12:00pm - 1:00pm|
Microbiology and Immunology Department Seminar
Speaker: George O'Toole, PhD. Professor of Microbiology and Immunology, Dartmouth, Geisel School of Medicine.
Host: Scott Butler
Title: To Build a Biofilm
Abstract: Biofilms are surface-attached microbial communities. c-di-GMP is a conserved dinucleotide signal that regulates biofilm formation by bacteria. Synthesis of c-di-GMP by diguanylate cyclases (DGCs) and its degradation by phosphodiesterases (PDEs) is well established, and progress has also been made in elucidating c-di-GMP output systems. For example, our group has characterized a membrane protein, LapD, which binds c-di-GMP via a degenerate PDE domain; this c-di-GMP receptor regulates localization of the LapA adhesin to the cell surface, which is a critical event for biofilm formation by Pseudomonas fluorescens. A central open question in the field is how bacteria like P. fluorescens and P. aeruginosa, with 50+ proteins that make, break and bind c-di-GMP, coordinate the action of these many proteins to provide a coordinated, c-di-GMP-regulated output. I will discuss recent work from the lab exploring mechanisms of c-di-GMP signaling specificity that impact the control of a biofilm adhesion system that is conserved in 1000+ bacterial genomes.
|Location: ||Upper Auditorium (Room 3-7619)|
Posted by: Jack McMahon, Micro & Immunolgy, 30-Mar-17 12:24pm ET