Does this test have other names?
Adrenocorticotropic hormone blood test, corticotropin
What is this test?
This is a blood test that measures the amount of adrenocorticotropic hormone (ACTH)
the pituitary gland produces. This gland is a tiny organ that sits just below your
brain. It secretes adrenocorticotropic hormone, which controls the production of another
hormone called cortisol.
Cortisol is produced by your adrenal glands, which are located at the top of your
kidneys. Cortisol helps break down protein, sugar, and fat in your food. It also helps
to regulate your blood pressure and your body's ability to fight infection. Cortisol
is also one of the hormones that helps you deal with stress. Cortisol levels should
peak in the morning and be at their lowest in the evening.
Why do I need this test?
You might have this test if your healthcare provider suspects you have hormone problems.
This test is used along with other tests to diagnose conditions, including:
Cushing disease, in which the pituitary gland makes too much ACTH
Cushing syndrome, in which the adrenal glands make too much cortisol
Addison disease, in which the adrenal glands don't make enough cortisol
Hypopituitarism, a disorder of the pituitary gland that keeps it from producing enough vital hormones
What other tests might I have along with this test?
Your healthcare provider also might order tests to measure your cortisol levels, including:
Adrenocorticotropic hormone stimulation test to determine why your adrenal glands aren't working properly
Dexamethasone suppression test to find an underlying reason for Cushing
Adrenocorticotropic hormone stimulation with metyrapone test also to find an underlying reason for Cushing
What do my test results mean?
Many things may affect your lab test results. These include the method each lab uses
to do the test. Even if your test results are different from the normal value, you
may not have a problem. To learn what the results mean for you, talk with your healthcare
ACTH is measured in picograms per milliliter (pg/mL). Test results are influenced
by the time of day the test was done. Normal results are:
If your ACTH level is low or high you may have Cushing syndrome. If your ACTH level
is high you may have Addison disease. A low ACTH level can also be an indication of
How is this test done?
The test requires a blood sample, which is drawn through a needle from a vein in your
You may have blood drawn in the morning and in the afternoon or evening. This is to
check for variations in your levels of ACTH hormone.
Does this test pose any risks?
Taking a blood sample with a needle carries risks that include bleeding, infection,
bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight
stinging sensation or pain. Afterward, the site may be slightly sore.
What might affect my test results?
Your test results might be affected if you:
Are under a great deal of stress
Recently experienced a trauma
Are menstruating or pregnant
Are taking certain drugs, including steroids, hormones, or insulin
Did not sleep well the night before the test
How do I get ready for this test?
Don't eat after midnight on the day of your test. Get a good night's sleep. Follow
any other directions from your healthcare provider. Be sure your healthcare provider
knows about all medicines, herbs, vitamins, and supplements you are taking. This includes
medicines that don't need a prescription and any illicit drugs you may use.