Research Meetings
February through March 2017


February 20, 2017 ( Monday )

12:00pm - 1:00pm
Microbiology and Immunology Department Seminar

"A Liposomal Vaccine Adjuvant that binds to His-tagged Antigens"

Monday, February 20, 2017 12:00-1:00 PM Class of '62 Auditorium (Room G-9425)

Hosted by Sanjay Maggirwar, Ph.D

Co-Sponsored by CFAR and T32AI049815, Training in HIV Replication and Pathogenesis

We recently found that liposomes incorporating an unconventional and unnatural phospholipid (Cobalt (III) porphyrin phospholipid) can coordinate with his-tag ligands within the bilayer. This lends to stable and simple antigen decoration of liposomes, following incubation with his-tagged proteins or peptides. In preliminary studies, we have found several potentially promising characteristics for this approach: 1) Higher IgG responses compared to other adjuvants (sometimes by orders of magnitude) 2) Rapid vaccine development and potentially deployment 3) Good multiplexing capabilities

Location:  Class of '62 Auditorium G-9425

Posted by:  Jack McMahon, Micro & Immunolgy, 14-Feb-17 3:40pm ET


February 22, 2017 ( Wednesday )

12:30pm - 1:30pm
Center for Oral Biology Bagel Talk Series 2017-2018

Christopher Kovacs

Microbiology & Immunology Graduate Student

(Robert Quivey laboratory)

"The major cell surface glycopolymer of Streptococcus mutans is required for maintenance of stress-adaption and virulence traits"

Location:  Conference Room- Center for Oral Biology, G-9654, KMRB

Posted by:  Nicole Beaumont, Center for Oral Biology, 8-Feb-17 12:41pm ET


February 24, 2017 ( Friday )

3:00pm - 4:00pm
Department of Biology E2G2 Seminar

Ching-Ho Chang, University of Rochester

"Population dynamics and sperm chromatin remodeling in Segregation Distortion system"

Location:  Hutchison Hall, Room 316

Posted by:  Deborah Lawrence, Biology, 10-Feb-17 4:15pm ET


February 27, 2017 ( Monday )

12:00pm
Department of Biology Donut Talk

Dr. Matthew Herron, Georgia Institute of Technology

"Origins of multicellular development in the volvocine algae"

Location:  Lander Auditorium - Hutchison 140

Posted by:  Brenna Rybak, Biology, 4-Jan-17 2:22pm ET


12:00pm - 1:00pm
Microbiology and Immunology Department Seminar

Caroline Genco, Ph.D Professor and Chair, Department of Integrative Physiology & Pathobiology, Tufts University

Microbiota, Immune Subversion, and Chronic Inflammation

Monday, February 27, 2017 12:00-1:00 PM Upper Auditorium (Room 3-7619)

Hosted by Marty Pavelka, Ph.D

Several host-adapted pathogens and commensals have evolved mechanisms to evade the host innate immune system inducing a state of low-grade inflammation. Epidemiological studies have also documented the association of a subset of these microorganisms with chronic inflammatory disorders. In this seminar I will summarize recent studies demonstrating the role of the microbiota in chronic inflammatory diseases and discuss how specific microorganisms subvert or inhibit protective signaling normally induced by Toll-like receptors (TLRs). I will highlight our work on the oral pathogen Porphyromonas gingivalis and discuss the role of microbial modulation of lipid A structures in evasion of TLR4 signaling and resulting systemic immunopathology associated with atherosclerosis. P. gingivalis intrinsically expresses underacylated lipid A moieties and can modify the phosphorylation of lipid A, leading to altered TLR4 signaling. Using P. gingivalis mutant strains expressing distinct lipid A moieties, we demonstrated that expression of antagonist lipid A was associated with P. gingivalis-mediated systemic inflammation and immunopathology, whereas strains expressing agonist lipid A exhibited modest systemic inflammation. Likewise mice deficient in TLR4 were more susceptible to vascular inflammation after oral infection with P. gingivalis wild type strain compared to mice possessing functional TLR4. Collectively, our studies support a role for P. gingivalis-mediated dysregulation of innate and adaptive responses resulting in immunopathology and systemic inflammation. We propose that anti-TLR4 interventions must be designed with caution, given the balance between the protective and destructive roles of TLR signaling in response to microbiota and associated immunopathologies.


Location:  Upper Auditorium 3-7619

Posted by:  Jack McMahon, Micro & Immunolgy, 14-Feb-17 3:41pm ET


March 8, 2017 ( Wednesday )

3:00pm - 4:00pm
The Aab CVRI Seminar Series

SPEAKER: Joshua Beckman, M.D., MS Professor of Medicine and Director, Section of Vascular Medicine, Vanderbilt Heart and Vascular Institute (VHVI), Vanderbilt University School of Medicine, Nashville, TN

TITLE OF TALK: "Diabetic vascular dysfunction and atherosclerosis" (tentative)

Location:  CVRI Conf. Room # G.11211/G.11213 MRBX/Delmonte Bldg - (Ground floor)

Posted by:  Jacqueline Velazquez, Cardiovascular Research Institute, 9-Feb-17 11:11am ET


March 10, 2017 ( Friday )

3:00pm - 4:00pm
Department of Biology E2G2 Seminar

Binshuang Li, University of Rochester

TBA

Location:  Hutchison Hall, Room 316

Posted by:  Deborah Lawrence, Biology, 30-Jan-17 10:12am ET


March 24, 2017 ( Friday )

3:00pm - 4:00pm
Department of Biology E2G2 Seminar

Dr. Josephine Reinhardt, SUNY Geneseo

"Impacts of selfish genes on genome evolution in the stalk-eyed flies"

Location:  Hutchison Hall, Room 316

Posted by:  Deborah Lawrence, Biology, 30-Jan-17 10:14am ET


March 27, 2017 ( Monday )

12:00pm - 1:00pm
Department of Biology Donut Talk

Dr. Barbara Mellone, University of Connecticut

One and only: ectopic centromere formation and inactivation in Drosophila

Location:  Hutchison Hall, Lander Auditorium

Posted by:  Deborah Lawrence, Biology, 16-Jan-17 8:02am ET


March 31, 2017 ( Friday )

3:00pm - 4:00pm
Department of Biology E2G2 Seminar

Mary Grantham, University of Rochester

TBA

Location:  Hutchison Hall, Room 316

Posted by:  Deborah Lawrence, Biology, 30-Jan-17 10:13am ET

 
 
https://www.urmc.rochester.edu/calendar/index.html