4:00pm - 5:00pm|
Aab CVRI Seminar Series
SPEAKER: Nigel Mackman, B.Sc., Ph.D., FAHA
Director of the UNC McAllister Heart Institute
School of Medicine, UNC-Chapel Hill, Immunology
University of North Carolina at Chapel Hill
Chapel Hill, NC
TITLE OF TALK: "Roles of Tissue Factor in Hemostasis, Thrombosis, Cardiac Injury and Viral Infection"
ABSTRACT: Dr. Mackman is interested in mechanisms of hemostasis and thrombosis, and the crosstalk between coagulation and inflammation. In particular, I study the role of tissue factor (TF), coagulation proteases, protease activated receptors (PARs) and microvesicles (MVs) in ischemia-reperfusion (I/R) injury, cancer, sickle cell disease, obesity, viral infection, atherosclerosis and liver injury. My lab has generated several unique mouse lines that have altered levels of TF, PAR1 and PAR2. For instance, we have made mice expressing only ~1% of wild-type TF levels. These mice have been used extensively by us and others to study the role of TF in hemostasis, thrombosis and other processes, such as inflammation in sickle cell disease. My lab also generated TF floxed mice that allows deletion of the TF gene in different cell types by crossing these mice with mice expressing the Cre recombinase in a cell type-specific manner.
|Location: ||CVRI Conf. Room # G.11211/G.11213|
Posted by: Jacqueline Velazquez, Cardiovascular Research Institute, 18-Jul-16 10:20am ET