Diabetes Autoantibody Panel
Does this test have other names?
Islet autoantibodies and diabetes mellitus autoantibody panel
What is this test?
This blood test checks for substances called antibodies. These are made by your body
as it tries to fight off foreign substances such as germs. But sometimes, antibodies
attack normal things in your body. This can include cells that make insulin and other
chemicals related to insulin. Problems with insulin can lead to diabetes.
Your healthcare provider uses this test to find out if you have type 1 diabetes.
Type 1 diabetes is more common in children, teens, and young adults. Type 2 diabetes
is the most common type of diabetes. It can happen at any age.
The antibodies tested for are:
Islet cell cytoplasmic autoantibodies (ICA)
Glutamic acid decarboxylase autoantibodies (GADA)
Insulinoma-associated-2 autoantibodies (IA-2A)
Insulin autoantibodies (IAA)
If you have some combination of these antibodies in high levels, it could mean you
have type 1 diabetes. Or it could mean you are at risk of developing it. These antibodies
often show up years before symptoms begin. So this test is useful if you have a family
history of type 1 diabetes.
People with type 2 diabetes don't have these antibodies, so the test is also useful
to tell which type of diabetes a person has.
Why do I need this test?
You may need this blood test to confirm that you have type 1 diabetes.
What other tests might I have along with this test?
The diabetes antibody panel is just one test used to check for type 1 diabetes. Your
healthcare provider may also order a C-peptide test or an insulin assay test.
Before having a diabetes antibody panel to find out if you have type 1 diabetes, you
may have a random or fasting plasma glucose test. Or you may have an oral glucose
tolerance test. A fasting plasma glucose test is a blood test done after you fast
for 8 hours. In an oral glucose tolerance test, your blood is checked after you fast
for a period of time and then drink a sugary solution. Many healthcare providers will
also do a test called a hemoglobin A1C. This test gives an average of your blood sugar
over 2 to 3 months.
What do my test results mean?
Test results may vary depending on your age, sex, health history, the method used
for the test, and other things. Your test results may not mean you have a problem.
Ask your healthcare provider what your test results mean for you.
In general, if the antibodies are in your blood, you could have type 1 diabetes. Or
you could be at risk of developing it. If the antibodies are not in your blood, you
might have type 2 diabetes. But some people with type 1 diabetes will test negative
for these antibodies.
How is this test done?
The test is done with a blood sample. A needle is used to draw blood from a vein in
your arm or hand.
Does this test pose any risks?
Having a blood test with a needle has some risks. These include bleeding, infection,
bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may
feel a slight sting or pain. Afterward, the site may be sore.
What might affect my test results?
Taking insulin before the test will prevent an accurate result.
How do I get ready for this test?
You don't need to prepare for this test. Be sure your healthcare provider knows about
all medicines, herbs, vitamins, and supplements you are taking. This includes medicines
that don't need a prescription and any illegal drugs you may use.