URMC / Labs / Lee Lab / Publications Publications Silvers CRMiyamoto HMessing EMNetto GJLee YF (2017 Oct 31). Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer. Oncotarget. Silvers CRLiu YRWu CHMiyamoto HMessing EMLee YF (2016 Mar 10). Identification of extracellular vesicle-borne periostin as a feature of muscle-invasive bladder cancer. Oncotarget. Yasmin-Karim SKing MRMessing EMLee YF (2014 Dec 15). E-selectin ligand-1 controls circulating prostate cancer cell rolling/adhesion and metastasis. Oncotarget. Beckham CJOlsen JYin PNWu CHTing HJHagen FKScosyrev EMessing EMLee YF (2014 Aug). Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression. The Journal of urology. Lin SJLee SOLee YFMiyamoto HYang DRLi GChang C (2014 Jun). TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system. Carcinogenesis. Hsu JWYin PNWood RMessing JMessing ELee YF (2013 Dec). 1 alpha, 25-dihydroxylvitamin D3 promotes Bacillus Calmette-Guérin immunotherapy of bladder cancer. Oncotarget. Ting HJMessing JYasmin-Karim SLee YF (2013 Jan 4). Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin D. The Journal of biological chemistry. Yan SJLee YFTing HJLiu NCLiu SLin SJYeh SDLi GChang C (2012 Jun). Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation. Cellular & molecular biology letters. Ting HJYasmin-Karim SYan SJHsu JWLin THZeng WMessing JSheu TJBao BYLi WXMessing ELee YF (2012 Feb 15). A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. Cancer research. Lin SJHo HCLee YFLiu NCLiu SLi GShyr CRChang C (2012). Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis. Reproductive biology and endocrinology : RB&E. Liu SYan SJLee YFLiu NCTing HJLi GWu QChen LMChang C (2011 Nov 4). Testicular nuclear receptor 4 (TR4) regulates UV light-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair. The Journal of biological chemistry. Liu SLee YFChou SUno HLi GBrookes PMassett MPWu QChen LMChang C (2011 Aug). Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I. Molecular endocrinology (Baltimore, Md.). Lee YFLiu SLiu NCWang RSChen LMLin WJTing HJHo HCLi GPuzas EJWu QChang C (2011 Jul). Premature aging with impaired oxidative stress defense in mice lacking TR4. American journal of physiology. Endocrinology and metabolism. Xie SNi JLee YFLiu SLi GShyr CRChang C (2011 Jun 17). Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation. The Journal of biological chemistry. Kim ELiu NCYu ICLin HYLee YFSparks JDChen LMChang C (2011 May). Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity. Diabetes. Hsu JWYasmin-Karim SKing MRWojciechowski JCMickelsen DBlair MLTing HJMa WLLee YF (2011 Feb). Suppression of prostate cancer cell rolling and adhesion to endothelium by 1α,25-dihydroxyvitamin D3. The American journal of pathology. Collins LLLee YFTing HJLin WJLiu NCMeshul CKUno HBao BYChen YTChang C (2011). The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice. Reproductive biology and endocrinology : RB&E. Bao BYTing HJHsu JWYasmin-Karim SMessing ELee YF (2010 May). Down-regulation of NF-kappaB signals is involved in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness. The Journal of steroid biochemistry and molecular biology. Liu NCLin WJYu ICLin HYLiu SLee YFChang C (2009 Oct). Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling. Endocrine. Xie SLee YFKim EChen LMNi JFang LYLiu SLin SJAbe JBerk BHo FMChang C (2009 Aug 11). TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. Proceedings of the National Academy of Sciences of the United States of America. Cai YLee YFLi GLiu SBao BYHuang JHsu CLChang C (2008 Jul 1). A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor. International journal of cancer. Li GLee YFLiu SCai YXie SLiu NCBao BYChen ZChang C (2008 Jul). Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a. Endocrinology. Bao BYTing HJHsu JWLee YF (2008 Jun 15). Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells. International journal of cancer. Chen LMWang RSLee YFLiu NCChang YJWu CCXie SHung YCChang C (2008 Apr). Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4. Molecular endocrinology (Baltimore, Md.). Liu NCLin WJKim ECollins LLLin HYYu ICSparks JDChen LMLee YFChang C (2007 Dec). Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis. Diabetes. Ting HJBao BYReeder JEMessing EMLee YF (2007 Sep). Increased expression of corepressors in aggressive androgen-independent prostate cancer cells results in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness. Molecular cancer research : MCR. Zhang YChen YTXie SWang LLee YFChang SSChang C (2007 Apr). Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain. Molecular endocrinology (Baltimore, Md.). Ting HJHsu JBao BYLee YF (2007 Mar 8). Docetaxel-induced growth inhibition and apoptosis in androgen independent prostate cancer cells are enhanced by 1alpha,25-dihydroxyvitamin D3. Cancer letters. Chen TCPersons KSZheng SMathieu JHolick MFLee YFBao BArai MAKittaka A (2007 Mar). Evaluation of C-2-substituted 19-nor-1alpha,25-dihydroxyvitamin D3 analogs as therapeutic agents for prostate cancer. The Journal of steroid biochemistry and molecular biology. Wang CPLee YFChang CLee HJ (2006 Dec 8). Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor. Biochemical and biophysical research communications. Bao BYYao JLee YF (2006 Sep). 1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis. Carcinogenesis. Bao BYYeh SDLee YF (2006 Jan). 1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases. Carcinogenesis. Chuang KHLee YFLin WJChu CYAltuwaijri SWan YJChang C (2005 May). 9-cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor. Molecular endocrinology (Baltimore, Md.). Ting HJBao BYHsu CLLee YF (2005 Feb). Androgen-receptor coregulators mediate the suppressive effect of androgen signals on vitamin D receptor activity. Endocrine. Lee YFBao BYChang C (2004 Oct 22). Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor. Biochemical and biophysical research communications. Collins LLLee YFHeinlein CALiu NCChen YTShyr CRMeshul CKUno HPlatt KAChang C (2004 Oct 19). Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4. Proceedings of the National Academy of Sciences of the United States of America. Lee YFJohn MFalconer AEdwards SClark JFlohr PRoe TWang RShipley JGrimer RJMangham DCThomas JMFisher CJudson ICooper CS (2004 Oct 15). A gene expression signature associated with metastatic outcome in human leiomyosarcomas. Cancer research. Chen HHLee YFChan MHLo PS (2004 Oct). The role of N-methyl-D-aspartate receptors in neurobehavioral changes induced by toluene exposure during synaptogenesis. Annals of the New York Academy of Sciences. Mu XLee YFLiu NCChen YTKim EShyr CRChang C (2004 Jul). Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis. Molecular and cellular biology. Bao BYHu YCTing HJLee YF (2004 Apr 22). Androgen signaling is required for the vitamin D-mediated growth inhibition in human prostate cancer cells. Oncogene. Kim EXie SYeh SDLee YFCollins LLHu YCShyr CRMu XMLiu NCChen YTWang PHChang C (2003 Nov 21). Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster. The Journal of biological chemistry. Lin WJLi JLee YFYeh SDAltuwaijri SOu JHChang C (2003 Mar 14). Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4. The Journal of biological chemistry. Inui SLee YFChang EShyr CRChang C (2003 Feb). Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes. Journal of dermatological science. Lee YFLin WJHuang JMessing EMChan FLWilding GChang C (2002 Nov 1). Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells. Cancer research. Lee YFLee HJChang C (2002 Aug). Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily. The Journal of steroid biochemistry and molecular biology. Lee HJLee YFChang C (2001 Aug 3). TR4 orphan receptor represses the human steroid 21-hydroxylase gene expression through the monomeric AGGTCA motif. Biochemical and biophysical research communications. Lee YFShyr CRThin THLin WJChang C (1999 Dec 21). Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily. Proceedings of the National Academy of Sciences of the United States of America. Lee YFYoung WJLin WJShyr CRChang C (1999 Jun 4). Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. The Journal of biological chemistry. Inui SLee YFHaake ARGoldsmith LAChang C (1999 Apr). Induction of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytes. The Journal of investigative dermatology. Lee HJLee YFChang C (1999 Apr). Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor. Molecular and cellular biochemistry.