Recent Publications

• 1. Lohela TJ
  2. Lilius TO
  3. Nedergaard M
  The glymphatic system: implications for drugs for central nervous system diseases.; Nature reviews. Drug discovery. 2022 Aug 10.
• 1. Wostyn P
  2. Mader TH
  3. Gibson CR
  4. Nedergaard M
  The effect of long-duration spaceflight on perivascular spaces within the brain.; Proceedings of the National Academy of Sciences of the United States of America; Vol 119(32), pp. e2207724119. 2022 Jul 18.
• 1. Kjaerby C
  2. Andersen M
  3. Hauglund N
  4. Untiet V
  5. Dall C
  6. Sigurdsson B
  7. Ding F
  8. Feng J
  9. Li Y
  10. Weikop P
  11. Hirase H
  12. Nedergaard M
  Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine.; Nature neuroscience. 2022 Jul 07.
• 1. Mestre H
  2. Verma N
  3. Greene TD
  4. Lin LA
  5. Ladron-de-Guevara A
  6. Sweeney AM
  7. Liu G
  8. Thomas VK
  9. Galloway CA
  10. de Mesy Bentley KL
  11. Nedergaard M
  12. Mehta RI
  Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease.; Nature communications; Vol 13(1). 2022 Jul 06.
• 1. Tithof J
  2. Boster KAS
  3. Bork PAR
  4. Nedergaard M
  5. Thomas JH
  6. Kelley DH
  A network model of glymphatic flow under different experimentally-motivated parametric scenarios.; iScience; Vol 25(5). 2022 May 20.
• 1. Kananen J
  2. Järvelä M
  3. Korhonen V
  4. Tuovinen T
  5. Huotari N
  6. Raitamaa L
  7. Helakari H
  8. Väyrynen T
  9. Raatikainen V
  10. Nedergaard M
  11. Ansakorpi H
  12. Jacobs J
  13. LeVan P
  14. Kiviniemi V
  Increased interictal synchronicity of respiratory related brain pulsations in epilepsy.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2022 May 14.
• 1. Ladrón-de-Guevara A
  2. Shang JK
  3. Nedergaard M
  4. Kelley DH
  Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment.; Journal of theoretical biology. 2022 Mar 23.
• 1. Monai H
  2. Koketsu S
  3. Shinohara Y
  4. Ueki T
  5. Kusk P
  6. Hauglund NL
  7. Samson AJ
  8. Nedergaard M
  9. Hirase H
  Author Correction: Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.; Scientific reports; Vol 12(1). 2022 Mar 18.
• 1. Beaman EE
  2. Bonde AN
  3. Ulv Larsen SM
  4. Ozenne B
  5. Lohela TJ
  6. Nedergaard M
  7. Gíslason GH
  8. Knudsen GM
  9. Holst SC
  Blood-brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension.; Brain : a journal of neurology. 2022 Feb 23.
• 1. Helakari H
  2. Korhonen V
  3. Holst SC
  4. Piispala J
  5. Kallio M
  6. Väyrynen T
  7. Huotari N
  8. Raitamaa L
  9. Tuunanen J
  10. Kananen J
  11. Järvelä M
  12. Tuovinen T
  13. Raatikainen V
  14. Borchardt V
  15. Kinnunen H
  16. Nedergaard M
  17. Kiviniemi V
  Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations.; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 Feb 07.
• 1. Newell DW
  2. Nedergaard M
  3. Aaslid R
  Physiological Mechanisms and Significance of Intracranial B Waves.; Frontiers in neurology; Vol 13. 2022.
• 1. Wostyn P
  2. Mader TH
  3. Gibson CR
  4. Nedergaard M
  Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?; Eye and brain; Vol 14. 2022.
• 1. Martikainen MV
  2. Aakko-Saksa P
  3. van den Broek L
  4. Cassee FR
  5. Carare RO
  6. Chew S
  7. Dinnyes A
  8. Giugno R
  9. Kanninen KM
  10. Malm T
  11. Muala A
  12. Nedergaard M
  13. Oudin A
  14. Oyola P
  15. Pfeiffer TV
  16. Rönkkö T
  17. Saarikoski S
  18. Sandström T
  19. Schins RPF
  20. Topinka J
  21. Yang M
  22. Zeng X
  23. Westerink RHS
  24. Jalava PI
  TUBE Project: Transport-Derived Ultrafines and the Brain Effects.; International journal of environmental research and public health; Vol 19(1). 2021 Dec 28.
• 1. Battistella R
  2. Kritsilis M
  3. Matuskova H
  4. Haswell D
  5. Cheng AX
  6. Meissner A
  7. Nedergaard M
  8. Lundgaard I
  Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature.; International journal of molecular sciences; Vol 22(21). 2021 Oct 26.
• 1. Hablitz LM
  2. Nedergaard M
  The glymphatic system.; Current biology : CB; Vol 31(20). 2021 Oct 25.
• 1. Du T
  2. Mestre H
  3. Kress BT
  4. Liu G
  5. Sweeney AM
  6. Samson AJ
  7. Rasmussen MK
  8. Mortensen KN
  9. Bork PAR
  10. Peng W
  11. Olveda GE
  12. Bashford L
  13. Toro ER
  14. Tithof J
  15. Kelley DH
  16. Thomas JH
  17. Hjorth PG
  18. Martens EA
  19. Mehta RI
  20. Hirase H
  21. Mori Y
  22. Nedergaard M
  Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.; Brain : a journal of neurology. 2021 Sep 28.
• 1. Hablitz LM
  2. Nedergaard M
  The Glymphatic System: A Novel Component of Fundamental Neurobiology.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 41(37). 2021 Sep 15.
• 1. Pavan C
  2. L R Xavier A
  3. Ramos M
  4. Fisher J
  5. Kritsilis M
  6. Linder A
  7. Bentzer P
  8. Nedergaard M
  9. Lundgaard I
  DNase Treatment Prevents Cerebrospinal Fluid Block in Early Experimental Pneumococcal Meningitis.; Annals of neurology. 2021 Aug 16.
• 1. Benveniste H
  2. Nedergaard M
  Cerebral small vessel disease: A glymphopathy?; Current opinion in neurobiology; Vol 72. 2021 Aug 15.
• 1. Mogensen FL
  2. Delle C
  3. Nedergaard M
  The Glymphatic System (En)during Inflammation.; International journal of molecular sciences; Vol 22(14). 2021 Jul 13.
• 1. Wardlaw JM
  2. Benveniste H
  3. Nedergaard M
  4. Zlokovic BV
  5. Charpak S
  6. Smith KJ
  7. Black SE
  Reply to: Rethink the classical view of cerebrospinal fluid production.; Nature reviews. Neurology. 2021 Jul 12.
• 1. Rasmussen MK
  2. Mestre H
  3. Nedergaard M
  Fluid Transport in the Brain.; Physiological reviews. 2021 May 05.
• 1. Monai H
  2. Koketsu S
  3. Shinohara Y
  4. Ueki T
  5. Kusk P
  6. Hauglund NL
  7. Samson AJ
  8. Nedergaard M
  9. Hirase H
  Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.; Scientific reports; Vol 11(1). 2021 Apr 14.
• 1. Rajna Z
  2. Mattila H
  3. Huotari N
  4. Tuovinen T
  5. Krüger J
  6. Holst SC
  7. Korhonen V
  8. Remes AM
  9. Seppänen T
  10. Hennig J
  11. Nedergaard M
  12. Kiviniemi V
  Cardiovascular brain impulses in Alzheimer's disease.; Brain : a journal of neurology. 2021 Mar 31.
• 1. Yuste R
  2. Hawrylycz M
  3. Aalling N
  4. Aguilar-Valles A
  5. Arendt D
  6. Armañanzas R
  7. Ascoli GA
  8. Bielza C
  9. Bokharaie V
  10. Bergmann TB
  11. Bystron I
  12. Capogna M
  13. Chang Y
  14. Clemens A
  15. de Kock CPJ
  16. DeFelipe J
  17. Dos Santos SE
  18. Dunville K
  19. Feldmeyer D
  20. Fiáth R
  21. Fishell GJ
  22. Foggetti A
  23. Gao X
  24. Ghaderi P
  25. Goriounova NA
  26. Güntürkün O
  27. Hagihara K
  28. Hall VJ
  29. Helmstaedter M
  30. Herculano-Houzel S
  31. Hilscher MM
  32. Hirase H
  33. Hjerling-Leffler J
  34. Hodge R
  35. Huang J
  36. Huda R
  37. Khodosevich K
  38. Kiehn O
  39. Koch H
  40. Kuebler ES
  41. Kühnemund M
  42. Larrañaga P
  43. Lelieveldt B
  44. Louth EL
  45. Lui JH
  46. Mansvelder HD
  47. Marin O
  48. Martinez-Trujillo J
  49. Chameh HM
  50. Mohapatra AN
  51. Munguba H
  52. Nedergaard M
  53. Němec P
  54. Ofer N
  55. Pfisterer UG
  56. Pontes S
  57. Redmond W
  58. Rossier J
  59. Sanes JR
  60. Scheuermann RH
  61. Serrano-Saiz E
  62. Staiger JF
  63. Somogyi P
  64. Tamás G
  65. Tolias AS
  66. Tosches MA
  67. García MT
  68. Wozny C
  69. Wuttke TV
  70. Liu Y
  71. Yuan J
  72. Zeng H
  73. Lein E
  Author Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types.; Nature neuroscience. 2021 Mar 19.
• 1. Raghunandan A
  2. Ladron-de-Guevara A
  3. Tithof J
  4. Mestre H
  5. Du T
  6. Nedergaard M
  7. Thomas JH
  8. Kelley DH
  Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection.; eLife; Vol 10. 2021 Mar 09.
• 1. Stanton EH
  2. Persson NDÅ
  3. Gomolka RS
  4. Lilius T
  5. Sigurðsson B
  6. Lee H
  7. Xavier ALR
  8. Benveniste H
  9. Nedergaard M
  10. Mori Y
  Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia.; Magnetic resonance in medicine. 2021 Jan 11.
• 1. Liu G
  2. Mestre H
  3. Sweeney AM
  4. Sun Q
  5. Weikop P
  6. Du T
  7. Nedergaard M
  Direct Measurement of Cerebrospinal Fluid Production in Mice.; Cell reports; Vol 33(12). 2020 Dec 22.
• 1. Tuovinen T
  2. Kananen J
  3. Rajna Z
  4. Lieslehto J
  5. Korhonen V
  6. Rytty R
  7. Mattila H
  8. Huotari N
  9. Raitamaa L
  10. Helakari H
  11. Elseoud AA
  12. Krüger J
  13. LeVan P
  14. Tervonen O
  15. Hennig J
  16. Remes AM
  17. Nedergaard M
  18. Kiviniemi V
  The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies.; Scientific reports; Vol 10(1). 2020 Dec 09.
• 1. Yuste R
  2. Hawrylycz M
  3. Aalling N
  4. Aguilar-Valles A
  5. Arendt D
  6. Arnedillo RA
  7. Ascoli GA
  8. Bielza C
  9. Bokharaie V
  10. Bergmann TB
  11. Bystron I
  12. Capogna M
  13. Chang Y
  14. Clemens A
  15. de Kock CPJ
  16. DeFelipe J
  17. Dos Santos SE
  18. Dunville K
  19. Feldmeyer D
  20. Fiáth R
  21. Fishell GJ
  22. Foggetti A
  23. Gao X
  24. Ghaderi P
  25. Goriounova NA
  26. Güntürkün O
  27. Hagihara K
  28. Hall VJ
  29. Helmstaedter M
  30. Herculano S
  31. Hilscher MM
  32. Hirase H
  33. Hjerling-Leffler J
  34. Hodge R
  35. Huang J
  36. Huda R
  37. Khodosevich K
  38. Kiehn O
  39. Koch H
  40. Kuebler ES
  41. Kühnemund M
  42. Larrañaga P
  43. Lelieveldt B
  44. Louth EL
  45. Lui JH
  46. Mansvelder HD
  47. Marin O
  48. Martinez-Trujillo J
  49. Moradi Chameh H
  50. Nath A
  51. Nedergaard M
  52. Němec P
  53. Ofer N
  54. Pfisterer UG
  55. Pontes S
  56. Redmond W
  57. Rossier J
  58. Sanes JR
  59. Scheuermann R
  60. Serrano-Saiz E
  61. Steiger JF
  62. Somogyi P
  63. Tamás G
  64. Tolias AS
  65. Tosches MA
  66. García MT
  67. Vieira HM
  68. Wozny C
  69. Wuttke TV
  70. Yong L
  71. Yuan J
  72. Zeng H
  73. Lein E
  Publisher Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types.; Nature neuroscience. 2020 Dec 04.
• 1. Goldman N
  2. Hablitz LM
  3. Mori Y
  4. Nedergaard M
  The Glymphatic System and Pain.; Medical acupuncture; Vol 32(6). 2020 Dec 01.
• 1. Min Rivas F
  2. Liu J
  3. Martell BC
  4. Du T
  5. Mestre H
  6. Nedergaard M
  7. Tithof J
  8. Thomas JH
  9. Kelley DH
  Surface periarterial spaces of the mouse brain are open, not porous.; Journal of the Royal Society, Interface; Vol 17(172). 2020 Nov.
• 1. Nedergaard M
  2. Goldman SA
  Glymphatic failure as a final common pathway to dementia.; Science (New York, N.Y.); Vol 370(6512). 2020 Oct 02.
• 1. Giannetto M
  2. Xia M
  3. Stæger FF
  4. Metcalfe T
  5. Vinitsky HS
  6. Dang JAML
  7. Xavier ALR
  8. Kress BT
  9. Nedergaard M
  10. Hablitz LM
  Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice.; Scientific reports; Vol 10(1). 2020 Sep 30.
• 1. Hablitz LM
  2. Plá V
  3. Giannetto M
  4. Vinitsky HS
  5. Stæger FF
  6. Metcalfe T
  7. Nguyen R
  8. Benrais A
  9. Nedergaard M
  Circadian control of brain glymphatic and lymphatic fluid flow.; Nature communications; Vol 11(1). 2020 Sep 02.
• 1. Yuste R
  2. Hawrylycz M
  3. Aalling N
  4. Aguilar-Valles A
  5. Arendt D
  6. Arnedillo RA
  7. Ascoli GA
  8. Bielza C
  9. Bokharaie V
  10. Bergmann TB
  11. Bystron I
  12. Capogna M
  13. Chang Y
  14. Clemens A
  15. de Kock CPJ
  16. DeFelipe J
  17. Dos Santos SE
  18. Dunville K
  19. Feldmeyer D
  20. Fiáth R
  21. Fishell GJ
  22. Foggetti A
  23. Gao X
  24. Ghaderi P
  25. Goriounova NA
  26. Güntürkün O
  27. Hagihara K
  28. Hall VJ
  29. Helmstaedter M
  30. Herculano S
  31. Hilscher MM
  32. Hirase H
  33. Hjerling-Leffler J
  34. Hodge R
  35. Huang J
  36. Huda R
  37. Khodosevich K
  38. Kiehn O
  39. Koch H
  40. Kuebler ES
  41. Kühnemund M
  42. Larrañaga P
  43. Lelieveldt B
  44. Louth EL
  45. Lui JH
  46. Mansvelder HD
  47. Marin O
  48. Martinez-Trujillo J
  49. Moradi Chameh H
  50. Nath A
  51. Nedergaard M
  52. Němec P
  53. Ofer N
  54. Pfisterer UG
  55. Pontes S
  56. Redmond W
  57. Rossier J
  58. Sanes JR
  59. Scheuermann R
  60. Serrano-Saiz E
  61. Steiger JF
  62. Somogyi P
  63. Tamás G
  64. Tolias AS
  65. Tosches MA
  66. García MT
  67. Vieira HM
  68. Wozny C
  69. Wuttke TV
  70. Yong L
  71. Yuan J
  72. Zeng H
  73. Lein E
  A community-based transcriptomics classification and nomenclature of neocortical cell types.; Nature neuroscience. 2020 Aug 24.
• 1. Ng Kee Kwong KC
  2. Mehta AR
  3. Nedergaard M
  4. Chandran S
  Defining novel functions for cerebrospinal fluid in ALS pathophysiology.; Acta neuropathologica communications; Vol 8(1). 2020 Aug 20.
• 1. Rangroo Thrane V
  2. Hynnekleiv L
  3. Wang X
  4. Thrane AS
  5. Krohn J
  6. Nedergaard M
  Twists and turns of ocular glymphatic clearance - new study reveals surprising findings in glaucoma.; Acta ophthalmologica. 2020 Jul 24.
• 1. Stæger FF
  2. Mortensen KN
  3. Nielsen MSN
  4. Sigurdsson B
  5. Kaufmann LK
  6. Hirase H
  7. Nedergaard M
  A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices.; Scientific data; Vol 7(1). 2020 Jul 13.
• 1. Windrem MS
  2. Schanz SJ
  3. Zou L
  4. Chandler-Militello D
  5. Kuypers NJ
  6. Nedergaard M
  7. Lu Y
  8. Mariani JN
  9. Goldman SA
  Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.; Cell reports; Vol 31(7). 2020 May 19.
• 1. Mestre H
  2. Mori Y
  3. Nedergaard M
  The Brain's Glymphatic System: Current Controversies.; Trends in neurosciences. 2020 May 15.
• 1. Rasmussen R
  2. O'Donnell J
  3. Ding F
  4. Nedergaard M
  Interstitial ions: A key regulator of state-dependent neural activity?; Progress in neurobiology. 2020 May 12.
• 1. Ulv Larsen SM
  2. Landolt HP
  3. Berger W
  4. Nedergaard M
  5. Knudsen GM
  6. Holst SC
  Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep.; PLoS biology; Vol 18(5). 2020 May.
• 1. Viggiano D
  2. Wagner CA
  3. Martino G
  4. Nedergaard M
  5. Zoccali C
  6. Unwin R
  7. Capasso G
  Mechanisms of cognitive dysfunction in CKD.; Nature reviews. Nephrology. 2020 Mar 31.
• 1. Wang X
  2. Lou N
  3. Eberhardt A
  4. Yang Y
  5. Kusk P
  6. Xu Q
  7. Förstera B
  8. Peng S
  9. Shi M
  10. Ladrón-de-Guevara A
  11. Delle C
  12. Sigurdsson B
  13. Xavier ALR
  14. Ertürk A
  15. Libby RT
  16. Chen L
  17. Thrane AS
  18. Nedergaard M
  An ocular glymphatic clearance system removes β-amyloid from the rodent eye.; Science translational medicine; Vol 12(536). 2020 Mar 25.
• 1. Hauglund NL
  2. Kusk P
  3. Kornum BR
  4. Nedergaard M
  Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 40(11). 2020 Mar 11.
• 1. Karimy JK
  2. Reeves BC
  3. Damisah E
  4. Duy PQ
  5. Antwi P
  6. David W
  7. Wang K
  8. Schiff SJ
  9. Limbrick DD
  10. Alper SL
  11. Warf BC
  12. Nedergaard M
  13. Simard JM
  14. Kahle KT
  Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.; Nature reviews. Neurology. 2020 Mar 09.
• 1. Koundal S
  2. Elkin R
  3. Nadeem S
  4. Xue Y
  5. Constantinou S
  6. Sanggaard S
  7. Liu X
  8. Monte B
  9. Xu F
  10. Nostrand WV
  11. Nedergaard M
  12. Lee H
  13. Wardlaw J
  14. Benveniste H
  15. Tannenbaum A
  Publisher Correction: Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.; Scientific reports; Vol 10(1). 2020 Feb 27.
• 1. Wardlaw JM
  2. Benveniste H
  3. Nedergaard M
  4. Zlokovic BV
  5. Mestre H
  6. Lee H
  7. Doubal FN
  8. Brown R
  9. Ramirez J
  10. MacIntosh BJ
  11. Tannenbaum A
  12. Ballerini L
  13. Rungta RL
  14. Boido D
  15. Sweeney M
  16. Montagne A
  17. Charpak S
  18. Joutel A
  19. Smith KJ
  20. Black SE
  Perivascular spaces in the brain: anatomy, physiology and pathology.; Nature reviews. Neurology. 2020 Feb 24.
• 1. Li Q
  2. Aalling NN
  3. Förstera B
  4. Ertürk A
  5. Nedergaard M
  6. Møllgård K
  7. Xavier ALR
  Aquaporin 1 and the Na+/K+/2Cl- cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system.; Fluids and barriers of the CNS; Vol 17(1). 2020 Feb 11.