" and includes three drugs: ifosfamide, carboplatin, and eto...
Publications
Journal Articles
Welaya K, Casulo C
Hematology/oncology clinics of North America.. 2019 August 33 (4):627-638. Epub 05/18/2019.
Lansigan F, Horwitz SM, Pinter-Brown LC, Rosen ST, Pro B, Hsi ED, Federico M, Gisselbrecht C, Schwartz M, Bellm LA, Acosta M, Shustov AR, Advani RH, Feldman T, Lechowicz MJ, Smith SM, Tulpule A, Craig MD, Greer JP, Kahl BS, Leach JW, Morganstein N, Casulo C, Park SI, Foss FM
Acta haematologica.. 2019 July 17 :1-11. Epub 07/17/2019.
Loh KP, Baran A, Lee CY, Alshaibani A, Rutherford SC, Hu J, Casulo C, Barr PM, Friedberg JW, Reagan PM
Leukemia & lymphoma.. 2019 July 8 :1-4. Epub 07/08/2019.
Casulo C
British journal of haematology.. 2019 June 7 Epub 06/07/2019.
Zelenetz AD, Salles G, Mason KD, Casulo C, Le Gouill S, Sehn LH, Tilly H, Cartron G, Chamuleau MED, Goy A, Tam CS, Lugtenburg PJ, Petrich AM, Sinha A, Samineni D, Herter S, Ingalla E, Szafer-Glusman E, Klein C, Sampath D, Kornacker M, Mobasher M, Morschhauser F
Blood.. 2019 May 2133 (18):1964-1976. Epub 03/08/2019.
Burkitt lymphoma- a rare but challenging lymphoma. Casulo C, Friedberg JW. Best Pract Res Clin Haematol. 2018 Sep;31(3):279-284.
2018; 1.
Casulo C, Nastoupil L, Fowler NH, Friedberg JW, Flowers CR
Annals of oncology : official journal of the European Society for Medical Oncology. 2017 September 128 (9):2094-2106. Epub 1900 01 01.
Carson KR, Horwitz SM, Pinter-Brown LC, Rosen ST, Pro B, Hsi ED, Federico M, Gisselbrecht C, Schwartz M, Bellm LA, Acosta MA, Shustov AR, Advani RH, Feldman TA, Lechowicz MJ, Smith SM, Lansigan F, Tulpule A, Craig MD, Greer JP, Kahl BS, Leach JW, Morganstein N, Casulo C, Park SI, Foss FM
Cancer.. 2017 April 1123 (7):1174-1183. Epub 12/02/2016.
Hsi ED, Horwitz SM, Carson KR, Pinter-Brown LC, Rosen ST, Pro B, Federico M, Gisselbrecht C, Schwartz M, Bellm LA, Acosta M, Collie AM, Gruver AM, Grzywacz BJ, Turakhia S, Shustov AR, Advani RH, Feldman T, Lechowicz MJ, Smith SM, Lansigan F, Tulpule A, Craig MD, Greer JP, Kahl BS, Leach JW, Morganstein N, Casulo C, Park SI, Foss FM
Clinical lymphoma, myeloma & leukemia.. 2017 April 17 (4):193-200. Epub 01/10/2017.
Hunter BD, Herr M, Meacham PJ, Barlaskar F, Evans AG, Burack WR, Liesveld JL, Becker MW, Milner LA, Constine LS, Dhakal S, Barr PM, Friedberg JW, Casulo C
Clinical lymphoma, myeloma & leukemia.. 2017 March 17 (3):145-151. Epub 11/23/2016.
Casulo C, O'Connor O, Shustov A, Fanale M, Friedberg JW, Leonard JP, Kahl BS, Little RF, Pinter-Brown L, Advani R, Horwitz S
Journal of the National Cancer Institute.. 2017 February 109 (2)Epub 12/31/2016.
Casulo C, Friedberg J
Best practice & research. Clinical haematology.. 2017 30 (1-2):131-138. Epub 11/04/2016.
Casulo C
Hematology. 2016 December 22016 (1):269-276. Epub 1900 01 01.
Dhakal S, Bates JE, Casulo C, Friedberg JW, Becker MW, Liesveld JL, Constine LS
International journal of radiation oncology, biology, physics.. 2016 October 196 (2):372-378. Epub 05/27/2016.
Kumar A, Casulo C, Yahalom J, Schöder H, Barr PM, Caron P, Chiu A, Constine LS, Drullinsky P, Friedberg JW, Gerecitano JF, Hamilton A, Hamlin PA, Horwitz SM, Jacob AG, Matasar MJ, McArthur GN, McCall SJ, Moskowitz AJ, Noy A, Palomba ML, Portlock CS, Straus DJ, VanderEls N, Verwys SL, Yang J, Younes A, Zelenetz AD, Zhang Z, Moskowitz CH
Blood.. 2016 September 15128 (11):1458-64. Epub 07/25/2016.
Reagan PM, Baran A, Kelly JL, Barr PM, Casulo C, Chengazi VU, Friedberg JW
Clinical lymphoma, myeloma & leukemia.. 2016 June 16 (6):322-328.e2. Epub 04/02/2016.
Anastasia A, Rossi G
Mediterranean journal of hematology and infectious diseases.. 2016 8 (1):e2016061. Epub 11/01/2016.
Casulo C, Day B, Dawson KL, Zhou X, Flowers CR, Farber CM, Hainsworth JD, Cerhan JR, Link BK, Zelenetz AD, Friedberg JW
Annals of oncology : official journal of the European Society for Medical Oncology. 2015 November 26 (11):2311-7. Epub 09/11/2015.
Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J
Oncotarget.. 2015 June 206 (17):14796-813. Epub 1900 01 01.
Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget, in press May 2015.
Mary Pulvino, Luojing Chen, David Oleksyn, Jing Li, George Compitello, Randy Rossi, Stephen Spence, Vijaya Balakrishnan, Craig Jordan, Brian Poligone, Carla Carla, Richard Burack, Joel Shapiro, Steven Bernstein, Jonathan Friedberg, Raymond Deshaies, Hartmut Land, and Jiyong Zhao.
2015; .
Treatment of Burkitt Lymphoma in Adults. Current Hematologic Malignancy Reports, in press May 2015.
Casulo, C, Friedberg JF.
2015; .
Relapse of Follicular Lymphoma After R-CHOP Defines Patients at High Risk for Death: An Analysis from the National LymphoCare Study. Blood, November 15, 2015.
Casulo, C, Byrtek M, Dawson K, Zhou X, Farber C, Flowers C, Hainsworth J, Maurer M, Cerhn J, Link B, Zelenetz A, Friedberg J. Early.
2015; .
Transformed Follicular Non Hodgkin Lymphoma. Blood, January 2015
Casulo C, Burack R, Friedberg J.
2015; .
Kiebala M, Skalska J, Casulo C, Brookes PS, Peterson DR, Hilchey SP, Dai Y, Grant S, Magginwar SB, Bernstein SH. Dual Targeting of the Thioredoxin and Glutahione Antioxidant Systems in Malignant B Cells: A Novel Synergistic Therapeutic Approach. Exp Hematol 2015 Feb; 42(2): 89-99.
Kiebala M, Skalska J, Casulo C, Brookes PS, Peterson DR, Hilchey SP, Dai Y, Grant S, Magginwar SB, Bernstein SH.
2015; .
A Phase I Study of PRO131921, a Novel Anti-CD20 Monoclonal Antibody in Patients with Relapsed/Refractory CD20+ Indolent NHL: Correlation between Clinical Responses and AUC Pharmacokinetics Corresponding Author: Dr. Carla Casulo
Casulo, C; Vose, J;Ho, W; Kahl,B; Brunvand, M; Goy, A; Kasamon, Y; Cheson,B; Friedberg, J.
2014; .
Systematic Review of the Effectiveness of Fine-Needle Aspiration and/or Core Needle Biopsy for Sub-classifying Lymphoma. Archives of Pathology & Laboratory Medicine, May 2014
Feeney J, Sharma S, Casulo C, Burack R.
2014; .
Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma. Blood, 2014
Barr PM, Miller TP, Friedberg JW, Peterson DR, Baran AM, Herr M, Spier CM, Cui H, Roe DJ, Persky DO, Casulo C, Littleton J, Schwartz M, Puvvada S, Landowski TH, Rimsza LM, Dorr RT, Fisher RI, Bernstein SH, Briehl MM.
2014; .
Casulo C, Schöder H, Feeney J, Lim R, Maragulia J, Zelenetz AD, Horwitz S
Leukemia & lymphoma.. 2013 October 54 (10):2163-7. Epub 03/04/2013.
Casulo C, Arcila M, Bohn OL, Teruya-Feldstein J, Maragulia J, Moskowitz CH
Leukemia research.. 2013 September 37 (9):1178-83. Epub 05/21/2013.
Incidence of Hypogammalobulinemia in Patients Receiving Rituximab and the Use of Intravenous Immunoglobulin for Recurrent Infections
Casulo, C; Maragulia, J; Zelenetz AD.
Clin Lymphoma Myeloma Leukemia. 2013; Epub ahead of print.
Treatment of early-stage follicular lymphoma: do as I say, not as I do
Casulo, C; Friedberg J.
International Journal of Hematologic Oncology. 2013; 2(1): 1-3.
Book Review Lymphoma: Diagnosis and Treatment, Edited by Anas Younes, Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New york, NY; Bertrand Coiffer, Service d'Hematologie CHU Lyon-Sud, Pierre Benite, France, Humana Press, ISBN 978-1-62703-4
Casulo,C.
Leukemia Research. 2013; 37(12): 1757.
Casulo C, Horwitz S
Current oncology reports.. 2010 November 12 (6):374-82. Epub 1900 01 01.
Metabolic Abnormalities Detected in Phase II Evaluation of Doxycycline in Dogs with Multicentric B-Cell Lymphoma.
How I treat early-relapsing follicular lymphoma
Casulo C, Barr PM.
Blood. 2019 Apr 4;133(14):1540-1547. doi: 10.1182/blood-2018-08-822148. Epub 2019 Jan 30. Review.
The role of autologous stem cell transplantation in patients with nodal peripheral T-cell lymphomas in first complete remission: Report from COMPLETE, a prospective, multicenter cohort study.
Park SI, Horwitz SM, Foss FM, Pinter-Brown LC, Carson KR, Rosen ST, Pro B, Hsi ED, Federico M, Gisselbrecht C, Schwartz M, Bellm LA, Acosta M, Advani RH, Feldman T, Lechowicz MJ, Smith SM, Lansigan F, Tulpule A, Craig MD, Greer JP, Kahl BS, Leach JW, Morganstein N, Casulo C, Shustov AR; COMPLETE Investigators.
Cancer. 2019 May 1;125(9):1507-1517. doi: 10.1002/cncr.31861. Epub 2019 Jan 29. Erratum in: Cancer. 2019 Nov 1;125(21):3893.
Rituximab maintenance in elderly patients with follicular lymphoma.
Casulo C.
Leuk Res. 2019 Jan;76:96-97. doi: 0.1016/j.leukres.2018.10.014. Epub 2018 Oct 28. No abstract available.
Ibrutinib Dose Adherence and Therapeutic Efficacy in Non-Hodgkin Lymphoma: A Single-Center Experience.
Williams AM, Baran AM, Casulo C, Reagan P, Friedberg JW, Helber M, Moore J, Baloga E, Zent CS, Barr PM.
Clin Lymphoma Myeloma Leuk. 2019 Jan;19(1):41-47. doi: 10.1016/j.clml.2018.10.005. Epub 2018 Oct 13.
Autologous Transplantation in Follicular Lymphoma with Early Therapy Failure: A National LymphoCare Study and Center for International Blood and Marrow Transplant Research Analysis.
Casulo C, Friedberg JW, Ahn KW, Flowers C, DiGilio A, Smith SM, Ahmed S, Inwards D, Aljurf M, Chen AI, Choe H, Cohen J, Copelan E, Farooq U, Fenske TS, Freytes C, Gaballa S, Ganguly S, Jethava Y, Kamble RT, Kenkre VP, Lazarus H, Lazaryan A, Olsson RF, Rezvani AR, Rizzieri D, Seo S, Shah GL, Shah N, Solh M, Sureda A, William B, Cumpston A, Zelenetz AD, Link BK, Hamadani M.
Biol Blood Marrow Transplant. 2018 Jun;24(6):1163-1171. doi: 10.1016/j.bbmt.2017.12.771. Epub 2017 Dec 11.
When to Choose Transplant in Follicular Lymphoma: Navigating a Complex Landscape.
Casulo C, Flowers CR.
J Oncol Pract. 2017 Dec;13(12):808-809. doi: 10.1200/JOP.2017.028340. No abstract available.
Outcomes of adults and children with primary mediastinal B-cell lymphoma treated with dose-adjusted EPOCH-R.
Giulino-Roth L, O'Donohue T, Chen Z, Bartlett NL, LaCasce A, Martin-Doyle W, Barth MJ, Davies K, Blum KA, Christian B, Casulo C, Smith SM, Godfrey J, Termuhlen A, Oberley MJ, Alexander S, Weitzman S, Appel B, Mizukawa B, Svoboda J, Afify Z, Pauly M, Dave H, Gardner R, Stephens DM, Zeitler WA, Forlenza C, Levine J, Williams ME, Sima JL, Bollard CM, Leonard JP.
Br J Haematol. 2017 Dec;179(5):739-747. doi: 10.1111/bjh.14951. Epub 2017 Oct 29.
Benefit from the inclusion of radiation therapy in the treatment of patients with stage III classical Hodgkin lymphoma: A propensity matched analysis of the Surveillance, Epidemiology, and End Results database.
Bates JE, Dhakal S, Mazloom A, Casulo C, Constine LS.
Radiother Oncol. 2017 Aug;124(2):325-330. doi: 10.1016/j.radonc.2017.07.016. Epub 2017 Aug 1.
Chemotherapy free treatment of indolent lymphoma.
Casulo C, Friedberg JW.
Hematol Oncol. 2017 Jun;35 Suppl 1:20-24. doi: 10.1002/hon.2395. Review. No abstract available.
Books
Lugano Educational Book (2017)
Chapter: Chemotherapy Free Treatment for Follicular Lymphoma
Authors: Carla Casulo
Publisher: Lugano, International Conference for Malignant Lymphoma - Lugano Educational Book 2017
Williams Hematology Malignant Lymphoid Disease (2017)
Chapter: Burkitt Lymphoma
Authors: Carla Casulo, Jonathan Friedberg, and Andrew G. Evans
Publisher: Cenveo Publisher Services 2017
Hematology-Oncology Therapy (2014)
Chapter: Lymphoma, Non Hodgkin
Authors: Schafer-Cutillo J, Casulo C, Friedberg J, Fisher R
Publisher: McGraw-Hill 2014
Non-Hodgkin Lymphoma Cancer Drug Discovery and Development (2013)
Chapter: The Role of Hematopoietic Stem Cell Transplantation in Peripheral T-Cell Lymphomas
Authors: Goldberg JD, Casulo C, Horwitz SM
Publisher: Springer 2013