Glycyrrhiza glabra, Family: Fabaceae
licorice, sweet root
Licorice is a perennial herb. It’s mostly grown in Greece, Turkey, and western Asia.
It’s been used since ancient times as a flavoring agent. It’s also been used as an
expectorant, helping to clear excess mucus from the upper and lower airways.
The medicinal parts of the plant are the unpeeled dried roots and runners, and the
underground stem (rhizome). Licorice contains the compound glycyrrhizin, which is
50 times sweeter than sugar. Taking in too much glycyrrhizin glycoside from ingesting
too much licorice in food or supplement form can cause fluid retention and lead to
elevated blood pressure (hypertension).
Uses as a medicine
Licorice is mainly used a flavoring agent. It’s used in products such as toothpaste,
throat lozenges, and tobacco. Most "licorice" candy is flavored with anise oil and
not real licorice.
A few clinical trials outside the U.S. show that licorice extract given as a shot
may help treat the hepatitis C virus, although more research is needed.
Licorice has also been used historically in traditional Chinese medicine and other
integrative medicine approaches for its adaptogenic properties to enhance resistance
and recovery from stress-related responses.
Claims not backed up
Note that this section reports on claims that have not yet been proved through studies.
Licorice has been linked with a wide range of claims. It may help:
Ease a cough and bronchitis
Reduce inflammation, especially in the stomach
Lower high cholesterol and triglyceride levels
Prevent plaque, gum disease, and tooth decay
Treat microbial or viral infections, including viral liver disease
Protect your liver
Treat snakebites. It may be used as an antivenin.
Suppress your immune system
Treat tetanus and globefish toxins
Act as a possible antidote for the toxic effects of cocaine abuse
Aid in treating skin issues when put on the skin
How much to take
Licorice comes in capsules and tablets, and as a liquid extract. Follow the dosing
instructions on the label and work with a naturopathic physician, functional medicine
doctor, or herbalist who is trained in botanical medicine.
Side effects, toxicity, and interactions
Licorice can cause serious side effects if you take too much of it or use it for too
long. It has an effect similar to aldosterone. Aldosterone is a hormone that causes
your body to retain salt (sodium) and lose potassium.
Taking too much licorice can cause high blood pressure. This can be severe. It can
cause the following symptoms:
Swelling because your body is retaining water (edema)
Lack of energy (lethargy)
Heart failure or cardiac arrest
You can even become poisoned from eating too much candy that contains real licorice
or using licorice-containing tobacco.
You shouldn’t take licorice if you have certain health issues. These include:
Low potassium levels (hypokalemia)
Cholestatic liver disease
Heart rhythm issues and other heart diseases
High blood pressure
Severe kidney problems
A tumor in your adrenal glands (pheochromocytoma)
You also shouldn’t take it if you drink a lot of alcohol. Women who are pregnant or
breastfeeding also shouldn’t use this herb.
Don’t take licorice while fasting. Doing so can lead to a serious electrolyte imbalance.
Licorice can also interact with some medicines. Thiazide water pills (diuretics) may
increase the amount of potassium you lose when used with licorice. Licorice may also
increase the effects of digitalis. This is because digitalis sensitivity is increased
by low potassium levels.
Licorice may interfere with the effects of aldactone. This is a medicine used to treat
high blood pressure. Talk with your healthcare provider before you take licorice.
You also shouldn’t take licorice if you take warfarin. It may increase your metabolism
and decrease the effectiveness of warfarin.