URMC / Labs / O'Connell Lab / Publications Publications Liu LXu ZMolina Vargas AMDollery SJSchrlau MGCormier DO'Connell MRTobin GJDu K Aerosol Jet Printing-Enabled Dual-Function Electrochemical and Colorimetric Biosensor for SARS-CoV-2 Detection.; Analytical chemistry. 2023 Jul 28. Vargas AMMOsborn RSinha SArantes PRPatel ADewhurst SPalermo GO'Connell MR New design strategies for ultra-specific CRISPR-Cas13a-based RNA-diagnostic tools with single-nucleotide mismatch sensitivity.; bioRxiv : the preprint server for biology. 2023 Jul 28. Sinha SMolina Vargas AMArantes PRPatel AO'Connell MRPalermo G RNA-mediated Allosteric Activation in CRISPR-Cas13a.; bioRxiv : the preprint server for biology. 2023 Jul 27. Hollinger JWu JAwayda KMO'Connell MRYao P Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli.; Protein expression and purification; Vol 210, pp. 106322. 2023 Jun 15. VanderWal ARPark JUPolevoda BNicosia JKMolina Vargas AMKellogg EHO'Connell MR Csx28 is a membrane pore that enhances CRISPR-Cas13b-dependent antiphage defense.; Science (New York, N.Y.); Vol 380(6643), pp. 410-415. 2023 Apr 27. Knott GJLapinaite AO'Connell MR Methods special issue: RNA-targeting technologies.; Methods (San Diego, Calif.); Vol 212, pp. 10-11. 2023 Feb 13. Molina Vargas AMSinha SOsborn RArantes PRPatel ADewhurst SHardy DJCameron APalermo GO'Connell MR New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity.; Nucleic acids research. 2023 Jan 30. Sinha SMolina Vargas AMArantes PRPatel AO'Connell MRPalermo G Unveiling the RNA-mediated allosteric activation discloses functional hotspots in CRISPR-Cas13a.; Nucleic acids research. 2023 Jan 30. Joseph Davis Burris BMoises Molina Vargas APark BJO'Connell MR Optimization of specific RNA knockdown in mammalian cells with CRISPR-Cas13.; Methods (San Diego, Calif.). 2022 Aug 17. Walker EJBettinger JQWelle KAHryhorenko JRMolina Vargas AMO'Connell MRGhaemmaghami S Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues.; The Journal of biological chemistry. 2022 Mar 25. Broly MPolevoda BVAwayda KMTong NLentini JBesnard TDeb WO'Rourke DBaptista JEllard SAlmannai MHashem MAbdulwahab FShamseldin HAl-Tala SAlkuraya FSLeon Avan Loon RLEFerlini ASanchini MBigoni SCiorba Avan Bokhoven HIqbal ZAl-Maawali AAl-Murshedi FGanesh AAl-Mamari WLim SCPais LSBrown NRiazuddin SBézieau SFu DIsidor BCogné BO'Connell MR THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder.; American journal of human genetics. 2022 Feb 11. Waitkus JChang YLiu LPuttaswamy SVChung TVargas AMMDollery SJO'Connell MRCai HTobin GJBhalla NDu K Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On-Chip CRISPR-Cas13a Sensing.; Advanced materials interfaces; Vol 10(1). 2022 Jan 27. Liu LXu ZAwayda KDollery SJBao MFan JCormier DO'Connell MTobin GJDu K Gold Nanoparticle-Labeled CRISPR-Cas13a Assay for the Sensitive Solid-State Nanopore Molecular Counting.; Advanced materials technologies; Vol 7(3). 2022 Jan 22. Davis BJO'Connell MR Put on Your Para-spectacles: The Development of Optimized CRISPR-Cas13-Based Approaches to Image RNA Dynamics in Real Time.; Molecular cell; Vol 77(2). 2020 Jan 16. Tambe AEast-Seletsky AKnott GJDoudna JAO'Connell MR RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.; Cell reports; Vol 24(4). 2018 Jul 24. O'Connell M Molecular Mechanisms of RNA-Targeting by Cas13-containing Type VI CRISPR-Cas Systems.; Journal of molecular biology. 2018 Jun 22. De Franco SO'Connell MRVandevenne M Engineering RNA-Binding Proteins by Modular Assembly of RanBP2-Type Zinc Fingers.; Methods in molecular biology (Clifton, N.J.); Vol 1867. 2018. Knott GJEast-Seletsky ACofsky JCHolton JMCharles EO'Connell MRDoudna JA Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.; Nature structural & molecular biology; Vol 24(10). 2017 Oct. East-Seletsky AO'Connell MRBurstein DKnott GJDoudna JA RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.; Molecular cell; Vol 66(3). 2017 May 04. East-Seletsky AO'Connell MRKnight SCBurstein DCate JHTjian RDoudna JA Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.; Nature; Vol 538(7624). 2016 Oct 13. Nelles DAFang MYO'Connell MRXu JLMarkmiller SJDoudna JAYeo GW Programmable RNA Tracking in Live Cells with CRISPR/Cas9.; Cell; Vol 165(2). 2016 Apr 07. Ma EHarrington LBO'Connell MRZhou KDoudna JA Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes.; Molecular cell; Vol 60(3). 2015 Nov 05. O'Connell MROakes BLSternberg SHEast-Seletsky AKaplan MDoudna JA Programmable RNA recognition and cleavage by CRISPR/Cas9.; Nature; Vol 516(7530). 2014 Dec 11. Vandevenne MO'Connell MRHelder SShepherd NEMatthews JMKwan AHSegal DJMackay JP Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA.; Angewandte Chemie (International ed. in English); Vol 53(30). 2014 Jul 21. Clifton MKWestman BJThong SYO'Connell MRWebster MWShepherd NEQuinlan KGCrossley MBlobel GAMackay JP The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.; PloS one; Vol 9(8). 2014. Gamsjaeger RO'Connell MRCubeddu LShepherd NELowry JAKwan AHVandevenne MSwanton MKMatthews JMMackay JP A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers.; The Journal of biological chemistry; Vol 288(49). 2013 Dec 06. Bendak KLoughlin FECheung VO'Connell MRCrossley MMackay JP A rapid method for assessing the RNA-binding potential of a protein.; Nucleic acids research; Vol 40(14). 2012 Aug. O'Connell MRVandevenne MNguyen CDMatthews JMGamsjaeger RSegal DJMackay JP Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA.; Angewandte Chemie (International ed. in English); Vol 51(22). 2012 May 29. Burdach JO'Connell MRMackay JPCrossley M Two-timing zinc finger transcription factors liaising with RNA.; Trends in biochemical sciences; Vol 37(5). 2012 May. Hsieh YSWilkinson BLO'Connell MRMackay JPMatthews JMPayne RJ Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants.; Organic letters; Vol 14(7). 2012 Apr 06. O'Connell MRGamsjaeger RMackay JP The structural analysis of protein-protein interactions by NMR spectroscopy.; Proteomics; Vol 9(23). 2009 Dec.