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Land Lab

Welcome to the Land Lab

cancer cells

Cancer cells: blue is cell nucleus
and yellow represents the garbage recycling process
that occurs as cancer grows.

Cooperation of oncogenic mutations in the control of malignancy:

  • Understand the molecular basis for oncogene cooperation
  • Identify unique features of gene networks in cancer cells vs. normal cells
  • Exploit such features of cancer cells for targeted approaches towards therapeutic intervention
  • Systems biology of cancer cells

Carcinogenesis is a process driven by multiple co-operating oncogenic mutations in which features of the cancer cell phenotype, such as proliferative advantage, only emerge as a result of the interplay between these mutations. This is consistent with the notion that many divergent cancers share a limited number of disease mechanisms with common underlying signaling networks, despite the many genes implicated in the disease.

The Land laboratory has pioneered investigation of the nature and underlying principles of cancer gene cooperation originating with the discovery that multiple oncogenic mutations are required for malignant cell transformation. Using a wide variety of experimental approaches, including genomics and systems biology, the laboratory has demonstrated that the cooperation of cancer-promoting genetic lesions is strongly reflected by synergistic modulation in signaling and the gene networks of malignant cells.

Hartmut K. Land, Ph.D.

Hartmut K. Land, Ph.D.

Principal Investigator

Selected Publications

Smith, B., Schafer, X. L., Ambeskovic, A., Spencer, C. M., Land, H. and Munger, J. (2016) Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells. Cell Reports 17: 821-836. PMCID: PMC5108179

Komisarof, J., McCall, M., Newman, L., Bshara, W., Mohler, J.L., Morrison, C. and Land, H. (2017) A Four Gene Signature Predictive of Recurrent Prostate Cancer. Oncotarget, 8: 3430-3440.

Kinsey, C., Balakrishnan, V., O’Dell, M. R., Huang, J. L., Newman, L., Whitney-Miller, C. L., Hezel, A. F. and Land, H.. (2014). Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression. Cell Reports, pii: S2211-1247(14)00258-7. doi: 10.1016/j.celrep.2014.03.061. [Epub ahead of print]

Sampson E.R., McMurray, H.R., Hassane, D.C., Newman, L., Salzman, P., Jordan C.T. and Land, H.. (2013). Gene signature critical to cancer phenotype as a paradigm for anti-cancer drug discovery. Oncogene, 32: 3809-3818. Epub 2012 Sep 10.

Ashton, J.M., Balys, M., Neering, S.J., Hassane, D.C., Cowley, G., Root, D.E., Miller, P.G., Ebert, B.L., McMurray, H.R., Land, H. and Jordan. C.T. (2012). Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. Cell Stem Cell 11: 359-372.

Smith, B and Land, H. (2012). Tumor suppressor activity of the cholesterol exporter gene Abca1. Cell Reports 2: 580-590.

McMurray, H.R., Sampson, E. R., Compitello, G., Kinsey, C., Newman, L., Smith, B., Chen, S., Klebanov, L., Salzman, P, Yakovlev, A and Land, H. (2008). Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype. Nature, 453:1112-1116.

Xia, M. and Land, H. (2007). Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility. Nature Structural & Molecular Biology 14:215-223.

More papers:PubMed


Lab Personnel

Jiyong Zhao

Jiyong Zhao, Ph.D.

Research Associate Professor

Laurel Newman

Laurel Newman

Technical Associate

Katie Singleton

Katie Singleton, Ph.D.

Staff Scientist

Bradley Smith

Bradley Smith, Ph.D.

Staff Scientist

Derek Crowe

Derek Crowe

Graduate Student

Brandon Davis

Brandon Davis

Rotation Student

Contact Us

  Land Lab
601 Elmwood Ave
Rochester, NY 14642

 (585) 273-1445

  (585) 273-1450