Recent Publications

• 1. Nedergaard M
  2. Goldman SA
  Glymphatic failure as a final common pathway to dementia.; Science (New York, N.Y.); Vol 370(6512). 2020 Oct 02.
• 1. Giannetto M
  2. Xia M
  3. Stæger FF
  4. Metcalfe T
  5. Vinitsky HS
  6. Dang JAML
  7. Xavier ALR
  8. Kress BT
  9. Nedergaard M
  10. Hablitz LM
  Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice.; Scientific reports; Vol 10(1). 2020 Sep 30.
• 1. Hablitz LM
  2. Plá V
  3. Giannetto M
  4. Vinitsky HS
  5. Stæger FF
  6. Metcalfe T
  7. Nguyen R
  8. Benrais A
  9. Nedergaard M
  Circadian control of brain glymphatic and lymphatic fluid flow.; Nature communications; Vol 11(1). 2020 Sep 02.
• 1. Yuste R
  2. Hawrylycz M
  3. Aalling N
  4. Aguilar-Valles A
  5. Arendt D
  6. Arnedillo RA
  7. Ascoli GA
  8. Bielza C
  9. Bokharaie V
  10. Bergmann TB
  11. Bystron I
  12. Capogna M
  13. Chang Y
  14. Clemens A
  15. de Kock CPJ
  16. DeFelipe J
  17. Dos Santos SE
  18. Dunville K
  19. Feldmeyer D
  20. Fiáth R
  21. Fishell GJ
  22. Foggetti A
  23. Gao X
  24. Ghaderi P
  25. Goriounova NA
  26. Güntürkün O
  27. Hagihara K
  28. Hall VJ
  29. Helmstaedter M
  30. Herculano S
  31. Hilscher MM
  32. Hirase H
  33. Hjerling-Leffler J
  34. Hodge R
  35. Huang J
  36. Huda R
  37. Khodosevich K
  38. Kiehn O
  39. Koch H
  40. Kuebler ES
  41. Kühnemund M
  42. Larrañaga P
  43. Lelieveldt B
  44. Louth EL
  45. Lui JH
  46. Mansvelder HD
  47. Marin O
  48. Martinez-Trujillo J
  49. Moradi Chameh H
  50. Nath A
  51. Nedergaard M
  52. Němec P
  53. Ofer N
  54. Pfisterer UG
  55. Pontes S
  56. Redmond W
  57. Rossier J
  58. Sanes JR
  59. Scheuermann R
  60. Serrano-Saiz E
  61. Steiger JF
  62. Somogyi P
  63. Tamás G
  64. Tolias AS
  65. Tosches MA
  66. García MT
  67. Vieira HM
  68. Wozny C
  69. Wuttke TV
  70. Yong L
  71. Yuan J
  72. Zeng H
  73. Lein E
  A community-based transcriptomics classification and nomenclature of neocortical cell types.; Nature neuroscience. 2020 Aug 24.
• 1. Ng Kee Kwong KC
  2. Mehta AR
  3. Nedergaard M
  4. Chandran S
  Defining novel functions for cerebrospinal fluid in ALS pathophysiology.; Acta neuropathologica communications; Vol 8(1). 2020 Aug 20.
• 1. Rangroo Thrane V
  2. Hynnekleiv L
  3. Wang X
  4. Thrane AS
  5. Krohn J
  6. Nedergaard M
  Twists and turns of ocular glymphatic clearance - new study reveals surprising findings in glaucoma.; Acta ophthalmologica. 2020 Jul 24.
• 1. Stæger FF
  2. Mortensen KN
  3. Nielsen MSN
  4. Sigurdsson B
  5. Kaufmann LK
  6. Hirase H
  7. Nedergaard M
  A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices.; Scientific data; Vol 7(1). 2020 Jul 13.
• 1. Windrem MS
  2. Schanz SJ
  3. Zou L
  4. Chandler-Militello D
  5. Kuypers NJ
  6. Nedergaard M
  7. Lu Y
  8. Mariani JN
  9. Goldman SA
  Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.; Cell reports; Vol 31(7). 2020 May 19.
• 1. Mestre H
  2. Mori Y
  3. Nedergaard M
  The Brain's Glymphatic System: Current Controversies.; Trends in neurosciences. 2020 May 15.
• 1. Rasmussen R
  2. O'Donnell J
  3. Ding F
  4. Nedergaard M
  Interstitial ions: A key regulator of state-dependent neural activity?; Progress in neurobiology. 2020 May 12.
• 1. Ulv Larsen SM
  2. Landolt HP
  3. Berger W
  4. Nedergaard M
  5. Knudsen GM
  6. Holst SC
  Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep.; PLoS biology; Vol 18(5). 2020 May.
• 1. Viggiano D
  2. Wagner CA
  3. Martino G
  4. Nedergaard M
  5. Zoccali C
  6. Unwin R
  7. Capasso G
  Mechanisms of cognitive dysfunction in CKD.; Nature reviews. Nephrology. 2020 Mar 31.
• 1. Wang X
  2. Lou N
  3. Eberhardt A
  4. Yang Y
  5. Kusk P
  6. Xu Q
  7. Förstera B
  8. Peng S
  9. Shi M
  10. Ladrón-de-Guevara A
  11. Delle C
  12. Sigurdsson B
  13. Xavier ALR
  14. Ertürk A
  15. Libby RT
  16. Chen L
  17. Thrane AS
  18. Nedergaard M
  An ocular glymphatic clearance system removes β-amyloid from the rodent eye.; Science translational medicine; Vol 12(536). 2020 Mar 25.
• 1. Hauglund NL
  2. Kusk P
  3. Kornum BR
  4. Nedergaard M
  Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 40(11). 2020 Mar 11.
• 1. Karimy JK
  2. Reeves BC
  3. Damisah E
  4. Duy PQ
  5. Antwi P
  6. David W
  7. Wang K
  8. Schiff SJ
  9. Limbrick DD
  10. Alper SL
  11. Warf BC
  12. Nedergaard M
  13. Simard JM
  14. Kahle KT
  Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.; Nature reviews. Neurology. 2020 Mar 09.
• 1. Koundal S
  2. Elkin R
  3. Nadeem S
  4. Xue Y
  5. Constantinou S
  6. Sanggaard S
  7. Liu X
  8. Monte B
  9. Xu F
  10. Nostrand WV
  11. Nedergaard M
  12. Lee H
  13. Wardlaw J
  14. Benveniste H
  15. Tannenbaum A
  Publisher Correction: Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.; Scientific reports; Vol 10(1). 2020 Feb 27.
• 1. Wardlaw JM
  2. Benveniste H
  3. Nedergaard M
  4. Zlokovic BV
  5. Mestre H
  6. Lee H
  7. Doubal FN
  8. Brown R
  9. Ramirez J
  10. MacIntosh BJ
  11. Tannenbaum A
  12. Ballerini L
  13. Rungta RL
  14. Boido D
  15. Sweeney M
  16. Montagne A
  17. Charpak S
  18. Joutel A
  19. Smith KJ
  20. Black SE
  Perivascular spaces in the brain: anatomy, physiology and pathology.; Nature reviews. Neurology. 2020 Feb 24.
• 1. Li Q
  2. Aalling NN
  3. Förstera B
  4. Ertürk A
  5. Nedergaard M
  6. Møllgård K
  7. Xavier ALR
  Aquaporin 1 and the Na+/K+/2Cl- cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system.; Fluids and barriers of the CNS; Vol 17(1). 2020 Feb 11.
• 1. Koundal S
  2. Elkin R
  3. Nadeem S
  4. Xue Y
  5. Constantinou S
  6. Sanggaard S
  7. Liu X
  8. Monte B
  9. Xu F
  10. Van Nostrand W
  11. Nedergaard M
  12. Lee H
  13. Wardlaw J
  14. Benveniste H
  15. Tannenbaum A
  Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.; Scientific reports; Vol 10(1). 2020 Feb 06.
• 1. Mestre H
  2. Du T
  3. Sweeney AM
  4. Liu G
  5. Samson AJ
  6. Peng W
  7. Mortensen KN
  8. Stæger FF
  9. Bork PAR
  10. Bashford L
  11. Toro ER
  12. Tithof J
  13. Kelley DH
  14. Thomas JH
  15. Hjorth PG
  16. Martens EA
  17. Mehta RI
  18. Solis O
  19. Blinder P
  20. Kleinfeld D
  21. Hirase H
  22. Mori Y
  23. Nedergaard M
  Cerebrospinal fluid influx drives acute ischemic tissue swelling.; Science (New York, N.Y.). 2020 Jan 30.
• 1. Reeves BC
  2. Karimy JK
  3. Kundishora AJ
  4. Mestre H
  5. Cerci HM
  6. Matouk C
  7. Alper SL
  8. Lundgaard I
  9. Nedergaard M
  10. Kahle KT
  Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus.; Trends in molecular medicine. 2020 Jan 17.
• 1. Kananen J
  2. Helakari H
  3. Korhonen V
  4. Huotari N
  5. Järvelä M
  6. Raitamaa L
  7. Raatikainen V
  8. Rajna Z
  9. Tuovinen T
  10. Nedergaard M
  11. Jacobs J
  12. LeVan P
  13. Ansakorpi H
  14. Kiviniemi V
  Respiratory-related brain pulsations are increased in epilepsy-a two-centre functional MRI study.; Brain communications; Vol 2(2). 2020.
• 1. Yoon C
  2. Qi Y
  3. Mestre H
  4. Canavesi C
  5. Marola OJ
  6. Cogliati A
  7. Nedergaard M
  8. Libby RT
  9. Rolland JP
  Gabor domain optical coherence microscopy combined with laser scanning confocal fluorescence microscopy.; Biomedical optics express; Vol 10(12). 2019 Dec 01.
• 1. Dietz AG
  2. Goldman SA
  3. Nedergaard M
  Glial cells in schizophrenia: a unified hypothesis.; The lancet. Psychiatry. 2019 Nov 05.
• 1. Ji RR
  2. Donnelly CR
  3. Nedergaard M
  Astrocytes in chronic pain and itch.; Nature reviews. Neuroscience; Vol 20(11). 2019 Nov.
• 1. Grutzendler J
  2. Nedergaard M
  Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas.; Trends in neurosciences; Vol 42(8). 2019 Aug.
• 1. Rasmussen R
  2. Nicholas E
  3. Petersen NC
  4. Dietz AG
  5. Xu Q
  6. Sun Q
  7. Nedergaard M
  Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice.; Cell reports; Vol 28(5). 2019 Jul 30.
• 1. Sweeney AM
  2. Plá V
  3. Du T
  4. Liu G
  5. Sun Q
  6. Peng S
  7. Plog BA
  8. Kress BT
  9. Wang X
  10. Mestre H
  11. Nedergaard M
  In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.; Journal of visualized experiments : JoVE. 2019 Jul 29.
• 1. Zvietcovich F
  2. Ge GR
  3. Mestre H
  4. Giannetto M
  5. Nedergaard M
  6. Rolland JP
  7. Parker KJ
  Longitudinal shear waves for elastic characterization of tissues in optical coherence elastography.; Biomedical optics express; Vol 10(7). 2019 Jul 01.
• 1. Smith NA
  2. Bekar LK
  3. Nedergaard M
  Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression.; Neurochemical research. 2019 Jun 28.
• 1. Lilius TO
  2. Blomqvist K
  3. Hauglund NL
  4. Liu G
  5. Stæger FF
  6. Bærentzen S
  7. Du T
  8. Ahlström F
  9. Backman JT
  10. Kalso EA
  11. Rauhala PV
  12. Nedergaard M
  Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.; Journal of controlled release : official journal of the Controlled Release Society; Vol 304. 2019 Jun 28.
• 1. Liu Z
  2. Osipovitch M
  3. Benraiss A
  4. Huynh NPT
  5. Foti R
  6. Bates J
  7. Chandler-Militello D
  8. Findling RL
  9. Tesar PJ
  10. Nedergaard M
  11. Windrem MS
  12. Goldman SA
  Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.; Cell reports; Vol 27(13). 2019 Jun 25.
• 1. Tithof J
  2. Kelley DH
  3. Mestre H
  4. Nedergaard M
  5. Thomas JH
  Hydraulic resistance of periarterial spaces in the brain.; Fluids and barriers of the CNS; Vol 16(1). 2019 Jun 20.
• 1. Nygaard Mortensen K
  2. Sanggaard S
  3. Mestre H
  4. Lee H
  5. Kostrikov S
  6. Xavier ALR
  7. Gjedde A
  8. Benveniste H
  9. Nedergaard M
  Impaired Glymphatic Transport in Spontaneously Hypertensive Rats.; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 Jun 17.
• 1. Plog BA
  2. Lou N
  3. Pierre CA
  4. Cove A
  5. Kenney HM
  6. Hitomi E
  7. Kang H
  8. Iliff JJ
  9. Zeppenfeld DM
  10. Nedergaard M
  11. Vates GE
  When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow.; Journal of neurosurgery. 2019 May 17.
• 1. Monai H
  2. Wang X
  3. Yahagi K
  4. Lou N
  5. Mestre H
  6. Xu Q
  7. Abe Y
  8. Yasui M
  9. Iwai Y
  10. Nedergaard M
  11. Hirase H
  Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke.; Proceedings of the National Academy of Sciences of the United States of America. 2019 May 16.
• 1. Zhou S
  2. Giannetto M
  3. DeCourcey J
  4. Kang H
  5. Kang N
  6. Li Y
  7. Zheng S
  8. Zhao H
  9. Simmons WR
  10. Wei HS
  11. Bodine DM
  12. Low PS
  13. Nedergaard M
  14. Wan J
  Oxygen tension-mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia.; Science advances; Vol 5(5). 2019 May.
• 1. Munk AS
  2. Wang W
  3. Bèchet NB
  4. Eltanahy AM
  5. Cheng AX
  6. Sigurdsson B
  7. Benraiss A
  8. Mäe MA
  9. Kress BT
  10. Kelley DH
  11. Betsholtz C
  12. Møllgård K
  13. Meissner A
  14. Nedergaard M
  15. Lundgaard I
  PDGF-B Is Required for Development of the Glymphatic System.; Cell reports; Vol 26(11). 2019 Mar 12.
• 1. Cai R
  2. Pan C
  3. Ghasemigharagoz A
  4. Todorov MI
  5. Förstera B
  6. Zhao S
  7. Bhatia HS
  8. Parra-Damas A
  9. Mrowka L
  10. Theodorou D
  11. Rempfler M
  12. Xavier ALR
  13. Kress BT
  14. Benakis C
  15. Steinke H
  16. Liebscher S
  17. Bechmann I
  18. Liesz A
  19. Menze B
  20. Kerschensteiner M
  21. Nedergaard M
  22. Ertürk A
  Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.; Nature neuroscience; Vol 22(2). 2019 Feb.
• 1. Hablitz LM
  2. Vinitsky HS
  3. Sun Q
  4. Stæger FF
  5. Sigurdsson B
  6. Mortensen KN
  7. Lilius TO
  8. Nedergaard M
  Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.; Science advances; Vol 5(2). 2019 Feb.
• 1. Koundal S
  2. Liu X
  3. Sanggaard S
  4. Mortensen K
  5. Wardlaw J
  6. Nedergaard M
  7. Benveniste H
  8. Lee H
  Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI.; Neuroscience; Vol 404. 2019 Jan 26.
• 1. Ramos M
  2. Burdon Bechet N
  3. Battistella R
  4. Pavan C
  5. Xavier ALR
  6. Nedergaard M
  7. Lundgaard I
  Cisterna Magna Injection in Rats to Study Glymphatic Function.; Methods in molecular biology (Clifton, N.J.); Vol 1938. 2019.
• 1. Sweeney MD
  2. Montagne A
  3. Sagare AP
  4. Nation DA
  5. Schneider LS
  6. Chui HC
  7. Harrington MG
  8. Pa J
  9. Law M
  10. Wang DJJ
  11. Jacobs RE
  12. Doubal FN
  13. Ramirez J
  14. Black SE
  15. Nedergaard M
  16. Benveniste H
  17. Dichgans M
  18. Iadecola C
  19. Love S
  20. Bath PM
  21. Markus HS
  22. Salman RA
  23. Allan SM
  24. Quinn TJ
  25. Kalaria RN
  26. Werring DJ
  27. Carare RO
  28. Touyz RM
  29. Williams SCR
  30. Moskowitz MA
  31. Katusic ZS
  32. Lutz SE
  33. Lazarov O
  34. Minshall RD
  35. Rehman J
  36. Davis TP
  37. Wellington CL
  38. González HM
  39. Yuan C
  40. Lockhart SN
  41. Hughes TM
  42. Chen CLH
  43. Sachdev P
  44. O'Brien JT
  45. Skoog I
  46. Pantoni L
  47. Gustafson DR
  48. Biessels GJ
  49. Wallin A
  50. Smith EE
  51. Mok V
  52. Wong A
  53. Passmore P
  54. Barkof F
  55. Muller M
  56. Breteler MMB
  57. Román GC
  58. Hamel E
  59. Seshadri S
  60. Gottesman RF
  61. van Buchem MA
  62. Arvanitakis Z
  63. Schneider JA
  64. Drewes LR
  65. Hachinski V
  66. Finch CE
  67. Toga AW
  68. Wardlaw JM
  69. Zlokovic BV
  Vascular dysfunction-The disregarded partner of Alzheimer's disease.; Alzheimer's & dementia : the journal of the Alzheimer's Association; Vol 15(1). 2019 Jan.
• 1. Wang M
  2. Qin C
  3. Luo X
  4. Wang J
  5. Wang X
  6. Xie M
  7. Hu J
  8. Cao J
  9. Hu T
  10. Goldman SA
  11. Nedergaard M
  12. Wang W
  Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.; Theranostics; Vol 9(15). 2019.
• 1. DiNuzzo M
  2. Walls AB
  3. Öz G
  4. Seaquist ER
  5. Waagepetersen HS
  6. Bak LK
  7. Nedergaard M
  8. Schousboe A
  State-Dependent Changes in Brain Glycogen Metabolism.; Advances in neurobiology; Vol 23. 2019.
• 1. Verkhratsky A
  2. Nedergaard M
  3. Steardo L
  4. Li B
  Editorial: Sleep and Mood Disorders.; Frontiers in psychiatry; Vol 10. 2019.
• 1. Mestre H
  2. Hablitz LM
  3. Xavier AL
  4. Feng W
  5. Zou W
  6. Pu T
  7. Monai H
  8. Murlidharan G
  9. Castellanos Rivera RM
  10. Simon MJ
  11. Pike MM
  12. Plá V
  13. Du T
  14. Kress BT
  15. Wang X
  16. Plog BA
  17. Thrane AS
  18. Lundgaard I
  19. Abe Y
  20. Yasui M
  21. Thomas JH
  22. Xiao M
  23. Hirase H
  24. Asokan A
  25. Iliff JJ
  26. Nedergaard M
  Aquaporin-4-dependent glymphatic solute transport in the rodent brain.; eLife; Vol 7. 2018 Dec 18.
• 1. Plog BA
  2. Mestre H
  3. Olveda GE
  4. Sweeney AM
  5. Kenney HM
  6. Cove A
  7. Dholakia KY
  8. Tithof J
  9. Nevins TD
  10. Lundgaard I
  11. Du T
  12. Kelley DH
  13. Nedergaard M
  Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.; JCI insight; Vol 3(23). 2018 Dec 06.
• 1. Mestre H
  2. Tithof J
  3. Du T
  4. Song W
  5. Peng W
  6. Sweeney AM
  7. Olveda G
  8. Thomas JH
  9. Nedergaard M
  10. Kelley DH
  Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.; Nature communications; Vol 9(1). 2018 Nov 19.
• 1. Rasmussen MK
  2. Mestre H
  3. Nedergaard M
  The glymphatic pathway in neurological disorders.; The Lancet. Neurology; Vol 17(11). 2018 Nov.