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Ganguly Lab

Welcome to the Ganguly Lab

Example image of a neuronsThe overall goal of our lab is to identify conserved molecular signals regulating the trafficking of proteins from their site of synthesis (in the ER-Golgi network) to specific sub-cellular compartments, where they function. This process is critical for proper cellular function of polarized epithelial cells such as neurons. Proteins synthesized in the neuronal cell body travel along the length of the axon to morphologically specialized distal structures called pre-synapses. These transported proteins play a critical role in neuronal communication at synapses and are essential for both innate and learned behaviors. Defects in axonal transport and synaptic communication are often seen across neurodegenerative and neurodevelopmental disorders. Our lab uses patient derived human neurons (iNeurons) as well as murine models of neuronal disorders to define changes in axonal trafficking. We combine high resolution live-imaging techniques that quantify axonal trafficking with whole-cell/optical electrophysiology to determine associated changes in synaptic transmission.

Lab Members

Archan Ganguly, Ph.D.

Archan Ganguly, Ph.D.
Principal Investigator

Select Publications

Ganguly A, Sharma R, Boyer NP, Wernert F, Phan S, Boassa D, Parra L, Das U, Caillol G, Han X, Yates JR, Ellisman MH, Leterrier C, Roy S. Clathrin packets move in slow axonal transport and deliver functional payloads to synapses.; Neuron; Vol 109(18), pp. 2884-2901.e7. 2021 Sep 15.

Ganguly A, Qi C, Bajaj J, Lee D. Serotonin receptor 5-HT7 in Drosophila mushroom body neurons mediates larval appetitive olfactory learning.; Scientific reports; Vol 10(1). 2020 Dec 04.

Kapur M, Ganguly A, Nagy G, Adamson SI, Chuang JH, Frankel WN, Ackerman SL. Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility.; Neuron; Vol 108(1), pp. 193-208.e9. 2020 Aug 26.

Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.; The Journal of cell biology; Vol 216(7), pp. 2059-2074. 2017 May 30.

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Contact Us

  Ganguly Lab
G.9812B, KMRB
Rochester, NY 14642