Mechanisms of Metabolic Reprogramming by Human Cytomegalovirus
A major focus of our laboratory is on human cytomegalovirus (HCMV), a herpes virus, which is the leading cause of congenital viral infection, occurring in approximately 1% of all live births. Congenital HCMV infection results in central nervous system damage in the majority of symptomatic newborns.
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Oncogene-Induced Metabolic Reprogramming
It has been known for decades that this cancerous transformation induces gross metabolic changes in normal cells. However, many questions remain about the specific activities induced and the upstream mechanisms that are responsible. More recently, several reports indicate the importance of these metabolic changes for tumorigenesis, highlighting the likelihood that inhibition of these activities could prevent cancer associated disease.
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