Association of the oral microbial community with oral cancer
Oral cancer is one of the top ten most common cancers, with the incidence increasing in the United States and many other parts of the world. The prognosis for oral cancer is markedly poor, with the average all-stage, 5-year survival rate under 50%. Worldwide, oral cancer is the sixth most prevalent cancer with over 300,000 new cases diagnosed each year. In the United States alone, 30,000 new cases are diagnosed each year with an anticipated 8,000 deaths attributed to the disease.
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Staphylococcus aureus is one of the most successful human pathogens, asymptomatically colonizing over 2 billion individuals worldwide and capable of causing invasive and deadly opportunistic infections. We are using genomic approaches to identify virulence determinants associated with S. aureus infections and determine their roles in pathogenicity.
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