Recent Publications

• 1. Plog BA
  2. Mestre H
  3. Olveda GE
  4. Sweeney AM
  5. Kenney HM
  6. Cove A
  7. Dholakia KY
  8. Tithof J
  9. Nevins TD
  10. Lundgaard I
  11. Du T
  12. Kelley DH
  13. Nedergaard M
  Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.; JCI insight; Vol 3(23). 2018 Dec 06.
• 1. Mestre H
  2. Tithof J
  3. Du T
  4. Song W
  5. Peng W
  6. Sweeney AM
  7. Olveda G
  8. Thomas JH
  9. Nedergaard M
  10. Kelley DH
  Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.; Nature communications; Vol 9(1). 2018 Nov 19.
• 1. Rasmussen MK
  2. Mestre H
  3. Nedergaard M
  The glymphatic pathway in neurological disorders.; The Lancet. Neurology; Vol 17(11). 2018 Nov.
• 1. Plog BA
  2. Mestre H
  3. Olveda GE
  4. Sweeney AM
  5. Kenney HM
  6. Cove A
  7. Dholakia KY
  8. Tithof J
  9. Nevins TD
  10. Lundgaard I
  11. Du T
  12. Kelley DH
  13. Nedergaard M
  Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.; JCI insight; Vol 3(20). 2018 Oct 18.
• 1. Michaelsen SR
  2. Staberg M
  3. Pedersen H
  4. Jensen KE
  5. Majewski W
  6. Broholm H
  7. Nedergaard MK
  8. Meulengracht C
  9. Urup T
  10. Villingshøj M
  11. Lukacova S
  12. Skjøth-Rasmussen J
  13. Brennum J
  14. Kjær A
  15. Lassen U
  16. Stockhausen MT
  17. Poulsen HS
  18. Hamerlik P
  VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes glioblastoma maintenance.; Neuro-oncology; Vol 20(11). 2018 Oct 09.
• 1. Kananen J
  2. Tuovinen T
  3. Ansakorpi H
  4. Rytky S
  5. Helakari H
  6. Huotari N
  7. Raitamaa L
  8. Raatikainen V
  9. Rasila A
  10. Borchardt V
  11. Korhonen V
  12. LeVan P
  13. Nedergaard M
  14. Kiviniemi V
  Altered physiological brain variation in drug-resistant epilepsy.; Brain and behavior; Vol 8(9). 2018 Sep.
• 1. Aalling NN
  2. Nedergaard M
  3. DiNuzzo M
  Cerebral Metabolic Changes During Sleep.; Current neurology and neuroscience reports; Vol 18(9). 2018 Jul 16.
• 1. Xavier ALR
  2. Hauglund NL
  3. von Holstein-Rathlou S
  4. Li Q
  5. Sanggaard S
  6. Lou N
  7. Lundgaard I
  8. Nedergaard M
  Cannula Implantation into the Cisterna Magna of Rodents.; Journal of visualized experiments : JoVE. 2018 May 23.
• 1. Obara-Michlewska M
  2. Ding F
  3. Popek M
  4. Verkhratsky A
  5. Nedergaard M
  6. Zielinska M
  7. Albrecht J
  Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure.; Neurochemistry international. 2018 May 14.
• 1. Brown R
  2. Benveniste H
  3. Black SE
  4. Charpak S
  5. Dichgans M
  6. Joutel A
  7. Nedergaard M
  8. Smith KJ
  9. Zlokovic BV
  10. Wardlaw JM
  Understanding the role of the perivascular space in cerebral small vessel disease.; Cardiovascular research. 2018 May 02.
• 1. Horsburgh K
  2. Wardlaw JM
  3. van Agtmael T
  4. Allan SM
  5. Ashford MLJ
  6. Bath PM
  7. Brown R
  8. Berwick J
  9. Cader MZ
  10. Carare RO
  11. Davis JB
  12. Duncombe J
  13. Farr TD
  14. Fowler JH
  15. Goense J
  16. Granata A
  17. Hall CN
  18. Hainsworth AH
  19. Harvey A
  20. Hawkes CA
  21. Joutel A
  22. Kalaria RN
  23. Kehoe PG
  24. Lawrence CB
  25. Lockhart A
  26. Love S
  27. Macleod MR
  28. Macrae IM
  29. Markus HS
  30. McCabe C
  31. McColl BW
  32. Meakin PJ
  33. Miller A
  34. Nedergaard M
  35. O'Sullivan M
  36. Quinn TJ
  37. Rajani R
  38. Saksida LM
  39. Smith C
  40. Smith KJ
  41. Touyz RM
  42. Trueman RC
  43. Wang T
  44. Williams A
  45. Williams SCR
  46. Work LM
  Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.; Clinical science (London, England : 1979); Vol 132(8). 2018 Apr 30.
• 1. Lundgaard I
  2. Wang W
  3. Eberhardt A
  4. Vinitsky HS
  5. Reeves BC
  6. Peng S
  7. Lou N
  8. Hussain R
  9. Nedergaard M
  Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.; Scientific reports; Vol 8(1). 2018 Feb 02.
• 1. Smith NA
  2. Kress BT
  3. Lu Y
  4. Chandler-Militello D
  5. Benraiss A
  6. Nedergaard M
  Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.; Science signaling; Vol 11(515). 2018 Jan 30.
• 1. von Holstein-Rathlou S
  2. Petersen NC
  3. Nedergaard M
  Voluntary running enhances glymphatic influx in awake behaving, young mice.; Neuroscience letters; Vol 662. 2018 Jan 01.
• 1. Verkhratsky A
  2. Nedergaard M
  Physiology of Astroglia.; Physiological reviews; Vol 98(1). 2018 Jan 01.
• 1. Plog BA
  2. Nedergaard M
  The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future.; Annual review of pathology. 2017 Dec 01.
• 1. DiNuzzo M
  2. Nedergaard M
  Brain energetics during the sleep-wake cycle.; Current opinion in neurobiology; Vol 47. 2017 Oct 09.
• 1. Benveniste H
  2. Lee H
  3. Ding F
  4. Sun Q
  5. Al-Bizri E
  6. Makaryus R
  7. Probst S
  8. Nedergaard M
  9. Stein EA
  10. Lu H
  Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane.; Anesthesiology. 2017 Sep 22.
• 1. Mestre H
  2. Kostrikov S
  3. Mehta RI
  4. Nedergaard M
  Perivascular spaces, glymphatic dysfunction, and small vessel disease.; Clinical science (London, England : 1979); Vol 131(17). 2017 Sep 01.
• 1. Louveau A
  2. Plog BA
  3. Antila S
  4. Alitalo K
  5. Nedergaard M
  6. Kipnis J
  Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.; The Journal of clinical investigation; Vol 127(9). 2017 Sep 01.
• 1. Oberheim Bush NA
  2. Nedergaard M
  Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain?; Neurochemical research. 2017 Aug 19.
• 1. Windrem MS
  2. Osipovitch M
  3. Liu Z
  4. Bates J
  5. Chandler-Militello D
  6. Zou L
  7. Munir J
  8. Schanz S
  9. McCoy K
  10. Miller RH
  11. Wang S
  12. Nedergaard M
  13. Findling RL
  14. Tesar PJ
  15. Goldman SA
  Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.; Cell stem cell; Vol 21(2). 2017 Aug 03.
• 1. Lee H
  2. Mortensen K
  3. Sanggaard S
  4. Koch P
  5. Brunner H
  6. Quistorff B
  7. Nedergaard M
  8. Benveniste H
  Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T.; Magnetic resonance in medicine. 2017 Jun 19.
• 1. Sun W
  2. Cornwell A
  3. Li J
  4. Peng S
  5. Osorio MJ
  6. Aalling N
  7. Wang S
  8. Benraiss A
  9. Lou N
  10. Goldman SA
  11. Nedergaard M
  SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 37(17). 2017 Apr 26.
• 1. Ratner V
  2. Gao Y
  3. Lee H
  4. Elkin R
  5. Nedergaard M
  6. Benveniste H
  7. Tannenbaum A
  Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport.; NeuroImage; Vol 152. 2017 Mar 18.
• 1. de Leon MJ
  2. Li Y
  3. Okamura N
  4. Tsui WH
  5. Saint Louis LA
  6. Glodzik L
  7. Osorio RS
  8. Fortea J
  9. Butler T
  10. Pirraglia E
  11. Fossati S
  12. Kim HJ
  13. Carare RO
  14. Nedergaard M
  15. Benveniste H
  16. Rusinek H
  CSF clearance in Alzheimer Disease measured with dynamic PET.; Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2017 Mar 16.
• 1. Wang M
  2. Ding F
  3. Deng S
  4. Guo X
  5. Wang W
  6. Iliff JJ
  7. Nedergaard M
  Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 37(11). 2017 Mar 15.
• 1. Cotrina ML
  2. Lou N
  3. Tome-Garcia J
  4. Goldman J
  5. Nedergaard M
  Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke.; Neuroscience; Vol 343. 2017 Feb 20.
• 1. Kjaerby C
  2. Rasmussen R
  3. Andersen M
  4. Nedergaard M
  Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?; Neurochemical research. 2017 Feb 16.
• 1. Achariyar TM
  2. Li B
  3. Peng W
  4. Verghese PB
  5. Shi Y
  6. McConnell E
  7. Benraiss A
  8. Kasper T
  9. Song W
  10. Takano T
  11. Holtzman DM
  12. Nedergaard M
  13. Deane R
  Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.; Molecular neurodegeneration; Vol 12(1). 2017 Jan 12.
• 1. Achariyar TM
  2. Li B
  3. Peng W
  4. Verghese PB
  5. Shi Y
  6. McConnell E
  7. Benraiss A
  8. Kasper T
  9. Song W
  10. Takana T
  11. Holtzman DM
  12. Nedergaard M
  13. Deane R
  Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.; Molecular neurodegeneration; Vol 11(1). 2016 Dec 08.
• 1. Bosetti F
  2. Galis ZS
  3. Bynoe MS
  4. Charette M
  5. Cipolla MJ
  6. Del Zoppo GJ
  7. Gould D
  8. Hatsukami TS
  9. Jones TL
  10. Koenig JI
  11. Lutty GA
  12. Maric-Bilkan C
  13. Stevens T
  14. Tolunay HE
  15. Koroshetz W
  "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop.; Journal of the American Heart Association; Vol 5(11). 2016 Nov 04.
• 1. Wang F
  2. Wang X
  3. Shapiro LA
  4. Cotrina ML
  5. Liu W
  6. Wang EW
  7. Gu S
  8. Wang W
  9. He X
  10. Nedergaard M
  11. Huang JH
  NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.; Brain structure & function. 2016 Sep 1.
• 1. Verkhratsky A
  2. Nedergaard M
  The homeostatic astroglia emerges from evolutionary specialization of neural cells.; Philosophical transactions of the Royal Society of London. Series B, Biological sciences; Vol 371(1700). 2016 Aug 5.
• 1. Lundgaard I
  2. Lu ML
  3. Yang E
  4. Peng W
  5. Mestre H
  6. Hitomi E
  7. Deane R
  8. Nedergaard M
  Glymphatic clearance controls state-dependent changes in brain lactate concentration.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Aug 1.
• 1. Jiang Q
  2. Zhang L
  3. Ding G
  4. Davoodi-Bojd E
  5. Li Q
  6. Li L
  7. Sadry N
  8. Nedergaard M
  9. Chopp M
  10. Zhang Z
  Impairment of the glymphatic system after diabetes.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Jun 15.
• 1. Benraiss A
  2. Wang S
  3. Herrlinger S
  4. Li X
  5. Chandler-Militello D
  6. Mauceri J
  7. Burm HB
  8. Toner M
  9. Osipovitch M
  10. Jim Xu Q
  11. Ding F
  12. Wang F
  13. Kang N
  14. Kang J
  15. Curtin PC
  16. Brunner D
  17. Windrem MS
  18. Munoz-Sanjuan I
  19. Nedergaard M
  20. Goldman SA
  Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.; Nature communications; Vol 7. 2016 Jun 07.
• 1. Peng W
  2. Achariyar TM
  3. Li B
  4. Liao Y
  5. Mestre H
  6. Hitomi E
  7. Regan S
  8. Kasper T
  9. Peng S
  10. Ding F
  11. Benveniste H
  12. Nedergaard M
  13. Deane R
  Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.; Neurobiology of disease. 2016 May 24.
• 1. Ding F
  2. O'Donnell J
  3. Xu Q
  4. Kang N
  5. Goldman N
  6. Nedergaard M
  Changes in the composition of brain interstitial ions control the sleep-wake cycle.; Science (New York, N.Y.); Vol 352(6285). 2016 Apr 29.
• 1. Nedergaard M
  2. Goldman SA
  BRAIN DRAIN.; Scientific American; Vol 314(3). 2016 Mar.
• 1. Lou N
  2. Takano T
  3. Pei Y
  4. Xavier AL
  5. Goldman SA
  6. Nedergaard M
  Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.; Proceedings of the National Academy of Sciences of the United States of America; Vol 113(4). 2016 Jan 26.
• 1. Rasmussen R
  2. Nedergaard M
  3. Petersen NC
  Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used.; Scientific reports; Vol 6. 2016.
• 1. Xie L
  2. Kang H
  3. Nedergaard M
  A Novel Model of Transient Occlusion of the Middle Cerebral Artery in Awake Mice.; Journal of nature and science; Vol 2(2). 2016.
• 1. Kiviniemi V
  2. Wang X
  3. Korhonen V
  4. Keinänen T
  5. Tuovinen T
  6. Autio J
  7. LeVan P
  8. Keilholz S
  9. Zang YF
  10. Hennig J
  11. Nedergaard M
  Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms?; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2015 Dec 21.
• 1. McConnell ED
  2. Wei HS
  3. Reitz KM
  4. Kang H
  5. Takano T
  6. Vates GE
  7. Nedergaard M
  Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2015 Oct 14.
• 1. Sreetama SC
  2. Takano T
  3. Nedergaard M
  4. Simon SM
  5. Jaiswal JK
  Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.; Cell death and differentiation. 2015 Oct 9.
• 1. Iliff JJ
  2. Goldman SA
  3. Nedergaard M
  Implications of the discovery of brain lymphatic pathways.; The Lancet. Neurology; Vol 14(10). 2015 Oct.
• 1. Ribeiro Xavier AL
  2. Kress BT
  3. Goldman SA
  4. Lacerda de Menezes JR
  5. Nedergaard M
  A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(34). 2015 Aug 26.
• 1. Lee H
  2. Xie L
  3. Yu M
  4. Kang H
  5. Feng T
  6. Deane R
  7. Logan J
  8. Nedergaard M
  9. Benveniste H
  The Effect of Body Posture on Brain Glymphatic Transport.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(31). 2015 Aug 5.
• 1. Goldman SA
  2. Nedergaard M
  3. Windrem MS
  Modeling cognition and disease using human glial chimeric mice.; Glia; Vol 63(8). 2015 Aug.