Recent Publications
Recent Publications
- Acidosis induces antimicrobial peptide expression and resistance to uropathogenic E. coli infection in kidney collecting duct cells via HIF-1α.; American journal of physiology. Renal physiology; Vol 318(2). 2020 Feb 01.
- The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis.; eNeuro; Vol 5(6). 2018 Nov.
- Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.; Science signaling; Vol 11(532). 2018 May 29.
- JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.; Neurobiology of disease; Vol 46(2). 2012 May.
- Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway.; Molecular neurodegeneration; Vol 6. 2011.
- Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 30(46). 2010 Nov 17.
- Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.; Molecular pharmacology; Vol 75(5). 2009 May.
- The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL).; Oncogene; Vol 28(16). 2009 Apr 23.
- Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.; Science signaling; Vol 2(78). 2009.
- Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.; Annals of the New York Academy of Sciences; Vol 1147. 2008 Dec.
- Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.; Journal of neurochemistry; Vol 106(2). 2008 Jul.
- Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation.; Journal of neurochemistry; Vol 103(5). 2007 Dec.
- EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability.; The Journal of biological chemistry; Vol 282(17). 2007 Apr 27.
- A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress".; Free radical biology & medicine; Vol 41(1). 2006 Jul 1.
- Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.; Cancer cell; Vol 8(2). 2005 Aug.
- Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after Rickettsia rickettsii infection: regulation by nuclear transcription factor NF-kappaB.; International journal of medical microbiology : IJMM; Vol 295(4). 2005 Aug.
- Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1.; The Journal of cell biology; Vol 168(6). 2005 Mar 14.
- Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders.; Current drug targets. CNS and neurological disorders; Vol 4(1). 2005 Feb.
- NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha.; Infection and immunity; Vol 73(1). 2005 Jan.
- Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities.; Oncogene; Vol 23(10). 2004 Mar 11.
- NGF deprivation-induced gene expression: after ten years, where do we stand?; Progress in brain research; Vol 146. 2004.
- Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons.; Cell death and differentiation; Vol 10(9). 2003 Sep.
- SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases.; Molecules and cells; Vol 16(1). 2003 Aug 31.
- Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death.; Journal of neurochemistry; Vol 85(2). 2003 Apr.
- Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20.; Laboratory investigation; a journal of technical methods and pathology; Vol 82(10). 2002 Oct.
- Analysis of the NF-kappa B and PI 3-kinase/Akt survival pathways in nerve growth factor-dependent neurons.; Molecular and cellular neurosciences; Vol 18(3). 2001 Sep.
- SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons.; The Journal of biological chemistry; Vol 276(7). 2001 Feb 16.
- Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal.; The Journal of biological chemistry; Vol 275(44). 2000 Nov 3.
- The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt.; Journal of neurochemistry; Vol 73(2). 1999 Aug.
- Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons.; Journal of neurochemistry; Vol 73(1). 1999 Jul.
- Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 18(24). 1998 Dec 15.
- Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 18(8). 1998 Apr 15.
- Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.; The Journal of cell biology; Vol 127(6 Pt 1). 1994 Dec.
- Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death.; Neuron; Vol 12(2). 1994 Feb.
- NGF deprivation and neuronal degeneration trigger altered beta-amyloid precursor protein gene expression in the rat superior cervical ganglia in vivo and in vitro.; Brain research. Molecular brain research; Vol 17(3-4). 1993 Mar.
- Cell death genes in invertebrates and (maybe) vertebrates.; Current opinion in neurobiology; Vol 3(1). 1993 Feb.
- Phosphorylation of conserved serine residues does not regulate the ability of mosxe protein kinase to induce oocyte maturation or function as cytostatic factor.; The Journal of cell biology; Vol 116(3). 1992 Feb.
- Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle.; Biochemistry; Vol 30(9). 1991 Mar 5.
- Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosXe.; Molecular and cellular biology; Vol 11(3). 1991 Mar.
- Effects of the v-mos oncogene on Xenopus development: meiotic induction in oocytes and mitotic arrest in cleaving embryos.; The Journal of cell biology; Vol 111(2). 1990 Aug.
- Transforming mutant v-mos protein kinases that are deficient in in vitro autophosphorylation.; Molecular and cellular biology; Vol 9(9). 1989 Sep.
- Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.; Proceedings of the National Academy of Sciences of the United States of America; Vol 86(15). 1989 Aug.