URMC / Labs / Freeman Lab / Publications Recent Publications Fernandes KAHarder JMFornarola LBFreeman RSClark AFPang IHJohn SWLibby RT (2012 May). JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death. Neurobiology of disease. Guo HBarrett TMZhong ZFernández JAGriffin JHFreeman RSZlokovic BV (2011). Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Molecular neurodegeneration. Zhong ZWang YGuo HSagare AFernández JABell RDBarrett TMGriffin JHFreeman RSZlokovic BV (2010 Nov 17). Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. The Journal of neuroscience : the official journal of the Society for Neuroscience. Lomb DJDesouza LAFranklin JLFreeman RS (2009 May). Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons. Molecular pharmacology. Guo YSchoell MCFreeman RS (2009 Apr 23). The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL). Oncogene. Xie LXiao KWhalen EJForrester MTFreeman RSFong GGygi SPLefkowitz RJStamler JS (2009). Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Science signaling. Ratan RRSiddiq AAminova LLangley BMcConoughey SKarpisheva KLee HHCarmichael TKornblum HCoppola GGeschwind DHHoke ASmirnova NRink CRoy SSen CBeattie MSHart RPGrumet MSun DFreeman RSSemenza GLGazaryan I (2008 Dec). Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Annals of the New York Academy of Sciences. Barone MCDesouza LAFreeman RS (2008 Jul). Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity. Journal of neurochemistry. Lomb DJStraub JAFreeman RS (2007 Dec). Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. Journal of neurochemistry. Fu JMenzies KFreeman RSTaubman MB (2007 Apr 27). EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability. The Journal of biological chemistry. Brookes PSFreeman RSBarone MC (2006 Jul 1). A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress". Free radical biology & medicine. Lee SNakamura EYang HWei WLinggi MSSajan MPFarese RVFreeman RSCarter BDKaelin WGSchlisio S (2005 Aug). Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer cell. Clifton DRRydkina EHuyck HPryhuber GFreeman RSSilverman DJSahni SK (2005 Aug). Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after Rickettsia rickettsii infection: regulation by nuclear transcription factor NF-kappaB. International journal of medical microbiology : IJMM. Xie LJohnson RSFreeman RS (2005 Mar 14). Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1. The Journal of cell biology. Freeman RSBarone MC (2005 Feb). Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders. Current drug targets. CNS and neurological disorders. Clifton DRRydkina EFreeman RSSahni SK (2005 Jan). NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha. Infection and immunity. Farhana LDawson MIHuang YZhang YRishi AKReddy KBFreeman RSFontana JA (2004 Mar 11). Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. Freeman RSBurch RLCrowder RJLomb DJSchoell MCStraub JAXie L (2004). NGF deprivation-induced gene expression: after ten years, where do we stand? Progress in brain research. Besirli CGDeckwerth TLCrowder RJFreeman RSJohnson EM (2003 Sep). Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell death and differentiation. Freeman RSHasbani DMLipscomb EAStraub JAXie L (2003 Aug 31). SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases. Molecules and cells. Straub JALipscomb EAYoshida ESFreeman RS (2003 Apr). Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death. Journal of neurochemistry. Wolf GHarendza SSchroeder RWenzel UZahner GButzmann UFreeman RSStahl RA (2002 Oct). Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20. Laboratory investigation; a journal of technical methods and pathology. Sarmiere PDFreeman RS (2001 Sep). Analysis of the NF-kappa B and PI 3-kinase/Akt survival pathways in nerve growth factor-dependent neurons. Molecular and cellular neurosciences. Lipscomb EASarmiere PDFreeman RS (2001 Feb 16). SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons. The Journal of biological chemistry. Crowder RJFreeman RS (2000 Nov 3). Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal. The Journal of biological chemistry. Crowder RJFreeman RS (1999 Aug). The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt. Journal of neurochemistry. Lipscomb EASarmiere PDCrowder RJFreeman RS (1999 Jul). Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons. Journal of neurochemistry. Maggirwar SBSarmiere PDDewhurst SFreeman RS (1998 Dec 15). Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. Crowder RJFreeman RS (1998 Apr 15). Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. Estus SZaks WJFreeman RSGruda MBravo RJohnson EM (1994 Dec). Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. The Journal of cell biology. Freeman RSEstus SJohnson EM (1994 Feb). Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death. Neuron. Smith CJJohnson EMOsborne PFreeman RSNeveu IBrachet P (1993 Mar). NGF deprivation and neuronal degeneration trigger altered beta-amyloid precursor protein gene expression in the rat superior cervical ganglia in vivo and in vitro. Brain research. Molecular brain research. Freeman RSEstus SHorigome KJohnson EM (1993 Feb). Cell death genes in invertebrates and (maybe) vertebrates. Current opinion in neurobiology. Freeman RSMeyer ANLi JDonoghue DJ (1992 Feb). Phosphorylation of conserved serine residues does not regulate the ability of mosxe protein kinase to induce oocyte maturation or function as cytostatic factor. The Journal of cell biology. Freeman RSDonoghue DJ (1991 Mar 5). Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle. Biochemistry. Freeman RSBallantyne SMDonoghue DJ (1991 Mar). Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosXe. Molecular and cellular biology. Freeman RSKanki JPBallantyne SMPickham KMDonoghue DJ (1990 Aug). Effects of the v-mos oncogene on Xenopus development: meiotic induction in oocytes and mitotic arrest in cleaving embryos. The Journal of cell biology. Freeman RSDonoghue DJ (1989 Sep). Transforming mutant v-mos protein kinases that are deficient in in vitro autophosphorylation. Molecular and cellular biology. Freeman RSPickham KMKanki JPLee BAPena SVDonoghue DJ (1989 Aug). Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America.