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Jason Mendler, M.D., Ph.D.

Jason Mendler, M.D., Ph.D.

Cancer

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Appointment (585) 275-5823
Fax (585) 273-1051

About Me

I chose oncology because of its richness and the ability to impact people's lives in a positive way. The field is unmatched in terms of the interpersonal relationships that are developed, medical complexity and research opportunities.

My philosophy is that optimal patient care stems from both...
I chose oncology because of its richness and the ability to impact people's lives in a positive way. The field is unmatched in terms of the interpersonal relationships that are developed, medical complexity and research opportunities.

My philosophy is that optimal patient care stems from both a thorough understanding of the disease process, as well as intimate knowledge of the patient as a human being. I continually work to deepen my relationships with patients in order to improve outcomes.

I am a regular person who is as comfortable coaching my kids' sports teams as I am with a stethoscope around my neck. I love spending time with my family, which includes my wife Ticia and children Caleb, Ava and Megan. My area of expertise includes myeloid leukemias.

Conditions I Treat

- Acute leukemia, all types
- Chronic myeloid leukemia
- Myelodysplastic syndrome
- Myeloproliferative disorders including polycythemia vera, myelofibrosis and essential thrombocythemia

Professional Background

Jason Harold Mendler, MD, PhD, Assistant Professor of Oncology, received his bachelor's degree, Summa Cum Laude, from Washington University in St. Louis, Missouri. He then went on to earn his PhD in Genetics and his medical degree at the University of Rochester School of Medicine and Dentistry in Ro...
Jason Harold Mendler, MD, PhD, Assistant Professor of Oncology, received his bachelor's degree, Summa Cum Laude, from Washington University in St. Louis, Missouri. He then went on to earn his PhD in Genetics and his medical degree at the University of Rochester School of Medicine and Dentistry in Rochester, New York. Prior to joining Wilmot Cancer Center, Dr. Mendler completed his residency at and served as chief resident of the University of Rochester Medical Center, Department of Medicine. Most recently, he completed a clinical fellowship in oncology at Ohio State University Medical Center in Columbus, Ohio and he served one year on the faculty as a clinical instructor. The recipient of numerous awards and honors, Dr. Mendler has also authored several oncology-related publications. His areas of clinical interest include acute leukemia, CML, MDS, bone marrow transplant and myeloproliferative diseases. Dr. Mendler is certified by the American Board of Internal Medicine.

Faculty Appointments

Associate Professor - Department of Medicine, Hematology/Oncology (SMD)

Credentials

Residency & Fellowship

Fellowship, Medical Oncology, Ohio State University Wexner Medical Center. 2009 - 2011

Residency, Internal Medicine, University of Rochester Medical Center. 2006 - 2008

Internship, Internal Medicine, University of Rochester Medical Center. 2005 - 2006

Education

MD | University of Rochester School of Medicine/Dentistry. 2005

PHD | University of Rochester School of Medicine/Dentistry. 2004

Awards

James 14th Annual Scientific Meeting award for one of top 3 Translational Research Poster. 2012

James V. Warren Award for accomplishments as the most outstanding research fellow in the Department of Internal Medicine. 2011

ASH news daily author. 2010

Distinction in research, Internal Medicine Residency Program. 2008

Raphael Dolin Resident Research Award for dedication to patient care, critical scholarship, and teaching. 2008

Rochester city-wide Internal Medicine resident poster day 1st place, scientific division. 2007

Class of 1990 Resident Teaching Award. 2007

: University of Rochester School of Medicine Class of 1976 Prize (In. 2005

Arnold P. Gold Foundation 2004 Humanism in Medicine Essay contest-2nd prize. 2004

Alpha Omega Alpha. 2004

Phi Beta Kappa. 1997

Summa Cum Laude. 1997

Publications

Journal Articles

Exercise and epigenetic ages in older adults with myeloid malignancies.

Loh KP, Sanapala C, Jensen-Battaglia M, Rana A, Sohn MB, Watson E, Gilmore N, Klepin HD, Mendler JH, Liesveld J, Huselton E, LoCastro M, Susiarjo M, Netherby-Winslow C, Williams AM, Mustian K, Vertino P, Janelsins MC

European journal of medical research.. 2023 May 3028 (1):180. Epub 05/30/2023.

Patient preferences, regret, and health-related quality of life among older adults with acute myeloid leukemia: A pilot longitudinal study.

LoCastro M, Wang Y, Sanapala C, Jensen-Battaglia M, Wittink M, Norton S, Klepin HD, Richardson DR, Mendler JH, Liesveld J, Huselton E, Loh KP

Journal of geriatric oncology.. 2023 May 2514 (5):101529. Epub 05/25/2023.

Myelodysplastic syndromes disable human CD271 VCAM1 CD146 niches supporting normal hematopoietic stem/progenitor cells.

Kawano Y, Kawano H, Ghoneim D, Fountaine TJ, Byun DK, LaMere MW, Mendler JH, Ho T, Salama NA, Myers JR, Hussein SE, Frisch BJ, Ashton JM, Azadniv M, Liesveld JL, Kfoury Y, Scadden DT, Becker MW, Calvi LM

bioRxiv : the preprint server for biology.. 2023 April 10 Epub 04/10/2023.

Patient-centered communication tool for older patients with acute myeloid leukemia, their caregivers, and oncologists: A single-arm pilot study.

LoCastro M, Sanapala C, Wang Y, Jensen-Battaglia M, Wittink M, Norton S, Klepin HD, Richardson DR, Mendler JH, Liesveld J, Huselton E, O'Dwyer K, Cortes AM, Rodriguez C, Dale W, Loh KP

Cancer medicine. 2022 December 19 Epub 12/19/2022.

Adaptation of Serious Illness Care Program to be Delivered via Telehealth for Older Patients with Hematologic Malignancy.

Locastro M, Sanapala C, Mendler JH, Norton SA, Bernacki R, Carroll T, Klepin HD, Watson EE, Liesveld JL, Huselton EJ, O'Dwyer KM, Baran AM, Flannery M, Kluger B, Loh KP

Blood advances.. 2022 December 15 Epub 12/15/2022.

Referral to and receipt of allogeneic hematopoietic stem cell transplantation in older adults with acute myeloid leukemia.

Manogna D, Lipof JJ, Baran AM, Said B, Becker MW, Mendler JH, Aljitawi OS, O'Dwyer KM, Huselton E, Burack R, Blaney M, Liesveld JL, Loh KP

Journal of geriatric oncology.. 2022 November 10 Epub 11/10/2022.

The ABNL-MARRO 001 study: a phase 1-2 study of randomly allocated active myeloid target compound combinations in MDS/MPN overlap syndromes.

Moyo TK, Mendler JH, Itzykson R, Kishtagari A, Solary E, Seegmiller AC, Gerds AT, Ayers GD, Dezern AE, Nazha A, Valent P, van de Loosdrecht AA, Onida F, Pleyer L, Cirici BX, Tibes R, Geissler K, Komrokji RS, Zhang J, Germing U, Steensma DP, Wiseman DH, Pfeilstöecker M, Elena C, Cross NCP, Kiladjian JJ, Luebbert M, Mesa RA, Montalban-Bravo G, Sanz GF, Platzbecker U, Patnaik MM, Padron E, Santini V, Fenaux P, Savona MR,

BMC cancer.. 2022 September 2422 (1):1013. Epub 09/24/2022.

Advance care planning in older patients with acute myeloid leukemia and myelodysplastic syndromes.

LoCastro M, Sanapala C, Mendler JH, Norton S, Bernacki R, Carroll T, Klepin H, Watson E, Liesveld J, Huselton E, O'Dwyer K, Baran A, Flannery M, Kluger BM, Loh KP

Journal of geriatric oncology.. 2022 September 10 Epub 09/10/2022.

Older patients' experiences following initial diagnosis of acute myeloid leukemia: A qualitative study.

Abdallah M, Kadambi S, Parsi M, Rai M, Mendler JH, Wittink M, Duberstein PR, Tsang M, Klepin HD, Loh KP

Journal of geriatric oncology.. 2022 September 2 Epub 09/02/2022.

Adapting a patient-centered communication tool for older patients with acute myeloid leukemia and their oncologist.

Watson EE, Sanapala C, Cortes AM, Klepin HD, Wittink M, Norton SA, Richardson DR, Dale W, Magnuson A, Mendler JH, Liesveld JL, Huselton EJ, O'Dwyer KM, LeBlanc TW, El-Jawahri A, Wong M, Loh KP

Blood advances.. 2022 August 5 Epub 08/05/2022.

How Genetics Can Drive Initial Therapy Choices for Older Patients with Acute Myeloid Leukemia.

Moore JW, Torres N, Superdock M, Mendler JH, Loh KP

Current treatment options in oncology.. 2022 June 10 Epub 06/10/2022.

A single-arm pilot study of a mobile health exercise intervention (GO-EXCAP) in older patients with myeloid neoplasms.

Loh KP, Sanapala C, Watson EE, Jensen-Battaglia M, Janelsins MC, Klepin HD, Schnall R, Culakova E, Vertino P, Susiarjo M, Lin PJ, Mendler JH, Liesveld JL, Huselton EJ, Taberner K, Mohile SG, Mustian K

Blood advances.. 2022 March 23 Epub 03/23/2022.

Protocol for a pilot randomized controlled trial of a mobile health exercise intervention for older patients with myeloid neoplasms (GO-EXCAP 2).

Loh KP, Sanapala C, Janelsins M, Klepin HD, Schnall R, Culakova E, Sohn MB, Vertino P, Susiarjo M, Jensen-Battaglia M, Becker MW, Liesveld J, Mendler JH, Huselton E, Lin PJ, Mustian K

Journal of geriatric oncology.. 2021 December 20 Epub 12/20/2021.

A phase II study of sequential decitabine and rapamycin in acute myelogenous leukemia.

Liesveld JL, Baran A, Azadniv M, Misch H, Nedrow K, Becker M, Loh KP, O'Dwyer KM, Mendler JH

Leukemia research.. 2021 November 11112 :106749. Epub 11/11/2021.

Portable Medical Orders and End of Life Measures in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Locastro M, Baran A, Liesveld JL, Huselton EJ, Becker MW, O'Dwyer KM, Aljitawi OS, Baumgart M, Snyder E, Kluger B, Loh KP, Mendler JH

Blood advances.. 2021 September 15 Epub 09/15/2021.

Developing and adapting a mobile health exercise intervention for older patients with myeloid neoplasms: A qualitative study.

Loh KP, Sanapala C, Di Giovanni G, Klepin HD, Janelsins M, Schnall R, Culakova E, Vertino P, Susiarjo M, Mendler JH, Liesveld JL, Lin PJ, Dunne RF, Kleckner I, Mustian K, Mohile SG

Journal of geriatric oncology.. 2021 March 3 Epub 03/03/2021.

Remission of anti-TIF1? dermatomyositis after allogeneic hematopoietic stem cell transplant for myelodysplastic syndrome.

Bawany F, Tbakhi B, Mendler JH, Richardson CT, Bennett JM, Aljitawi OS

Blood advances.. 2020 November 244 (22):5698-5701. Epub 1900 01 01.

Treatment decision-making in acute myeloid leukemia: a qualitative study of older adults and community oncologists.

Loh KP, Abdallah M, Kadambi S, Wells M, Kumar AJ, Mendler JH, Liesveld JL, Wittink M, O'Dwyer K, Becker MW, McHugh C, Stock W, Majhail NS, Wildes TM, Duberstein P, Mohile SG, Klepin HD

Leukemia & lymphoma.. 2020 October 11 :1-12. Epub 10/11/2020.

Barriers to Hematopoietic Cell Transplantation for Adults in the United States: A Systematic Review with a Focus on Age.

Flannelly C, Tan BE, Tan JL, McHugh CM, Sanapala C, Lagu T, Liesveld JL, Aljitawi O, Becker MW, Mendler JH, Klepin HD, Stock W, Wildes TM, Artz A, Majhail NS, Loh KP

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.. 2020 September 19 Epub 09/19/2020.

Management of Acute Myeloid Leukemia (AML) in Older Patients.

Abdallah M, Xie Z, Ready A, Manogna D, Mendler JH, Loh KP

Current oncology reports.. 2020 July 2822 (10):103. Epub 07/28/2020.

Effects of Neddylation and mTOR Inhibition in Acute Myelogenous Leukemia.

Guo N, Azadniv M, Coppage M, Nemer M, Mendler J, Becker M, Liesveld J

Translational oncology.. 2019 January 2712 (4):602-613. Epub 01/27/2019.

Novel mHealth App to Deliver Geriatric Assessment-Driven Interventions for Older Adults With Cancer: Pilot Feasibility and Usability Study.

Loh KP, Ramsdale E, Culakova E, Mendler JH, Liesveld JL, O'Dwyer KM, McHugh C, Gilles M, Lloyd T, Goodman M, Klepin HD, Mustian KM, Schnall R, Mohile SG

JMIR cancer.. 2018 October 294 (2):e10296. Epub 10/29/2018.

ABO identical and washed blood transfusions as candidate strategies to reduce early mortality in acute promyelocytic leukemia.

Sahai T, Henrichs K, Refaai M, Heal JM, Kirkley SA, Schmidt AE, Mendler JH, Masel D, Liesveld J, Aquina C, Blumberg N

Leukemia research.. 2017 November 62 :1-3. Epub 09/23/2017.

Index case of acute myeloid leukemia in a family harboring a novel germ line mutation.

Ram J, Flamm G, Balys M, Sivagnanalingam U, Rothberg PG, Iqbal A, Myers JR, Corbett A, Ashton JM, Mendler JH

Blood advances.. 2017 March 141 (8):500-503. Epub 03/14/2017.

Improved outcomes in acute myeloid leukemia patients treated with washed transfusions.

Greener D, Henrichs KF, Liesveld JL, Heal JM, Aquina CT, Phillips GL, Kirkley SA, Milner LA, Refaai MA, Mendler JH, Szydlowski J, Masel D, Schmidt A, Boscoe FP, Schymura MJ, Blumberg N

American journal of hematology.. 2017 January 92 (1):E8-E9. Epub 1900 01 01.

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression.

Ho TC, LaMere M, Stevens BM, Ashton JM, Myers JR, O'Dwyer KM, Liesveld JL, Mendler JH, Guzman M, Morrissette JD, Zhao J, Wang ES, Wetzler M, Jordan CT, Becker MW

Blood.. 2016 September 29128 (13):1671-8. Epub 07/15/2016.

Spontaneous Remission in an Older Patient with Relapsed ITD Mutant AML.

Vachhani P, Mendler JH, Evans A, Deeb G, Starostik P, Wallace PK, Wang ES

Case reports in hematology.. 2016 2016 :1259759. Epub 12/29/2016.

Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia.

Khalife J, Radomska HS, Santhanam R, Huang X, Neviani P, Saultz J, Wang H, Wu YZ, Alachkar H, Anghelina M, Dorrance A, Curfman J, Bloomfield CD, Medeiros BC, Perrotti D, Lee LJ, Lee RJ, Caligiuri MA, Pichiorri F, Croce CM, Garzon R, Guzman ML, Mendler JH, Marcucci G

Leukemia.. 2015 October 29 (10):1981-92. Epub 05/14/2015.

Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia.

Niederwieser C, Kohlschmidt J, Volinia S, Whitman SP, Metzeler KH, Eisfeld AK, Maharry K, Yan P, Frankhouser D, Becker H, Schwind S, Carroll AJ, Nicolet D, Mendler JH, Curfman JP, Wu YZ, Baer MR, Powell BL, Kolitz JE, Moore JO, Carter TH, Bundschuh R, Larson RA, Stone RM, Mrózek K, Marcucci G, Bloomfield CD

Leukemia.. 2015 March 29 (3):567-75. Epub 09/10/2014.

Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid Leukemia.

Sivagnanalingam U, Balys M, Eberhardt A, Wang N, Myers JR, Ashton JM, Becker MW, Calvi LM, Mendler JH

PloS one.. 2015 10 (7):e0132375. Epub 07/15/2015.

Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8.

Becker H, Maharry K, Mrózek K, Volinia S, Eisfeld AK, Radmacher MD, Kohlschmidt J, Metzeler KH, Schwind S, Whitman SP, Mendler JH, Wu YZ, Nicolet D, Paschka P, Powell BL, Carter TH, Wetzler M, Kolitz JE, Carroll AJ, Baer MR, Caligiuri MA, Stone RM, Marcucci G, Bloomfield CD

Leukemia.. 2014 August 28 (8):1754-1758. Epub 03/21/2014.

GAS6 expression identifies high-risk adult AML patients: potential implications for therapy.

Whitman SP, Kohlschmidt J, Maharry K, Volinia S, Mrózek K, Nicolet D, Schwind S, Becker H, Metzeler KH, Mendler JH, Eisfeld AK, Carroll AJ, Powell BL, Carter TH, Baer MR, Kolitz JE, Park IK, Stone RM, Caligiuri MA, Marcucci G, Bloomfield CD

Leukemia.. 2014 June 28 (6):1252-1258. Epub 12/11/2013.

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome.

Alachkar H, Santhanam R, Maharry K, Metzeler KH, Huang X, Kohlschmidt J, Mendler JH, Benito JM, Hickey C, Neviani P, Dorrance AM, Anghelina M, Khalife J, Tarighat SS, Volinia S, Whitman SP, Paschka P, Hoellerbauer P, Wu YZ, Han L, Bolon BN, Blum W, Mrózek K, Carroll AJ, Perrotti D, Andreeff M, Caligiuri MA, Konopleva M, Garzon R, Bloomfield CD, Marcucci G

The Journal of clinical investigation.. 2014 April 124 (4):1512-24. Epub 03/03/2014.

Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score.

Marcucci G, Yan P, Maharry K, Frankhouser D, Nicolet D, Metzeler KH, Kohlschmidt J, Mrózek K, Wu YZ, Bucci D, Curfman JP, Whitman SP, Eisfeld AK, Mendler JH, Schwind S, Becker H, Bär C, Carroll AJ, Baer MR, Wetzler M, Carter TH, Powell BL, Kolitz JE, Byrd JC, Plass C, Garzon R, Caligiuri MA, Stone RM, Volinia S, Bundschuh R, Bloomfield CD

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2014 February 2032 (6):548-56. Epub 12/30/2013.

Reply to "rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases". Haematologica 2014;99(2):e20-21.

Mendler JH, Marcucci G, Bloomfield CD

Haematologica.. 2014 February 99 (2):e22. Epub 1900 01 01.

Extracellular crystals in plasma cell myeloma.

Brown JT, Burack WR, Becker MW, Vlad-Vonica R, Nadasdy T, Bennett JM, Mendler JH

Leukemia research reports.. 2014 3 (2):49-50. Epub 06/18/2014.

A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia.

Metzeler KH, Maharry K, Kohlschmidt J, Volinia S, Mrózek K, Becker H, Nicolet D, Whitman SP, Mendler JH, Schwind S, Eisfeld AK, Wu YZ, Powell BL, Carter TH, Wetzler M, Kolitz JE, Baer MR, Carroll AJ, Stone RM, Caligiuri MA, Marcucci G, Bloomfield CD

Leukemia.. 2013 October 27 (10):2023-31. Epub 06/14/2013.

In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline.

Mendler JH, Maharry K, Becker H, Eisfeld AK, Senter L, Mrózek K, Kohlschmidt J, Metzeler KH, Schwind S, Whitman SP, Khalife J, Caligiuri MA, Klisovic RB, Moore JO, Carter TH, Marcucci G, Bloomfield CD

Haematologica.. 2013 August 98 (8):e92-4. Epub 06/10/2013.

Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients.

Marcucci G, Maharry KS, Metzeler KH, Volinia S, Wu YZ, Mrózek K, Nicolet D, Kohlschmidt J, Whitman SP, Mendler JH, Schwind S, Becker H, Eisfeld AK, Carroll AJ, Powell BL, Kolitz JE, Garzon R, Caligiuri MA, Stone RM, Bloomfield CD

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2013 June 1031 (17):2086-93. Epub 05/06/2013.

RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.

Mendler JH, Maharry K, Radmacher MD, Mrózek K, Becker H, Metzeler KH, Schwind S, Whitman SP, Khalife J, Kohlschmidt J, Nicolet D, Powell BL, Carter TH, Wetzler M, Moore JO, Kolitz JE, Baer MR, Carroll AJ, Larson RA, Caligiuri MA, Marcucci G, Bloomfield CD

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2012 September 130 (25):3109-18. Epub 07/02/2012.

miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia.

Eisfeld AK, Marcucci G, Maharry K, Schwind S, Radmacher MD, Nicolet D, Becker H, Mrózek K, Whitman SP, Metzeler KH, Mendler JH, Wu YZ, Liyanarachchi S, Patel R, Baer MR, Powell BL, Carter TH, Moore JO, Kolitz JE, Wetzler M, Caligiuri MA, Larson RA, Tanner SM, de la Chapelle A, Bloomfield CD

Blood.. 2012 July 12120 (2):249-58. Epub 04/23/2012.

The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia.

Whitman SP, Caligiuri MA, Maharry K, Radmacher MD, Kohlschmidt J, Becker H, Mrózek K, Wu YZ, Schwind S, Metzeler KH, Mendler JH, Wen J, Baer MR, Powell BL, Carter TH, Kolitz JE, Wetzler M, Carroll AJ, Larson RA, Marcucci G, Bloomfield CD

Leukemia.. 2012 July 26 (7):1713-7. Epub 02/07/2012.

Salvage therapy in Hodgkin's lymphoma.

Mendler JH, Friedberg JW

The oncologist.. 2009 April 14 (4):425-32. Epub 04/02/2009.

Bortezomib and gemcitabine in relapsed or refractory Hodgkin's lymphoma.

Mendler JH, Kelly J, Voci S, Marquis D, Rich L, Rossi RM, Bernstein SH, Jordan CT, Liesveld J, Fisher RI, Friedberg JW

Annals of oncology : official journal of the European Society for Medical Oncology. 2008 October 19 (10):1759-64. Epub 05/25/2008.

A medical experience that taught me about humanism in medicine.

Mendler J

Academic medicine : journal of the Association of American Medical Colleges.. 2005 November 80 (11):1066. Epub 1900 01 01.

TCR antigen-induced cell death occurs from a late G1 phase cell cycle check point.

Lissy NA, Van Dyk LF, Becker-Hapak M, Vocero-Akbani A, Mendler JH, Dowdy SF

Immunity.. 1998 January 8 (1):57-65. Epub 1900 01 01.