Recent Publications

• 1. Bork PAR
  2. Hauglund NL
  3. Mori Y
  4. Møllgård K
  5. Hjorth PG
  6. Nedergaard M
  Modeling of brain efflux: Constraints of brain surfaces.; Proceedings of the National Academy of Sciences of the United States of America; Vol 121(16), pp. e2318444121. 2024 Apr 10.
• 1. Beinlich FRM
  2. Asiminas A
  3. Untiet V
  4. Bojarowska Z
  5. Plá V
  6. Sigurdsson B
  7. Timmel V
  8. Gehrig L
  9. Graber MH
  10. Hirase H
  11. Nedergaard M
  Oxygen imaging of hypoxic pockets in the mouse cerebral cortex.; Science (New York, N.Y.); Vol 383(6690), pp. 1471-1478. 2024 Mar 28.
• 1. Delle C
  2. Wang X
  3. Giannetto M
  4. Newbold E
  5. Peng W
  6. Gomolka RS
  7. Ladrón-de-Guevara A
  8. Cankar N
  9. Schiøler Nielsen E
  10. Kjaerby C
  11. Weikop P
  12. Mori Y
  13. Nedergaard M
  Transient but not chronic hyperglycemia accelerates ocular glymphatic transport.; Fluids and barriers of the CNS; Vol 21(1), pp. 26. 2024 Mar 12.
• 1. Ding F
  2. Sun Q
  3. Long C
  4. Rasmussen RN
  5. Peng S
  6. Xu Q
  7. Kang N
  8. Song W
  9. Weikop P
  10. Goldman SA
  11. Nedergaard M
  Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.; Brain : a journal of neurology. 2024 Mar 11.
• 1. Hablitz L
  2. Nedergaard M
  Synchronized neuronal activity drives waste fluid flow.; Nature. 2024 Feb 28.
• 1. Giannetto MJ
  2. Gomolka RS
  3. Gahn-Martinez D
  4. Newbold EJ
  5. Bork PAR
  6. Chang E
  7. Gresser M
  8. Thompson T
  9. Mori Y
  10. Nedergaard M
  Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271.; Glia. 2024 Feb 16.
• 1. Beschorner N
  2. Nedergaard M
  Glymphatic system dysfunction in neurodegenerative diseases.; Current opinion in neurology. 2024 Feb 13.
• 1. Eisen A
  2. Nedergaard M
  3. Gray E
  4. Kiernan MC
  THE GLYMPHATIC SYSTEM AND AMYOTROPHIC LATERAL SCLEROSIS.; Progress in neurobiology. 2024 Jan 22.
• 1. Hussain R
  2. Nedergaard M
  Managing noradrenaline after traumatic brain injury.; Clinical and translational medicine; Vol 14(1), pp. e1562. 2024 Jan.
• 1. Untiet V
  2. Nedergaard M
  3. Verkhratsky A
  Astrocyte chloride, excitatory-inhibitory balance and epilepsy.; Neural regeneration research; Vol 19(9), pp. 1887. 2023 Dec 15.
• 1. Dietz AG
  2. Weikop P
  3. Hauglund N
  4. Andersen M
  5. Petersen NC
  6. Rose L
  7. Hirase H
  8. Nedergaard M
  Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(40), pp. e2305071120. 2023 Sep 29.
• 1. Hussain R
  2. Graham U
  3. Elder A
  4. Nedergaard M
  Air pollution, glymphatic impairment, and Alzheimer's disease.; Trends in neurosciences. 2023 Sep 28.
• 1. Gan Y
  2. Holstein-Rønsbo S
  3. Nedergaard M
  4. Boster KAS
  5. Thomas JH
  6. Kelley DH
  Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism.; Journal of the Royal Society, Interface; Vol 20(206), pp. 20230288. 2023 Sep 20.
• 1. Holstein-Rønsbo S
  2. Gan Y
  3. Giannetto MJ
  4. Rasmussen MK
  5. Sigurdsson B
  6. Beinlich FRM
  7. Rose L
  8. Untiet V
  9. Hablitz LM
  10. Kelley DH
  11. Nedergaard M
  Publisher Correction: Glymphatic influx and clearance are accelerated by neurovascular coupling.; Nature neuroscience. 2023 Sep 04.
• 1. Ozawa K
  2. Nagao M
  3. Konno A
  4. Iwai Y
  5. Vittani M
  6. Kusk P
  7. Mishima T
  8. Hirai H
  9. Nedergaard M
  10. Hirase H
  Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes.; International journal of molecular sciences; Vol 24(17). 2023 Sep 02.
• 1. Staudt M
  2. Shalgunov V
  3. Nedergaard M
  4. Herth MM
  Development of 11 C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species.; Journal of labelled compounds & radiopharmaceuticals. 2023 Aug 31.
• 1. Andersen M
  2. Tsopanidou A
  3. Radovanovic T
  4. Compere VN
  5. Hauglund N
  6. Nedergaard M
  7. Kjaerby C
  Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep.; Bio-protocol; Vol 13(15), pp. e4734. 2023 Aug 05.
• 1. Kim D
  2. Gan Y
  3. Nedergaard M
  4. Kelley DH
  5. Tithof J
  Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow.; bioRxiv : the preprint server for biology. 2023 Jul 24.
• 1. Miyakoshi LM
  2. Stæger FF
  3. Li Q
  4. Pan C
  5. Xie L
  6. Kang H
  7. Pavan C
  8. Dang J
  9. Sun Q
  10. Ertürk A
  11. Nedergaard M
  The state of brain activity modulates cerebrospinal fluid transport.; Progress in neurobiology. 2023 Jul 21.
• 1. Raicevic N
  2. Forer JM
  3. Ladrón-de-Guevara A
  4. Du T
  5. Nedergaard M
  6. Kelley DH
  7. Boster K
  Sizes and shapes of perivascular spaces surrounding murine pial arteries.; Fluids and barriers of the CNS; Vol 20(1), pp. 56. 2023 Jul 17.
• 1. Bork PAR
  2. Ladrón-de-Guevara A
  3. Christensen AH
  4. Jensen KH
  5. Nedergaard M
  6. Bohr T
  Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow.; Journal of the Royal Society, Interface; Vol 20(204), pp. 20230050. 2023 Jul 12.
• 1. Vittani M
  2. Knak PAG
  3. Fukuda M
  4. Nagao M
  5. Wang X
  6. Kjaerby C
  7. Konno A
  8. Hirai H
  9. Nedergaard M
  10. Hirase H
  Virally induced CRISPR/Cas9-based knock-in of fluorescent albumin allows long-term visualization of cerebral circulation in infant and adult mice.; bioRxiv : the preprint server for biology. 2023 Jul 10.
• 1. Mathiesen BK
  2. Miyakoshi LM
  3. Cederroth CR
  4. Tserga E
  5. Versteegh C
  6. Bork PAR
  7. Hauglund NL
  8. Gomolka RS
  9. Mori Y
  10. Edvall NK
  11. Rouse S
  12. Møllgård K
  13. Holt JR
  14. Nedergaard M
  15. Canlon B
  Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice.; Science translational medicine; Vol 15(702), pp. eabq3916. 2023 Jun 28.
• 1. Hirase H
  2. Nedergaard M
  Locomotion Induces Fundamentally Different Patterns of Ca2+ Signaling in Astrocytes and Neurons.; Function (Oxford, England); Vol 4(4), pp. zqad028. 2023 Jun 05.
• 1. Holstein-Rønsbo S
  2. Gan Y
  3. Giannetto MJ
  4. Rasmussen MK
  5. Sigurdsson B
  6. Beinlich FRM
  7. Rose L
  8. Untiet V
  9. Hablitz LM
  10. Kelley DH
  11. Nedergaard M
  Glymphatic influx and clearance are accelerated by neurovascular coupling.; Nature neuroscience. 2023 Jun 01.
• 1. Raizen DM
  2. Mullington J
  3. Anaclet C
  4. Clarke G
  5. Critchley H
  6. Dantzer R
  7. Davis R
  8. Drew KL
  9. Fessel J
  10. Fuller PM
  11. Gibson EM
  12. Harrington M
  13. Lipkin WI
  14. Klerman EB
  15. Klimas N
  16. Komaroff AL
  17. Koroshetz W
  18. Krupp L
  19. Kuppuswamy A
  20. Lasselin J
  21. Lewis LD
  22. Magistretti PJ
  23. Matos HY
  24. Miaskowski C
  25. Miller AH
  26. Nath A
  27. Nedergaard M
  28. Opp MR
  29. Ritchie MD
  30. Rogulja D
  31. Rolls A
  32. Salamone JD
  33. Saper C
  34. Whittemore V
  35. Wylie G
  36. Younger J
  37. Zee PC
  38. Heller HC
  Beyond the Symptom: The Biology of Fatigue.; Sleep. 2023 May 24.
• 1. Agarwal N
  2. Lewis LD
  3. Hirschler L
  4. Rivera LR
  5. Naganawa S
  6. Levendovszky SR
  7. Ringstad G
  8. Klarica M
  9. Wardlaw J
  10. Iadecola C
  11. Hawkes C
  12. Carare RO
  13. Wells J
  14. Bakker ENTP
  15. Kurtcuoglu V
  16. Bilston L
  17. Nedergaard M
  18. Mori Y
  19. Stoodley M
  20. Alperin N
  21. de Leon M
  22. van Osch MJP
  Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome.; Journal of magnetic resonance imaging : JMRI. 2023 May 04.
• 1. Kjaerby C
  2. Andersen M
  3. Hauglund N
  4. Untiet V
  5. Dall C
  6. Ding F
  7. Hirase H
  8. Nedergaard M
  Reply to: 'Do all norepinephrine surges disrupt sleep?'.; Nature neuroscience. 2023 Apr 20.
• 1. Untiet V
  2. Beinlich FRM
  3. Kusk P
  4. Kang N
  5. Ladrón-de-Guevara A
  6. Song W
  7. Kjaerby C
  8. Andersen M
  9. Hauglund N
  10. Bojarowska Z
  11. Sigurdsson B
  12. Deng S
  13. Hirase H
  14. Petersen NC
  15. Verkhratsky A
  16. Nedergaard M
  Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice.; Nature communications; Vol 14(1), pp. 1871. 2023 Apr 04.
• 1. Parka A
  2. Volbracht C
  3. Hall B
  4. Bastlund JF
  5. Nedergaard M
  6. Laursen B
  7. Botta P
  8. Sotty F
  Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model.; Journal of Alzheimer's disease : JAD. 2023 Mar 31.
• 1. Ge GR
  2. Rolland JP
  3. Song W
  4. Nedergaard M
  5. Parker KJ
  Fluid compartments influence elastography of the aging mouse brain.; Physics in medicine and biology. 2023 Mar 30.
• 1. Boster KAS
  2. Cai S
  3. Ladrón-de-Guevara A
  4. Sun J
  5. Zheng X
  6. Du T
  7. Thomas JH
  8. Nedergaard M
  9. Karniadakis GE
  10. Kelley DH
  Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(14), pp. e2217744120. 2023 Mar 29.
• 1. Delle C
  2. Cankar N
  3. Digebjerg Holgersson C
  4. Hvorup Knudsen H
  5. Schiøler Nielsen E
  6. Kjaerby C
  7. Mori Y
  8. Nedergaard M
  9. Weikop P
  Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice.; Scientific reports; Vol 13(1), pp. 4137. 2023 Mar 13.
• 1. Sigurdsson B
  2. Hauglund NL
  3. Lilius TO
  4. Mogensen FL
  5. Mortensen KN
  6. Beschorner N
  7. Klinger L
  8. Bærentzen SL
  9. Rosenholm MP
  10. Shalgunov V
  11. Herth M
  12. Mori Y
  13. Nedergaard M
  A SPECT-based method for dynamic imaging of the glymphatic system in rats.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023 Feb 21.
• 1. Raicevic N
  2. Forer JM
  3. Ladron-de-Guevara A
  4. Du T
  5. Nedergaard M
  6. Kelley DH
  7. Boster KAS
  Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries.; Research square. 2023 Feb 17.
• 1. Gomolka RS
  2. Hablitz LM
  3. Mestre H
  4. Giannetto M
  5. Du T
  6. Hauglund NL
  7. Xie L
  8. Peng W
  9. Martinez PM
  10. Nedergaard M
  11. Mori Y
  Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.; eLife; Vol 12. 2023 Feb 09.
• 1. Plá V
  2. Bitsika S
  3. Giannetto M
  4. Ladron-de-Guevara A
  5. Gahn-Martinez D
  6. Mori Y
  7. Nedergaard M
  8. Møllgård K
  Structural characterization of SLYM - a 4th meningeal membrane.; Research square. 2023 Jan 31.
• 1. Lilius TO
  2. Mortensen KN
  3. Deville C
  4. Lohela TJ
  5. Stæger FF
  6. Sigurdsson B
  7. Fiordaliso EM
  8. Rosenholm M
  9. Kamphuis C
  10. Beekman FJ
  11. Jensen AI
  12. Nedergaard M
  Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles.; Journal of controlled release : official journal of the Controlled Release Society. 2023 Jan 30.
• 1. Plá V
  2. Bitsika S
  3. Giannetto M
  4. Ladron-de-Guevara A
  5. Gahn-Martinez D
  6. Mori Y
  7. Nedergaard M
  8. Møllgård K
  Structural characterization of SLYM - a 4 th meningeal membrane.; bioRxiv : the preprint server for biology. 2023 Jan 28.
• 1. Nasu Y
  2. Aggarwal A
  3. Le GNT
  4. Vo CT
  5. Kambe Y
  6. Wang X
  7. Beinlich FRM
  8. Lee AB
  9. Ram TR
  10. Wang F
  11. Gorzo KA
  12. Kamijo Y
  13. Boisvert M
  14. Nishinami S
  15. Kawamura G
  16. Ozawa T
  17. Toda H
  18. Gordon GR
  19. Ge S
  20. Hirase H
  21. Nedergaard M
  22. Paquet ME
  23. Drobizhev M
  24. Podgorski K
  25. Campbell RE
  Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging.; Nature communications; Vol 14(1), pp. 6598. 2023 Jan 27.
• 1. Esmail T
  2. Nedergaard M
  3. Beinlich FRM
  Protocol to study molecule exchange between venous blood and CSF in live mice using transcranial bioluminescence imaging.; STAR protocols; Vol 4(4), pp. 102652. 2023 Jan 25.
• 1. Parka A
  2. Degel C
  3. Dreyer J
  4. Richter U
  5. Hall B
  6. Bastlund JF
  7. Laursen B
  8. Nedergaard M
  9. Sotty F
  10. Botta P
  Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model.; Neurobiology of disease; Vol 178, pp. 106012. 2023 Jan 23.
• 1. Hussain R
  2. Tithof J
  3. Wang W
  4. Cheetham-West A
  5. Song W
  6. Peng W
  7. Sigurdsson B
  8. Kim D
  9. Sun Q
  10. Peng S
  11. Plá V
  12. Kelley DH
  13. Hirase H
  14. Castorena-Gonzalez JA
  15. Weikop P
  16. Goldman SA
  17. Davis MJ
  18. Nedergaard M
  Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema.; Nature. 2023 Jan 15.
• 1. Plá V
  2. Bitsika S
  3. Giannetto MJ
  4. Ladron-de-Guevara A
  5. Gahn-Martinez D
  6. Mori Y
  7. Nedergaard M
  8. Møllgård K
  Structural characterization of SLYM-a 4th meningeal membrane.; Fluids and barriers of the CNS; Vol 20(1), pp. 93. 2023 Jan 14.
• 1. Wang X
  2. Delle C
  3. Peng W
  4. Plá V
  5. Giannetto M
  6. Kusk P
  7. Sigurdsson B
  8. Sakurai S
  9. Sweeney A
  10. Sun Q
  11. Du T
  12. Libby RT
  13. Nedergaard M
  Age- and glaucoma-induced changes to the ocular glymphatic system.; Neurobiology of disease. 2023 Jan 11.
• 1. Møllgård K
  2. Beinlich FRM
  3. Kusk P
  4. Miyakoshi LM
  5. Delle C
  6. Plá V
  7. Hauglund NL
  8. Esmail T
  9. Rasmussen MK
  10. Gomolka RS
  11. Mori Y
  12. Nedergaard M
  A mesothelium divides the subarachnoid space into functional compartments.; Science (New York, N.Y.); Vol 379(6627), pp. 84-88. 2023 Jan 05.
• 1. Ge GR
  2. Song W
  3. Nedergaard M
  4. Rolland JP
  5. Parker KJ
  Corrigendum: Theory of sleep/wake cycles affecting brain elastography (2022Phys. Med. Biol.67225013).; Physics in medicine and biology; Vol 68(21). 2023 Jan 02.
• 1. Helakari H
  2. Järvelä M
  3. Väyrynen T
  4. Tuunanen J
  5. Piispala J
  6. Kallio M
  7. Ebrahimi SM
  8. Poltojainen V
  9. Kananen J
  10. Elabasy A
  11. Huotari N
  12. Raitamaa L
  13. Tuovinen T
  14. Korhonen V
  15. Nedergaard M
  16. Kiviniemi V
  Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations.; Frontiers in neuroscience; Vol 17, pp. 1275184. 2023 Jan 01.
• 1. Lilius TO
  2. Rosenholm M
  3. Klinger L
  4. Mortensen KN
  5. Sigurdsson B
  6. Mogensen FL
  7. Hauglund NL
  8. Nielsen MSN
  9. Rantamäki T
  10. Nedergaard M
  SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline.; iScience; Vol 25(10), pp. 105250. 2022 Sep 29.
• 1. Lopes van den Broek S
  2. Shalgunov V
  3. García Vázquez R
  4. Beschorner N
  5. Bidesi NSR
  6. Nedergaard M
  7. Knudsen GM
  8. Sehlin D
  9. Syvänen S
  10. Herth MM
  Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?; Pharmaceuticals (Basel, Switzerland); Vol 15(10). 2022 Sep 27.