Recent Publications

• 1. Ackerman JE
  2. Best KT
  3. Muscat SN
  4. Pritchett EM
  5. Nichols AEC
  6. Wu CL
  7. Loiselle AE
  Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function.; Cell reports; Vol 41(8), pp. 111706. 2022 Nov 22.
• 1. Kenney HM
  2. Wu CL
  3. Loiselle AE
  4. Xing L
  5. Ritchlin CT
  6. Schwarz EM
  Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model.; Arthritis research & therapy; Vol 24(1). 2022 Mar 07.
• 1. Wu CL
  2. Dicks A
  3. Steward N
  4. Tang R
  5. Katz DB
  6. Choi YR
  7. Guilak F
  Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis.; Nature communications; Vol 12(1). 2021 Jan 13.
• 1. Oestreich AK
  2. Collins KH
  3. Harasymowicz NS
  4. Wu CL
  5. Guilak F
  Is Obesity a Disease of Stem Cells?; Cell stem cell; Vol 27(1). 2020 Jul 02.
• 1. Wu CL
  2. Harasymowicz NS
  3. Klimak MA
  4. Collins KH
  5. Guilak F
  The role of macrophages in osteoarthritis and cartilage repair.; Osteoarthritis and cartilage; Vol 28(5). 2020 May.
• 1. Bailey KN
  2. Furman BD
  3. Zeitlin J
  4. Kimmerling KA
  5. Wu CL
  6. Guilak F
  7. Olson SA
  Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee.; Osteoarthritis and cartilage; Vol 28(5). 2020 May.
• 1. Tang R
  2. Harasymowicz NS
  3. Wu CL
  4. Collins KH
  5. Choi YR
  6. Oswald SJ
  7. Guilak F
  Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity.; Science advances; Vol 6(19). 2020 May.
• 1. Kimmerling KA
  2. Oswald SJ
  3. Huebner JL
  4. Little D
  5. Kraus VB
  6. Kang JX
  7. Wu CL
  8. Guilak F
  Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis.; Arthritis research & therapy; Vol 22(1). 2020 Apr 15.
• 1. Harasymowicz NS
  2. Choi YR
  3. Wu CL
  4. Iannucci L
  5. Tang R
  6. Guilak F
  Intergenerational Transmission of Diet-Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice.; Arthritis & rheumatology (Hoboken, N.J.); Vol 72(4). 2020 Apr.
• 1. Dicks A
  2. Wu CL
  3. Steward N
  4. Adkar SS
  5. Gersbach CA
  6. Guilak F
  Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter.; Stem cell research & therapy; Vol 11(1). 2020 Feb 18.
• 1. Choi YR
  2. Collins KH
  3. Springer LE
  4. Pferdehirt L
  5. Ross AK
  6. Wu CL
  7. Moutos FT
  8. Harasymowicz NS
  9. Brunger JM
  10. Pham CT
  Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug Delivery.; bioRxiv; Vol 535609. 2019 Jan 01.
• 1. Votava L
  2. Schwartz AG
  3. Harasymowicz NS
  4. Wu CL
  5. Guilak F
  Effects of dietary fatty acid content on humeral cartilage and bone structure in a mouse model of diet-induced obesity.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 37(3). 2019 Mar.
• 1. Harasymowicz NS
  2. Dicks A
  3. Wu CL
  4. Guilak F
  Physiologic and pathologic effects of dietary free fatty acids on cells of the joint.; Annals of the New York Academy of Sciences; Vol 1440(1). 2019 Mar.
• 1. Adkar SS
  2. Wu CL
  3. Willard VP
  4. Dicks A
  5. Ettyreddy A
  6. Steward N
  7. Bhutani N
  8. Gersbach CA
  9. Guilak F
  Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.; Stem cells (Dayton, Ohio); Vol 37(1). 2019 Jan.
• 1. Tang R
  2. Jing L
  3. Willard VP
  4. Wu CL
  5. Guilak F
  6. Chen J
  7. Setton LA
  Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells.; Stem cell research & therapy; Vol 9(1). 2018 Mar 09.
• 1. Guilak F
  2. Nims RJ
  3. Dicks A
  4. Wu CL
  5. Meulenbelt I
  Osteoarthritis as a disease of the cartilage pericellular matrix.; Matrix biology : journal of the International Society for Matrix Biology; Vol 71-72. 2018 Jan.
• 1. Wu CL
  2. McNeill J
  3. Goon K
  4. Little D
  5. Kimmerling K
  6. Huebner J
  7. Kraus V
  8. Guilak F
  Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.; Arthritis & rheumatology (Hoboken, N.J.); Vol 69(9). 2017 Sep.
• 1. Wu CL
  2. Kimmerling KA
  3. Little D
  4. Guilak F
  Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair.; Scientific reports; Vol 7. 2017 Mar 20.
• 1. Adkar SS
  2. Brunger JM
  3. Willard VP
  4. Wu CL
  5. Gersbach CA
  6. Guilak F
  Genome Engineering for Personalized Arthritis Therapeutics.; Trends in molecular medicine; Vol 23(10). 2017 Jan.
• 1. O'Conor CJ
  2. Ramalingam S
  3. Zelenski NA
  4. Benefield HC
  5. Rigo I
  6. Little D
  7. Wu CL
  8. Chen D
  9. Liedtke W
  10. McNulty AL
  11. Guilak F
  Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.; Scientific reports; Vol 6. 2016 Jul 08.
• 1. Wu CL
  2. Jain D
  3. McNeill JN
  4. Little D
  5. Anderson JA
  6. Huebner JL
  7. Kraus VB
  8. Rodriguiz RM
  9. Wetsel WC
  10. Guilak F
  Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury.; Annals of the rheumatic diseases; Vol 74(11). 2015 Nov.
• 1. McNeill JN
  2. Wu CL
  3. Rabey KN
  4. Schmitt D
  5. Guilak F
  Life-long caloric restriction does not alter the severity of age-related osteoarthritis.; Age (Dordrecht, Netherlands); Vol 36(4). 2014.
• 1. Wu CL
  2. Diekman BO
  3. Jain D
  4. Guilak F
  Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fat pad: the effects of free fatty acids.; International journal of obesity (2005); Vol 37(8). 2013 Aug.
• 1. Diekman BO
  2. Wu CL
  3. Louer CR
  4. Furman BD
  5. Huebner JL
  6. Kraus VB
  7. Olson SA
  8. Guilak F
  Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis.; Cell transplantation; Vol 22(8). 2013.