Publications

Gonzalez PR, Cesur MF, Anchan A, Abu-Salah A, Cakir T, Malovic E, and Sarkar S. 2026 Comparative proteomic analysis of environmental and genetic models of parkinson's disease highlights the role of purine metabolism. bioRxiv. 2026.02.02.703282.

Gigas J, Meadow ME, Guo J, Lan C, Hillpot E, Martinez JC, Tombline G, Bellomio P, Almodovar VR, Welle KA, Swovick K, Hryhorenko JR, Ablaeva J, Ghaemmaghami S, Seluanov A, and Gorbunova V. 2026 Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress. bioRxiv. 2026.04.22.718469.

Chiang W, Li H, Le L, David-Bercholz J, Caceres AI, Ahmad D, Squire E, Stecyk KS, Marrero M, Pereira A, Squire R, Lim C, McGrath JL, Majewska AK, Terrando N, and Gelbard HA. 2026 Dynamics of neutrophilia at the neurovascular unit arising from repeated pulmonary inflammation. J Neuroinflammation. 23(1). 148.

Peng W, Chung KB, Al-Qazzaz A, Straut A, O'Banion MK, Lawrence BP, Dirksen RT, and Onukwufor JO. 2026 Iron toxicity potentiates cell-type specific amyloid beta proteotoxicity in C. elegans via altered energy homeostasis. bioRxiv. 2026.03.25.714217

Carroll T, Pfendler D, Alhaj Arhayem H, Thoma R, Muller-Eigner A, Straut A, Johnson GVW, and Nehrke K. 2026 Tunable tau expression in C. elegans neurons reveals that early-AD tau phosphorylation selectively impacts behavior and mitochondrial quality control. Neurobiol Dis. 222:107350.

Emma Waight*, Yuxi Zhu*, Ashley Caudell, Velia S Vizcarra, Evan Newbold, Michael J Giannetto, Evalien Duyvestyn, Estephanie Balbuena, Wei Song, Tanzil M. Arefin, Yuki Mori, Maiken Nedergaard, Lauren M Hablitz. Chronotherapy to improve glymphatic function and post-stroke recovery. J Clin Invest

Reina-Gonzalez P, Ay M, Langley M, Plunk E, Strazdins R, Abu-Salah A, Anchan A, Shah A, and Sarkar S. 2025 Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration. Toxicol Sci. 207(1):20–8.

Lin H, Ramanan S, Kaplan S, King DH, Bunn D, and Johnson GVW. 2025 One BAG Does Not Fit All: Differences and similarities of bag family members in mediating central nervous system homeostasis. Biol Psychiatry. 98(3):208–18.

Le LHD, Feidler AM, Rodriguez LC, Cealie M, Plunk E, Li H, Kara-Pabani K, Lamantia C, O'Banion MK, and Majewska AK. 2025 Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial beta2 adrenergic receptors. Brain Behav Immun. 128:307–22.

Calcines-Rodriguez L, Noyes-Martel N, Becker JL, Nguyen SK, Osabutey MA, Trojanczyk LA, Majewska AK, and O'Banion MK. 2025 Microglial interferon signaling and Abeta plaque pathology are enhanced in female 5xFAD Alzheimer's disease mice, independent of estrous cycle stage. J Neuroinflammation. 23(1):41.

Isei MO, Crockett M, Chen E, Rodwell-Bullock J, Carroll T, Girardi PA, Nehrke K, and Johnson GVW. 2025 Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation. PLoS One. 20(1):e0307358.

Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, Lu JY, Zheng Z, Perelli L, Gurreri E, Zhang L, Guo J, Korotkov A, Volobaev V, Biashad SA, Zhang Z, Heid J, Maslov AY, Sun S, Wu Z, Gigas J, Hillpot EC, Martinez JC, Lee M, Williams A, Gilman A, Hamilton N, Strelkova E, Haseljic E, Patel A, Straight ME, Miller N, Ablaeva J, Tam LM, Couderc C, Hoopmann MR, Moritz RL, Fujii S, Pelletier A, Hayman DJ, Liu H, Cai Y, Leung AKL, Zhang Z, Nelson CB, Abegglen LM, Schiffman JD, Gladyshev VN, Maley CC, Modesti M, Genovese G, Simons MJP, Vijg J, Seluanov A, and Gorbunova V. 2025 Evidence for improved DNA repair in the long-lived bowhead whale. Nature. 648(8094):717–25.

Martinez JC, Seluanov A, and Gorbunova V. 2025 Longevity steps on the cGAS. Science. 390(6769):126–7.

Meadow ME, Broas S, Hoare M, Ahmed M, Alimohammadi F, Welle KA, Swovick K, Hryhorenko JR, Jain A, Martinez JC, Seluanov A, Gorbunova V, Buchwalter A, and Ghaemmaghami S. 2025 Proteome Birthdating: A single-sample approach for measuring global turnover dynamics and . Bio Protoc. 15(9):e5296.

Duyvesteyn E, Vizcarra VS, Waight E, Balbuena E, and Hablitz LM. 2025 Biological fluid flows: Signaling mediums for circadian timing. J Biol Rhythms. 40(3):234–48.

Abu-Salah A, Cesur MF, Anchan A, Ay M, Langley MR, Shah A, Reina-Gonzalez P, Strazdins R, Cakir T, and Sarkar S. 2024 Comparative proteomics highlights that genx exposure leads to metabolic defects and inflammation in astrocytes. Environ Sci Technol. 58(46):20525–39.

Isei MO, Girardi PA, Rodwell-Bullock J, Nehrke K, and Johnson GVW. 2024 Site-specific phosphorylation of tau impacts mitochondrial function and response to stressors. J Neurochem. 168(6):1019–29.

Martinez JC, Morandini F, Fitzgibbons L, Sieczkiewicz N, Bae SJ, Meadow ME, Hillpot E, Cutting J, Paige V, Biashad SA, Simon M, Sedivy J, Seluanov A, and Gorbunova V. 2024 cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation. bioRxiv. 2024.10.10.617645.

Martinez JC, Seluanov A, and Gorbunova V. 2024 LINE1 and its host: one cell's junk is another cell's treasure. EMBO J. 43(17):3547–9.

Meadow ME, Broas S, Hoare M, Alimohammadi F, Welle KA, Swovick K, Hryhorenko JR, Martinez JC, Biashad SA, Seluanov A, Gorbunova V, Buchwalter A, and Ghaemmaghami S. 2024 Proteome Birthdating Reveals Age-Selectivity of Protein Ubiquitination. Mol Cell Proteomics. 23(7):100791.

Vizcarra VS, Fame RM, and Hablitz LM. 2024 Circadian mechanisms in brain fluid biology. Circ Res. 134(6):711–26.

Berk BC, Pereira A, Vizcarra VS, Proschel C, and Hsu CG.2024 Spinal cord injury enhances lung inflammation and exacerbates immune response following exposure to LPS. Front Immunol. 15:1483402.

Emerson J, Delgado T, Girardi P, and Johnson GVW. 2023 Deletion of transglutaminase 2 from mouse astrocytes significantly improves their ability to promote neurite outgrowth on an inhibitory matrix. Int J Mol Sci. 24(7) 6058.

Lin H, Tang M, Ji C, Girardi P, Cvetojevic G, Chen D, Koren SA, and Johnson GVW. 2022 BAG3 Regulation of RAB35 mediates the endosomal sorting complexes required for transport/endolysosome pathway and tau clearance. Biol Psychiatry. 92(1):10–24.

Lin H, Koren SA, Cvetojevic G, Girardi P, and Johnson GVW. 2022 The role of BAG3 in health and disease: A 'Magic BAG of Tricks'. J Cell Biochem. 123(1):4–21.

Hogestyn JM, Salois G, Xie LApa C, Youngyunpipatkul J, Pröschel C, Mayer-Pröschel M Expression of the human herpesvirus 6A latency-associated transcript U94A impairs cytoskeletal functions in human neural cells.; Molecular and cellular neurosciences. 2022 Aug 30.