“My goal is to educate my patients about their cancer and help them make the best choice for themselves and their family on how it should be treated. I provide the same level of care that I would give to any member of my family.”

Areas of Expertise

• Liver cancer
• Pancreatic cancer
• Gallbladder and Bile duct cancer
• Metastatic colon cancer to the liver
• Gastric cancer
• Gastrointestinal neuroendocrine tumors

I chose this field to treat hepatobiliary and pancreatic cancer because they are aggressive cancers that require a high degree of complex multidisciplinary oncologic management. This is challenging, but can also be very rewarding. I wanted to apply myself to this field not only to try to help patients afflicted with these cancers, but to also move the field forward through research.

In addition, I chose the field of liver surgery for several reasons. For one, I am fascinated by the liver. It is one of the most complex organs in the body both structurally and functionally and is essential for life. It is one of the most common places that cancers spread to as they progress and, it is the only organ capable of regeneration. As a surgeon, I can use this to my advantage when performing liver surgery as we have techniques to grow more liver when it is necessary to remove a very large part to treat a cancer.

Patients and providers alike can be confident knowing I have devoted the greater part of my career to the study of cancer and the treatment of it. This is due to the strong empathy I have for cancer patients and my intense passion for cancer research. I also have a Ph.D. in molecular and cell biology and have been performing cancer research for over 20 years. I am intensely curious, which drives my desire to understand what we do not know. My curiosity is also fueled by experiences in patient care, resulting in new clinical trials that I lead as well as research conducted by my laboratory.

Certified Specialties

Surgery (General Surgery) - American Board of Surgery

Faculty Appointments

Professor - Department of Surgery, Oncology (SMD)

Professor - Department of Biomedical Genetics (SMD) - Joint

Professor - Cancer Center - Joint

Credentials

Residency & Fellowship

Fellowship, Surgical Oncology, Memorial Sloan-Kettering Cancer Center. 2006 - 2008

Internship, Surgery (General Surgery), Mattel Children's Hospital at UCLA Medical Center. 1997 - 1998

Education

PHD | University of California Los Angeles Medical Center. Pathology, Medical Microbiology. 2003

MD | University of Illinois College of Medicine (USA). 1997

Awards

Elected Membership. 2019

Elected Membership. 2018

Harrington Scholar Innovator Award. 2013

Most Outstanding Faculty Basic Science Research Paper. 2013

Sidney Kimmel Scholar Award. 2012

Scientific Day Research Award. 2006

Scientific Day Research Award. 2005

Scholar in Training Award. 2003

Resident Teaching Award. 2003

Scholar in Training Award. 2001

Postdoctoral Investigators. 2001

Scholar in Training Award. 2000

Medical Honor Society. 1997

Student Abstract Prize. 1994

Student Research Award. 1993

Research

Gastrointestinal cancers such as pancreatic, bile duct and liver cancers are plagued by ineffective systemic therapies underscoring the tremendous unmet need for novel therapies. The Carpizo Laboratory studies cancer biology with an emphasis on developmental therapeutics. Our studies range from early drug discovery projects to translational studies of novel therapies that are about to enter or just have entered into clinical trials. These translational studies employ a variety of experimental systems including mouse cancer models, patient derived tissues as well as therapeutic clinical protocols.

Another major avenue of research in the Carpizo lab is the study of cancer metastasis and dormancy. Most solid organ cancers (i.e. breast, lung, pancreas) are treated with surgery when it appears that the disease has not spread to distant organs. This is highly effective (curative) for a number of tumor types such as breast, prostate, and thyroid cancer. However, for a number of gastrointestinal cancers such as pancreas, liver and bile duct cancer, surgery is relatively ineffective as the majority of these patients go on to suffer metastatic recurrence. This means that at the time of the surgery, they harbor disseminated tumor cells in their bodies that for a period of time after surgery remain dormant. We want to understand what the molecular mechanisms that control cancer dormancy are, what awakens these cells and how can we devise therapies that either maintain the dormant state, or drive the cells into senescence.

Research Lab

Visit Research Lab Website

Publications

Journal Articles

Protocol for isolating extracellular vesicles from pancreatic cancer cells for liver metastatic niche research.

Casabianca A, Bellina M, Dudgeon C, Nezhad MS, Harris C, Fiore S, Bernet A, Narrow W, Prela O, Wang L, Astsaturov I, Mehlen P, Carpizo DR

STAR protocols.. 2024 September 205 (3):103256. Epub 08/13/2024.

Transforming the Future of Surgeon-Scientists.

Ladner DP, Goldstein AM, Billiar TR, Cameron AM, Carpizo DR, Chu DI, Coopersmith CM, DeMatteo RP, Feng SH, Gallagher KA, Gillanders WE, Lal BK, Lipshutz GS, Liu A, Maier RV, Mittendorf EA, Morris AM, Sicklick JK, Velazquez OC, Whitson BA, Wilke LG, Yoon SS, Zeiger MA, Farmer DL, Hwang ES,

Annals of surgery.. 2024 February 1279 (2):231-239. Epub 11/02/2023.

Identifying the optimal treatment strategy in patients with resectable non-cardia gastric cancer.

Ajay PS, Rajamanickam RK, Rhee K, NeMoyer R, Goyal S, Switchenko JM, Lin Y, Jabbour SK, Carpizo DR, Kennedy TJ, Shah MM

Surgical endoscopy.. 2024 January 38 (1):136-147. Epub 11/07/2023.

Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling.

Dudgeon C, Casabianca A, Harris C, Ogier C, Bellina M, Fiore S, Bernet A, Ducarouoge B, Goldschneider D, Su X, Pitarresi J, Hezel A, De S, Narrow W, Soliman F, Shields C, Vendramini-Costa DB, Prela O, Wang L, Astsaturov I, Mehlen P, Carpizo DR

Cell reports.. 2023 November 2842 (11):113369. Epub 11/03/2023.

Does non-metastatic gastric cancer of the cardia warrant a different treatment strategy?

Ajay PS, NeMoyer R, Goyal S, Switchenko JM, Lin Y, Jabbour SK, Carpizo DR, Paulos CM, Kennedy TJ, Shah MM

Journal of surgical oncology.. 2023 August 128 (2):231-241. Epub 04/10/2023.

Surgery in combination with systemic chemotherapy is associated with improved survival in stage IV gallbladder cancer.

Casabianca AS, Tsagkalidis V, Burchard PR, Chacon A, Melucci A, Reitz A, Swift DA, McCook AA, Switchenko JM, Shah MM, Carpizo DR

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.. 2022 December 48 (12):2448-2454. Epub 06/22/2022.

A review of hepatic epithelioid hemangioendothelioma-Analyzing patient characteristics and treatment strategies.

Ajay PS, Tsagkalidis V, Casabianca A, Burchard PR, Melucci AD, Chacon A, Goyal S, Switchenko JM, Kooby DA, Carpizo DR, Shah MM

Journal of surgical oncology.. 2022 December 126 (8):1423-1429. Epub 08/17/2022.

Reply to: Radical treatment for stage IV gallbladder cancers: Is surgery a worthwhile exercise in advanced cancers?

Ajay PS, Casabianca A, Shah MM, Carpizo DR

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.. 2022 December 48 (12):2570-2571. Epub 08/27/2022.

ASO Author Reflections: Pretreatment CA 19-9 Threshold of 98 U/mL is a Reasonable Cutoff for Prognostication of Clinical Stage I and II Pancreatic Cancer.

Melucci AD, Carpizo DR, Shah MM

Annals of surgical oncology.. 2022 December 29 (13):8548-8549. Epub 09/10/2022.

The Impact of Carbohydrate Antigen 19-9 on Survival in Patients with Clinical Stage I and II Pancreatic Cancer.

Melucci AD, Chacon AC, Burchard PR, Tsagkalidis V, Casabianca AS, Goyal S, Switchenko JM, Kooby DA, Staley CA, Carpizo DR, Shah MM

Annals of surgical oncology.. 2022 December 29 (13):8536-8547. Epub 09/19/2022.

Surgery is Associated With Improved Overall Survival in Patients With Metastatic Gastric Cancer: A National Cancer Database Analysis.

Greco SH, Chao JC, Heath NG, Lin Y, Gall VA, Grandhi MS, Kennedy TJ, Carpizo DR, Alexander HR, Langan RC, August DA

The American surgeon.. 2022 November 88 (11):2637-2643. Epub 06/01/2022.

Tumor microbiome links cellular programs and immunity in pancreatic cancer.

Ghaddar B, Biswas A, Harris C, Omary MB, Carpizo DR, Blaser MJ, De S

Cancer cell.. 2022 October 1040 (10):1240-1253.e5. Epub 1900 01 01.

ASO Visual Abstract: The Impact of Carbohydrate Antigen 19-9 on Survival in Patients with Clinical Stage I and II Pancreatic Cancer.

Melucci AD, Chacon AC, Burchard PR, Tsagkalidis V, Casabianca AS, Goyal S, Switchenko JM, Kooby DA, Staley CA, Carpizo DR, Shah MM

Annals of surgical oncology.. 2022 September 10 Epub 09/10/2022.

Early postoperative ERAS compliance predicts decreased length of stay and complications following liver resection.

Burchard PR, Dave YA, Loria AP, Parikh NB, Pineda-Solis K, Ruffolo LI, Strawderman M, Schoeniger LO, Galka E, Tomiyama K, Orloff MS, Carpizo DR, Linehan DC, Hernandez-Alejandro R

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2022 September 24 (9):1425-1432. Epub 01/25/2022.

Management of hepatic haemangioma in pregnancy.

Casabianca AS, Hernandez Caballero AI, Thornburg LL, Carpizo D

BMJ case reports.. 2022 June 1015 (6)Epub 06/10/2022.

Defining the role of systemic therapy in resectable pancreatic acinar cell carcinoma.

Burchard PR, Chacon AC, Melucci A, Casabianca AS, Goyal S, Switchenko JM, Maithel SK, Kooby DA, Carpizo DR, Shah MM

Journal of surgical oncology.. 2022 April 125 (5):856-864. Epub 01/07/2022.

p53 and Zinc: A Malleable Relationship.

Ha JH, Prela O, Carpizo DR, Loh SN

Frontiers in molecular biosciences.. 2022 9 :895887. Epub 04/13/2022.

Urea Denaturation, Zinc Binding, and DNA Binding Assays of Mutant p53 DNA-binding Domains and Full-length Proteins.

Ha JH, Yu X, Carpizo DR, Loh SN

Bio-protocol.. 2021 October 2011 (20):e4188. Epub 10/20/2021.

Genetic Drivers of Ileal Neuroendocrine Tumors.

Carpizo DR, Harris CR

Cancers.. 2021 October 1013 (20)Epub 10/10/2021.

Delayed cytokine release syndrome after neoadjuvant nivolumab: a case report and literature review.

Ciner AT, Hochster HS, August DA, Carpizo DR, Spencer KR

Immunotherapy.. 2021 September 13 (13):1071-1078. Epub 07/21/2021.

Does Major Pancreatic Surgery Have Utility in Nonagenarians with Pancreas Cancer?

Meltzer RS, Kooby DA, Switchenko JM, Datta J, Carpizo DR, Maithel SK, Shah MM

Annals of surgical oncology.. 2021 April 28 (4):2265-2272. Epub 11/03/2020.

Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.

Gilleran JA, Yu X, Blayney AJ, Bencivenga AF, Na B, Augeri DJ, Blanden AR, Kimball SD, Loh SN, Roberge JY, Carpizo DR

Journal of medicinal chemistry.. 2021 February 2564 (4):2024-2045. Epub 02/04/2021.

ASO Visual Abstract: Does Major Pancreatic Surgery have Utility for Nonagenarians with Pancreas Cancer?

Meltzer RS, Kooby DA, Switchenko JM, Datta J, Carpizo DR, Maithel SK, Shah MM

Annals of surgical oncology.. 2021 January 7 Epub 01/07/2021.

Safety and feasibility of initiating a hepatic artery infusion pump chemotherapy program for unresectable colorectal liver metastases: A multicenter, retrospective cohort study.

Muaddi H, D'Angelica M, Wiseman JT, Dillhoff M, Latchana N, Roke R, Ko YJ, Carpizo D, Spencer K, Fields RC, Williams G, Aucejo F, Acevedo-Moreno LA, Billingsley KG, Walker BS, Mayo SC, Karanicolas PJ

Journal of surgical oncology.. 2021 January 123 (1):252-260. Epub 10/23/2020.

Neoadjuvant therapy is associated with lower margin positivity rates after Pancreaticoduodenectomy in T1 and T2 pancreatic head cancers: An analysis of the National Cancer Database.

Greco SH, August DA, Shah MM, Chen C, Moore DF, Masanam M, Turner AL, Jabbour SK, Javidian P, Grandhi MS, Kennedy TJ, Alexander HR, Carpizo DR, Langan RC

Surgery open science.. 2021 January 3 :22-28. Epub 12/16/2020.

Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants.

Blanden AR, Yu X, Blayney AJ, Demas C, Ha JH, Liu Y, Withers T, Carpizo DR, Loh SN

eLife.. 2020 December 29 Epub 12/02/2020.

Conditional survival analysis of hepatocellular carcinoma.

Shah MM, Meyer BI, Rhee K, NeMoyer RE, Lin Y, Tzeng CD, Jabbour SK, Kennedy TJ, Nosher JL, Kooby DA, Maithel SK, Carpizo DR

Journal of surgical oncology.. 2020 September 122 (4):684-690. Epub 06/10/2020.

Clinical Trials for the Surgical Oncologist: Opportunities and Hurdles.

Park KU, Mamounas EP, Katz MHG, Unzeitig G, Carpizo D, You YN, Francescatti A, Hunt KK, Boughey JC

Annals of surgical oncology.. 2020 July 27 (7):2269-2275. Epub 04/21/2020.

Disparities in utilization of services for racial and ethnic minorities with hepatocellular carcinoma associated with hepatitis C.

Kangas-Dick A, Gall V, Hilden P, Turner A, Greenbaum A, Sesti J, Paul S, Carpizo D, Kennedy T, Sadaria Grandhi M, Alexander HR, Wang S, Geffner S, August D, Langan RC

Surgery.. 2020 July 168 (1):49-55. Epub 05/13/2020.

IGF2 drives formation of ileal neuroendocrine tumors in patients and mice.

Contractor T, Clausen R, Harris G, Rosenfeld J, Carpizo D, Tang L, Harris C

Endocrine-related cancer.. 2020 March 27 (3):175-186. Epub 1900 01 01.

Subcategorizing T1 Staging in Pancreatic Adenocarcinoma Predicts Survival in Patients Undergoing Resection: An Analysis of the National Cancer Database.

Shah MM, NeMoyer RE, Greco SH, Chen C, Moore DF, Grandhi MS, Langan RC, Kennedy TJ, Javidian P, Jabbour SK, Alexander HR, August DA, Carpizo DR

Journal of pancreatic cancer.. 2020 6 (1):64-72. Epub 07/14/2020.

The Evolving Role of Radiotherapy in Locally Advanced Rectal Cancer and the Potential for Nonoperative Management.

Khullar K, Patel NM, Anderson C, Chundury A, Carpizo D, Feingold D, Grandhi M, Hochster H, Jani K, Kennedy T, Langan R, Spencer K, August D, Jabbour SK

Oncology & hematology review.. 2020 16 (1):43-51. Epub 04/27/2020.

Outcomes Following Major Oncologic Operations for Non-AIDS-Defining Cancers in the HIV Population: A Matched Comparison to the General Population.

Chi A, Adams BE, Sesti J, Paul S, Turner AL, August D, Carpizo D, Kennedy T, Grandhi M, Alexander HR, Libutti SK, Geffner S, Langan RC

World journal of surgery.. 2019 December 43 (12):3019-3026. Epub 1900 01 01.

Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding.

Zaman S, Yu X, Bencivenga AF, Blanden AR, Liu Y, Withers T, Na B, Blayney AJ, Gilleran J, Boothman DA, Loh SN, Kimball SD, Carpizo DR

Molecular cancer therapeutics.. 2019 August 18 (8):1355-1365. Epub 06/13/2019.

Conditional Survival Analysis of Metastatic Colorectal Cancer Patients Living ?24 Months: A Single Institutional Study.

Ali ND, Donohue K, Zandieh S, Chen C, Moore D, Poplin E, Shah MM, Nosher J, Gui B, Jabbour SK, Spencer K, Carpizo DR

American journal of clinical oncology.. 2019 June 42 (6):512-518. Epub 1900 01 01.

Aberrant arc between the common hepatic artery and a replaced right hepatic artery resulting in misperfusion in a patient with a hepatic arterial infusion pump.

Hasan O, Greco S, Kennedy T, Carpizo D, Kempf J, Nosher J

Surgical and radiologic anatomy : SRA.. 2019 March 41 (3):355-358. Epub 01/05/2019.

Liver haematoma as a presentation of peliosis hepatis.

Dave YA, Gupta A, Shah MM, Carpizo D

BMJ case reports.. 2019 February 2212 (2)Epub 02/22/2019.

Flipping the "switch" on mutant p53 by zinc metallochaperones: how a brief pulse of zinc can reactivate mutant p53 to kill cancer.

Yu X, Carpizo DR

Oncotarget.. 2019 January 2910 (9):918-919. Epub 01/29/2019.

Therapeutic targeting of and mutant breast cancer through mutant p53 reactivation.

Na B, Yu X, Withers T, Gilleran J, Yao M, Foo TK, Chen C, Moore D, Lin Y, Kimball SD, Xia B, Ganesan S, Carpizo DR

NPJ breast cancer.. 2019 5 :14. Epub 04/15/2019.

Rethinking the Role of Radiation Therapy in the Treatment of Unresectable Hepatocellular Carcinoma: A Data Driven Treatment Algorithm for Optimizing Outcomes.

Sayan M, Yegya-Raman N, Greco SH, Gui B, Zhang A, Chundury A, Grandhi MS, Hochster HS, Kennedy TJ, Langan RC, Malhotra U, Rustgi VK, Shah MM, Spencer KR, Carpizo DR, Nosher JL, Jabbour SK

Frontiers in oncology.. 2019 9 :345. Epub 06/18/2019.

Modernizing the clinical risk score to more accurately predict survival following resection of colorectal liver metastases.

Langan RC, Carpizo DR

Translational gastroenterology and hepatology.. 2019 4 :49. Epub 06/26/2019.

Zinc Metallochaperones Reactivate Mutant p53 Using an ON/OFF Switch Mechanism: A New Paradigm in Cancer Therapeutics.

Yu X, Kogan S, Chen Y, Tsang AT, Withers T, Lin H, Gilleran J, Buckley B, Moore D, Bertino J, Chan C, Kimball SD, Loh SN, Carpizo DR

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2018 September 1524 (18):4505-4517. Epub 06/18/2018.

Assessment of the Albumin-Bilirubin (ALBI) Grade as a Prognostic Indicator for Hepatocellular Carcinoma Patients Treated With Radioembolization.

Gui B, Weiner AA, Nosher J, Lu SE, Foltz GM, Hasan O, Kim SK, Gendel V, Mani NB, Carpizo DR, Saad NE, Kennedy TJ, Zuckerman DA, Olsen JR, Parikh PJ, Jabbour SK

American journal of clinical oncology.. 2018 September 41 (9):861-866. Epub 1900 01 01.

Predictors of Survival after Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases.

Weiner AA, Gui B, Newman NB, Nosher JL, Yousseff F, Lu SE, Foltz GM, Carpizo D, Lowenthal J, Zuckerman DA, Benson B, Olsen JR, Jabbour SK, Parikh PJ

Journal of vascular and interventional radiology : JVIR.. 2018 August 29 (8):1094-1100. Epub 05/10/2018.

Adjuvant therapeutic strategies for resectable pancreatic adenocarcinoma.

Yegya-Raman N, Shah MM, Grandhi MS, Poplin E, August DA, Kennedy TJ, Malhotra U, Spencer KR, Carpizo DR, Jabbour SK

Annals of pancreatic cancer.. 2018 August 1 Epub 08/06/2018.

Accessory bile duct: a rare but important anatomical variant.

Casabianca AS, Shah MM, Carpizo D

BMJ case reports.. 2018 June 172018 Epub 06/17/2018.

Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics.

Kogan S, Carpizo DR

Cancers.. 2018 May 2910 (6)Epub 05/29/2018.

Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.

Shimada K, Reznik E, Stokes ME, Krishnamoorthy L, Bos PH, Song Y, Quartararo CE, Pagano NC, Carpizo DR, deCarvalho AC, Lo DC, Stockwell BR

Cell chemical biology.. 2018 May 1725 (5):585-594.e7. Epub 03/22/2018.

A novel combined interventional radiologic and hepatobiliary surgical approach to a complex traumatic hilar biliary stricture.

NeMoyer RE, Shah MM, Hasan O, Nosher JL, Carpizo DR

International journal of surgery case reports.. 2018 44 :185-190. Epub 03/03/2018.

U1 Adaptors Suppress the Oncogenic Axis in Human Pancreatic Cancer Xenografts.

Tsang AT, Dudgeon C, Yi L, Yu X, Goraczniak R, Donohue K, Kogan S, Brenneman MA, Ho ES, Gunderson SI, Carpizo DR

Molecular cancer therapeutics.. 2017 August 16 (8):1445-1455. Epub 04/04/2017.

A Comparison of Yttrium-90 Microsphere Radioembolization to Hepatic Arterial Infusional Chemotherapy for Patients with Chemo-refractory Hepatic Colorectal Metastases.

Cercek A, Gendel V, Jabbour S, Moore D, Chen C, Nosher J, Capanu M, Chou JF, Boucher T, Kemeny N, Carpizo DR

Current treatment options in oncology.. 2017 July 18 (7):42. Epub 1900 01 01.

Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

Yu X, Blanden A, Tsang AT, Zaman S, Liu Y, Gilleran J, Bencivenga AF, Kimball SD, Loh SN, Carpizo DR

Molecular pharmacology.. 2017 June 91 (6):567-575. Epub 03/20/2017.

Pharmacological targeting of mutant p53.

Kogan S, Carpizo D

Translational cancer research.. 2016 December 5 (6):698-706. Epub 1900 01 01.

Corrigendum to "Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer" [Drug Discov. Today 20 (11) (2015) 1391-1397].

Blanden AR, Yu X, Loh SN, Levine AJ, Carpizo DR

Drug discovery today.. 2016 October 21 (10):1728. Epub 07/29/2016.

Fluid administration and morbidity in transhiatal esophagectomy.

Eng OS, Arlow RL, Moore D, Chen C, Langenfeld JE, August DA, Carpizo DR

The Journal of surgical research.. 2016 January 200 (1):91-7. Epub 07/16/2015.

A sensitive liquid chromatography-mass spectrometry bioanalytical assay for a novel anticancer candidate--ZMC1.

Lin H, Yu X, Eng OS, Buckley B, Kong AN, Bertino JR, Carpizo DR, Gounder MK

Biomedical chromatography : BMC.. 2015 November 29 (11):1708-14. Epub 05/05/2015.

Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer.

Blanden AR, Yu X, Loh SN, Levine AJ, Carpizo DR

Drug discovery today.. 2015 November 20 (11):1391-7. Epub 07/20/2015.

Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2.

Yue W, Zheng X, Lin Y, Yang CS, Xu Q, Carpizo D, Huang H, DiPaola RS, Tan XL

Oncotarget.. 2015 August 286 (25):21208-24. Epub 1900 01 01.

Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing.

Chiou SH, Winters IP, Wang J, Naranjo S, Dudgeon C, Tamburini FB, Brady JJ, Yang D, Grüner BM, Chuang CH, Caswell DR, Zeng H, Chu P, Kim GE, Carpizo DR, Kim SK, Winslow MM

Genes & development.. 2015 July 1529 (14):1576-85. Epub 07/15/2015.

Hepatocellular Carcinoma Without Cirrhosis Presenting With Hypercalcemia: Case Report and Literature Review.

Newman NB, Jabbour SK, Hon JD, Berman JJ, Malik D, Carpizo D, Moss RA

Journal of clinical and experimental hepatology.. 2015 June 5 (2):163-6. Epub 04/18/2015.

Early vs. Late Chemoradiation Therapy and the Postoperative Interval to Adjuvant Therapy Do Not Correspond to Local Recurrence in Resected Pancreatic Cancer.

Patel AA, Nagarajan S, Scher ED, Schonewolf CA, Balasubramanian S, Poplin E, Moss R, August D, Carpizo D, Melstrom L, Jabbour SK

Pancreatic disorders & therapy.. 2015 June 5 (2)Epub 04/02/2015.

Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore.

Blanden AR, Yu X, Wolfe AJ, Gilleran JA, Augeri DJ, O'Dell RS, Olson EC, Kimball SD, Emge TJ, Movileanu L, Carpizo DR, Loh SN

Molecular pharmacology.. 2015 May 87 (5):825-31. Epub 02/20/2015.

Outcomes of microwave ablation for colorectal cancer liver metastases: a single center experience.

Eng OS, Tsang AT, Moore D, Chen C, Narayanan S, Gannon CJ, August DA, Carpizo DR, Melstrom LG

Journal of surgical oncology.. 2015 March 15111 (4):410-3. Epub 12/29/2014.

The relationship of perioperative fluid administration to outcomes in colorectal and pancreatic surgery: a review of the literature.

Eng OS, Melstrom LG, Carpizo DR

Journal of surgical oncology.. 2015 March 15111 (4):472-7. Epub 02/02/2015.

Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism.

Yu X, Blanden AR, Narayanan S, Jayakumar L, Lubin D, Augeri D, Kimball SD, Loh SN, Carpizo DR

Oncotarget.. 2014 October 155 (19):8879-92. Epub 1900 01 01.

Small molecule compounds targeting the p53 pathway: are we finally making progress?

Yu X, Narayanan S, Vazquez A, Carpizo DR

Apoptosis : an international journal on programmed cell death.. 2014 July 19 (7):1055-68. Epub 1900 01 01.

Pilot study of angiogenic response to yttrium-90 radioembolization with resin microspheres.

Carpizo DR, Gensure RH, Yu X, Gendel VM, Greene SJ, Moore DF, Jabbour SK, Nosher JL

Journal of vascular and interventional radiology : JVIR.. 2014 February 25 (2):297-306.e1. Epub 12/20/2013.

Safety and efficacy of LigaSure usage in pancreaticoduodenectomy.

Eng OS, Goswami J, Moore D, Chen C, Brumbaugh J, Gannon CJ, August DA, Carpizo DR

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2013 October 15 (10):747-52. Epub 06/19/2013.

Intraoperative fluid administration is associated with perioperative outcomes in pancreaticoduodenectomy: a single center retrospective analysis.

Eng OS, Goswami J, Moore D, Chen C, Gannon CJ, August DA, Carpizo DR

Journal of surgical oncology.. 2013 September 108 (4):242-7. Epub 08/01/2013.

Repair of a post-hepatectomy posterior sectoral duct injury secondary to anomalous bile duct anatomy using a novel combined surgical-interventional radiologic approach.

Shanker BA, Eng OS, Gendel V, Nosher J, Carpizo DR

Case reports in surgery.. 2013 2013 :202315. Epub 09/12/2013.

Evaluation of hepatic tumor response to yttrium-90 radioembolization therapy using texture signatures generated from contrast-enhanced CT images.

Gensure RH, Foran DJ, Lee VM, Gendel VM, Jabbour SK, Carpizo DR, Nosher JL, Yang L

Academic radiology.. 2012 October 19 (10):1201-7. Epub 07/26/2012.

Allele-specific p53 mutant reactivation.

Yu X, Vazquez A, Levine AJ, Carpizo DR

Cancer cell.. 2012 May 1521 (5):614-625. Epub 1900 01 01.

Dose-painted intensity modulated radiation therapy improves local control for locally advanced pancreas cancer.

Tunceroglu A, Park JH, Balasubramanian S, Poppe M, Anker CJ, Poplin E, Moss RA, Yue NJ, Carpizo D, Gannon CJ, Haffty BG, Jabbour SK

ISRN oncology.. 2012 2012 :572342. Epub 10/18/2012.

Liver resection for metastatic colorectal cancer in the presence of extrahepatic disease.

Carpizo DR, D'Angelica M

Annals of surgical oncology.. 2009 September 16 (9):2411-21. Epub 06/25/2009.

Liver resection for metastatic colorectal cancer in patients with concurrent extrahepatic disease: results in 127 patients treated at a single center.

Carpizo DR, Are C, Jarnagin W, Dematteo R, Fong Y, Gönen M, Blumgart L, D'Angelica M

Annals of surgical oncology.. 2009 August 16 (8):2138-46. Epub 06/03/2009.

Liver resection for metastatic colorectal cancer in the presence of extrahepatic disease.

Carpizo DR, D'Angelica M

The Lancet. Oncology.. 2009 August 10 (8):801-9. Epub 1900 01 01.

Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion.

Rodríguez-Manzaneque JC, Carpizo D, Plaza-Calonge Mdel C, Torres-Collado AX, Thai SN, Simons M, Horowitz A, Iruela-Arispe ML

The international journal of biochemistry & cell biology.. 2009 April 41 (4):800-10. Epub 08/15/2008.

Management and extent of resection for intrahepatic cholangiocarcinoma.

Carpizo DR, D'Angelica M

Surgical oncology clinics of North America.. 2009 April 18 (2):289-305, viii-ix. Epub 1900 01 01.

Current management of cystic neoplasms of the pancreas.

Carpizo DR, Allen PJ, Brennan MF

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.. 2008 October 6 (5):298-307. Epub 1900 01 01.

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.

Lee S, Jilani SM, Nikolova GV, Carpizo D, Iruela-Arispe ML

The Journal of cell biology.. 2005 May 23169 (4):681-91. Epub 1900 01 01.

ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165.

Luque A, Carpizo DR, Iruela-Arispe ML

The Journal of biological chemistry.. 2003 June 27278 (26):23656-65. Epub 04/25/2003.

ADAMTS1: a matrix metalloprotease with angioinhibitory properties.

Iruela-Arispe ML, Carpizo D, Luque A

Annals of the New York Academy of Sciences.. 2003 May 995 :183-90. Epub 1900 01 01.

Endogenous regulators of angiogenesis--emphasis on proteins with thrombospondin--type I motifs.

Carpizo D, Iruela-Arispe ML

Cancer metastasis reviews.. 2000 19 (1-2):159-65. Epub 1900 01 01.

Acute acid exposure increases rabbit esophageal cell proliferation.

Carpizo DR, Reaka AJ, Glaws WR, Pooley N, Schmidt L, Halline AG, Goldstein JL, Layden TJ

The Journal of laboratory and clinical medicine.. 1998 February 131 (2):157-62. Epub 1900 01 01.

Books

Precision Molecular Pathology of Liver Cancer (2018)

Authors: Greco SH, Spencer K, Carpizo DR

Publisher: Springer Publishing 2018

: Metastatic Liver Cancer in Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach. (2008)

Authors: Fong Y, Carpizo D, Kemeny NE, Covey AM, Willet CG, Czito BG

Publisher: Blackwell Publishing 2008

Handbook of Re-operative General Surgery (2004)

Chapter: Brooks: Re-operative Breast Surgery

Authors: Chang H, Carpizo, DR

Publisher: Blackwell Publishing, Inc., Malden, MA 2004

Ratings & Comments

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Ratings

During this visit, did this provider spend enough time with you?

4.9

During this visit, did this provider show respect for what you had to say?

5.0

During this visit did this provider give you easy to understand information about these health questions or concerns?

4.8

During this visit, did this provider listen carefully to you?

5.0

During this visit, did this provider explain things in a way that was easy to understand?

4.9

Patient Comments

I felt I was with the "A" team, and would be well taken care of.

Sep 23, 2024

Excellent visit with Dr. Carpizo. He's mature and was open to my experience helping a friend go through the Whipple procedure, which was very negative for her and for me. He also understands concern of elderly facing serious illness (I'm 86). H promised a follow-up for treatment (I received call for that today). Dr. Carpizo explained function of the pancreas and showed me the CT scan I had of it several weeks ago. He increased my confidence in making a good future decision about treatment options.

Sep 03, 2024

All good

Aug 25, 2024

5.0

Dr. Carpizo was thorough discussing my MRI. He answered all my concerns and questions.

Feb 26, 2024

5.0

Provided detailed explanation of my condition in terms that I could easily understand - Doc Carpizo & nurse were excellent as both listened attentively to my concerns.

Feb 06, 2024

5.0

Outstanding - went above & beyond to help me & even spoke to my [...] provider to do what was best for me.

Aug 22, 2023

5.0

Dr. Carpizo is the first surgeon I have ever met with a good "bedside manner.

May 05, 2023

Dr Carpizo is absolutely the finest physician I have ever encountered

Feb 19, 2023

5.0

Excellent bedside manner/wonderful sense of humor!

Feb 07, 2023

5.0

We were very thankful for the amount of time Dr Carpizo spent with us during this visit. He listened to everything we had to say and made us feel very confident that Dr Carpizo understands this very long standing health issue and is competent to resolve it.

Jun 30, 2022

5.0

Couldn't be better

Mar 05, 2022