URMC / Labs / Bohmann Lab / Publications Recent Publications Li XEberhardt AHansen JNBohmann DLi HSchor NF (2017 Feb 17). Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Chatterjee NTian MSpirohn KBoutros MBohmann D (2016 May). Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein. PLoS genetics. Li XChatterjee NSpirohn KBoutros MBohmann D (2016). Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes. Scientific reports. Pitoniak ABohmann D (2015 Nov). Mechanisms and functions of Nrf2 signaling in Drosophila. Free radical biology & medicine. Bohmann DDhillon P (2014 May). Towards a systems-level understanding of aging and cancer: an interview with Dirk Bohmann. Disease models & mechanisms. Tsakiri ENSykiotis GPPapassideri ISTerpos EDimopoulos MAGorgoulis VGBohmann DTrougakos IP (2013 Oct). Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging. Aging cell. Rahman MMSykiotis GPNishimura MBodmer RBohmann D (2013 Aug). Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes. Aging cell. Tsakiri ENSykiotis GPPapassideri ISGorgoulis VGBohmann DTrougakos IP (2013 Jun). Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Barone MCBohmann D (2013). Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining. Journal of visualized experiments : JoVE. Chatterjee NBohmann D (2012). A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture. PloS one. Barone MCSykiotis GPBohmann D (2011 Sep). Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease. Disease models & mechanisms. Kriete ALechner MClearfield DBohmann D (2011 Jul). Computational systems biology of aging. Wiley interdisciplinary reviews. Systems biology and medicine. Schreck IAl-Rawi MMingot JMScholl CDiefenbacher MEO'Donnell PBohmann DWeiss C (2011 Apr 22). c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK. Biochemical and biophysical research communications. Hochmuth CEBiteau BBohmann DJasper H (2011 Feb 4). Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell stem cell. Sykiotis GPHabeos IGSamuelson AVBohmann D (2011 Jan). The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation. Current opinion in clinical nutrition and metabolic care. Wang QUhlirova MBohmann D (2010 Jan 19). Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis. Developmental cell. Sekyrova PBohmann DJindra MUhlirova M (2010 Jan). Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. Development (Cambridge, England). Sykiotis GPBohmann D (2010). Stress-activated cap'n'collar transcription factors in aging and human disease. Science signaling. Wu HWang MCBohmann D (2009 Aug). JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mechanisms of development. Sykiotis GPBohmann D (2008 Jan). Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Developmental cell. Luo XPuig OHyun JBohmann DJasper H (2007 Jan 24). Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. The EMBO journal. Sykiotis GPBohmann D (2007 Jan 01). Stress-Activated Protein Kinase Signaling in Drosophila Topics in Current Genetics. Uhlirova MBohmann D (2006 Nov 15). JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. The EMBO journal. Hyun JBécam IYanicostas CBohmann D (2006 Nov). Control of G2/M transition by Drosophila Fos. Molecular and cellular biology. Homsy JGJasper HPeralta XGWu HKiehart DPBohmann D (2006 Feb). JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. Miotto BSagnier TBerenger HBohmann DPradel JGraba Y (2006 Jan 1). Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis. Genes & development. Uhlirova MJasper HBohmann D (2005 Sep 13). Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proceedings of the National Academy of Sciences of the United States of America. Hyun JJasper HBohmann D (2005 Jul). DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs. Molecular and cellular biology. Wang MCBohmann DJasper H (2005 Apr 08). JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell. Letsou ABohmann D (2005 Mar). Small flies--big discoveries: nearly a century of Drosophila genetics and development. Developmental dynamics : an official publication of the American Association of Anatomists. Etter PDNarayanan RNavratilova ZPatel CBohmann DJasper HRamaswami M (2005). Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons. BMC neuroscience. Portman DSBohmann D (2004 Jun 18). Toward the computable transcriptome. Molecular cell. Su CGao GSchneider SHelt CWeiss CO'Reilly MABohmann DZhao J (2004 Mar 10). DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway. The EMBO journal. Weiss CBohmann D (2004 Feb). Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis. Cell cycle (Georgetown, Tex.). Wang MCBohmann DJasper H (2003 Nov). JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Developmental cell. Weiss CSchneider SWagner EFZhang XSeto EBohmann D (2003 Jul 15). JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. The EMBO journal. Jasper HBohmann D (2002 Nov). Drosophila innate immunity: a genomic view of pathogen defense. Molecular cell. Jasper HBenes VAtzberger ASauer SAnsorge WBohmann D (2002 Oct). A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye. Developmental cell. Gallo ACuozzo CEsposito IMaggiolini MBonofiglio DVivacqua AGarramone MWeiss CBohmann DMusti AM (2002 Sep 19). Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation. Oncogene. Lafarga MBerciano MTPena EMayo ICastaño JGBohmann DRodrigues JPTavanez JPCarmo-Fonseca M (2002 Aug). Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. Molecular biology of the cell. Ciapponi LBohmann D (2002 Jul). An essential function of AP-1 heterodimers in Drosophila development. Mechanisms of development. Gritzan UWeiss CBrennecke JBohmann D (2002 Jul). Transrepression of AP-1 by nuclear receptors in Drosophila. Mechanisms of development. Westermarck JWeiss CSaffrich RKast JMusti AMWessely MAnsorge WSéraphin BWilm MValdez BCBohmann D (2002 Feb 1). The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription. The EMBO journal. Jasper HBenes VSchwager CSauer SClauder-Münster SAnsorge WBohmann D (2001 Oct). The genomic response of the Drosophila embryo to JNK signaling. Developmental cell. Leppä SEriksson MSaffrich RAnsorge WBohmann D (2001 Jul). Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells. Molecular and cellular biology. Ciapponi LJackson DBMlodzik MBohmann D (2001 Jun 15). Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes & development. Kockel LHomsy JGBohmann D (2001 Apr 30). Drosophila AP-1: lessons from an invertebrate. Oncogene. Mihaly JKockel LGaengel KWeber UBohmann DMlodzik M (2001 Apr). The role of the Drosophila TAK homologue dTAK during development. Mechanisms of development. Barilá DMangano RGonfloni SKretzschmar JMoro MBohmann DSuperti-Furga G (2000 Jan 17). A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK. The EMBO journal. Valcárcel RWeber UJackson DBBenes VAnsorge WBohmann DMlodzik M (1999 Dec). Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development. Journal of cell science.