What are cranial neuropathies?
Nerves power your entire body. But those nerves can be damaged by injury or an illness
such as diabetes. Neuropathy is a disorder caused by nerve damage. It affects your
ability to feel and move. Exactly how your body and your movement are affected depends
on where in the body the damaged nerves are located. When nerves in the brain or brainstem
are affected, it is called cranial neuropathy.
The cranial nerves are those that arise directly from your brain or brainstem. They
often affect areas like the face and eyes. Some of the different types of cranial
Bell palsy. This health problem occurs when the facial nerve (seventh cranial nerve) is affected.
Microvascular cranial nerve palsy. This health problem affects one or more nerves, typically those that go to the eye.
It is most common in people who have diabetes and high blood pressure.
Third nerve palsy. This condition affects the third cranial nerve. This nerve helps manage muscles that
control eye movement as well as the size of the pupil.
Fourth nerve palsy. This is also called superior oblique palsy. It affects the superior oblique muscle,
which helps you converge your eyes (to look at the tip of your nose).
Sixth nerve palsy. This is also called cranial nerve VI or abducens palsy. It affects the sixth cranial
nerve, which also helps control eye movement.
If several different cranial nerves are affected, it is called multiple cranial neuropathies
What causes cranial neuropathies?
Cranial neuropathy can develop for many different reasons. These include:
Infections. Infections in the spinal fluid can irritate cranial nerves. For example, Lyme disease
often affects the seventh nerve. But it can cause problems with any cranial nerve.
Cancer. Cancer cells can spread to the spinal fluid and damage one or more cranial nerves.
Sometimes cancer can press on cranial nerves as they run through the skull.
Increased intracranial pressure from a tumor, head trauma, or brain swelling. This can injure cranial nerves. Pressure can also be raised in certain headaches.
Cranial nerves 3, 4, and 6 are most often affected.
Congenital cranial neuropathies. These are nerve injuries from trauma that occurs at birth. Or they can occur before
birth from developmental problems or infection.
Microvascular cranial nerve palsy. This can develop in people who have high blood pressure or other vascular risks,
such as diabetes or smoking. Poor circulation to the cranial nerves injures them.
It most often affects cranial nerves 3, 4, and 6.
Autoimmune abnormalities. These occur when the immune system attacks one's own cranial nerves. This can happen
in Guillain-Barré syndrome or lupus.
Aneurysm. This can press on nearby nerves. It most often affects cranial nerves, 3, 4, and
Inflammatory diseases. These include sarcoidosis and multiple sclerosis.
What are the symptoms of cranial neuropathies?
Different types of neuropathies can cause different symptoms. They are based on which
nerves are damaged and where they are located. Generally, neuropathies can cause:
Some of the symptoms of different types of cranial neuropathies include:
Bell palsy can cause drooping of part of the face. It usually affects only one side of the face.
Microvascular cranial nerve palsy can cause double vision, droopy eyelid, and other problems with eyesight.
Third nerve palsy can cause an eyelid to sag and droop, double vision, trouble moving the eye, and
a pupil that is bigger than normal.
Fourth nerve palsy causes the eye or eyes to turn abnormally. It sometimes makes you see double. It
may force you to tilt your head when looking.
Sixth nerve palsy can cause abnormal movement of the eye and double vision.
How are cranial neuropathies diagnosed?
A healthcare provider will often do a variety of tests to diagnose neuropathy. Depending
on the type of cranial neuropathy your healthcare provider suspects, you may need:
Nervous system exam to test sensation, reflexes, balance, and mental status
Blood tests to look for infections or health conditions such as diabetes
Electromyography (EMG), which measures the electrical activity of muscles when working
and at rest
CT or MRI scans, which are imaging tests that allow healthcare providers to see the
Nerve conduction velocity tests to help find out how and where the nerve is damaged
Biopsies of the skin and nerves to find out how severely nerves are damaged
Spinal tap (lumbar puncture) to look for infection or inflammation in the spinal fluid
Angiography, which is a special X-ray that uses contrast dye and takes pictures of
your heart and blood vessels
How are cranial neuropathies treated?
A cranial neuropathy could be the sign of a life-threatening emergency. It should
be assessed by a healthcare provider right away. Many types of cranial neuropathies
will get better with time, without any treatment. Sometimes medicines can be used
to treat an infection, help reduce swelling in or near a nerve, or help if the neuropathy
is causing pain. For some types of neuropathies and in some cases, surgery may help.
Other times, the nerve damage can't be treated or fixed.
But it's important to diagnose and treat any health conditions that are causing the
neuropathy. Treating common causes like high blood pressure, infections, and diabetes
can help to treat the neuropathy. Eating nutritious foods, avoiding smoking, and limiting
alcohol can also help manage neuropathy.
Can cranial neuropathies be prevented?
Cranial neuropathy can't always be prevented. But controlling common causes can help
to reduce the risk of developing neuropathy. You can:
Reduce your risk factors for diabetes, stroke, and head injury
Manage your diabetes well, if you have the disease
Lower your blood pressure, if needed
Follow a healthy lifestyle that includes not smoking, getting regular exercise, staying
at a healthy weight, and eating a balanced diet
Living with cranial neuropathy
Cranial neuropathies are often not dangerous. They may get better on their own with
time. But they can certainly be bothersome for the people who have them.
Your best strategy for managing a cranial neuropathy is to manage possible causes.
These include diabetes, high blood pressure, infections, and brain tumors. You should
also prevent head injury.
If the symptoms do not go away on their own, your healthcare team might recommend
physical therapy, occupational therapy, or other options to help with them. Talk with
your healthcare provider about other possible options, such as surgery, if a cranial
neuropathy is affecting your quality of life.
When should I call my healthcare provider?
If you have been diagnosed with a cranial neuropathy, talk with your healthcare providers
about when you might need to call them. They will likely advise you to call if your
symptoms get worse or if you develop new symptoms such as pain, numbness, weakness,
or changes in vision.
Key points about cranial neuropathies
Cranial neuropathies are caused by damage to one or more cranial nerves. These are
nerves that arise directly from the brain. They affect movement and feeling in the
eyes and face.
The causes of cranial neuropathies include poorly controlled diabetes or high blood
pressure, head injuries, infections, strokes, and brain tumors.
Common symptoms can include weakness or loss of sensation in part of the face, or
changes in vision.
Some cranial neuropathies go away on their own. But others might be permanent. Controlling
diabetes and high blood pressure can sometimes help. If symptoms do not go away, medicines,
surgery, or other treatments might be helpful as well.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your provider tells
At the visit, write down the name of a new diagnosis and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you.
Know why a new medicine or treatment is prescribed and how it will help you. Also
know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that
Know how you can contact your provider if you have questions.