URMC / Labs / Nedergaard Lab / Publications

Recent Publications

1. Hauglund NL
2. Nedergaard M
Is glymphatic clearance the secret to restorative sleep?; Brain : a journal of neurology. 2025 Dec 01.
1. Kipnis J
2. Benveniste H
3. Eichmann A
4. Thomas JL
5. Reich DS
6. Lewis LD
7. Tsai LH
8. Drieu A
9. Bakker ENTP
10. Kelley DH
11. Lundgaard I
12. Mestre H
13. Zott B
14. Eide PK
15. van Osch MJP
16. van Veluw SJ
17. Iliff J
18. Yang AC
19. Santambrogio L
20. Da Mesquita S
21. Daneman R
22. Rustenhoven J
23. Goldman SA
24. Nedergaard M
Resolving the mysteries of brain clearance and immune surveillance.; Neuron. 2025 Nov 24.
1. Ulv Larsen SM
2. Holst SC
3. Olsen AS
4. Ozenne B
5. Zilstorff DB
6. Brendstrup-Brix K
7. Weikop P
8. Pleinert S
9. Kiviniemi V
10. Jennum PJ
11. Nedergaard M
12. Knudsen GM
Sleep deprivation and sleep intensity exert distinct effects on cerebral vasomotion and brain pulsations driven by the respiratory and cardiac cycles.; PLoS biology; Vol 23(11), pp. e3003500. 2025 Nov 20.
1. Ranjan A
2. Wong DT
3. Huang Q
4. Ghanizada H
5. Nedergaard M
6. Kelley DH
7. Boster KAS
Comparison of approaches for surface vessel diameter and pulsatility quantification.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2025 Nov 14.
1. Guo Y
2. Bork PAR
3. Nedergaard M
4. Kelley DH
Dynamics of brain valves: ostensible rectification mechanisms for cerebrospinal fluid flow.; Journal of the Royal Society, Interface; Vol 22(231), pp. 20250419. 2025 Oct 29.
1. Persson NDÅ
2. Lohela TJ
3. Anttila JE
4. Mäkelä J
5. Rosenholm M
6. Peltoniemi M
7. Jalonen SC
8. García-Horsman JA
9. Sarparanta M
10. Nedergaard M
11. Rantamäki T
12. Lilius TO
General anesthesia and systemic hyperosmolality modulate lumbar intrathecal drug distribution in female rats.; Anesthesiology. 2025 Oct 09.
1. Finkelstein AJ
2. Sipple MT
3. Akkipeddi SMK
4. Whyte R
5. Kohli GS
6. Susa S
7. Singh R
8. Romiyo P
9. Zhong J
10. Bhalla T
11. Mattingly T
12. Nguyen VN
13. Nedergaard M
14. Bender MT
15. Schartz D
Role of post-thrombectomy glymphatic flow in futile recanalization in large-vessel occlusion ischemic stroke.; Journal of neurosurgery. 2025 Sep 19.
1. Hablitz LM
2. Nedergaard M
Cerebrospinal fluid flow modulates brain health.; The Journal of clinical investigation; Vol 135(17). 2025 Sep 02.
1. Andersen JV
2. Aldana BI
3. Bak LK
4. Behar KL
5. Borges K
6. Carruthers A
7. Cumming P
8. Derouiche A
9. Díaz-García CM
10. Drew KL
11. Duarte JMN
12. Ferreira GC
13. Giove F
14. Gjedde A
15. Hyder F
16. Ioannou MS
17. Kann O
18. Kristian T
19. Lai JCK
20. Mason GF
21. McNay EC
22. Nedergaard M
23. Nowak TS
24. Patel AB
25. Rae CD
26. Ryan TA
27. Schuck PF
28. Simpson IA
29. Vannucci SJ
30. Waagepetersen HS
31. Yellen G
32. McKenna MC
Embracing Scientific Debate in Brain Metabolism.; Journal of neurochemistry; Vol 169(9), pp. e70230. 2025 Sep.
1. Cona A
2. Newbold E
3. Kesmen D
4. Snape R
5. Danner J
6. White N
7. Borden W
8. Iseson A
9. Schanz SJ
10. Chandler-Militello D
11. Li X
12. Cano JC
13. Mariani JN
14. Nedergaard M
15. Benraiss A
16. Goldman SA
In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells.; bioRxiv : the preprint server for biology. 2025 Jul 04.
1. Vittani M
2. Herlo R
3. Wang X
4. Christensen MDB
5. Vo CT
6. Mishima T
7. Kusk P
8. Konno A
9. Hirai H
10. Tsuboi T
11. Kitaguchi T
12. Kjaerby C
13. Asiminas A
14. Yokoyama T
15. Sakamoto M
16. Nedergaard M
17. Hirase H
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice.; Proceedings of the National Academy of Sciences of the United States of America; Vol 122(27), pp. e2422069122. 2025 Jul 01.
1. Andersen M
2. Hirase H
3. Kjaerby C
4. Nedergaard M
Neuroglia's signaling: orchestrating neuronal gamma synchrony?; Current opinion in neurology. 2025 Jun 06.
1. Gahn-Martinez D
2. Giannetto M
3. Chang E
4. Beam N
5. Tobin P
6. Plá V
7. Nedergaard M
Chronic Intraventricular Cannulation for the Study of Glymphatic Transport.; eNeuro. 2025 Jun 02.
1. Pinho-Correia LM
2. McCullough SJC
3. Ghanizada H
4. Nedergaard M
5. Rustenhoven J
6. Da Mesquita S
CSF transport at the brain-meningeal border: effects on neurological health and disease.; The Lancet. Neurology; Vol 24(6), pp. 535-547. 2025 Jun.
1. Rose L
2. Zahid AN
3. Piilgaard L
4. Egebjerg C
5. Sørensen FL
6. Andersen M
7. Radovanovic T
8. Tsopanidou A
9. Bastianini S
10. Berteotti C
11. Lo Martire V
12. Borsa M
13. Tisdale RK
14. Sun Y
15. Nedergaard M
16. Silvani A
17. Zoccoli G
18. Adamantidis A
19. Kilduff TS
20. Sakai N
21. Nishino S
22. Arthaud S
23. Peyron C
24. Fort P
25. Mørup M
26. Mignot E
27. Kornum BR
Probability estimation of narcolepsy type 1 in DTA mice using unlabeled EEG and EMG data.; Sleep advances : a journal of the Sleep Research Society; Vol 6(2), pp. zpaf025. 2025 May 10.
1. Capasso G
2. Franssen CFM
3. Perna AF
4. Massy ZA
5. Menzies RI
6. Zoccali C
7. Tessitore A
8. Nedergaard M
9. Okusa MD
10. Ortiz A
11. Wagner CA
12. Unwin RJ
Drivers and mechanisms of cognitive decline in chronic kidney disease.; Nature reviews. Nephrology. 2025 Apr 25.
1. Wostyn P
2. Nedergaard M
Sleep deprivation and glymphatic dysfunction: Perspectives on the risk of Spaceflight Associated Neuro-ocular Syndrome (SANS).; Life sciences in space research; Vol 46, pp. 137-138. 2025 Apr 17.
1. Cano JC
2. Mangiamele C
3. Nedergaard M
4. Benraiss A
5. Goldman SA
Newly generated striatal neurons rescue motor circuitry in a Huntington's disease mouse model.; Cell reports. 2025 Apr 05.
1. Mortensen KN
2. Lilius T
3. Rosenholm M
4. Sigurðsson B
5. Kelley DH
6. Nedergaard M
Perivascular cerebrospinal fluid inflow matches interstitial fluid efflux in anesthetized rats.; iScience; Vol 28(5), pp. 112323. 2025 Mar 30.
1. Vittani M
2. Lee AB
3. Wang X
4. Hiraoka Y
5. Konno A
6. Knak PG
7. Kusk P
8. Nagao M
9. Asiminas A
10. Courtin J
11. Putranto MF
12. Nasu Y
13. Tsuno S
14. Ueda K
15. Osuga Y
16. Tsuboi T
17. Bienvenu T
18. Terunuma M
19. Hirai H
20. Nedergaard M
21. Tanaka K
22. Hirase H
Functional and structural profiling of circulation via genetically encoded modular fluorescent probes.; bioRxiv : the preprint server for biology. 2025 Mar 18.
1. Zoccali C
2. Mallamaci F
3. Wagner CA
4. Unwin R
5. Nedergaard M
6. Hafez G
7. Malyszko J
8. Pepin M
9. Massy Z
10. Paolisso G
11. Remuzzi G
12. Capasso GB
Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD.; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association; Vol 40(Supplement_2), pp. ii64-ii75. 2025 Mar 13.
1. Plá V
2. Kroesbergen E
3. Deng S
4. Giannetto MJ
5. Hablitz LM
6. Newbold E
7. Ladrón-de-Guevara A
8. Esmail T
9. Gomolka RS
10. Mori Y
11. Goldman SA
12. Kelley DH
13. Thomas JH
14. Nedergaard M
A curious concept of CNS clearance.; Nature neuroscience. 2025 Mar 11.
1. Wostyn P
2. Nedergaard M
Should poor sleep be added to the list of risk factors for normal-tension glaucoma in the future?; Eye (London, England). 2025 Mar 05.
1. Wostyn P
2. Nedergaard M
Could Sleep Be an Antidote to Optic Disc Edema in Astronauts?; Life (Basel, Switzerland); Vol 15(2). 2025 Jan 26.
1. Lüthi A
2. Nedergaard M
Anything but small: Microarousals stand at the crossroad between noradrenaline signaling and key sleep functions.; Neuron. 2025 Jan 08.
1. Ghanizada H
2. Nedergaard M
The glymphatic system.; Handbook of clinical neurology; Vol 209, pp. 161-170. 2025.
1. Sartipi S
2. Andersen M
3. Hauglund N
4. Kjaerby C
5. Untiet V
6. Nedergaard M
7. Cetin M
LG-Sleep: Local and Global Temporal Dependencies for Mice Sleep Scoring.; IEEE sensors letters; Vol 9(2). 2024 Dec 26.
1. Kritsilis M
2. Vanherle L
3. Rosenholm M
4. In 't Zandt R
5. Yao Y
6. Swanberg KM
7. Weikop P
8. Gottschalk M
9. Shanbhag NC
10. Luo J
11. Boster K
12. Nedergaard M
13. Meissner A
14. Lundgaard I
Loss of glymphatic homeostasis in heart failure.; Brain : a journal of neurology. 2024 Dec 18.
1. Hauglund NL
2. Andersen M
3. Tokarska K
4. Radovanovic T
5. Kjaerby C
6. Sørensen FL
7. Bojarowska Z
8. Untiet V
9. Ballestero SB
10. Kolmos MG
11. Weikop P
12. Hirase H
13. Nedergaard M
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep.; Cell. 2024 Dec 17.
1. Untiet V
2. Rose CR
3. Nedergaard M
4. Verkhratsky A
Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology.; Cell calcium; Vol 125, pp. 102984. 2024 Dec 07.
1. Toscano JD
2. Wu C
3. Ladrón-de-Guevara A
4. Du T
5. Nedergaard M
6. Kelley DH
7. Karniadakis GE
8. Boster KAS
Inferring in vivo murine cerebrospinal fluid flow using artificial intelligence velocimetry with moving boundaries and uncertainty quantification.; Interface focus; Vol 14(6), pp. 20240030. 2024 Dec 06.
1. Bork PAR
2. Gianetto M
3. Newbold E
4. Hablitz L
5. Bohr T
6. Nedergaard M
Blood osmolytes such as sugar can drive brain fluid flows in a poroelastic model.; Scientific reports; Vol 14(1), pp. 29017. 2024 Nov 22.
1. Cankar N
2. Beschorner N
3. Tsopanidou A
4. Qvist FL
5. Colaço AR
6. Andersen M
7. Kjaerby C
8. Delle C
9. Lambert M
10. Mundt F
11. Weikop P
12. Jucker M
13. Mann M
14. Skotte NH
15. Nedergaard M
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model.; Cell reports; Vol 43(11), pp. 114977. 2024 Nov 13.
1. Sun Q
2. Peng S
3. Xu Q
4. Weikop P
5. Hussain R
6. Song W
7. Nedergaard M
8. Ding F
Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice.; Nature communications; Vol 15(1), pp. 9600. 2024 Nov 06.
1. Wostyn P
2. Mader TH
3. Gibson CR
4. Nedergaard M
New insights in brain-to-eye transport: can excess cerebrospinal fluid in astronauts escape into the eye?; Eye (London, England). 2024 Nov 04.
1. Li B
2. Sun Q
3. Ding F
4. Xu Q
5. Kang N
6. Xue Y
7. Ladron-de-Guevara A
8. Hirase H
9. Weikop P
10. Gong S
11. Nathan S
12. Nedergaard M
Anti-seizure effects of norepinephrine-induced free fatty acid release.; Cell metabolism. 2024 Oct 29.
1. Iden CR
2. Mustafa SM
3. Øgaard N
4. Henriksen T
5. Jensen SØ
6. Ahlborn LB
7. Egebjerg K
8. Baeksgaard L
9. Garbyal RS
10. Nedergaard MK
11. Achiam MP
12. Andersen CL
13. Mau-Sørensen M
Circulating tumor DNA predicts recurrence and survival in patients with resectable gastric and gastroesophageal junction cancer.; Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2024 Oct 05.
1. Asiminas A
2. Gomolka RS
3. Gregoriades S
4. Hirase H
5. Nedergaard M
6. Beinlich FRM
Protocol to study oxygen dynamics in the in vivo mouse brain using bioluminescence microscopy.; STAR protocols; Vol 5(4), pp. 103334. 2024 Sep 25.
1. Cao Q
2. Yang S
3. Wang X
4. Sun H
5. Chen W
6. Wang Y
7. Gao J
8. Wu Y
9. Yang Q
10. Chen X
11. Yuan S
12. Xiao M
13. Nedergaard M
14. Huo Y
15. Liu Q
Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer's disease.; The Journal of experimental medicine; Vol 221(11). 2024 Sep 24.
1. Kroesbergen E
2. Riesselmann LV
3. Gomolka RS
4. Plá V
5. Esmail T
6. Stenmo VH
7. Kovács ER
8. Nielsen ES
9. Goldman SA
10. Nedergaard M
11. Weikop P
12. Mori Y
Glymphatic clearance is enhanced during sleep.; bioRxiv : the preprint server for biology. 2024 Sep 15.
1. Plá V
2. Bitsika S
3. Giannetto MJ
4. Ladrón-de-Guevara A
5. Gahn-Martinez D
6. Mori Y
7. Nedergaard M
8. Møllgård K
Response to Commentary on "Structural characterization of SLYM - a 4th meningeal membrane" by Julie Siegenthaler and Christer Betsholtz.; Fluids and barriers of the CNS; Vol 21(1), pp. 70. 2024 Sep 09.
1. Xu C
2. Nedergaard M
3. Fowell DJ
4. Friedl P
5. Ji N
Multiphoton fluorescence microscopy for in vivo imaging.; Cell; Vol 187(17), pp. 4458-4487. 2024 Aug 22.
1. Du T
2. Raghunandan A
3. Mestre H
4. Plá V
5. Liu G
6. Ladrón-de-Guevara A
7. Newbold E
8. Tobin P
9. Gahn-Martinez D
10. Pattanayak S
11. Huang Q
12. Peng W
13. Nedergaard M
14. Kelley DH
Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage.; Nature aging. 2024 Aug 15.
1. Smyth LCD
2. Beschorner N
3. Nedergaard M
4. Kipnis J
Cellular Contributions to Glymphatic and Lymphatic Waste Clearance in the Brain.; Cold Spring Harbor perspectives in biology. 2024 Aug 12.
1. Wostyn P
2. Nedergaard M
The potential influence of sleep on translaminar pressure dynamics and ocular glymphatic outflow in microgravity: implications for optic disc edema in astronauts.; Eye (London, England). 2024 Jul 30.
1. Kaag Rasmussen M
2. Møllgård K
3. Bork PAR
4. Weikop P
5. Esmail T
6. Drici L
7. Wewer Albrechtsen NJ
8. Carlsen JF
9. Huynh NPT
10. Ghitani N
11. Mann M
12. Goldman SA
13. Mori Y
14. Chesler AT
15. Nedergaard M
Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model.; Science (New York, N.Y.); Vol 385(6704), pp. 80-86. 2024 Jul 04.
1. Plá V
2. Bitsika S
3. Giannetto MJ
4. Ladron-de-Guevara A
5. Gahn-Martinez D
6. Mori Y
7. Nedergaard M
8. Møllgård K
In response to "An "outer subarachnoid space": fact or artifact? A commentary on "Structural characterization of SLYM: a 4th meningeal membrane" fluids and barriers of the CNS (2023) 20:93 by V. Plá et al.".; Fluids and barriers of the CNS; Vol 21(1), pp. 49. 2024 Jun 03.
1. Ge GR
2. Song W
3. Giannetto MJ
4. Rolland JP
5. Nedergaard M
6. Parker KJ
Mouse Brain Elastography Changes with Sleep/Wake Cycles, Aging, and Alzheimer's Disease.; NeuroImage. 2024 May 30.
1. Delle C
2. Wang X
3. Nedergaard M
The Ocular Glymphatic System-Current Understanding and Future Perspectives.; International journal of molecular sciences; Vol 25(11). 2024 May 24.
1. Persson NDÅ
2. Lohela TJ
3. Mortensen KN
4. Rosenholm M
5. Li Q
6. Weikop P
7. Nedergaard M
8. Lilius TO
Anesthesia blunts carbon dioxide effects on glymphatic cerebrospinal fluid dynamics in mechanically ventilated rats.; Anesthesiology. 2024 May 24.