Does this test have other names?
Serum osmolality, osmolality serum, plasma osmolality
What is this test?
This test measures the concentration of dissolved particles (osmolality) in your blood.
This test can help diagnose a fluid or electrolyte imbalance, including dehydration.
Electrolytes are mineral salts that help move nutrients into your cells and waste
products out of your cells.
Electrolytes also control your acidity and pH levels. The more diluted your blood
and urine are, the lower the concentration of particles is. When there is less water
in your blood, the concentration of particles is greater. Osmolality increases when
you are dehydrated and decreases when you have too much fluid in your blood.
Your body has a unique way to control osmolality. When osmolality increases, it triggers
your body to make antidiuretic hormone (ADH). This hormone tells your kidneys to keep
more water inside your blood vessels and your urine becomes more concentrated. When
osmolality decreases, your body doesn't make as much ADH. Your blood and urine become
Why do I need this test?
You may need this test if you have seizures or problems with ADH. You may also have
this test if you are dehydrated or if your healthcare provider thinks you might have
diabetes insipidus (DI). Diabetes insipidus happens when your body makes less ADH.
It's also called arginine vasopressin or AVP. DI can also happen if your kidneys are
not responding to ADH, even though you are making enough of it. Symptoms of DI include:
You might also have this test if you have symptoms of hyponatremia. This is a condition
in which your body retains fluid because it doesn't have enough sodium, an electrolyte.
Symptoms of hyponatremia include:
Nausea and vomiting
Spasms or cramps
Seizures or passing out
You may also have this test if you are in a coma. When osmolality increases, it can
cause fatal grand mal seizures.
What other tests might I have along with this test?
You may also need a urine osmolality test. The results of both urine osmolality and
blood osmolality tests help your healthcare provider figure out the cause of osmolality
You may also need these tests:
What do my test results mean?
Test results may vary depending on your age, gender, health history, the method used
for the test, and other things. Your test results may not mean you have a problem.
Ask your healthcare provider what your test results mean for you.
Results are given in milliosmoles per kilogram (mOsm/kg). Normal results are:
If your levels are higher than normal, it may mean you have one of these conditions:
A level that's beyond normal range may also be caused by blood loss. This may be due
to injury or prolonged vomiting or diarrhea.
If your levels are lower than normal, it may mean that you have one of these conditions:
Too much antidiuretic hormone
Underactive thyroid gland
Too much water or fluid intake
How is this test done?
The test is done with a blood sample, which is drawn through a needle from a vein
in your arm.
Does this test pose any risks?
Having a blood test with a needle carries some risks. These include bleeding, infection,
bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may
feel a slight sting or pain. Afterward, the site may be sore.
What might affect my test results?
Eating a poor diet or drinking too much water can affect your results. Intense exercise
and being under stress can also affect your results. Certain medicines and the illegal
drug Ecstasy can also affect your results.
How do I get ready for this test?
Talk with your healthcare provider about any instructions you need to follow before
the test. Be sure your healthcare provider knows about all medicines, herbs, vitamins,
and supplements you are taking. This includes medicines that don't need a prescription
and any illegal drugs you may use. Also tell your provider if you have been drinking
a lot of water.