Recent Publications

• 1. Cai R
  2. Pan C
  3. Ghasemigharagoz A
  4. Todorov MI
  5. Förstera B
  6. Zhao S
  7. Bhatia HS
  8. Parra-Damas A
  9. Mrowka L
  10. Theodorou D
  11. Rempfler M
  12. Xavier ALR
  13. Kress BT
  14. Benakis C
  15. Steinke H
  16. Liebscher S
  17. Bechmann I
  18. Liesz A
  19. Menze B
  20. Kerschensteiner M
  21. Nedergaard M
  22. Ertürk A
  Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.; Nature neuroscience; Vol 22(2). 2019 Feb.
• 1. Hablitz LM
  2. Vinitsky HS
  3. Sun Q
  4. Stæger FF
  5. Sigurdsson B
  6. Mortensen KN
  7. Lilius TO
  8. Nedergaard M
  Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.; Science advances; Vol 5(2). 2019 Feb.
• 1. Koundal S
  2. Liu X
  3. Sanggaard S
  4. Mortensen K
  5. Wardlaw J
  6. Nedergaard M
  7. Benveniste H
  8. Lee H
  Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI.; Neuroscience; Vol 404. 2019 Jan 26.
• 1. Ramos M
  2. Burdon Bechet N
  3. Battistella R
  4. Pavan C
  5. Xavier ALR
  6. Nedergaard M
  7. Lundgaard I
  Cisterna Magna Injection in Rats to Study Glymphatic Function.; Methods in molecular biology (Clifton, N.J.); Vol 1938. 2019.
• 1. Sweeney MD
  2. Montagne A
  3. Sagare AP
  4. Nation DA
  5. Schneider LS
  6. Chui HC
  7. Harrington MG
  8. Pa J
  9. Law M
  10. Wang DJJ
  11. Jacobs RE
  12. Doubal FN
  13. Ramirez J
  14. Black SE
  15. Nedergaard M
  16. Benveniste H
  17. Dichgans M
  18. Iadecola C
  19. Love S
  20. Bath PM
  21. Markus HS
  22. Salman RA
  23. Allan SM
  24. Quinn TJ
  25. Kalaria RN
  26. Werring DJ
  27. Carare RO
  28. Touyz RM
  29. Williams SCR
  30. Moskowitz MA
  31. Katusic ZS
  32. Lutz SE
  33. Lazarov O
  34. Minshall RD
  35. Rehman J
  36. Davis TP
  37. Wellington CL
  38. González HM
  39. Yuan C
  40. Lockhart SN
  41. Hughes TM
  42. Chen CLH
  43. Sachdev P
  44. O'Brien JT
  45. Skoog I
  46. Pantoni L
  47. Gustafson DR
  48. Biessels GJ
  49. Wallin A
  50. Smith EE
  51. Mok V
  52. Wong A
  53. Passmore P
  54. Barkof F
  55. Muller M
  56. Breteler MMB
  57. Román GC
  58. Hamel E
  59. Seshadri S
  60. Gottesman RF
  61. van Buchem MA
  62. Arvanitakis Z
  63. Schneider JA
  64. Drewes LR
  65. Hachinski V
  66. Finch CE
  67. Toga AW
  68. Wardlaw JM
  69. Zlokovic BV
  Vascular dysfunction-The disregarded partner of Alzheimer's disease.; Alzheimer's & dementia : the journal of the Alzheimer's Association; Vol 15(1). 2019 Jan.
• 1. Mestre H
  2. Hablitz LM
  3. Xavier AL
  4. Feng W
  5. Zou W
  6. Pu T
  7. Monai H
  8. Murlidharan G
  9. Castellanos Rivera RM
  10. Simon MJ
  11. Pike MM
  12. Plá V
  13. Du T
  14. Kress BT
  15. Wang X
  16. Plog BA
  17. Thrane AS
  18. Lundgaard I
  19. Abe Y
  20. Yasui M
  21. Thomas JH
  22. Xiao M
  23. Hirase H
  24. Asokan A
  25. Iliff JJ
  26. Nedergaard M
  Aquaporin-4-dependent glymphatic solute transport in the rodent brain.; eLife; Vol 7. 2018 Dec 18.
• 1. Plog BA
  2. Mestre H
  3. Olveda GE
  4. Sweeney AM
  5. Kenney HM
  6. Cove A
  7. Dholakia KY
  8. Tithof J
  9. Nevins TD
  10. Lundgaard I
  11. Du T
  12. Kelley DH
  13. Nedergaard M
  Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.; JCI insight; Vol 3(23). 2018 Dec 06.
• 1. Mestre H
  2. Tithof J
  3. Du T
  4. Song W
  5. Peng W
  6. Sweeney AM
  7. Olveda G
  8. Thomas JH
  9. Nedergaard M
  10. Kelley DH
  Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.; Nature communications; Vol 9(1). 2018 Nov 19.
• 1. Rasmussen MK
  2. Mestre H
  3. Nedergaard M
  The glymphatic pathway in neurological disorders.; The Lancet. Neurology; Vol 17(11). 2018 Nov.
• 1. Plog BA
  2. Mestre H
  3. Olveda GE
  4. Sweeney AM
  5. Kenney HM
  6. Cove A
  7. Dholakia KY
  8. Tithof J
  9. Nevins TD
  10. Lundgaard I
  11. Du T
  12. Kelley DH
  13. Nedergaard M
  Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.; JCI insight; Vol 3(20). 2018 Oct 18.
• 1. Michaelsen SR
  2. Staberg M
  3. Pedersen H
  4. Jensen KE
  5. Majewski W
  6. Broholm H
  7. Nedergaard MK
  8. Meulengracht C
  9. Urup T
  10. Villingshøj M
  11. Lukacova S
  12. Skjøth-Rasmussen J
  13. Brennum J
  14. Kjær A
  15. Lassen U
  16. Stockhausen MT
  17. Poulsen HS
  18. Hamerlik P
  VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes glioblastoma maintenance.; Neuro-oncology; Vol 20(11). 2018 Oct 09.
• 1. Kananen J
  2. Tuovinen T
  3. Ansakorpi H
  4. Rytky S
  5. Helakari H
  6. Huotari N
  7. Raitamaa L
  8. Raatikainen V
  9. Rasila A
  10. Borchardt V
  11. Korhonen V
  12. LeVan P
  13. Nedergaard M
  14. Kiviniemi V
  Altered physiological brain variation in drug-resistant epilepsy.; Brain and behavior; Vol 8(9). 2018 Sep.
• 1. Aalling NN
  2. Nedergaard M
  3. DiNuzzo M
  Cerebral Metabolic Changes During Sleep.; Current neurology and neuroscience reports; Vol 18(9). 2018 Jul 16.
• 1. Xavier ALR
  2. Hauglund NL
  3. von Holstein-Rathlou S
  4. Li Q
  5. Sanggaard S
  6. Lou N
  7. Lundgaard I
  8. Nedergaard M
  Cannula Implantation into the Cisterna Magna of Rodents.; Journal of visualized experiments : JoVE. 2018 May 23.
• 1. Obara-Michlewska M
  2. Ding F
  3. Popek M
  4. Verkhratsky A
  5. Nedergaard M
  6. Zielinska M
  7. Albrecht J
  Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure.; Neurochemistry international. 2018 May 14.
• 1. Brown R
  2. Benveniste H
  3. Black SE
  4. Charpak S
  5. Dichgans M
  6. Joutel A
  7. Nedergaard M
  8. Smith KJ
  9. Zlokovic BV
  10. Wardlaw JM
  Understanding the role of the perivascular space in cerebral small vessel disease.; Cardiovascular research. 2018 May 02.
• 1. Horsburgh K
  2. Wardlaw JM
  3. van Agtmael T
  4. Allan SM
  5. Ashford MLJ
  6. Bath PM
  7. Brown R
  8. Berwick J
  9. Cader MZ
  10. Carare RO
  11. Davis JB
  12. Duncombe J
  13. Farr TD
  14. Fowler JH
  15. Goense J
  16. Granata A
  17. Hall CN
  18. Hainsworth AH
  19. Harvey A
  20. Hawkes CA
  21. Joutel A
  22. Kalaria RN
  23. Kehoe PG
  24. Lawrence CB
  25. Lockhart A
  26. Love S
  27. Macleod MR
  28. Macrae IM
  29. Markus HS
  30. McCabe C
  31. McColl BW
  32. Meakin PJ
  33. Miller A
  34. Nedergaard M
  35. O'Sullivan M
  36. Quinn TJ
  37. Rajani R
  38. Saksida LM
  39. Smith C
  40. Smith KJ
  41. Touyz RM
  42. Trueman RC
  43. Wang T
  44. Williams A
  45. Williams SCR
  46. Work LM
  Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.; Clinical science (London, England : 1979); Vol 132(8). 2018 Apr 30.
• 1. Lundgaard I
  2. Wang W
  3. Eberhardt A
  4. Vinitsky HS
  5. Reeves BC
  6. Peng S
  7. Lou N
  8. Hussain R
  9. Nedergaard M
  Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.; Scientific reports; Vol 8(1). 2018 Feb 02.
• 1. Smith NA
  2. Kress BT
  3. Lu Y
  4. Chandler-Militello D
  5. Benraiss A
  6. Nedergaard M
  Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.; Science signaling; Vol 11(515). 2018 Jan 30.
• 1. von Holstein-Rathlou S
  2. Petersen NC
  3. Nedergaard M
  Voluntary running enhances glymphatic influx in awake behaving, young mice.; Neuroscience letters; Vol 662. 2018 Jan 01.
• 1. Verkhratsky A
  2. Nedergaard M
  Physiology of Astroglia.; Physiological reviews; Vol 98(1). 2018 Jan 01.
• 1. Plog BA
  2. Nedergaard M
  The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future.; Annual review of pathology. 2017 Dec 01.
• 1. DiNuzzo M
  2. Nedergaard M
  Brain energetics during the sleep-wake cycle.; Current opinion in neurobiology; Vol 47. 2017 Oct 09.
• 1. Benveniste H
  2. Lee H
  3. Ding F
  4. Sun Q
  5. Al-Bizri E
  6. Makaryus R
  7. Probst S
  8. Nedergaard M
  9. Stein EA
  10. Lu H
  Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane.; Anesthesiology. 2017 Sep 22.
• 1. Mestre H
  2. Kostrikov S
  3. Mehta RI
  4. Nedergaard M
  Perivascular spaces, glymphatic dysfunction, and small vessel disease.; Clinical science (London, England : 1979); Vol 131(17). 2017 Sep 01.
• 1. Louveau A
  2. Plog BA
  3. Antila S
  4. Alitalo K
  5. Nedergaard M
  6. Kipnis J
  Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.; The Journal of clinical investigation; Vol 127(9). 2017 Sep 01.
• 1. Oberheim Bush NA
  2. Nedergaard M
  Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain?; Neurochemical research. 2017 Aug 19.
• 1. Windrem MS
  2. Osipovitch M
  3. Liu Z
  4. Bates J
  5. Chandler-Militello D
  6. Zou L
  7. Munir J
  8. Schanz S
  9. McCoy K
  10. Miller RH
  11. Wang S
  12. Nedergaard M
  13. Findling RL
  14. Tesar PJ
  15. Goldman SA
  Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.; Cell stem cell; Vol 21(2). 2017 Aug 03.
• 1. Lee H
  2. Mortensen K
  3. Sanggaard S
  4. Koch P
  5. Brunner H
  6. Quistorff B
  7. Nedergaard M
  8. Benveniste H
  Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T.; Magnetic resonance in medicine. 2017 Jun 19.
• 1. Sun W
  2. Cornwell A
  3. Li J
  4. Peng S
  5. Osorio MJ
  6. Aalling N
  7. Wang S
  8. Benraiss A
  9. Lou N
  10. Goldman SA
  11. Nedergaard M
  SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 37(17). 2017 Apr 26.
• 1. Ratner V
  2. Gao Y
  3. Lee H
  4. Elkin R
  5. Nedergaard M
  6. Benveniste H
  7. Tannenbaum A
  Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport.; NeuroImage; Vol 152. 2017 Mar 18.
• 1. de Leon MJ
  2. Li Y
  3. Okamura N
  4. Tsui WH
  5. Saint Louis LA
  6. Glodzik L
  7. Osorio RS
  8. Fortea J
  9. Butler T
  10. Pirraglia E
  11. Fossati S
  12. Kim HJ
  13. Carare RO
  14. Nedergaard M
  15. Benveniste H
  16. Rusinek H
  CSF clearance in Alzheimer Disease measured with dynamic PET.; Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2017 Mar 16.
• 1. Wang M
  2. Ding F
  3. Deng S
  4. Guo X
  5. Wang W
  6. Iliff JJ
  7. Nedergaard M
  Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 37(11). 2017 Mar 15.
• 1. Cotrina ML
  2. Lou N
  3. Tome-Garcia J
  4. Goldman J
  5. Nedergaard M
  Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke.; Neuroscience; Vol 343. 2017 Feb 20.
• 1. Kjaerby C
  2. Rasmussen R
  3. Andersen M
  4. Nedergaard M
  Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?; Neurochemical research. 2017 Feb 16.
• 1. Achariyar TM
  2. Li B
  3. Peng W
  4. Verghese PB
  5. Shi Y
  6. McConnell E
  7. Benraiss A
  8. Kasper T
  9. Song W
  10. Takano T
  11. Holtzman DM
  12. Nedergaard M
  13. Deane R
  Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.; Molecular neurodegeneration; Vol 12(1). 2017 Jan 12.
• 1. Achariyar TM
  2. Li B
  3. Peng W
  4. Verghese PB
  5. Shi Y
  6. McConnell E
  7. Benraiss A
  8. Kasper T
  9. Song W
  10. Takana T
  11. Holtzman DM
  12. Nedergaard M
  13. Deane R
  Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.; Molecular neurodegeneration; Vol 11(1). 2016 Dec 08.
• 1. Bosetti F
  2. Galis ZS
  3. Bynoe MS
  4. Charette M
  5. Cipolla MJ
  6. Del Zoppo GJ
  7. Gould D
  8. Hatsukami TS
  9. Jones TL
  10. Koenig JI
  11. Lutty GA
  12. Maric-Bilkan C
  13. Stevens T
  14. Tolunay HE
  15. Koroshetz W
  "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop.; Journal of the American Heart Association; Vol 5(11). 2016 Nov 04.
• 1. Wang F
  2. Wang X
  3. Shapiro LA
  4. Cotrina ML
  5. Liu W
  6. Wang EW
  7. Gu S
  8. Wang W
  9. He X
  10. Nedergaard M
  11. Huang JH
  NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.; Brain structure & function. 2016 Sep 1.
• 1. Verkhratsky A
  2. Nedergaard M
  The homeostatic astroglia emerges from evolutionary specialization of neural cells.; Philosophical transactions of the Royal Society of London. Series B, Biological sciences; Vol 371(1700). 2016 Aug 5.
• 1. Lundgaard I
  2. Lu ML
  3. Yang E
  4. Peng W
  5. Mestre H
  6. Hitomi E
  7. Deane R
  8. Nedergaard M
  Glymphatic clearance controls state-dependent changes in brain lactate concentration.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Aug 1.
• 1. Jiang Q
  2. Zhang L
  3. Ding G
  4. Davoodi-Bojd E
  5. Li Q
  6. Li L
  7. Sadry N
  8. Nedergaard M
  9. Chopp M
  10. Zhang Z
  Impairment of the glymphatic system after diabetes.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Jun 15.
• 1. Benraiss A
  2. Wang S
  3. Herrlinger S
  4. Li X
  5. Chandler-Militello D
  6. Mauceri J
  7. Burm HB
  8. Toner M
  9. Osipovitch M
  10. Jim Xu Q
  11. Ding F
  12. Wang F
  13. Kang N
  14. Kang J
  15. Curtin PC
  16. Brunner D
  17. Windrem MS
  18. Munoz-Sanjuan I
  19. Nedergaard M
  20. Goldman SA
  Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.; Nature communications; Vol 7. 2016 Jun 07.
• 1. Peng W
  2. Achariyar TM
  3. Li B
  4. Liao Y
  5. Mestre H
  6. Hitomi E
  7. Regan S
  8. Kasper T
  9. Peng S
  10. Ding F
  11. Benveniste H
  12. Nedergaard M
  13. Deane R
  Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.; Neurobiology of disease. 2016 May 24.
• 1. Ding F
  2. O'Donnell J
  3. Xu Q
  4. Kang N
  5. Goldman N
  6. Nedergaard M
  Changes in the composition of brain interstitial ions control the sleep-wake cycle.; Science (New York, N.Y.); Vol 352(6285). 2016 Apr 29.
• 1. Nedergaard M
  2. Goldman SA
  BRAIN DRAIN.; Scientific American; Vol 314(3). 2016 Mar.
• 1. Lou N
  2. Takano T
  3. Pei Y
  4. Xavier AL
  5. Goldman SA
  6. Nedergaard M
  Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.; Proceedings of the National Academy of Sciences of the United States of America; Vol 113(4). 2016 Jan 26.
• 1. Rasmussen R
  2. Nedergaard M
  3. Petersen NC
  Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used.; Scientific reports; Vol 6. 2016.
• 1. Xie L
  2. Kang H
  3. Nedergaard M
  A Novel Model of Transient Occlusion of the Middle Cerebral Artery in Awake Mice.; Journal of nature and science; Vol 2(2). 2016.
• 1. Kiviniemi V
  2. Wang X
  3. Korhonen V
  4. Keinänen T
  5. Tuovinen T
  6. Autio J
  7. LeVan P
  8. Keilholz S
  9. Zang YF
  10. Hennig J
  11. Nedergaard M
  Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms?; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2015 Dec 21.