Does this test have other names?
Test for concentration of pancreatic enzymes, direct pancreatic enzyme measurement
What is this test?
This test checks your stool sample for trypsin and chymotrypsin. These are two enzymes
made by the pancreas. The test measures how well your pancreas is working to see if
you have pancreatic insufficiency or cystic fibrosis (CF).
With pancreatic insufficiency, the pancreas doesn't make enough enzymes to digest
your food. This leads to problems absorbing the nutrients that the body needs. CF stops
the pancreas from making its normal digestive enzymes. In most cases, this problem
shows up during the first years of life.
People with pancreatic insufficiency or CF often have trouble absorbing nutrients
from their food. They may not put on weight. Children with CF may not grow normally.
Advances in treatment for people with CF have led to them living better quality lives.
But this requires correct medical care such as treatments for lung problems and replacement
pancreatic enzymes to help with digestion.
Based on the results from this test, your healthcare provider may prescribe replacement
Why do I need this test?
You may need this test if your healthcare provider thinks that your pancreas isn't
working the way it should. Symptoms that may mean your pancreas is not working correctly
Belly (abdominal) pain
Weight loss, because you don’t have the enzymes you need to help digest food
Low blood pressure
Pancreatitis that keeps coming back
What other tests might I have along with this test?
You may also have other tests to look at how your pancreas is working. These include:
Elastase and fat. Elastase is an enzyme that breaks down protein. Low levels of elastase or high levels
of fat in your stool mean that you may have a problem with your pancreas.
Pancreatic function. Your healthcare provider will stimulate your pancreas to make fluid. Then they will
collect it from your small intestine.
What do my test results mean?
Test results may vary depending on your age, gender, health history, and other things.
Your test results may be different depending on the lab used. They may not mean you
have a problem. Ask your healthcare provider what your test results mean for you.
Abnormal levels of trypsin or chymotrypsin mean that your pancreas isn't working properly.
How is this test done?
This test is done with a stool sample. Your healthcare provider may ask you to collect
a single stool sample or all of your bowel movements during a 72-hour period. Check
that the sample does not contain urine or toilet tissue.
Does this test pose any risks?
This test poses no known risks.
What might affect my test results?
Urine or toilet tissue in the sample can affect the results.
How do I get ready for this test?
You don't need to prepare for this test. But be sure your healthcare provider knows
about all medicines, herbs, vitamins, and supplements you are taking. This includes
medicines that don't need a prescription and any illegal drugs you may use.