URMC / Labs / Deane Lab / Publications Publications Achariyar TMLi BPeng WVerghese PBShi YMcConnell EBenraiss AKasper TSong WTakano THoltzman DMNedergaard MDeane R (2017 Jan 12). Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Molecular neurodegeneration. Achariyar TMLi BPeng WVerghese PBShi YMcConnell EBenraiss AKasper TSong WTakana THoltzman DMNedergaard MDeane R (2016 Dec 08). Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Molecular neurodegeneration. Lundgaard ILu MLYang EPeng WMestre HHitomi EDeane RNedergaard M (2016 Aug 1). Glymphatic clearance controls state-dependent changes in brain lactate concentration. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. Lee HXie LYu MKang HFeng TDeane RLogan JNedergaard MBenveniste H (2015 Aug 5). The Effect of Body Posture on Brain Glymphatic Transport. The Journal of neuroscience : the official journal of the Society for Neuroscience. Plog BADashnaw MLHitomi EPeng WLiao YLou NDeane RNedergaard M (2015 Jan 14). Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System. The Journal of neuroscience : the official journal of the Society for Neuroscience. Iliff JJChen MJPlog BAZeppenfeld DMSoltero MYang LSingh IDeane RNedergaard M (2014 Dec 03). Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. Kress BTIliff JJXia MWang MWei HSZeppenfeld DXie LKang HXu QLiew JAPlog BADing FDeane RNedergaard M (2014 Dec). Impairment of paravascular clearance pathways in the aging brain. Annals of neurology. Petraglia ALPlog BADayawansa SChen MDashnaw MLCzerniecka KWalker CTViterise THyrien OIliff JJDeane RNedergaard MHuang JH (2014 Jul 01). The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy. Journal of neurotrauma. Lundgaard ILi BXie LKang HSanggaard SHaswell JDSun WGoldman SBlekot SNielsen MTakano TDeane RNedergaard M (2015). Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism. Nature communications. Petraglia ALPlog BADayawansa SDashnaw MLCzerniecka KWalker CTChen MHyrien OIliff JJDeane RHuang JHNedergaard M (2014). The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy. Surgical neurology international. Iliff JJWang MZeppenfeld DMVenkataraman APlog BALiao YDeane RNedergaard M (2013 Nov 13). Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. Xie LKang HXu QChen MJLiao YThiyagarajan MO'Donnell JChristensen DJNicholson CIliff JJTakano TDeane RNedergaard M (2013 Oct 18). Sleep drives metabolite clearance from the adult brain. Science (New York, N.Y.). Singh ISagare APComa MPerlmutter DGelein RBell RDDeane RJZhong EParisi MCiszewski JKasper RTDeane R (2013 Sep 3). Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance. Proceedings of the National Academy of Sciences of the United States of America. Rangroo Thrane VThrane ASPlog BAThiyagarajan MIliff JJDeane RNagelhus EANedergaard M (2013). Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. Scientific reports. Iliff JJWang MLiao YPlogg BAPeng WGundersen GABenveniste HVates GEDeane RGoldman SANagelhus EANedergaard M (2012 Aug 15). A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science translational medicine. Bell RDWinkler EASingh ISagare APDeane RWu ZHoltzman DMBetsholtz CArmulik ASallstrom JBerk BCZlokovic BV (2012 May 24). Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. Deane RSingh ISagare APBell RDRoss NTLaRue BLove RPerry SPaquette NDeane RJThiyagarajan MZarcone TFritz GFriedman AEMiller BLZlokovic BV (2012 Apr). A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. The Journal of clinical investigation. Polesskaya OSilva JSanfilippo CDesrosiers TSun AShen JFeng CPolesskiy ADeane RZlokovic BKasischke KDewhurst S (2011 Feb 10). Methamphetamine causes sustained depression in cerebral blood flow. Brain research. Sagare APDeane RZetterberg HWallin ABlennow KZlokovic BV (2011). Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. Journal of Alzheimer's disease : JAD. Zlokovic BVDeane RSagare APBell RDWinkler EA (2010 Dec). Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. Journal of neurochemistry. Bell RDWinkler EASagare APSingh ILaRue BDeane RZlokovic BV (2010 Nov 4). Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. Zhu DWang YSingh IBell RDDeane RZhong ZSagare AWinkler EAZlokovic BV (2010 Jun 10). Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. Menon PDeane RSagare ALane SMZarcone TJO'Dell MRYan CZlokovic BVBerk BC (2010 Mar 4). Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain research. Zhong ZIlieva HHallagan LBell RSingh IPaquette NThiyagarajan MDeane RFernandez JALane SZlokovic ABLiu TGriffin JHChow NCastellino FJStojanovic KCleveland DWZlokovic BV (2009 Nov). Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. The Journal of clinical investigation. Deane RBell RDSagare AZlokovic BV (2009 Mar). Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS & neurological disorders drug targets. Guo HSingh IWang YDeane RBarrett TFernández JAChow NGriffin JHZlokovic BV (2009 Mar). Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. The European journal of neuroscience. Bell RDDeane RChow NLong XSagare ASingh IStreb JWGuo HRubio AVan Nostrand WMiano JMZlokovic BV (2009 Feb). SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature cell biology. Deane RLaRue BSagare APCastellino FJZhong ZZlokovic BV (2009 Jan). Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. Deane RSagare AHamm KParisi MLane SFinn MBHoltzman DMZlokovic BV (2008 Dec). apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. The Journal of clinical investigation. Zhong ZDeane RAli ZParisi MShapovalov YO'Banion MKStojanovic KSagare ABoillee SCleveland DWZlokovic BV (2008 Apr). ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nature neuroscience. Deane RSagare AZlokovic BV (2008). The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Current pharmaceutical design. Sagare ADeane RBell RDJohnson BHamm KPendu RMarky ALenting PJWu ZZarcone TGoate AMayo KPerlmutter DComa MZhong ZZlokovic BV (2007 Sep). Clearance of amyloid-beta by circulating lipoprotein receptors. Nature medicine. Bell RDSagare APFriedman AEBedi GSHoltzman DMDeane RZlokovic BV (2007 May). Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. Deane RZlokovic BV (2007 Apr). Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Current Alzheimer research. Takano THan XDeane RZlokovic BNedergaard M (2007 Feb). Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Annals of the New York Academy of Sciences. Chow NBell RDDeane RStreb JWChen JBrooks AVan Nostrand WMiano JMZlokovic BV (2007 Jan 16). Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proceedings of the National Academy of Sciences of the United States of America. Deane RZlokovic BV (2007 Jan 01). Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease Current Alzheimer's Research. Sagare AFriedman AEBedi GDeane RZlokovic BV (2007 Jan 01). Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J. J Cerebral Blood flow and Metabolism. Deane RZlokovic BV (2007 Jan 01). Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease Current Alzheimer's Research. Cheng TPetraglia ALLi ZThiyagarajan MZhong ZWu ZLiu DMaggirwar SBDeane RFernández JALaRue BGriffin JHChopp MZlokovic BV (2006 Nov). Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature medicine. Kassem NADeane RSegal MBPreston JE (2006 Jan 01). Role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus American Journal of Physiology - Regulatory Integrative & Comparative Physiology. Deane RSagare AHamm KParisi MLaRue BGuo HWu ZHoltzman DMZlokovic BV (2005 Dec 14). IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. Cirrito JRDeane RFagan AMSpinner MLParsadanian MFinn MBJiang HPrior JLSagare ABales KRPaul SMZlokovic BVPiwnica-Worms DHoltzman DM (2005 Nov). P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. The Journal of clinical investigation. Wu ZGuo HChow NSallstrom JBell RDDeane RBrooks AIKanagala SRubio ASagare ALiu DLi FArmstrong DGasiewicz TZidovetzki RSong XHofman FZlokovic BV (2005 Sep). Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nature medicine. Zlokovic BVDeane RSallstrom JChow NMiano JM (2005 Jan). Neurovascular pathways and Alzheimer amyloid beta-peptide. Brain pathology (Zurich, Switzerland). Deane RWu ZZlokovic BV (2004 Nov). RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke; a journal of cerebral circulation. LaRue BHogg ESagare AJovanovic SManess LMaurer CDeane RZlokovic BV (2004 Sep 30). Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. Journal of neuroscience methods. Deane RWu ZSagare ADavis JDu Yan SHamm KXu FParisi MLaRue BHu HWSpijkers PGuo HSong XLenting PJVan Nostrand WEZlokovic BV (2004 Aug 5). LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. Davis JXu FDeane RRomanov GPreviti MLZeigler KZlokovic BVVan Nostrand WE (2004 May 7). Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. The Journal of biological chemistry. Deane RZheng WZlokovic BV (2004 Feb). Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. Journal of neurochemistry.