12:00pm - 1:00pm|
Microbiology & Immunology Department Seminar
Stephen Nutt, Ph.D.
Walter and Eliza Hall Institute
Department Head, Molecular Immunology Division
"The Molecular Control of Humoral Immunity"
Host: Andrea Sant, PhD
Monday, May 2, 2016
Upper Auditorium (Room 3-7619)
Seminar Abstract: Our research focuses on the question of how cell fate and differentiation decisions are controlled in the immune system. The differentiation of B cells into either germinal center and memory B cells or antibody-secreting plasma cells is one such cell fate decision that is controlled by the interaction of a handful of transcription factors with extrinsic signals, including antigen and T cell derived cytokines such as IL-21. We have recently defined a molecular signature that highlights the stark transcriptional divide between B cells and plasma cells, and also demarcates antibody-secreting cells based on location and maturity. By focusing on the factors that control this differentiation process, including PU.1 and Irf8 that promote the B cell fate, and Irf4, Xbp1 and Blimp1 that drive plasma cell differentiation, we aim to develop a gene regulatory network describing the B-cell terminal differentiation process.
|Location: ||Upper Auditorium 3-7619|
Posted by: Brenda Knorr, Micro & Immunolgy, 25-Apr-16 8:00am ET