URMC / Labs / Frelinger Lab / Publications Publications Mikucki MESkitzki JJFrelinger JGOdunsi KGajewski TFLuster ADEvans SS (2016 May). Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy. Oncoimmunology. Skrombolas DWylie IMaharaj SFrelinger JG (2015 Sep). Characterization of an IL-12 p40/p35 Truncated Fusion Protein That can Inhibit the Action of IL-12. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. Mikucki MEFisher DTMatsuzaki JSkitzki JJGaulin NBMuhitch JBKu AWFrelinger JGOdunsi KGajewski TFLuster ADEvans SS (2015). Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Nature communications. Skrombolas DFrelinger JG (2014 Feb). Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy. Expert review of clinical immunology. Sedlacek ALGerber SARandall TDvan Rooijen NFrelinger JGLord EM (2013 Oct). Generation of a dual-functioning antitumor immune response in the peritoneal cavity. The American journal of pathology. Gerber SASedlacek ALCron KRMurphy SPFrelinger JGLord EM (2013 Jun). IFN-γ mediates the antitumor effects of radiation therapy in a murine colon tumor. The American journal of pathology. Gerber SASorensen EWSedlacek ALLim JYSkrombolas DFrelinger JGLord EM (2013 Mar). Local expression of interleukin-2 by B16 melanoma cells results in decreased tumour growth and long-term tumour dormancy. Immunology. Valentino MDAbdul-Alim CSMaben ZJSkrombolas DHensley LLKawula THDziejman MLord EMFrelinger JAFrelinger JG (2011 Oct 28). A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens. Journal of immunological methods. Puskas JSkrombolas DSedlacek ALord ESullivan MFrelinger J (2011 Jun). Development of an attenuated interleukin-2 fusion protein that can be activated by tumour-expressed proteases. Immunology. Valentino MDMaben ZJHensley LLWoolard MDKawula THFrelinger JAFrelinger JG (2011 Mar). Identification of T-cell epitopes in Francisella tularensis using an ordered protein array of serological targets. Immunology. Valentino MDAbdul-Alim CSMaben ZJSkrombolas DHensley LLKawula THDziejman MLord EMFrelinger JAFrelinger JG (2011 Jan 01). A broadly applicable approach to T cell epitope identification: Application to improving tumor associated epitopes and identifying epitopes in complex pathogens Journal of Immunological Methods (in press). Sorensen EWGerber SAFrelinger JGLord EM (2010 Feb 15). IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms. Journal of immunology (Baltimore, Md. : 1950). Valentino MFrelinger J (2009 Dec). An approach to the identification of T cell epitopes in the genomic era: application to Francisella tularensis. Immunologic research. Valentino MDHensley LLSkrombolas DMcPherson PLWoolard MDKawula THFrelinger JAFrelinger JG (2009 May). Identification of a dominant CD4 T cell epitope in the membrane lipoprotein Tul4 from Francisella tularensis LVS. Molecular immunology. Lugade AASorensen EWGerber SAMoran JPFrelinger JGLord EM (2008 Mar 1). Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity. Journal of immunology (Baltimore, Md. : 1950). Malboeuf CMSimon DALee YELankes HADewhurst SFrelinger JGRose RC (2007 Apr 30). Human papillomavirus-like particles mediate functional delivery of plasmid DNA to antigen presenting cells in vivo. Vaccine. Santos KDuke CMRodriguez-Colon SMDakwar AFan SKeefer MCFederoff HJFrelinger JGBowers WJDewhurst S (2007 Feb 19). Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. Santos KSimon DAConway EBowers WJMitra SFoster THLugade ALord EMFederoff HJDewhurst SFrelinger JG (2007 Feb). Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Human gene therapy. Ramanayake TSimon DAFrelinger JGLord EMRobert J (2007 Jan 27). In vivo study of T-cell responses to skin alloantigens in Xenopus using a novel whole-mount immunohistology method. Transplantation. Mitra SCassar SENiles DJPuskas JAFrelinger JGFoster TH (2006 Dec). Photodynamic therapy mediates the oxygen-independent activation of hypoxia-inducible factor 1alpha. Molecular cancer therapeutics. Gerber SARybalko VYBigelow CELugade AAFoster THFrelinger JGLord EM (2006 Nov). Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth. The American journal of pathology. Wagner VEFrelinger JGBarth RKIglewski BH (2006 Feb). Quorum sensing: dynamic response of Pseudomonas aeruginosa to external signals. Trends in microbiology. Lugade AAMoran JPGerber SARose RCFrelinger JGLord EM (2005 Jun 15). Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. Journal of immunology (Baltimore, Md. : 1950). Gerber SATurner MJLugade AAMoran JPFrelinger JGLord EM (2005 May 1). Characterization of a lymph node within the mouse prostate: Detailed analysis using whole mount histology. The Prostate. Bigelow CEVishwasrao HDFrelinger JGFoster TH (2004 Jul). Imaging enzyme activity with polarization-sensitive confocal fluorescence microscopy. Journal of microscopy. Mitra SGoren EMFrelinger JGFoster TH (2003 Dec). Activation of heat shock protein 70 promoter with meso-tetrahydroxyphenyl chlorin photodynamic therapy reported by green fluorescent protein in vitro and in vivo. Photochemistry and photobiology. Moran JPGerber SAMartin CAFrelinger JGLord EM (2003 Sep 20). Transfection of the genes for interleukin-12 into the K1735 melanoma and the EMT6 mammary sarcoma murine cell lines reveals distinct mechanisms of antitumor activity. International journal of cancer. Gerber SAMoran JPFrelinger JGFrelinger JAFenton BMLord EM (2003 May 6). Mechanism of IL-12 mediated alterations in tumour blood vessel morphology: analysis using whole-tissue mounts. British journal of cancer. Fisher TLNocera MWillis RATurner MJAbdul Alim CSBrown DMBourne PAdi Sant'Agnese PAMessing EMLord EMFrelinger JG (2002 May 15). Generation of monoclonal antibodies specific for human kallikrein 2 (hK2) using hK2-expressing tumors. The Prostate. Patel DFrelinger JGoudsmit JKim B (2001 Nov). In vitro assay for site-specific proteases using bead-attached GFP substrate. BioTechniques. Willis RABowers WJTurner MJFisher TLAbdul-Alim CSHoward DFFederoff HJLord EMFrelinger JG (2001 Oct 10). Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice. Human gene therapy. Turner MJAbdul-Alim CSWillis RAFisher TLLord EMFrelinger JG (2001 Oct 1). T-cell antigen discovery (T-CAD) assay: a novel technique for identifying T cell epitopes. Journal of immunological methods. Brown DMFisher TLWei CFrelinger JGLord EM (2001 Apr). Tumours can act as adjuvants for humoral immunity. Immunology. Skrincosky DWillis RAHocknell PKFrelinger JGMirandola PWang XDewhurst S (2001). Epitope mapping of human herpesvirus-7 gp65 using monoclonal antibodies. Archives of virology. Lee JMoran JPFenton BMKoch CJFrelinger JGKeng PCLord EM (2000 Feb). Alteration of tumour response to radiation by interleukin-2 gene transfer. British journal of cancer. Conway TFSabel MSSugano MFrelinger JGEgilmez NKChen FBankert RB (2000 Jan 13). Growth of human tumor xenografts in SCID mice quantified using an immunoassay for tumor marker protein in serum. Journal of immunological methods. Martin BKFrelinger JGTing JP (1999 Jun 1). Combination gene therapy with CD86 and the MHC class II transactivator in the control of lung tumor growth. Journal of immunology (Baltimore, Md. : 1950). Storozynsky EWoodward JGFrelinger JGLord EM (1999 May). Interleukin-3 and granulocyte-macrophage colony-stimulating factor enhance the generation and function of dendritic cells. Immunology. Wei CCallahan BPTurner MJWillis RALord EMBarth RKFrelinger JG (1998 Oct). Regulation of human prostate-specific antigen gene expression in transgenic mice: evidence for an enhancer between the PSA and human glandular kallikrein-1 genes. International journal of molecular medicine. Yeh KYMcAdam AJPulaski BAShastri NFrelinger JGLord EM (1998 Jun 15). IL-3 enhances both presentation of exogenous particulate antigen in association with class I major histocompatibility antigen and generation of primary tumor-specific cytolytic T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). Lord EMYeh KYMoran JAStorozynsky EFrelinger JG (1998 May). IL-3-mediated enhancement of particulate antigen presentation by macrophages. Journal of immunotherapy (Hagerstown, Md. : 1997). Lee JFenton BMKoch CJFrelinger JGLord EM (1998 Apr 1). Interleukin 2 expression by tumor cells alters both the immune response and the tumor microenvironment. Cancer research. Lord EMFrelinger JG (1998 Apr). Tumor immunotherapy: cytokines and antigen presentation. Cancer immunology, immunotherapy : CII. Willis RAWei CTurner MJCallahan BPPugh AEBarth RKLord EMFrelinger JG (1998 Feb). A transgenic strategy for analyzing the regulatory regions of the human prostate-specific antigen gene: potential applications for the treatment of prostate cancer (Review). International journal of molecular medicine. Ostberg JRDragone LLBorrello MAPhipps RPBarth RKFrelinger JG (1997 Sep). Expression of mouse CD43 in the B cell lineage of transgenic mice causes impaired immune responses to T-independent antigens. European journal of immunology. Wei CWillis RATilton BRLooney RJLord EMBarth RKFrelinger JG (1997 Jun 10). Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. McEvoy LMSun HFrelinger JGButcher EC (1997 Apr 21). Anti-CD43 inhibition of T cell homing. The Journal of experimental medicine. Ostberg JRDragone LLDriskell TMoynihan JAPhipps RBarth RKFrelinger JG (1996 Dec 1). Disregulated expression of CD43 (leukosialin, sialophorin) in the B cell lineage leads to immunodeficiency. Journal of immunology (Baltimore, Md. : 1950). Wei CStorozynsky EMcAdam AJYeh KYTilton BRWillis RABarth RKLooney RJLord EMFrelinger JG (1996 Jul). Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes. Cancer immunology, immunotherapy : CII. Pulaski BAYeh KYShastri NMaltby KMPenney DPLord EMFrelinger JG (1996 Apr 16). Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells. Proceedings of the National Academy of Sciences of the United States of America.