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Mello Lab

Welcome to the Mello Lab


The Mello lab is aimed at understanding how protein-coding genes and non-coding RNAs (ncRNAs) regulate transcription in pancreatic preneoplastic lesions and gain knowledge of their impact over cellular transformation and tumor initiation. To date, very little is known about the different processes and cell types that precede cancer. We are committed to describing and characterizing novel genes that play a role during early steps of tumor initiation.

We utilize physiologically relevant in vivo models and a systems biology approach, integrating multiple types of genomic data to delineate important cellular events in tumor initiation. Our research provide insights on early detection of malignant lesions, and in the development of novel strategies to treat pancreatic cancer, pancreatitis and diabetes.





Dr. Mello will be arriving September 2018. If you are interested in joining the lab please contact him at

Stephano Mello, Ph.D.

Stephano Mello, Ph.D.

Principal Investigator


Mello SS, Attardi LD. Neat-en-ing up our understanding of p53 pathways in tumor suppression. Cell Cycle. 2018 Jun 12. doi: 10.1080/15384101.2018.1464835. [Epub ahead of print] PubMed PMID: 29895201.

Mello SS, Attardi LD. Deciphering p53 signaling in tumor suppression. Curr Opin Cell Biol. 2018 Apr;51:65-72. doi: 10.1016/ Epub 2017 Nov 28. Review. PubMed PMID: 29195118; PubMed Central PMCID: PMC5949255.

Mello SS, Valente LJ, Raj N, Seoane JA, Flowers BM, McClendon J, Bieging-Rolett KT, Lee J, Ivanochko D, Kozak MM, Chang DT, Longacre TA, Koong AC, Arrowsmith CH, Kim SK, Vogel H, Wood LD, Hruban RH, Curtis C, Attardi LD. A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. Cancer Cell. 2017 Oct 9;32(4):460-473.e6. doi: 10.1016/j.ccell.2017.09.007. PubMed PMID: 29017057; PubMed Central PMCID: PMC5659188.

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Contact Us

  Mello Lab
601 Elmwood Ave
Rochester, NY 14642