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O'Connell Lab

Welcome to the O'Connell Lab

RNA Biology

The O’Connell lab is focused on understanding the biochemical mechanisms of RNA-mediated gene regulation, and on the development of new tools to study these processes. We are particularly interested in how RNA processing is involved in the control and dynamics of fundamental biological processes (such as cell fate decision and maintenance) and how these processes are dysregulated in disease.

We utilize a range of interdisciplinary approaches including molecular biology, protein and RNA biochemistry, CRISPR gene editing, CRISPR RNA-targeting strategies, structural biology, mass spectrometry, high-throughput sequencing, and bioinformatics to understand these processes.

Mitchell R. O'Connell, Ph.D.

Mitchell R. O'Connell, Ph.D.
Principal Investigator

Mitch O’Connell: A serendipitous path to CRISPR

CRISPR regularly graces health and medicine headlines, with no sign of stopping. Within the sprawling field, University of Rochester professor and researcher Mitch O’Connell is creating a niche by zeroing in on CRISPR-Cas13. His goal? To better understand prokaryotic antiviral immunity and RNA-mediated gene regulation, and to inform the development of RNA detection tools that could improve clinical diagnostics.


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Contact Us

  O'Connell Lab
601 Elmwood Ave
Rochester, NY 14642