Iron and Total Iron-Binding Capacity
Do these tests have other names?
Iron (Fe), serum iron, TIBC
What are these tests?
The serum iron test measures the amount of iron in your blood. The total iron-binding
capacity (TIBC) test looks at how well the iron moves through your body.
Iron is an important mineral that your body needs to stay healthy. Your body uses
iron to make hemoglobin. This is the protein in your red blood cells that carries
oxygen around your body. If you don't have enough iron, you may not have enough hemoglobin.
This is called iron deficiency anemia.
Iron in your body is carried, or bound, mainly to a protein made by your liver called
transferrin. The TIBC test is based on certain proteins, including transferrin, found
in the blood. Your transferrin levels are almost always measured along with iron and
Why do I need these tests?
You may need these tests if your healthcare provider thinks your iron level is too
low or too high. Not having enough iron in your diet is the most common cause of anemia.
It's the most common type of diet deficiency in the U.S. You may need this test to
look at your diet, nutrition, liver, or other conditions that cause iron to be low,
such as blood loss or pregnancy.
Symptoms of iron deficiency include:
Being tired and feeling weak
Getting frequent infections
Feeling cold all the time
Having swelling in the tongue
Struggling to keep up at school or work
In children, having delayed mental development
Symptoms of too much iron can include:
Feeling tired and weak
What other tests might I have along with this test?
Iron, TIBC, and transferrin blood tests are almost always done together. Your blood
may also be checked for:
Level of your hemoglobin
Your percentage of red blood cells, called hematocrit
The number of all the cells in your blood, called a complete blood count (CBC)
What do my test results mean?
Test results may vary depending on your age, sex, health history, the method used
for the test, and other things. Your test results may not mean you have a problem.
Ask your healthcare provider what your test results mean for you.
Normal results of iron testing may be different for men, women, and children. Iron
and TIBC are measured in micrograms per deciliter (mcg/dL). Normal results for iron
Normal results for TIBC are 250 to 450 mcg/dL for men and women.
Some common causes for a low amount of iron in your blood include:
Some common causes for too much iron in your blood include:
Conditions that cause red blood cells to die, called hemolytic anemia
Iron or lead poisoning
Iron overload, such as from hemochromatosis
Many blood transfusions
Your healthcare provider will look at your iron level along with the TIBC, transferrin,
and possibly other tests to see what the results mean.
How are these tests done?
The test is done with a blood sample. A needle is used to draw blood from a vein in
your arm or hand.
Do these tests pose any risks?
Having a blood test with a needle has some risks. These include bleeding, infection,
bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may
feel a slight sting or pain. Afterward, the site may be sore.
What might affect my test results?
Many medicines can affect the results of these blood tests. Some common medicines
that may affect your results include:
Alcohol can also affect the results. Women who are having their menstrual period may
have lower iron.
How do I get ready for these tests?
You may be asked to have these blood tests in the morning after fasting overnight.
Iron levels are closest to normal in the morning and get lower as the day goes on.
Tell your healthcare provider about all medicines, herbs, vitamins, and supplements
you are taking. This includes medicines that don't need a prescription and any illegal
drugs you may use.