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URMC / Labs / Brown Lab / News




Brown Lab awarded NSF grant to study the impact of collagen properties on tumor locomotion

Wednesday, June 1, 2022

Congratulations to the Brown Lab for a 3-year NSF grant entitled “Collaborative Research: Microenginered tumor-mimetic collagen landscapes to test the role of prognostic structural cues on cell migration through the extracellular matrix.” In this project the Brown Lab will collaborate with Dr. Vinay Abhyankar of RIT, holder of a linked grant, to explore the relationships between collagen fiber internal structure, overall orientation, and tumor cell motility patterns. This project is the result of Dr. Brown’s work exploring the use of collagen fiber orientation as a clinical prognostic of metastatic outcome, and Dr. Abhyankar’s work developing collagen gels with tunable orientation characteristics.

Brown Lab awarded Wilmot grant to quantify the effect of patient race on an optical predictor of metastatic outcome

Saturday, January 1, 2022

The Brown Lab is proud to have been awarded a Wilmot Center of Excellence Community Pilot Project award entitled “Differences in a prognostic signature of metastasis among ethnic groups.” This project arises from the Brown Lab’s discovery that collagen fiber internal structure, as quantified by the directionality of Second Harmonic light scattering, is an independent prognostic indicator of metastasis-free survival time. The primary goal of the project is to fully quantify the differences in this and other prognostic indicators of metastasis among racial groups.