Does this test have other names?
Plasma pancreatic polypeptide, PP, human pancreatic polypeptide
What is this test?
This test measures a substance in your blood called pancreatic polypeptide. Pancreatic
polypeptide is secreted by cells in your pancreas.
People who have neuroendocrine tumors have higher levels of this substance. These
tumors can be functional or nonfunctional. Nonfunctional tumors are more common. They
are called nonfunctional because they secrete substances that do not cause symptoms.
That means they may not cause any symptoms until they have grown large.
Why do I need this test?
You may need this test if your healthcare provider suspects that you have a pancreatic
neuroendocrine tumor. When these tumors cause symptoms, they can seem similar to many
other common digestive problems. Symptoms of nonfunctional pancreatic neuroendocrine
If you have already been diagnosed with a pancreatic neuroendocrine tumor, you may
need this test to help your healthcare provider decide on the best treatment for you.
What other tests might I have along with this test?
Your healthcare provider may also order other tests to look for other substances in
your blood that rise if you have a pancreatic neuroendocrine tumor. These substances
are called biochemical tumor markers.
Your provider may also order an imaging test that takes a picture of your pancreas.
He or she may also order a biopsy. This involves taking out a small piece of the tumor
and looking at it under a microscope.
What do my test results mean?
Many things may affect your lab test results. These include the method each lab uses
to do the test. Even if your test results are different from the normal value, you
may not have a problem. To learn what the results mean for you, talk with your healthcare
Pancreatic polypeptide is measured in picograms per milliliter (pg/mL). Normal results
increase with age and range from less than 228 pg/mL in your 20s to less than 332
pg/mL in your 70s.
A high blood level may mean you have:
How is this test done?
The test requires a blood sample, which is drawn through a needle from a vein in your
Does this test pose any risks?
Taking a blood sample with a needle carries risks that include bleeding, infection,
bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight
stinging sensation or pain. Afterward, the site may be slightly sore.
What might affect my test results?
Eating before the test will cause pancreatic polypeptide levels to rise.
How do I get ready for this test?
You will need to fast for 8 hours before this test. Be sure your healthcare provider
knows about all medicines, herbs, vitamins, and supplements you are taking. This includes
medicines that don't need a prescription and any illicit drugs you may use.