Recent Publications

• 1. Cheng Y
  2. Pitoniak A
  3. Wang J
  4. Bohmann D
  Preserving transcriptional stress responses as an anti-aging strategy.; Aging cell. 2021 Jan 20.
• 1. Mello S
  2. Bohmann D
  Counting the Minutes.; eLife; Vol 9. 2020 Jan 07.
• 1. Tian X
  2. Firsanov D
  3. Zhang Z
  4. Cheng Y
  5. Luo L
  6. Tombline G
  7. Tan R
  8. Simon M
  9. Henderson S
  10. Steffan J
  11. Goldfarb A
  12. Tam J
  13. Zheng K
  14. Cornwell A
  15. Johnson A
  16. Yang JN
  17. Mao Z
  18. Manta B
  19. Dang W
  20. Zhang Z
  21. Vijg J
  22. Wolfe A
  23. Moody K
  24. Kennedy BK
  25. Bohmann D
  26. Gladyshev VN
  27. Seluanov A
  28. Gorbunova V
  SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.; Cell; Vol 177(3). 2019 Apr 18.
• 1. Chatterjee N
  2. Bohmann D
  BET-ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors.; BioEssays : news and reviews in molecular, cellular and developmental biology. 2018 Mar 30.
• 1. Li X
  2. Eberhardt A
  3. Hansen JN
  4. Bohmann D
  5. Li H
  6. Schor NF
  Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 Feb 17.
• 1. Chatterjee N
  2. Tian M
  3. Spirohn K
  4. Boutros M
  5. Bohmann D
  Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.; PLoS genetics; Vol 12(5). 2016 May.
• 1. Li X
  2. Chatterjee N
  3. Spirohn K
  4. Boutros M
  5. Bohmann D
  Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.; Scientific reports; Vol 6. 2016.
• 1. Pitoniak A
  2. Bohmann D
  Mechanisms and functions of Nrf2 signaling in Drosophila.; Free radical biology & medicine; Vol 88(Pt B). 2015 Nov.
• 1. Bohmann D
  2. Dhillon P
  Towards a systems-level understanding of aging and cancer: an interview with Dirk Bohmann.; Disease models & mechanisms; Vol 7(5). 2014 May.
• 1. Tsakiri EN
  2. Sykiotis GP
  3. Papassideri IS
  4. Terpos E
  5. Dimopoulos MA
  6. Gorgoulis VG
  7. Bohmann D
  8. Trougakos IP
  Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.; Aging cell; Vol 12(5). 2013 Oct.
• 1. Rahman MM
  2. Sykiotis GP
  3. Nishimura M
  4. Bodmer R
  5. Bohmann D
  Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.; Aging cell; Vol 12(4). 2013 Aug.
• 1. Tsakiri EN
  2. Sykiotis GP
  3. Papassideri IS
  4. Gorgoulis VG
  5. Bohmann D
  6. Trougakos IP
  Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 27(6). 2013 Jun.
• 1. Barone MC
  2. Bohmann D
  Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining.; Journal of visualized experiments : JoVE. 2013.
• 1. Chatterjee N
  2. Bohmann D
  A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture.; PloS one; Vol 7(4). 2012.
• 1. Barone MC
  2. Sykiotis GP
  3. Bohmann D
  Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.; Disease models & mechanisms; Vol 4(5). 2011 Sep.
• 1. Kriete A
  2. Lechner M
  3. Clearfield D
  4. Bohmann D
  Computational systems biology of aging.; Wiley interdisciplinary reviews. Systems biology and medicine; Vol 3(4). 2011 Jul.
• 1. Schreck I
  2. Al-Rawi M
  3. Mingot JM
  4. Scholl C
  5. Diefenbacher ME
  6. O'Donnell P
  7. Bohmann D
  8. Weiss C
  c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK.; Biochemical and biophysical research communications; Vol 407(4). 2011 Apr 22.
• 1. Hochmuth CE
  2. Biteau B
  3. Bohmann D
  4. Jasper H
  Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila.; Cell stem cell; Vol 8(2). 2011 Feb 4.
• 1. Sykiotis GP
  2. Habeos IG
  3. Samuelson AV
  4. Bohmann D
  The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation.; Current opinion in clinical nutrition and metabolic care; Vol 14(1). 2011 Jan.
• 1. Wang Q
  2. Uhlirova M
  3. Bohmann D
  Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis.; Developmental cell; Vol 18(1). 2010 Jan 19.
• 1. Sekyrova P
  2. Bohmann D
  3. Jindra M
  4. Uhlirova M
  Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.; Development (Cambridge, England); Vol 137(1). 2010 Jan.
• 1. Sykiotis GP
  2. Bohmann D
  Stress-activated cap'n'collar transcription factors in aging and human disease.; Science signaling; Vol 3(112). 2010.
• 1. Wu H
  2. Wang MC
  3. Bohmann D
  JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy.; Mechanisms of development; Vol 126(8-9). 2009 Aug.
• 1. Sykiotis GP
  2. Bohmann D
  Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila.; Developmental cell; Vol 14(1). 2008 Jan.
• 1. Luo X
  2. Puig O
  3. Hyun J
  4. Bohmann D
  5. Jasper H
  Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation.; The EMBO journal; Vol 26(2). 2007 Jan 24.
• 1. Sykiotis GP
  2. Bohmann D
  Stress-Activated Protein Kinase Signaling in Drosophila; Topics in Current Genetics. 2007 Jan 01.
• 1. Uhlirova M
  2. Bohmann D
  JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila.; The EMBO journal; Vol 25(22). 2006 Nov 15.
• 1. Hyun J
  2. Bécam I
  3. Yanicostas C
  4. Bohmann D
  Control of G2/M transition by Drosophila Fos.; Molecular and cellular biology; Vol 26(22). 2006 Nov.
• 1. Homsy JG
  2. Jasper H
  3. Peralta XG
  4. Wu H
  5. Kiehart DP
  6. Bohmann D
  JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.; Developmental dynamics : an official publication of the American Association of Anatomists; Vol 235(2). 2006 Feb.
• 1. Miotto B
  2. Sagnier T
  3. Berenger H
  4. Bohmann D
  5. Pradel J
  6. Graba Y
  Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis.; Genes & development; Vol 20(1). 2006 Jan 1.
• 1. Uhlirova M
  2. Jasper H
  3. Bohmann D
  Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model.; Proceedings of the National Academy of Sciences of the United States of America; Vol 102(37). 2005 Sep 13.
• 1. Hyun J
  2. Jasper H
  3. Bohmann D
  DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.; Molecular and cellular biology; Vol 25(13). 2005 Jul.
• 1. Wang MC
  2. Bohmann D
  3. Jasper H
  JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.; Cell; Vol 121(1). 2005 Apr 08.
• 1. Letsou A
  2. Bohmann D
  Small flies--big discoveries: nearly a century of Drosophila genetics and development.; Developmental dynamics : an official publication of the American Association of Anatomists; Vol 232(3). 2005 Mar.
• 1. Etter PD
  2. Narayanan R
  3. Navratilova Z
  4. Patel C
  5. Bohmann D
  6. Jasper H
  7. Ramaswami M
  Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons.; BMC neuroscience; Vol 6. 2005.
• 1. Portman DS
  2. Bohmann D
  Toward the computable transcriptome.; Molecular cell; Vol 14(6). 2004 Jun 18.
• 1. Su C
  2. Gao G
  3. Schneider S
  4. Helt C
  5. Weiss C
  6. O'Reilly MA
  7. Bohmann D
  8. Zhao J
  DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway.; The EMBO journal; Vol 23(5). 2004 Mar 10.
• 1. Weiss C
  2. Bohmann D
  Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis.; Cell cycle (Georgetown, Tex.); Vol 3(2). 2004 Feb.
• 1. Wang MC
  2. Bohmann D
  3. Jasper H
  JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.; Developmental cell; Vol 5(5). 2003 Nov.
• 1. Weiss C
  2. Schneider S
  3. Wagner EF
  4. Zhang X
  5. Seto E
  6. Bohmann D
  JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun.; The EMBO journal; Vol 22(14). 2003 Jul 15.
• 1. Jasper H
  2. Bohmann D
  Drosophila innate immunity: a genomic view of pathogen defense.; Molecular cell; Vol 10(5). 2002 Nov.
• 1. Jasper H
  2. Benes V
  3. Atzberger A
  4. Sauer S
  5. Ansorge W
  6. Bohmann D
  A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye.; Developmental cell; Vol 3(4). 2002 Oct.
• 1. Gallo A
  2. Cuozzo C
  3. Esposito I
  4. Maggiolini M
  5. Bonofiglio D
  6. Vivacqua A
  7. Garramone M
  8. Weiss C
  9. Bohmann D
  10. Musti AM
  Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation.; Oncogene; Vol 21(42). 2002 Sep 19.
• 1. Lafarga M
  2. Berciano MT
  3. Pena E
  4. Mayo I
  5. Castaño JG
  6. Bohmann D
  7. Rodrigues JP
  8. Tavanez JP
  9. Carmo-Fonseca M
  Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.; Molecular biology of the cell; Vol 13(8). 2002 Aug.
• 1. Ciapponi L
  2. Bohmann D
  An essential function of AP-1 heterodimers in Drosophila development.; Mechanisms of development; Vol 115(1-2). 2002 Jul.
• 1. Gritzan U
  2. Weiss C
  3. Brennecke J
  4. Bohmann D
  Transrepression of AP-1 by nuclear receptors in Drosophila.; Mechanisms of development; Vol 115(1-2). 2002 Jul.
• 1. Westermarck J
  2. Weiss C
  3. Saffrich R
  4. Kast J
  5. Musti AM
  6. Wessely M
  7. Ansorge W
  8. Séraphin B
  9. Wilm M
  10. Valdez BC
  11. Bohmann D
  The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription.; The EMBO journal; Vol 21(3). 2002 Feb 1.
• 1. Jasper H
  2. Benes V
  3. Schwager C
  4. Sauer S
  5. Clauder-Münster S
  6. Ansorge W
  7. Bohmann D
  The genomic response of the Drosophila embryo to JNK signaling.; Developmental cell; Vol 1(4). 2001 Oct.
• 1. Leppä S
  2. Eriksson M
  3. Saffrich R
  4. Ansorge W
  5. Bohmann D
  Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells.; Molecular and cellular biology; Vol 21(13). 2001 Jul.
• 1. Ciapponi L
  2. Jackson DB
  3. Mlodzik M
  4. Bohmann D
  Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites.; Genes & development; Vol 15(12). 2001 Jun 15.