URMC / Cardiovascular Research Institute / Research / Morrell Lab / Publications Recent Publications Livada ACPariser DNMorrell CN Megakaryocytes in the lung: History and future perspectives.; Research and practice in thrombosis and haemostasis; Vol 7(2), pp. 100053. 2023 Jan 19. Hilt ZTTure SKMohan AArne AMorrell CN Platelet-derived β2m regulates age related monocyte/macrophage functions.; Aging; Vol 11. 2019 Dec 18. Morrell CNHilt ZTPariser DNMaurya P PAD4 and von Willebrand Factor Link Inflammation and Thrombosis.; Circulation research; Vol 125(5). 2019 Aug 16. Dugbartey GJQuinn BLuo LMickelsen DMTure SKMorrell CNCzyzyk JDoyley MMYan CBerk BCKorshunov VA The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.; The American journal of pathology. 2019 Jun 17. Bennett JATure SKSchmidt RAMastrangelo MACameron SJTerry LEYule DIMorrell CNLowenstein CJ Acetylcholine inhibits platelet activation.; The Journal of pharmacology and experimental therapeutics. 2019 Feb 14. Hilt ZTPariser DNTure SKMohan AQuijada PAsante ACameron SJSterling JAMerkel ARJohanson ALJenkins JLSmall EMMcGrath KEPalis JElliott MRMorrell CN Platelet-derived β2M regulates monocyte inflammatory responses.; JCI insight. 2019 Jan 31. Morrell CNPariser DNHilt ZTVega Ocasio D The Platelet Napoleon Complex-Small Cells, but Big Immune Regulatory Functions.; Annual review of immunology. 2018 Nov 28. Cameron SJMix DSTure SKSchmidt RAMohan APariser DStoner MCShah PChen LZhang HField DJModjeski KLToth SMorrell CN Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype.; Arteriosclerosis, thrombosis, and vascular biology. 2018 May 03. Schmidt RAMorrell CNLing FSSimlote PFernandez GRich DQAdler DGervase JCameron SJ The platelet phenotype in patients with ST-segment elevation myocardial infarction is different from non-ST-segment elevation myocardial infarction.; Translational research : the journal of laboratory and clinical medicine; Vol 195. 2018 May. Yang MKholmukhamedov ASchulte MLCooley BCScoggins NOWood JPCameron SJMorrell CNJobe SMSilverstein RL Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo.; Blood advances; Vol 2(21). 2018 Jan 13. Chapman LMTure SKField DJMorrell CN miR-451 limits CD4+ T cell proliferative responses to infection in mice.; Immunologic research; Vol 65(4). 2017 Aug. Yang MCooley BCLi WChen YVasquez-Vivar JScoggins NOCameron SJMorrell CNSilverstein RL Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions.; Blood; Vol 129(21). 2017 May 25. Croft DPCameron SJMorrell CNLowenstein CJLing FZareba WHopke PKUtell MJThurston SWThevenet-Morrison KEvans KAChalupa DRich DQ Associations between ambient wood smoke and other particulate pollutants and biomarkers of systemic inflammation, coagulation and thrombosis in cardiac patients.; Environmental research; Vol 154. 2017 Apr. Morrell CN Platelets: killers of parasites or patients?; Blood; Vol 129(12). 2017 Mar 23. Zhu QMKo KATure SMastrangelo MAChen MHJohnson ADO'Donnell CJMorrell CNMiano JMLowenstein CJ Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.; Arteriosclerosis, thrombosis, and vascular biology; Vol 37(2). 2017 Feb. Field DJAggrey-Amable AABlick SKTure SKJohanson ACameron SJRoy SMorrell CN Platelet factor 4 increases bone marrow B cell development and differentiation.; Immunologic research; Vol 65(5). 2017 Jan. Batchu SNHughson AWadosky KMMorrell CNFowell DJKorshunov VA Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension.; Arteriosclerosis, thrombosis, and vascular biology. 2016 Jun 30. Xu SLiu BYin MKoroleva MMastrangelo MTure SMorrell CNZhang DXFisher EAJin ZG A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis.; Oncotarget; Vol 7(25). 2016 Jun 21. Modjeski KLLevy SCTure SKField DJShi GKo KZhu QMorrell CN Glutamate Receptor Interacting Protein 1 Regulates CD4(+) CTLA-4 Expression and Transplant Rejection.; American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons; Vol 16(5). 2016 May. Lannan KLRefaai MATure SKMorrell CNBlumberg NPhipps RPSpinelli SL Resveratrol preserves the function of human platelets stored for transfusion.; British journal of haematology; Vol 172(5). 2016 Mar. Jackson JWSingh MVSingh VBJones LDDavidson GATure SMorrell CNSchifitto GMaggirwar SB Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis.; PloS one; Vol 11(6). 2016. Modjeski KLTure SKField DJCameron SJMorrell CN Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation.; PloS one; Vol 11(9). 2016. Batchu SNXia JKo KADoyley MMAbe JMorrell CNKorshunov VA Axl modulates immune activation of smooth muscle cells in vein graft remodeling.; American journal of physiology. Heart and circulatory physiology; Vol 309(6). 2015 Sep 15. Spitalnik SLTriulzi DDevine DVDzik WHEder AFGernsheimer TJosephson CDKor DJLuban NLRoubinian NHMondoro TWelniak LAZou SGlynn S 2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.; Transfusion; Vol 55(9). 2015 Sep. Cameron SJTure SKMickelsen DChakrabarti EModjeski KLMcNitt SSeaberry MField DJLe NTAbe JMorrell CN Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion.; Circulation; Vol 132(1). 2015 Jul 7. Cameron SJMorrell CNBao CSwaim AFRodriguez ALowenstein CJ A Novel Anti-Inflammatory Effect for High Density Lipoprotein.; PloS one; Vol 10(12). 2015. Morrell CN Understanding platelets in malaria infection.; Current opinion in hematology; Vol 21(5). 2014 Sep. Wang LSoe NNSowden MXu YModjeski KBaskaran PKim YSmolock EMMorrell CNBerk BC Cyclophilin A is an important mediator of platelet function by regulating integrin αIIbβ3 bidirectional signalling.; Thrombosis and haemostasis; Vol 111(5). 2014 May 05. Morrell CNAggrey AAChapman LMModjeski KL Emerging roles for platelets as immune and inflammatory cells.; Blood; Vol 123(18). 2014 May 1. Metcalf Pate KALyons CEDorsey JLQueen SEAdams RJMorrell CNMankowski JL TGFβ-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection.; Journal of acquired immune deficiency syndromes (1999); Vol 65(5). 2014 Apr 15. Modjeski KLMorrell CN Small cells, big effects: the role of platelets in transplant vasculopathy.; Journal of thrombosis and thrombolysis; Vol 37(1). 2014 Jan. Shi GField DJLong XMickelsen DKo KATure SKorshunov VAMiano JMMorrell CN Platelet factor 4 mediates vascular smooth muscle cell injury responses.; Blood; Vol 121(21). 2013 May 23. Aggrey AASrivastava KTure SField DJMorrell CN Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria.; Journal of immunology (Baltimore, Md. : 1950); Vol 190(9). 2013 May 1. Chapman LMAggrey AAField DJSrivastava KTure SYui KTopham DJBaldwin WMMorrell CN Platelets present antigen in the context of MHC class I.; Journal of immunology (Baltimore, Md. : 1950); Vol 189(2). 2012 Jul 15. Morrell CNMaggirwar SB Recently recognized platelet agonists.; Current opinion in hematology; Vol 18(5). 2011 Sep. Shi GMorrell CN Platelets as initiators and mediators of inflammation at the vessel wall.; Thrombosis research; Vol 127(5). 2011 May. Morrell CNSrivastava KSwaim ALee MTChen JNagineni CHooks JJDetrick B Beta interferon suppresses the development of experimental cerebral malaria.; Infection and immunity; Vol 79(4). 2011 Apr. Davidson DCHirschman MPSpinelli SLMorrell CNSchifitto GPhipps RPMaggirwar SB Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.; Journal of immunology (Baltimore, Md. : 1950); Vol 186(1). 2011 Jan 1. Morrell CN Immunomodulatory mediators in platelet transfusion reactions.; Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program; Vol 2011. 2011. Ombrello CBlock RCMorrell CN Our expanding view of platelet functions and its clinical implications.; Journal of cardiovascular translational research; Vol 3(5). 2010 Oct. Srivastava KField DJAggrey AYamakuchi MMorrell CN Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria.; PloS one; Vol 5(5). 2010. Steele BMHarper MTMacaulay ICMorrell CNPerez-Tamayo AFoy MHabas RPoole AWFitzgerald DJMaguire PB Canonical Wnt signaling negatively regulates platelet function.; Proceedings of the National Academy of Sciences of the United States of America; Vol 106(47). 2009 Nov 24. Sun HSwaim AHerrera JEBecker DBecker LSrivastava KThompson LEShero MRPerez-Tamayo ASuktitipat BMathias RContractor AFaraday NMorrell CN Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation.; Circulation research; Vol 105(6). 2009 Sep 11. Jeong YChaupin DFMatsushita KYamakuchi MCameron SJMorrell CNLowenstein CJ Aldosterone activates endothelial exocytosis.; Proceedings of the National Academy of Sciences of the United States of America; Vol 106(10). 2009 Mar 10. Srivastava KCockburn IASwaim AThompson LETripathi AFletcher CAShirk EMSun HKowalska MAFox-Talbot KSullivan DZavala FMorrell CN Platelet factor 4 mediates inflammation in experimental cerebral malaria.; Cell host & microbe; Vol 4(2). 2008 Aug 14. Morrell CNSun HIkeda MBeique JCSwaim AMMason EMartin TVThompson LEGozen OAmpagoomian DSprengel RRothstein JFaraday NHuganir RLowenstein CJ Glutamate mediates platelet activation through the AMPA receptor.; The Journal of experimental medicine; Vol 205(3). 2008 Mar 17. Shi CParker ARHua LMorrell CNLee SCBandaru VDumler JSWu TCEshleman JR Anti-gene padlocks eliminate Escherichia coli based on their genotype.; The Journal of antimicrobial chemotherapy; Vol 61(2). 2008 Feb. Yamakuchi MFerlito MMorrell CNMatsushita KFletcher CACao WLowenstein CJ Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor.; Methods in molecular biology (Clifton, N.J.); Vol 440. 2008. Morrell CNMason EAMartin TVSwaim AMBallard MMurata KBaldwin WM Alloantibodies to MHC Induce Platelet-Endothelial Cell Interactions; Circulation Research; Vol 102(7), pp. 777-785. 2008 Jan 01. Matsushita KMorrell CNMason RJYamakuchi MKhanday FAIrani KLowenstein CJ Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.; The Journal of cell biology; Vol 170(1). 2005 Jul 4. Morrell CNMatsushita KLowenstein CJ A novel inhibitor of N-ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis.; The Journal of pharmacology and experimental therapeutics; Vol 314(1). 2005 Jul. Yamakuchi MGreer JJCameron SJMatsushita KMorrell CNTalbot-Fox KBaldwin WMLefer DJLowenstein CJ HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size.; Circulation research; Vol 96(11). 2005 Jun 10. Matsushita KMorrell CNLowenstein CJ A novel class of fusion polypeptides inhibits exocytosis.; Molecular pharmacology; Vol 67(4). 2005 Apr. Morrell CNMatsushita KChiles KScharpf RBYamakuchi MMason RJBergmeier WMankowski JLBaldwin WMFaraday NLowenstein CJ Regulation of platelet granule exocytosis by S-nitrosylation.; Proceedings of the National Academy of Sciences of the United States of America; Vol 102(10). 2005 Mar 8. Matsushita KYamakuchi MMorrell CNOzaki MO'Rourke BIrani KLowenstein CJ Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis.; Blood; Vol 105(1). 2005 Jan 1. Bhatia RMatsushita KYamakuchi MMorrell CNCao WLowenstein CJ Ceramide triggers Weibel-Palade body exocytosis.; Circulation research; Vol 95(3). 2004 Aug 6. Matsushita KMorrell CNLowenstein CJ Sphingosine 1-phosphate activates Weibel-Palade body exocytosis.; Proceedings of the National Academy of Sciences of the United States of America; Vol 101(31). 2004 Aug 3. Matsushita KMorrell CNCambien BYang SXYamakuchi MBao CHara MRQuick RACao WO'Rourke BLowenstein JMPevsner JWagner DDLowenstein CJ Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor.; Cell; Vol 115(2). 2003 Oct 17. Chen WYZeng XCarter MGMorrell CNChiu Yen RWEsteller MWatkins DNHerman JGMankowski JLBaylin SB Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.; Nature genetics; Vol 33(2). 2003 Feb. Morrell CNVolk MVMankowski JL A carcinoid tumor in the gallbladder of a dog.; Veterinary pathology; Vol 39(6). 2002 Nov. Mathiowitz EJacob JSJong YSCarino GPChickering DEChaturvedi PSantos CAVijayaraghavan KMontgomery SBassett MMorrell C Biologically erodable microspheres as potential oral drug delivery systems.; Nature; Vol 386(6623). 1997 Mar 27. Chickering DEJacob JSDesai MHarrison WPMorrell CNChatuverdi PMathiowitz E Bioadhesive Microspheres: III. An In Vivo Transit and Bioavailability Study of Drug-Loaded Alginate and Poly(Fumaric-co-Sebacic Anhydride) Microspheres; Journal of Controlled Release; Vol 48, pp. 35-46. 1997 Jan 01.