Biological Therapy (Immunotherapy)
What is biological therapy?
Biological therapy is medicine that helps the body's immune system fight cancer. It is
Your immune system works to protect and defend your body against foreign invaders
such as bacteria or viruses. The immune system can also be used to help find and kill
Biological therapy does this by:
Stopping or controlling the processes that allow cancer to grow
Making cancer cells easier to find by the immune system so they can be killed
Increasing the killing power of immune system cells
Training immune cells to fight cancer cells
Stopping cancer cells from spreading to other parts of the body
Biological therapy can be used alone to treat cancer. Or it can be used with other
treatments. These include chemotherapy and radiation therapy.
How does the immune system fight cancer?
The immune system has different types of white blood cells. Each type of white blood
cell has a different way to fight against foreign or diseased cells, including cancer.
These types of white blood cells are in the bloodstream. They flow to every part of
the body. They protect you from cancer and other diseases.
The types of white blood cells include:
Lymphocytes. These include:
B cells. These make antibodies that tag foreign or abnormal cells. This is so other parts
of the immune system can destroy them.
T cells. These attack cancer cells. They also tell other immune system cells to defend the
Natural killer cells (NK cells). These cells find, stick to, and kill foreign or damaged cells in the body.
Macrophages. These are white blood cells that swallow foreign particles. They also tell other
immune system cells to do the same.
Dendritic cells. These bring the foreign cells to the immune system.
What are the types of biological therapy?
There are many types of biological therapy used to treat cancer. They include:
Read below to learn more about each type.
Nonspecific immunomodulating agents
These medicines boost the immune system in a general way. The 2 types often used to
treat cancer are:
Interferons (IFN). Interferons are a natural type of biological response modifier (BRM) in the body.
They are also made in the lab. They improve the way the immune system acts against
some kinds of cancer cells. The medicine may work directly on cancer cells to slow
their growth. Or it may cause cancer cells to change into cells that are more normal.
Some interferons may also tell white blood cells to fight cancer cells.
Interleukins (IL). These are proteins called cytokines. They are naturally in the body. They can also
be made in a lab. They boost the growth and activity of many immune cells. This can
help the immune cells destroy cancer cells.
Colony-stimulating factors (CSFs)
These medicines help stem cells in the bone marrow make more white blood cells. White
blood cells are part of your immune system. They help you fight off germs. Chemo and
other cancer treatments slow the bone marrow’s process for making new white blood
cells. This puts you more at risk for infections.
These are medicines that stick to certain parts of cancer cells. These medicines are
made in a lab. Some of these antibodies work by tagging cancer cells. This helps them
to be found and killed by parts of the immune system. Others work by stopping some
functions that cancer cells need to survive. In some cases, the antibodies are attached
to another substance. This may be another anticancer medicine, a radioactive substance,
or another BRM. When the antibodies attach to cancer cells, they send the other substance
into the cancer. This helps to destroy the cancer cells.
Vaccine therapy is a growing area of cancer research. Vaccine therapy may help the
body's immune system start attacking the cancer cells. For infectious illness such
as flu, vaccines are given before the disease starts. But cancer vaccines are given
after the disease starts. This is done when the amount of cancer is small. Scientists
are testing vaccines for treating many types of cancer. A vaccine may be used with
other types of biological therapy.
Side effects of biological therapy
Side effects vary depending to the type of therapy given. They may be mild or severe.
Or you may have no side effects. Side effects may include:
Skin rash, redness, itching and dryness
Loss of appetite
Extreme tiredness (fatigue)
Interleukins and interferons can cause:
Flu-like symptoms, such as fever, chills, aches, and fatigue
A rash or swelling at the injection site
Interleukins can also cause low blood pressure. Your blood pressure will be watched
closely in the hospital during treatment.
Monoclonal antibodies may cause mild to severe allergic reactions.
Talk with your healthcare team about what side effects you should watch for and when
they should be reported.