URMC / Labs / Nedergaard Lab / Publications

Recent Publications

1. Quirk K
2. Ladrón-de-Guevara A
3. Raghunandan A
4. Mestre H
5. Nedergaard M
6. Kelley DH
Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats.; Fluids and barriers of the CNS. 2026 Mar 07.
1. Nedergaard M
Evaluation policies in international non-governmental humanitarian organisations.; Evaluation and program planning; Vol 117, pp. 102775. 2026 Mar 03.
1. Morse I
2. Nedergaard M
3. Hablitz LM
Circadian timing of the dystrophin associated complex across the brain and body.; Fluids and barriers of the CNS. 2026 Feb 12.
1. Wostyn P
2. Nedergaard M
Ocular Glymphatic Dysfunction as a Potential Link Between Obstructive Sleep Apnea and Retinal Structural Changes. Comment on Pusic Sesar et al. Multimodal Assessment of Ocular Parameters in Patients with Severe Obstructive Sleep Apnea with Emphasis on Retinal Structural Changes. Life 2025, 15, 1307.; Life (Basel, Switzerland); Vol 16(2). 2026 Jan 28.
1. Gomolka RS
2. Ladrón-de-Guevara A
3. Grubb S
4. Hirschler L
5. Strom I
6. Weikop P
7. van Osch M
8. Nedergaard M
9. Mori Y
Unmasking the Bias: Can Diffusion-Weighted Imaging Reliably Assess Glymphatic Function in Awake and Anesthetized Brain?; NeuroImage. 2026 Jan 28.
1. Kang H
2. Zhou S
3. Giannetto M
4. McConnell ED
5. Kang N
6. Sun Q
7. Zhao H
8. Wei HS
9. Kramer K
10. Guo Y
11. Costa JS
12. Villeda SA
13. Nedergaard M
14. Wan J
Cortical O2 supply and metabolism are suppressed in the aged mice.; Proceedings of the National Academy of Sciences of the United States of America; Vol 123(4), pp. e2522765123. 2026 Jan 23.
1. Ghanizada H
2. Gomolka RS
3. Nedergaard M
Simultaneous Non-Invasive Electrocardiogram and Respiration Rate Recordings in Head-Fixed Awake Mice.; Bio-protocol; Vol 16(1), pp. e5556. 2026 Jan 05.
1. Kjaerby C
2. Radovanovic T
3. Kovács ER
4. Bojarowska Z
5. Tokarska KA
6. Tsopanidou A
7. Nielsen ES
8. Andersen M
9. Li Y
10. Weikop P
11. Untiet V
12. Nedergaard M
Coordinated infraslow cortical oscillations of neuromodulators during NREM sleep.; iScience; Vol 29(2), pp. 114554. 2025 Dec 29.
1. Kjaerby C
2. Radovanovic T
3. Kovács ER
4. Bojarowska Z
5. Tokarska KA
6. Tsopanidou A
7. Nielsen ES
8. Andersen M
9. Li Y
10. Weikop P
11. Untiet V
12. Nedergaard M
Coordinated infraslow cortical oscillations of neuromodulators during NREM sleep.; bioRxiv : the preprint server for biology. 2025 Dec 28.
1. Wang X
2. Delle C
3. Nedergaard M
4. Wostyn P
Glymphatic Transport and Ocular Diseases.; Progress in retinal and eye research. 2025 Dec 23.
1. Liu G
2. Wang J
3. Tong T
4. Arbanas LG
5. Liang S
6. Newbold E
7. Kroesbergen E
8. Boesen HC
9. Nedergaard M
10. Du T
Mechanical Ventilation Suppresses Glymphatic Function in Parallel with Delirium-Like Symptoms in Mice.; bioRxiv : the preprint server for biology. 2025 Dec 16.
1. Knak PG
2. Vittani M
3. Lee AB
4. Nedergaard L
5. Elleholm NV
6. Wang X
7. Bojarowska Z
8. Martens MC
9. Konno A
10. Hirai H
11. Nedergaard M
12. Hirase H
Towards enhancing photostability and adeno-associated viral vector delivery for genetically encoded plasma fluorescent labels.; Neurophotonics; Vol 12(Suppl 2), pp. S22811. 2025 Dec 12.
1. Du T
2. Liu G
3. Nedergaard M
Bridging veins in Alzheimer's disease: Decoding waste clearance failure.; The Journal of experimental medicine; Vol 223(2). 2025 Dec 10.
1. Hauglund NL
2. Nedergaard M
Is glymphatic clearance the secret to restorative sleep?; Brain : a journal of neurology. 2025 Dec 01.
1. Kipnis J
2. Benveniste H
3. Eichmann A
4. Thomas JL
5. Reich DS
6. Lewis LD
7. Tsai LH
8. Drieu A
9. Bakker ENTP
10. Kelley DH
11. Lundgaard I
12. Mestre H
13. Zott B
14. Eide PK
15. van Osch MJP
16. van Veluw SJ
17. Iliff J
18. Yang AC
19. Santambrogio L
20. Da Mesquita S
21. Daneman R
22. Rustenhoven J
23. Goldman SA
24. Nedergaard M
Resolving the mysteries of brain clearance and immune surveillance.; Neuron. 2025 Nov 24.
1. Ulv Larsen SM
2. Holst SC
3. Olsen AS
4. Ozenne B
5. Zilstorff DB
6. Brendstrup-Brix K
7. Weikop P
8. Pleinert S
9. Kiviniemi V
10. Jennum PJ
11. Nedergaard M
12. Knudsen GM
Sleep deprivation and sleep intensity exert distinct effects on cerebral vasomotion and brain pulsations driven by the respiratory and cardiac cycles.; PLoS biology; Vol 23(11), pp. e3003500. 2025 Nov 20.
1. Ranjan A
2. Wong DT
3. Huang Q
4. Ghanizada H
5. Nedergaard M
6. Kelley DH
7. Boster KAS
Comparison of approaches for surface vessel diameter and pulsatility quantification.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2025 Nov 14.
1. Guo Y
2. Bork PAR
3. Nedergaard M
4. Kelley DH
Dynamics of brain valves: ostensible rectification mechanisms for cerebrospinal fluid flow.; Journal of the Royal Society, Interface; Vol 22(231), pp. 20250419. 2025 Oct 29.
1. Persson NDÅ
2. Lohela TJ
3. Anttila JE
4. Mäkelä J
5. Rosenholm M
6. Peltoniemi M
7. Jalonen SC
8. García-Horsman JA
9. Sarparanta M
10. Nedergaard M
11. Rantamäki T
12. Lilius TO
General anesthesia and systemic hyperosmolality modulate lumbar intrathecal drug distribution in female rats.; Anesthesiology. 2025 Oct 09.
1. Finkelstein AJ
2. Sipple MT
3. Akkipeddi SMK
4. Whyte R
5. Kohli GS
6. Susa S
7. Singh R
8. Romiyo P
9. Zhong J
10. Bhalla T
11. Mattingly T
12. Nguyen VN
13. Nedergaard M
14. Bender MT
15. Schartz D
Role of post-thrombectomy glymphatic flow in futile recanalization in large-vessel occlusion ischemic stroke.; Journal of neurosurgery. 2025 Sep 19.
1. Hablitz LM
2. Nedergaard M
Cerebrospinal fluid flow modulates brain health.; The Journal of clinical investigation; Vol 135(17). 2025 Sep 02.
1. Andersen JV
2. Aldana BI
3. Bak LK
4. Behar KL
5. Borges K
6. Carruthers A
7. Cumming P
8. Derouiche A
9. Díaz-García CM
10. Drew KL
11. Duarte JMN
12. Ferreira GC
13. Giove F
14. Gjedde A
15. Hyder F
16. Ioannou MS
17. Kann O
18. Kristian T
19. Lai JCK
20. Mason GF
21. McNay EC
22. Nedergaard M
23. Nowak TS
24. Patel AB
25. Rae CD
26. Ryan TA
27. Schuck PF
28. Simpson IA
29. Vannucci SJ
30. Waagepetersen HS
31. Yellen G
32. McKenna MC
Embracing Scientific Debate in Brain Metabolism.; Journal of neurochemistry; Vol 169(9), pp. e70230. 2025 Sep.
1. Cona A
2. Newbold E
3. Kesmen D
4. Snape R
5. Danner J
6. White N
7. Borden W
8. Iseson A
9. Schanz SJ
10. Chandler-Militello D
11. Li X
12. Cano JC
13. Mariani JN
14. Nedergaard M
15. Benraiss A
16. Goldman SA
In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells.; bioRxiv : the preprint server for biology. 2025 Jul 04.
1. Vittani M
2. Herlo R
3. Wang X
4. Christensen MDB
5. Vo CT
6. Mishima T
7. Kusk P
8. Konno A
9. Hirai H
10. Tsuboi T
11. Kitaguchi T
12. Kjaerby C
13. Asiminas A
14. Yokoyama T
15. Sakamoto M
16. Nedergaard M
17. Hirase H
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice.; Proceedings of the National Academy of Sciences of the United States of America; Vol 122(27), pp. e2422069122. 2025 Jul 01.
1. Andersen M
2. Hirase H
3. Kjaerby C
4. Nedergaard M
Neuroglia's signaling: orchestrating neuronal gamma synchrony?; Current opinion in neurology. 2025 Jun 06.
1. Gahn-Martinez D
2. Giannetto M
3. Chang E
4. Beam N
5. Tobin P
6. Plá V
7. Nedergaard M
Chronic Intraventricular Cannulation for the Study of Glymphatic Transport.; eNeuro. 2025 Jun 02.
1. Pinho-Correia LM
2. McCullough SJC
3. Ghanizada H
4. Nedergaard M
5. Rustenhoven J
6. Da Mesquita S
CSF transport at the brain-meningeal border: effects on neurological health and disease.; The Lancet. Neurology; Vol 24(6), pp. 535-547. 2025 Jun.
1. Rose L
2. Zahid AN
3. Piilgaard L
4. Egebjerg C
5. Sørensen FL
6. Andersen M
7. Radovanovic T
8. Tsopanidou A
9. Bastianini S
10. Berteotti C
11. Lo Martire V
12. Borsa M
13. Tisdale RK
14. Sun Y
15. Nedergaard M
16. Silvani A
17. Zoccoli G
18. Adamantidis A
19. Kilduff TS
20. Sakai N
21. Nishino S
22. Arthaud S
23. Peyron C
24. Fort P
25. Mørup M
26. Mignot E
27. Kornum BR
Probability estimation of narcolepsy type 1 in DTA mice using unlabeled EEG and EMG data.; Sleep advances : a journal of the Sleep Research Society; Vol 6(2), pp. zpaf025. 2025 May 10.
1. Capasso G
2. Franssen CFM
3. Perna AF
4. Massy ZA
5. Menzies RI
6. Zoccali C
7. Tessitore A
8. Nedergaard M
9. Okusa MD
10. Ortiz A
11. Wagner CA
12. Unwin RJ
Drivers and mechanisms of cognitive decline in chronic kidney disease.; Nature reviews. Nephrology. 2025 Apr 25.
1. Wostyn P
2. Nedergaard M
Sleep deprivation and glymphatic dysfunction: Perspectives on the risk of Spaceflight Associated Neuro-ocular Syndrome (SANS).; Life sciences in space research; Vol 46, pp. 137-138. 2025 Apr 17.
1. Cano JC
2. Mangiamele C
3. Nedergaard M
4. Benraiss A
5. Goldman SA
Newly generated striatal neurons rescue motor circuitry in a Huntington's disease mouse model.; Cell reports. 2025 Apr 05.
1. Mortensen KN
2. Lilius T
3. Rosenholm M
4. Sigurðsson B
5. Kelley DH
6. Nedergaard M
Perivascular cerebrospinal fluid inflow matches interstitial fluid efflux in anesthetized rats.; iScience; Vol 28(5), pp. 112323. 2025 Mar 30.
1. Vittani M
2. Lee AB
3. Wang X
4. Hiraoka Y
5. Konno A
6. Knak PG
7. Kusk P
8. Nagao M
9. Asiminas A
10. Courtin J
11. Putranto MF
12. Nasu Y
13. Tsuno S
14. Ueda K
15. Osuga Y
16. Tsuboi T
17. Bienvenu T
18. Terunuma M
19. Hirai H
20. Nedergaard M
21. Tanaka K
22. Hirase H
Functional and structural profiling of circulation via genetically encoded modular fluorescent probes.; bioRxiv : the preprint server for biology. 2025 Mar 18.
1. Zoccali C
2. Mallamaci F
3. Wagner CA
4. Unwin R
5. Nedergaard M
6. Hafez G
7. Malyszko J
8. Pepin M
9. Massy Z
10. Paolisso G
11. Remuzzi G
12. Capasso GB
Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD.; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association; Vol 40(Supplement_2), pp. ii64-ii75. 2025 Mar 13.
1. Plá V
2. Kroesbergen E
3. Deng S
4. Giannetto MJ
5. Hablitz LM
6. Newbold E
7. Ladrón-de-Guevara A
8. Esmail T
9. Gomolka RS
10. Mori Y
11. Goldman SA
12. Kelley DH
13. Thomas JH
14. Nedergaard M
A curious concept of CNS clearance.; Nature neuroscience. 2025 Mar 11.
1. Wostyn P
2. Nedergaard M
Should poor sleep be added to the list of risk factors for normal-tension glaucoma in the future?; Eye (London, England). 2025 Mar 05.
1. Wostyn P
2. Nedergaard M
Could Sleep Be an Antidote to Optic Disc Edema in Astronauts?; Life (Basel, Switzerland); Vol 15(2). 2025 Jan 26.
1. Lüthi A
2. Nedergaard M
Anything but small: Microarousals stand at the crossroad between noradrenaline signaling and key sleep functions.; Neuron. 2025 Jan 08.
1. Ghanizada H
2. Nedergaard M
The glymphatic system.; Handbook of clinical neurology; Vol 209, pp. 161-170. 2025.
1. Sartipi S
2. Andersen M
3. Hauglund N
4. Kjaerby C
5. Untiet V
6. Nedergaard M
7. Cetin M
LG-Sleep: Local and Global Temporal Dependencies for Mice Sleep Scoring.; IEEE sensors letters; Vol 9(2). 2024 Dec 26.
1. Kritsilis M
2. Vanherle L
3. Rosenholm M
4. In 't Zandt R
5. Yao Y
6. Swanberg KM
7. Weikop P
8. Gottschalk M
9. Shanbhag NC
10. Luo J
11. Boster K
12. Nedergaard M
13. Meissner A
14. Lundgaard I
Loss of glymphatic homeostasis in heart failure.; Brain : a journal of neurology. 2024 Dec 18.
1. Hauglund NL
2. Andersen M
3. Tokarska K
4. Radovanovic T
5. Kjaerby C
6. Sørensen FL
7. Bojarowska Z
8. Untiet V
9. Ballestero SB
10. Kolmos MG
11. Weikop P
12. Hirase H
13. Nedergaard M
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep.; Cell. 2024 Dec 17.
1. Untiet V
2. Rose CR
3. Nedergaard M
4. Verkhratsky A
Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology.; Cell calcium; Vol 125, pp. 102984. 2024 Dec 07.
1. Toscano JD
2. Wu C
3. Ladrón-de-Guevara A
4. Du T
5. Nedergaard M
6. Kelley DH
7. Karniadakis GE
8. Boster KAS
Inferring in vivo murine cerebrospinal fluid flow using artificial intelligence velocimetry with moving boundaries and uncertainty quantification.; Interface focus; Vol 14(6), pp. 20240030. 2024 Dec 06.
1. Bork PAR
2. Gianetto M
3. Newbold E
4. Hablitz L
5. Bohr T
6. Nedergaard M
Blood osmolytes such as sugar can drive brain fluid flows in a poroelastic model.; Scientific reports; Vol 14(1), pp. 29017. 2024 Nov 22.
1. Cankar N
2. Beschorner N
3. Tsopanidou A
4. Qvist FL
5. Colaço AR
6. Andersen M
7. Kjaerby C
8. Delle C
9. Lambert M
10. Mundt F
11. Weikop P
12. Jucker M
13. Mann M
14. Skotte NH
15. Nedergaard M
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model.; Cell reports; Vol 43(11), pp. 114977. 2024 Nov 13.
1. Sun Q
2. Peng S
3. Xu Q
4. Weikop P
5. Hussain R
6. Song W
7. Nedergaard M
8. Ding F
Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice.; Nature communications; Vol 15(1), pp. 9600. 2024 Nov 06.
1. Wostyn P
2. Mader TH
3. Gibson CR
4. Nedergaard M
New insights in brain-to-eye transport: can excess cerebrospinal fluid in astronauts escape into the eye?; Eye (London, England). 2024 Nov 04.
1. Li B
2. Sun Q
3. Ding F
4. Xu Q
5. Kang N
6. Xue Y
7. Ladron-de-Guevara A
8. Hirase H
9. Weikop P
10. Gong S
11. Nathan S
12. Nedergaard M
Anti-seizure effects of norepinephrine-induced free fatty acid release.; Cell metabolism. 2024 Oct 29.
1. Iden CR
2. Mustafa SM
3. Øgaard N
4. Henriksen T
5. Jensen SØ
6. Ahlborn LB
7. Egebjerg K
8. Baeksgaard L
9. Garbyal RS
10. Nedergaard MK
11. Achiam MP
12. Andersen CL
13. Mau-Sørensen M
Circulating tumor DNA predicts recurrence and survival in patients with resectable gastric and gastroesophageal junction cancer.; Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2024 Oct 05.