12:00pm - 1:00pm|
Department of Microbiology & Immunology Seminar Series
Suzanne Ostrand-Rosenberg, Ph.D.
Professor of Biology
Robert & Jane Meyerhoff Professor of Biochemistry
University of Maryland Baltimore County
"Novel approaches for blocking the PD-1 immune suppressive pathway and enhancing antitumor immunity"
Host: Edith Lord
Monday, December 7, 2015
12:00 - 1:00
Upper Auditorium (3-7619)
Recent results using checkpoint blockade inhibitors (antibodies) and genetically modified T cells have demonstrated that the immune system is a powerful and effective agent for controlling, and in some cases eliminating, established tumors in both cancer patients and experimental animals. The current FDA-approved drugs are effective for a subset of patients with melanoma, renal cell carcinoma, and non-small cell lung cancer. However, a significant portion of patients do not respond to these treatments indicating that more effective treatments are needed. This talk will describe a novel non-antibody-mediated strategy for promoting cancer immunotherapy that combines in a single agent the ability to block the checkpoint inhibitor pathway Programmed Death 1 (PD1) and concomitantly activate tumor-reactive T cells. In vitro studies with both mouse and human immune cells and cancer cells, as well as in vivo studies with mice will be discussed.
|Location: ||Upper Auditorium 3-7619|
Posted by: Brenda Knorr, Micro & Immunolgy, 19-Nov-15 3:09pm ET