Immune System Disorders
Your immune system is your body’s defense against infections and other harmful invaders.
Without it, you would constantly get sick from germs such as bacteria or viruses.
Your immune system is made up of special cells, tissues, and organs that work together
to protect you.
The lymphatic system is a major part of the immune system. It's a network of lymph
nodes and vessels. Lymphatic vessels are thin tubes that spread, like blood vessels, all
over the body. They carry a clear fluid called lymph. Lymph contains tissue fluid,
waste products, and immune system cells. Lymph nodes are small, bean-shaped clumps
of immune system cells. They are connected by lymphatic vessels. They contain white
blood cells that trap viruses, bacteria, and other invaders, including cancer cells.
White blood cells are the cells of the immune system. They are made in one of your
lymph organs such as the spleen or thymus, and in the bone marrow.
What can go wrong with your immune system?
When your immune system doesn't work the way it should, it's called an immune system
disorder. You may:
Be born with a weak immune system. This is called primary immune deficiency.
Get a disease that weakens your immune system. This is called acquired immune deficiency.
Have an immune system that is too active. This may happen with an allergic reaction.
Have an immune system that turns against you. This is called autoimmune disease.
Immune system disorders
Here are some common examples:
Severe combined immunodeficiency (SCID). This is an example of an immune deficiency that is present at birth. Children are in
constant danger of infections from bacteria, viruses, and fungi. This disorder is
sometimes called “bubble boy disease.” In the 1970s, a boy had to live in a sterile
environment inside a plastic bubble. Children with SCID are missing important white
blood cells. This disease is deadly without treatment.
Temporary acquired immune deficiencies. Your immune system can be weakened by certain medicines, for example. This can happen
to people on chemotherapy or other medicines used to treat cancer. It can also happen
to people after organ transplants who take medicine to prevent organ rejection. Also,
infections such as the flu virus, mono (mononucleosis), and measles can weaken the
immune system for a short time. Your immune system can also be weakened by smoking,
alcohol, and poor nutrition.
AIDS. HIV, which causes AIDS, is an acquired viral infection that destroys important white
blood cells and weakens the immune system. People with HIV/AIDS can become seriously
ill with infections that most people can fight off. These infections are called “opportunistic
infections” because they take advantage of weak immune systems.
An overactive immune system
If you are born with certain genes, your immune system may react to substances in the
environment that are normally harmless. These substances are called allergens. Having
an allergic reaction is the most common example of an overactive immune system. Dust,
mold, pollen, and foods are examples of allergens.
Some conditions caused by an overactive immune system are:
Asthma. The response in your lungs can cause coughing, wheezing, and trouble breathing. Asthma
can be triggered by common allergens like dust or pollen or by an irritant like tobacco
Eczema. An allergen causes an itchy rash known as atopic dermatitis.
Hay fever (allergic rhinitis). Sneezing, a runny nose, sniffling, and swelling of your nasal passages from indoor
allergens such as dust and pets or outdoor allergens such as pollens or molds.
Food allergy. Severe allergic reactions that are caused by foods.
In autoimmune diseases, the body attacks normal, healthy tissues. Experts don't know
why. It's likely a combination of a person’s genes and something in the environment that
triggers those genes.
Three common autoimmune diseases are:
Type 1 diabetes. The immune system attacks the cells in the pancreas that make insulin. Insulin removes
sugar from the blood to use as energy.
Rheumatoid arthritis. This type of arthritis causes swelling and deformities of the joints. An auto-antibody
called rheumatoid factor or anti-CCP is in the blood of some people with rheumatoid
Lupus. This disease attacks body tissues, including the lungs, kidneys, and skin. Many types
of auto-antibodies are found in the blood of people with lupus.
Experts don't know what causes autoimmune diseases but many different factors seem
to be involved. If you have an immune system disorder, learn as much as you can about it
and work closely with your healthcare providers to manage it.