Research Meetings
January through February 2017


January 18, 2017 ( Wednesday )

4:00pm - 5:00pm
THE Aab CVRI Seminar Series

SPEAKER: Kirk M. McHugh, Ph.D. Professor & Director Division of Anatomy Department of Biomedical Education & Anatomy The Ohio State University Professor & Directors Nephrology & Urology Research Affinity Center for Biomedical and Translational Research Nationwide Children's Hospital

TITLE OF TALK: "Megabladder Mouse Model of Abnormal Detrusor and Cardiac Outflow Tract Smooth Muscle Development"

Research Summary: My research efforts focus on the normal development and pathogenesis of the urogenital system. Urinary tract malformations, obstructive nephropathy, and renal hypoplasia/dysplasia comprise over 50% of the children with end-stage renal disease worldwide. These defects are extremely important in the terms of health care costs, with end-stage renal disease costing 1.5 billion dollars annually. Studies in my lab focus on congenital defects in bladder development and the resulting sequelae associated with obstructive nephropathy and chronic kidney disease (CKD). We have identified a highly unique mouse model known as the megabladder (mgb) that represents the first animal model of congenital obstructive nephropathy. We use a wide range of genetic and molecular approaches to study the pathogenic changes in mgb-/- renal function that are associated with the development of chronic kidney disease (CKD) and end stage renal disease (ESRD). These studies have lead to a novel renal adaptation model that involves the integrated balance between TGF-mediated pathogenesis, retinoic acid mediated remodeling/repair and steroid hormone modulation. Genetic studies of the mgb-/- mouse mutation indicate that these animals possess a complex deletion/translocation defect associated with chromosomes 16 and 11. The deletion/translocation site on chromosome 11 occurs 1+ Mb upstream of the myocardin gene and appears to have disrupted a long-range, tissue-specific enhancer element that is responsible for up-regulation of myocardin expression in the bladder. These genetic defects result in the production of a hypomorphic allele that reduces myocardin expression in the bladder by 75%. Further reduction in myocardin expression to 90% results in the appearance of a second defect, patent ductus arteriosus, that results in early postnatal lethality in these animals.

Location:  CVRI Conf. Room # G.11211/G.11213 MRBX/Delmonte Bldg - (Ground floor)

Posted by:  Jacqueline Velazquez, Cardiovascular Research Institute, 9-Jan-17 2:07pm ET


January 20, 2017 ( Friday )

3:00pm - 4:00pm
Department of Biology E2G2 Seminar

Dr. Xin Li, URMC

"Domesticated chickens activate a piRNA defense against avian leukosis virus"

Location:  Hutchison Hall, Room 316

Posted by:  Deborah Lawrence, Biology, 21-Dec-16 10:16am ET


January 25, 2017 ( Wednesday )

12:30pm - 1:30pm
Center for Oral Biology Bagel Talk Series 2017-2018

Robert G. Quivey, Jr., Ph.D.

Director, Center for Oral Biology

Margaret and Cy Welcher Professorship in Dental Research

Professor of Microbiology & Immunology in the COB

"Bacterial stress adaptation and the search for new antimicrobials"

Location:  Conference Room- Center for Oral Biology, G-9654, KMRB

Posted by:  Nicole Beaumont, Center for Oral Biology, 13-Jan-17 8:43am ET


January 26, 2017 ( Thursday )

3:30pm
Department of Biology Donut Talk

Dr. Daniel Bolnick, University of Texas at Austin

"Honey, I shrunk the tapeworms!"

Location:  Lander Auditorium - Hutchison 140

Posted by:  Brenna Rybak, Biology, 4-Jan-17 12:49pm ET


January 30, 2017 ( Monday )

10:00am - 11:00am
Center for Oral Biology Presents Faculty Candidate Seminar

Junichi Iwata, PhD, DDS

Assistant Professor

Department of Diagnostic & Biomedical Sciences School of Dentistry

The University of Texas Health Science Center at Houston

" Cellular metabolism and membrane trafficking in craniofacial development and diseases "


Location:  Center for Oral Biology Conference Room, G9654

Posted by:  Nicole Beaumont, Center for Oral Biology, 20-Dec-16 11:34am ET


January 31, 2017 ( Tuesday )

9:00am - 9:45am
Center for Oral Biology Presents Faculty Candidate Chalk Talk

Junichi Iwata, PhD, DDS

Assistant Professor

Department of Diagnostic & Biomedical Sciences School of Dentistry

The University of Texas Health Science Center at Houston


Location:  Center for Oral Biology Conference Room, G9654

Posted by:  Nicole Beaumont, Center for Oral Biology, 20-Dec-16 11:35am ET


February 2, 2017 ( Thursday )

3:30pm
Department of Biology Donut Talk

Dr. Kira Delmore, Max Planck Institute for Evolutionary Biology

"Studying Speciation using Hybrid Zones"

Location:  Lander Auditorium - Hutchison 140

Posted by:  Brenna Rybak, Biology, 11-Jan-17 8:25am ET


February 6, 2017 ( Monday )

12:00pm
Department of Biology Donut Talk

Dr. Christina Zakas, NYU

"The genetic basis of evolutionary transitions in early development"

Location:  Lander Auditorium - Hutchison 140

Posted by:  Brenna Rybak, Biology, 4-Jan-17 2:17pm ET


February 9, 2017 ( Thursday )

3:30pm
Department of Biology Donut Talk

Dr. Joseph Parker, Columbia University

"An Inordinate Fondness for Rove Beetles: How Ants Have Shaped Beetle Diversity"

Location:  Lander Auditorium - Hutchison 140

Posted by:  Brenna Rybak, Biology, 4-Jan-17 1:24pm ET


February 13, 2017 ( Monday )

12:00pm
Department of Biology Donut Talk

Dr. Nancy Chen, University of California, Davis

"Evolutionary genomics of a pedigreed wild population"

Location:  Lander Auditorium - Hutchison 140

Posted by:  Brenna Rybak, Biology, 4-Jan-17 12:53pm ET


February 27, 2017 ( Monday )

12:00pm
Department of Biology Donut Talk

Dr. Matthew Herron, Georgia Institute of Technology

"Origins of multicellular development in the volvocine algae"

Location:  Lander Auditorium - Hutchison 140

Posted by:  Brenna Rybak, Biology, 4-Jan-17 2:22pm ET

 
 
https://www.urmc.rochester.edu/calendar/index.html