Does this test have other names?
Human epidermal growth factor receptor 2, ERBB2, HER2
What is this test?
This is a tissue test to check if a certain protein involved in cell growth (HER2/neu)
is present in some types of cancer cells. Some cancers, especially invasive breast
cancers, have more HER2/neu protein than normal. About 20% of breast cancers have
high numbers of these proteins on their cell surfaces.
If you have a biopsy that shows you have breast cancer or you have surgery for breast
cancer, this test will be done on the breast tissue that has been removed to check
for HER2/neu. Learning your HER2/neu status helps your healthcare providers plan the
best treatment for you.
HER2/neu can also be measured by a blood test. But it's not done very often.
Why do I need this test?
If you are diagnosed with breast cancer, you may have this test to find out more about
your condition. If you are being treated for breast cancer with a cancer medicine,
this test can help your healthcare provider find out how well you are responding to
What other tests might I have along with this test?
If your HER2/neu is being measured after biopsy or surgery, your healthcare provider
may order other tests on breast cancer cells to learn more about your cancer. If these
other tests find receptors for the female hormones estrogen and progesterone, it means
you may respond better to some types of cancer medicines.
What do my test results mean?
Many things may affect your lab test results. These include the method each lab uses
to do the test. Even if your test results are different from the normal value, you
may not have a problem. To learn what the results mean for you, talk with your healthcare
HER2/neu on cancer cells is measured in 2 ways.
If your cancer is HER2/neu positive, you may respond to a specific medicine that targets
Results for IHC:
A score of 0 or +1 means your tumor is HER2 negative.
A score of +2 means the results are unclear and FISH testing should be done.
A score of +3 means the tumor is HER2 positive.
FISH results are positive or negative.
If you are having the blood test, HER2/neu is measured in nanograms per milliliter
How is this test done?
The tissue sample test is done on the breast tissue that was removed in a biopsy or
The test may also require a blood sample, which is drawn through a needle from a vein
in your arm.
Does this test pose any risks?
The tissue sample does not pose any risk aside from the risks of the surgery.
Taking a blood sample with a needle carries risks that include bleeding, infection,
bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight
stinging sensation or pain. Afterward, the site may be slightly sore.
What might affect my test results?
Only the type of cancer you have and the type of treatment you receive can affect
How do I get ready for this test?
You don't need to prepare for this test. Be sure your healthcare provider knows about
all the medicines, herbs, vitamins, and supplements you are taking. This includes
medicines that don't need a prescription and any illegal drugs you may use.