URMC / Labs / Boyce Lab / Publications Recent Publications Yao ZAyoub ASrinivasan VWu JTang CDuan RMilosavljevic AXing LEbetino FHFrontier AJBoyce BF Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects.; Bone research; Vol 12(1), pp. 52. 2024 Sep 05. Bell RDBrendel MKonnaris MAXiang JOtero MFontana MABai ZKrenitsky DMMeednu NRangel-Moreno JScheel-Toellner DCarr HNayar SMcMurray JDiCarlo EAnolik JHDonlin LTOrange DEKenney HMSchwarz EMFiler AIvashkiv LBWang F Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.; Nature communications; Vol 15(1), pp. 7503. 2024 Aug 29. Duan RMilton PSittplangkoon CLiu XSui ZBoyce BFYao Z Chimeric antigen receptor dendritic cells targeted delivery of a single tumoricidal factor for cancer immunotherapy.; Cancer immunology, immunotherapy : CII; Vol 73(10), pp. 203. 2024 Aug 06. Law CWacleche VSCao YPillai ASowerby JHancock BHorisberger ABracero SSkidanova VLi ZAdejoorin IDillon EBenque IJNunez DPSimmons DPKeegan JChen LBaker TBrohawn PZAl-Mossawi HHao LYJones BRao NQu YAlves SEJonsson AHShaw KSVleugels RAMassarotti ECostenbader KHBrenner MBLederer JAHultquist JFChoi JRao DA Publisher Correction: Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.; Nature. 2024 Jul 26. Law CWacleche VSCao YPillai ASowerby JHancock BHorisberger ABracero SSkidanova VLi ZAdejoorin IDillon EBenque IJNunez DPSimmons DPKeegan JChen LBaker TBrohawn PZAl-Mossawi HHao LYJones BRao NQu YAlves SEJonsson AHShaw KSVleugels RAMassarotti ECostenbader KHBrenner MBLederer JAHultquist JFChoi JRao DA Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.; Nature. 2024 Jul 10. Scheller ELMcDonald MAndersen TLSumner DRNoda MErben RGBoyce BFCompston JEDempster DWTakahashi HEMalluche HHWronski TJ Celebrating 50-years: the history and future of the International Society of Bone Morphometry.; JBMR plus; Vol 8(7), pp. ziae070. 2024 Jun 12. Dunlap GWagner AMeednu NWang RZhang FEkabe JCJonsson AHWei KSakaue SNathan ABykerk VPDonlin LTGoodman SMFirestein GSBoyle DLHolers VMMoreland LWTabechian DPitzalis CFiler ARaychaudhuri SBrenner MBThakar JMcDavid ARao DAAnolik JH Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.; Nature communications; Vol 15(1), pp. 4991. 2024 Jun 11. Weinand KSakaue SNathan AJonsson AHZhang FWatts GFMAl Suqri MZhu ZRao DAAnolik JHBrenner MBDonlin LTWei KRaychaudhuri S The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis.; Nature communications; Vol 15(1), pp. 4650. 2024 May 31. Bai ZBartelo NAslam MMurphy EAHale CRBlachere NEParveen SSpolaore EDiCarlo EGravallese EMSmith MHFrank MOJiang CSZhang HPyrgaki CLewis MJSikandar SPitzalis CLesnak JBMazhar KPrice TJMalfait AMMiller REZhang FGoodman SDarnell RBWang FOrange DE Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.; Science translational medicine; Vol 16(742), pp. eadk3506. 2024 Apr 10. Sakaue SWeinand KIsaac SDey KKJagadeesh KKanai MWatts GFMZhu ZBrenner MBMcDavid ADonlin LTWei KPrice ALRaychaudhuri S Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.; Nature genetics. 2024 Apr 09. Zhang FJonsson AHNathan AMillard NCurtis MXiao QGutierrez-Arcelus MApruzzese WWatts GFMWeisenfeld DNayar SRangel-Moreno JMeednu NMarks KEMantel IKang JBRumker LMears JSlowikowski KWeinand KOrange DEGeraldino-Pardilla LDeane KDTabechian DCeponis AFirestein GSMaybury MSahbudin IBen-Artzi AMandelin AMNerviani ALewis MJRivellese FPitzalis CHughes LBHorowitz DDiCarlo EGravallese EMBoyce BFMoreland LWGoodman SMPerlman HHolers VMLiao KPFiler ABykerk VPWei KRao DADonlin LTAnolik JHBrenner MBRaychaudhuri S Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.; Nature; Vol 623(7987), pp. 616-624. 2023 Nov 08. Li JYao ZLiu XDuan RYi XAyoub ASanders JOMesfin AXing LBoyce BF TGFβ1+CCR5+ neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice.; Nature communications; Vol 14(1), pp. 159. 2023 Jan 11. Yao ZBoyce BF TGFβ priming promotes TNF-induced bone erosion: a promising new target in RA?; Nature reviews. Rheumatology. 2022 Sep 16. Ajabnoor RMQuinzi DACarmody EBoyce BF Intraligamentous synovial osteochondroma of the ligamentum teres: a series of 14 cases.; International journal of clinical and experimental pathology; Vol 15(7), pp. 282-288. 2022 Jul 15. Nazemi AKGrossi JTavernier FBBoyce BFKomatsu DEKhan FA Glomus Tumor of the Lower Extremity Previously Misdiagnosed as Complex Regional Pain Syndrome in Close Proximity to a Myxofibrosarcoma: A Case Report.; Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews; Vol 6(7). 2022 Jul 06. Liu JZhang JLin XBoyce BFZhang HXing L Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice.; The Journal of clinical investigation; Vol 132(8). 2022 Apr 15. Dong QXiu YWang YHodgson CBorcherding NJordan CBuchanan JTaylor EWagner BLeidinger MHolman CThiele DJO'Brien SXue HHZhao JLi QMeyerson HBoyce BFZhao C HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia.; Nature communications; Vol 13(1), pp. 6107. 2022 Jan 16. Lin XZhang HLiu JWu CLMcDavid ABoyce BFXing L Aged Callus Skeletal Stem/Progenitor Cells Contain an Inflammatory Osteogenic Population With Increased IRF and NF-κB Pathways and Reduced Osteogenic Potential.; Frontiers in molecular biosciences; Vol 9. 2022. Tao JSrinivasan VYi XZhao YZhang HLin XZhou XBoyce BFVillalta PWEbetino FHHo KKBoeckman RKXing L Bone-Targeted Bortezomib Inhibits Bortezomib-Resistant Multiple Myeloma in Mice by Providing Higher Levels of Bortezomib in Bone.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021 Dec 30. Zhao JXiu YFu LDong QBorcherding NWang YLi QDe Silva NSKlein UBoyce BFZhao C TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9.; iScience; Vol 24(12). 2021 Dec 17. Catheline SEBell RDOluoch LSJames MNEscalera-Rivera KMaynard RDChang MEDean CBotto EKetz JPBoyce BFZuscik MJJonason JH IKKβ-NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice.; Science signaling; Vol 14(701). 2021 Sep 21. Cole CLBachman JFYe JMurphy JGerber SABeck CABoyce BFMuthukrishnan GChakkalakal JVSchwarz EMLinehan D Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting.; Journal of cachexia, sarcopenia and muscle. 2021 May 07. Kronman HTorres-Berrío ASidoli SIssler OGodino ARamakrishnan AMews PLardner CKParise EMWalker DMvan der ZYBrowne CJBoyce BFNeve RGarcia BAShen LPeña CJNestler EJ Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons.; Nat Neurosci.; Vol 21 ;24(5). 2021 Jan 01. Lin XWang WMcDavid AXu HBoyce BFXing L The E3 ubiquitin ligase Itch limits the progression of post-traumatic osteoarthritis in mice by inhibiting macrophage polarization.; Osteoarthritis and cartilage. 2021 Apr 30. Li LMustahsan VMHe GTavernier FBSingh GBoyce BFKhan FKao I Classification of Soft Tissue Sarcoma Specimens with Raman Spectroscopy as Smart Sensing Technology.; Cyborg and bionic systems (Washington, D.C.); Vol 2021, pp. 9816913. 2021 Jan 06. Yao ZXing LBoyce BF RANKL-Based Osteoclastogenic Assay from Murine Bone Marrow Cells.; Methods in molecular biology (Clifton, N.J.); Vol 2230. 2021. Masters EAHao SPMark Kenney HMorita YGalloway CAde Mesy Bentley KLRicciardi BFBoyce BFSchwarz EMOh I Distinct Vasculotropic vs. Osteotropic Features of S. agalactiae vs. S. aureus Implant-Associated Bone Infection in Mice.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020 Dec 18. Sun STao JSedghizadeh PPCherian PJunka AFSodagar EXing LBoeckman RKSrinivasan VYao ZBoyce BFLipe BNeighbors JDRussell GMcKenna CEEbetino FH Bisphosphonates for delivering drugs to bone.; British journal of pharmacology. 2020 Sep 02. Zhang FMears JRShakib LBeynor JIShanaj SKorsunsky INathan ADonlin LTRaychaudhuri S IFN- γ and TNF- α drive a CXCL10 + CCL2 + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.; bioRxiv : the preprint server for biology. 2020 Aug 05. Qiu BJoo PAjabnoor RBoyce BMesfin A Surgical management of aggressive hemangiomas of the spine.; Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia; Vol 78. 2020 Aug. Lin XZhang HBoyce BFXing L Ubiquitination of interleukin-1α is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH.; The Journal of biological chemistry. 2020 Jun 25. Xing LEbetino FHBoeckman RKSrinivasan VTao JSawyer TKLi JYao ZBoyce BF Targeting anti-cancer agents to bone using bisphosphonates.; Bone. 2020 Jun 22. Lei WDuan RLi JLiu XHuston ABoyce BFYao Z The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice.; Scientific reports; Vol 10(1). 2020 Apr 24. Wei KKorsunsky IMarshall JLGao AWatts GFMMajor TCroft APWatts JBlazar PELange JKThornhill TSFiler ARaza KDonlin LTSiebel CWBuckley CDRaychaudhuri SBrenner MB Notch signalling drives synovial fibroblast identity and arthritis pathology.; Nature. 2020 Apr 22. Li JYi XYao ZChakkalakal JVXing LBoyce BF TNF receptor-associated factor 6 mediates TNFα-induced skeletal muscle atrophy in mice during aging.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2020 Apr 08. Dong QXiu YBossler ASyrbu SWang HXue WZhao JLi QJin MWang LBoyce BSakr HAnsari MQZhao C CLL dedifferentiation to clonally related myeloid cells.; Blood advances; Vol 4(24). 2020 Jan 22. Xiu YDong QFu LBossler ATang XBoyce BBorcherding NLeidinger MSardina JLXue HHLi QFeldman AAifantis IBoccalatte FWang LJin MKhoury JWang WHu SYuan YWang EYuan JJanz SColgan JHabelhah HWaldschmidt TMüschen MBagg ADarbro BZhao C Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion.; Blood; Vol 135(2). 2020 Jan 09. Wang WWang HZhou XLi XSun WDellinger MBoyce BFXing L Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 34(11). 2019 Nov. Wang HZhang HSrinivasan VTao JSun WLin XWu TBoyce BFEbetino FHBoeckman RKXing L Targeting Bortezomib to Bone Increases its Bone Anabolic Activity and Reduces Systemic Adverse Effects in Mice.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2019 Oct 14. Liang QZhang LWood RWJi RCBoyce BFSchwarz EMWang YXing L RelB regulates lymphatic endothelial cells during vessel maturation and is required for lymphatic vessel function in adult mice.; The American journal of pathology. 2019 Sep 17. Li JAyoub AXiu YYin XSanders JOMesfin AXing LYao ZBoyce BF TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.; Nature communications; Vol 10(1). 2019 Jun 26. Zhang FWei KSlowikowski KFonseka CYRao DAKelly SGoodman SMTabechian DHughes LBSalomon-Escoto KWatts GFMJonsson AHRangel-Moreno JMeednu NRozo CApruzzese WEisenhaure TMLieb DJBoyle DLMandelin AMBoyce BFDiCarlo EGravallese EMGregersen PKMoreland LFirestein GSHacohen NNusbaum CLederer JAPerlman HPitzalis CFiler AHolers VMBykerk VPDonlin LTAnolik JHBrenner MBRaychaudhuri S Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.; Nature immunology. 2019 May 06. Masters EATrombetta RPde Mesy Bentley KLBoyce BFGill ALGill SRNishitani KIshikawa MMorita YIto HBello-Irizarry SNNinomiya MBrodell JDLee CCHao SPOh IXie CAwad HADaiss JLOwen JRKates SLSchwarz EMMuthukrishnan G Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy".; Bone research; Vol 7. 2019. Sun WMeednu NRosenberg ARangel-Moreno JWang VGlanzman JOwen TZhou XZhang HBoyce BFAnolik JHXing L B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation.; Nature communications; Vol 9(1). 2018 Dec 03. Wang HXiao LTao JSrinivasan VBoyce BFEbetino FHOyajobi BOBoeckman RKXing L Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice.; Pharmaceutics; Vol 10(3). 2018 Sep 10. D'Amore TBoyce BMesfin A Chordoma of the mobile spine and sacrum: clinical management and prognosis.; Journal of spine surgery (Hong Kong); Vol 4(3). 2018 Sep. Donlin LTRao DAWei KSlowikowski KMcGeachy MJTurner JDMeednu NMizoguchi FGutierrez-Arcelus MLieb DJKeegan JMuskat KHillman JRozo CRicker EEisenhaure TMLi SBrowne EPChicoine ASutherby DNoma ANusbaum CKelly SPernis ABIvashkiv LBGoodman SMRobinson WHUtz PJLederer JAGravallese EMBoyce BFHacohen NPitzalis CGregersen PKFirestein GSRaychaudhuri SMoreland LWHolers VMBykerk VPFiler ABoyle DLBrenner MBAnolik JH Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue; Arthritis research & therapy; Vol 20(1). 2018 Jul 11. Xiu YDong QLi QLi FBorcherding NZhang WBoyce BXue HHZhao C Stabilization of NF-κB-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia.; Cell reports; Vol 22(2). 2018 Jan 09. Boyce BFLi JXing LYao Z Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption.; Frontiers in immunology; Vol 9. 2018. Boyce BF An update on the validation of whole slide imaging systems following FDA approval of a system for a routine pathology diagnostic service in the United States.; Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2017 Aug 24.