What is Guillain-Barré syndrome?
Guillain-Barré syndrome (GBS) is also called acute inflammatory demyelinating polyradiculoneuropathy
(AIDP). It is a neurological disorder in which the body's immune system attacks the
peripheral nervous system. This is the part of the nervous system outside the brain
and spinal cord. The onset of GBS can be quite sudden and unexpected. It requires
immediate hospitalization. It can develop over a few days. Or it may take up to several
weeks with the greatest weakness occurring within the first couple of weeks after
GBS is rare, affecting about 3,000 people in the U.S. It can affect people at any
age and both men and women equally. GBS often develops after a respiratory or gastrointestinal
What causes Guillain-Barré syndrome?
It’s not clear why some people get GBS. What is known is that the body's immune system
begins to attack the body itself.
Normally, the cells of the immune system attack only foreign material and invading
organisms. But in GBS, the immune system starts to destroy the myelin sheath that
surrounds the axons of many nerve cells, and sometimes, the axons themselves.
When this occurs, the nerves can’t send signals efficiently, the muscles lose their
ability to respond to the commands of the brain, and the brain receives fewer sensory
signals from the rest of the body. The result is weakness and an inability to feel
heat, pain, and other sensations.
GBS can occur after a viral infection, surgery, injury, or a reaction to an immunization.
What are the symptoms of Guillain-Barré syndrome?
These are the most common symptoms of GBS. But each person may have slightly different
The first symptom includes weakness or tingling sensations in the legs. This sometimes
spreads to the arms and upper body. A neurological exam usually reveals a loss of
all deep tendon reflexes. The symptoms may get worse. In some cases, you may not be
able to use your muscles at all. You become paralyzed, and breathing is hard. Your
blood pressure and heart function are affected. GBS is a medical emergency and needs
to be treated promptly.
Symptoms can become life-threatening. And even with the best care, there is a small
chance that a person may die. But most people have nearly a complete recovery. Many
are left with fatigue and pain. About 1 in 5 need some help to walk.
The symptoms of GBS may look like other health conditions. Always talk with your healthcare
provider for a diagnosis.
How is Guillain-Barré syndrome diagnosed?
The signs and symptoms of GBS vary. It can be difficult to diagnose in its earliest
These signs and symptoms are unique to GBS:
Symptoms on both sides of the body
Symptoms appear quickly--days or weeks instead of months
Loss of reflexes
High protein level in cerebrospinal fluid (CSF) (the fluid that surrounds the spinal
cord and brain)
To diagnose GBS, you may have the following tests:
Spinal tap (lumbar puncture). A special needle is placed into the lower back, into the spinal canal. This is the
area around the spinal cord. The pressure in the spinal canal and brain can then be
measured. A small amount of CSF is removed and sent for testing to find out if there
is high protein, an infection, or other problems.
Electrodiagnostic tests, such as electromyography (EMG) and nerve conduction velocity
(NCV). These studies are done to evaluate and diagnose disorders of the muscles and motor
neurons. Electrodes are inserted into the muscle, or placed on the skin overlying
a muscle or muscle group. Electrical activity and muscle response are recorded.
How is Guillain-Barré syndrome treated?
There is no known cure for GBS. Treatments, such as plasmapheresis or immunoglobulin,
suppress the immune system and reduce inflammation caused by the immune system’s response
to the disease. Either of these treatments can reduce the amount of time it takes
for you to walk or breathe on your own again.
Plasmapheresis is a procedure that removes the plasma (liquid part of the blood) and replaces it
with other fluids. Antibodies are also removed with the plasma, which is thought to
help reduce the symptoms of the disease.
Immunoglobulin is a blood product that helps to decrease the immune system’s attack on the nervous
Supportive treatment is also given to prevent breathing problems and relieve symptoms.
You will need to stay in the hospital for treatment. Medicines are used to control
pain and other conditions that may be present. Physical therapy can increase muscle
flexibility and strength.
Through research, new treatments for GBS are continually being identified.
Key points about Guillain-Barré syndrome
Guillain-Barré syndrome (GBS) is a neurological disorder in which the body's immune
system attacks part of the peripheral nervous system.
The onset can be quite sudden and unexpected. It requires immediate hospitalization.
The first symptoms include varying degrees of weakness or tingling sensations in the
legs, which sometimes spreads to the arms and upper body.
The goal of treatment is to prevent breathing problems and relieve symptoms.
Recovery can be lengthy. Residual muscle weakness or paralysis can occur.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your provider tells
At the visit, write down the name of a new diagnosis, and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you.
Know why a new medicine or treatment is prescribed, and how it will help you. Also
know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that
Know how you can contact your provider if you have questions.