Does this test have other names?
What is this test?
This test measures the amount of estradiol (E2), the form of estrogen made mainly
by the ovaries.
E2 plays a key role in the development of the female reproduction system, including
the uterus, fallopian tubes, vagina, and breasts. Women have higher amounts of E2
during their reproductive years and almost none after menopause.
Other estrogens include estrone and estriol. Estrone is the main estrogen made during
In men, E2 is secreted in moderate amounts by the testes throughout life.
Why do I need this test?
You may need this test if your healthcare provider thinks you have a problem caused
by high or low levels of E2. These problems include:
You may also have this test if you are being treated with assisted reproductive technology
(ART) for infertility. Or you may have the test if your healthcare provider is monitoring
your hormones during ART.
In adolescents, this test may be done to diagnose early puberty.
What other tests might I have along with this test?
Your healthcare provider may also order other tests, depending on what they suspect.
These tests may include:
Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) for menopausal problems
FSH, thyroid-stimulating hormone/free thyroxine (TSH/FT4), and prolactin, a hormone
needed for breastmilk production, if your periods have stopped
FSH and LH for early puberty
TSH, prolactin, FSH, and LH for both male and female infertility issues
What do my test results mean?
Test results may vary depending on your age, gender, health history, and other things.
Your test results may be different depending on the lab used. They may not mean you
have a problem. Ask your healthcare provider what your test results mean for you.
Results are given in picograms per milliliter (pg/mL). Normal levels for estradiol
If your results are lower, it may mean you have ovarian failure, also called early
menopause, or low estrogen from rapid weight loss or anorexia.
If your results are higher, it may suggest a tumor of the ovary, testes, or adrenal
How is this test done?
The test is done with a blood sample. A needle is used to draw blood from a vein in
your arm or hand.
Does this test pose any risks?
Having a blood test with a needle carries some risks. These include bleeding, infection,
bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may
feel a slight sting or pain. Afterward, the site may be sore.
What might affect my test results?
Taking birth control pills or hormone therapy may affect your results.
How do I get ready for this test?
You don't need to prepare for this test. Be sure your healthcare provider knows about
all medicines, herbs, vitamins, and supplements you are taking. This includes medicines
that don't need a prescription and any illegal drugs you may use.