URMC / Labs / Freeman Lab / Publications Recent Publications Bellizzi MJHammond JWLi HGantz Marker MAMarker DFFreeman RSGelbard HA The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis.; eNeuro; Vol 5(6). 2018 Nov. Papasergi-Scott MMStoveken HMMacConnachie LChan PYGabay MWong DFreeman RSBeg AATall GG Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.; Science signaling; Vol 11(532). 2018 May 29. Fernandes KAHarder JMFornarola LBFreeman RSClark AFPang IHJohn SWLibby RT JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.; Neurobiology of disease; Vol 46(2). 2012 May. Guo HBarrett TMZhong ZFernández JAGriffin JHFreeman RSZlokovic BV Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway.; Molecular neurodegeneration; Vol 6. 2011. Zhong ZWang YGuo HSagare AFernández JABell RDBarrett TMGriffin JHFreeman RSZlokovic BV Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 30(46). 2010 Nov 17. Lomb DJDesouza LAFranklin JLFreeman RS Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.; Molecular pharmacology; Vol 75(5). 2009 May. Guo YSchoell MCFreeman RS The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL).; Oncogene; Vol 28(16). 2009 Apr 23. Xie LXiao KWhalen EJForrester MTFreeman RSFong GGygi SPLefkowitz RJStamler JS Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.; Science signaling; Vol 2(78). 2009. Ratan RRSiddiq AAminova LLangley BMcConoughey SKarpisheva KLee HHCarmichael TKornblum HCoppola GGeschwind DHHoke ASmirnova NRink CRoy SSen CBeattie MSHart RPGrumet MSun DFreeman RSSemenza GLGazaryan I Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.; Annals of the New York Academy of Sciences; Vol 1147. 2008 Dec. Barone MCDesouza LAFreeman RS Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.; Journal of neurochemistry; Vol 106(2). 2008 Jul. Lomb DJStraub JAFreeman RS Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation.; Journal of neurochemistry; Vol 103(5). 2007 Dec. Fu JMenzies KFreeman RSTaubman MB EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability.; The Journal of biological chemistry; Vol 282(17). 2007 Apr 27. Brookes PSFreeman RSBarone MC A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress".; Free radical biology & medicine; Vol 41(1). 2006 Jul 1. Lee SNakamura EYang HWei WLinggi MSSajan MPFarese RVFreeman RSCarter BDKaelin WGSchlisio S Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.; Cancer cell; Vol 8(2). 2005 Aug. Clifton DRRydkina EHuyck HPryhuber GFreeman RSSilverman DJSahni SK Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after Rickettsia rickettsii infection: regulation by nuclear transcription factor NF-kappaB.; International journal of medical microbiology : IJMM; Vol 295(4). 2005 Aug. Xie LJohnson RSFreeman RS Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1.; The Journal of cell biology; Vol 168(6). 2005 Mar 14. Freeman RSBarone MC Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders.; Current drug targets. CNS and neurological disorders; Vol 4(1). 2005 Feb. Clifton DRRydkina EFreeman RSSahni SK NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha.; Infection and immunity; Vol 73(1). 2005 Jan. Farhana LDawson MIHuang YZhang YRishi AKReddy KBFreeman RSFontana JA Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities.; Oncogene; Vol 23(10). 2004 Mar 11. Freeman RSBurch RLCrowder RJLomb DJSchoell MCStraub JAXie L NGF deprivation-induced gene expression: after ten years, where do we stand?; Progress in brain research; Vol 146. 2004. Besirli CGDeckwerth TLCrowder RJFreeman RSJohnson EM Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons.; Cell death and differentiation; Vol 10(9). 2003 Sep. Freeman RSHasbani DMLipscomb EAStraub JAXie L SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases.; Molecules and cells; Vol 16(1). 2003 Aug 31. Straub JALipscomb EAYoshida ESFreeman RS Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death.; Journal of neurochemistry; Vol 85(2). 2003 Apr. Wolf GHarendza SSchroeder RWenzel UZahner GButzmann UFreeman RSStahl RA Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20.; Laboratory investigation; a journal of technical methods and pathology; Vol 82(10). 2002 Oct. Sarmiere PDFreeman RS Analysis of the NF-kappa B and PI 3-kinase/Akt survival pathways in nerve growth factor-dependent neurons.; Molecular and cellular neurosciences; Vol 18(3). 2001 Sep. Lipscomb EASarmiere PDFreeman RS SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons.; The Journal of biological chemistry; Vol 276(7). 2001 Feb 16. Crowder RJFreeman RS Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal.; The Journal of biological chemistry; Vol 275(44). 2000 Nov 3. Crowder RJFreeman RS The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt.; Journal of neurochemistry; Vol 73(2). 1999 Aug. Lipscomb EASarmiere PDCrowder RJFreeman RS Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons.; Journal of neurochemistry; Vol 73(1). 1999 Jul. Maggirwar SBSarmiere PDDewhurst SFreeman RS Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 18(24). 1998 Dec 15. Crowder RJFreeman RS Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 18(8). 1998 Apr 15. Estus SZaks WJFreeman RSGruda MBravo RJohnson EM Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.; The Journal of cell biology; Vol 127(6 Pt 1). 1994 Dec. Freeman RSEstus SJohnson EM Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death.; Neuron; Vol 12(2). 1994 Feb. Smith CJJohnson EMOsborne PFreeman RSNeveu IBrachet P NGF deprivation and neuronal degeneration trigger altered beta-amyloid precursor protein gene expression in the rat superior cervical ganglia in vivo and in vitro.; Brain research. Molecular brain research; Vol 17(3-4). 1993 Mar. Freeman RSEstus SHorigome KJohnson EM Cell death genes in invertebrates and (maybe) vertebrates.; Current opinion in neurobiology; Vol 3(1). 1993 Feb. Freeman RSMeyer ANLi JDonoghue DJ Phosphorylation of conserved serine residues does not regulate the ability of mosxe protein kinase to induce oocyte maturation or function as cytostatic factor.; The Journal of cell biology; Vol 116(3). 1992 Feb. Freeman RSDonoghue DJ Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle.; Biochemistry; Vol 30(9). 1991 Mar 5. Freeman RSBallantyne SMDonoghue DJ Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosXe.; Molecular and cellular biology; Vol 11(3). 1991 Mar. Freeman RSKanki JPBallantyne SMPickham KMDonoghue DJ Effects of the v-mos oncogene on Xenopus development: meiotic induction in oocytes and mitotic arrest in cleaving embryos.; The Journal of cell biology; Vol 111(2). 1990 Aug. Freeman RSDonoghue DJ Transforming mutant v-mos protein kinases that are deficient in in vitro autophosphorylation.; Molecular and cellular biology; Vol 9(9). 1989 Sep. Freeman RSPickham KMKanki JPLee BAPena SVDonoghue DJ Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.; Proceedings of the National Academy of Sciences of the United States of America; Vol 86(15). 1989 Aug.