Recent Publications

• 1. Gan Y
  2. Holstein-Rønsbo S
  3. Nedergaard M
  4. Boster KAS
  5. Thomas JH
  6. Kelley DH
  Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism.; Journal of the Royal Society, Interface; Vol 20(206), pp. 20230288. 2023 Sep 20.
• 1. Holstein-Rønsbo S
  2. Gan Y
  3. Giannetto MJ
  4. Rasmussen MK
  5. Sigurdsson B
  6. Beinlich FRM
  7. Rose L
  8. Untiet V
  9. Hablitz LM
  10. Kelley DH
  11. Nedergaard M
  Publisher Correction: Glymphatic influx and clearance are accelerated by neurovascular coupling.; Nature neuroscience. 2023 Sep 04.
• 1. Ozawa K
  2. Nagao M
  3. Konno A
  4. Iwai Y
  5. Vittani M
  6. Kusk P
  7. Mishima T
  8. Hirai H
  9. Nedergaard M
  10. Hirase H
  Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes.; International journal of molecular sciences; Vol 24(17). 2023 Sep 02.
• 1. Staudt M
  2. Shalgunov V
  3. Nedergaard M
  4. Herth MM
  Development of 11 C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species.; Journal of labelled compounds & radiopharmaceuticals. 2023 Aug 31.
• 1. Andersen M
  2. Tsopanidou A
  3. Radovanovic T
  4. Compere VN
  5. Hauglund N
  6. Nedergaard M
  7. Kjaerby C
  Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep.; Bio-protocol; Vol 13(15), pp. e4734. 2023 Aug 05.
• 1. Kim D
  2. Gan Y
  3. Nedergaard M
  4. Kelley DH
  5. Tithof J
  Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow.; bioRxiv : the preprint server for biology. 2023 Jul 24.
• 1. Miyakoshi LM
  2. Stæger FF
  3. Li Q
  4. Pan C
  5. Xie L
  6. Kang H
  7. Pavan C
  8. Dang J
  9. Sun Q
  10. Ertürk A
  11. Nedergaard M
  The state of brain activity modulates cerebrospinal fluid transport.; Progress in neurobiology. 2023 Jul 21.
• 1. Raicevic N
  2. Forer JM
  3. Ladrón-de-Guevara A
  4. Du T
  5. Nedergaard M
  6. Kelley DH
  7. Boster K
  Sizes and shapes of perivascular spaces surrounding murine pial arteries.; Fluids and barriers of the CNS; Vol 20(1), pp. 56. 2023 Jul 17.
• 1. Bork PAR
  2. Ladrón-de-Guevara A
  3. Christensen AH
  4. Jensen KH
  5. Nedergaard M
  6. Bohr T
  Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow.; Journal of the Royal Society, Interface; Vol 20(204), pp. 20230050. 2023 Jul 12.
• 1. Vittani M
  2. Knak PAG
  3. Fukuda M
  4. Nagao M
  5. Wang X
  6. Kjaerby C
  7. Konno A
  8. Hirai H
  9. Nedergaard M
  10. Hirase H
  Virally induced CRISPR/Cas9-based knock-in of fluorescent albumin allows long-term visualization of cerebral circulation in infant and adult mice.; bioRxiv : the preprint server for biology. 2023 Jul 10.
• 1. Mathiesen BK
  2. Miyakoshi LM
  3. Cederroth CR
  4. Tserga E
  5. Versteegh C
  6. Bork PAR
  7. Hauglund NL
  8. Gomolka RS
  9. Mori Y
  10. Edvall NK
  11. Rouse S
  12. Møllgård K
  13. Holt JR
  14. Nedergaard M
  15. Canlon B
  Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice.; Science translational medicine; Vol 15(702), pp. eabq3916. 2023 Jun 28.
• 1. Hirase H
  2. Nedergaard M
  Locomotion Induces Fundamentally Different Patterns of Ca2+ Signaling in Astrocytes and Neurons.; Function (Oxford, England); Vol 4(4), pp. zqad028. 2023 Jun 05.
• 1. Holstein-Rønsbo S
  2. Gan Y
  3. Giannetto MJ
  4. Rasmussen MK
  5. Sigurdsson B
  6. Beinlich FRM
  7. Rose L
  8. Untiet V
  9. Hablitz LM
  10. Kelley DH
  11. Nedergaard M
  Glymphatic influx and clearance are accelerated by neurovascular coupling.; Nature neuroscience. 2023 Jun 01.
• 1. Raizen DM
  2. Mullington J
  3. Anaclet C
  4. Clarke G
  5. Critchley H
  6. Dantzer R
  7. Davis R
  8. Drew KL
  9. Fessel J
  10. Fuller PM
  11. Gibson EM
  12. Harrington M
  13. Lipkin WI
  14. Klerman EB
  15. Klimas N
  16. Komaroff AL
  17. Koroshetz W
  18. Krupp L
  19. Kuppuswamy A
  20. Lasselin J
  21. Lewis LD
  22. Magistretti PJ
  23. Matos HY
  24. Miaskowski C
  25. Miller AH
  26. Nath A
  27. Nedergaard M
  28. Opp MR
  29. Ritchie MD
  30. Rogulja D
  31. Rolls A
  32. Salamone JD
  33. Saper C
  34. Whittemore V
  35. Wylie G
  36. Younger J
  37. Zee PC
  38. Heller HC
  Beyond the Symptom: The Biology of Fatigue.; Sleep. 2023 May 24.
• 1. Agarwal N
  2. Lewis LD
  3. Hirschler L
  4. Rivera LR
  5. Naganawa S
  6. Levendovszky SR
  7. Ringstad G
  8. Klarica M
  9. Wardlaw J
  10. Iadecola C
  11. Hawkes C
  12. Carare RO
  13. Wells J
  14. Bakker ENTP
  15. Kurtcuoglu V
  16. Bilston L
  17. Nedergaard M
  18. Mori Y
  19. Stoodley M
  20. Alperin N
  21. de Leon M
  22. van Osch MJP
  Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome.; Journal of magnetic resonance imaging : JMRI. 2023 May 04.
• 1. Kjaerby C
  2. Andersen M
  3. Hauglund N
  4. Untiet V
  5. Dall C
  6. Ding F
  7. Hirase H
  8. Nedergaard M
  Reply to: 'Do all norepinephrine surges disrupt sleep?'.; Nature neuroscience. 2023 Apr 20.
• 1. Untiet V
  2. Beinlich FRM
  3. Kusk P
  4. Kang N
  5. Ladrón-de-Guevara A
  6. Song W
  7. Kjaerby C
  8. Andersen M
  9. Hauglund N
  10. Bojarowska Z
  11. Sigurdsson B
  12. Deng S
  13. Hirase H
  14. Petersen NC
  15. Verkhratsky A
  16. Nedergaard M
  Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice.; Nature communications; Vol 14(1), pp. 1871. 2023 Apr 04.
• 1. Parka A
  2. Volbracht C
  3. Hall B
  4. Bastlund JF
  5. Nedergaard M
  6. Laursen B
  7. Botta P
  8. Sotty F
  Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model.; Journal of Alzheimer's disease : JAD. 2023 Mar 31.
• 1. Ge GR
  2. Rolland JP
  3. Song W
  4. Nedergaard M
  5. Parker KJ
  Fluid compartments influence elastography of the aging mouse brain.; Physics in medicine and biology. 2023 Mar 30.
• 1. Boster KAS
  2. Cai S
  3. Ladrón-de-Guevara A
  4. Sun J
  5. Zheng X
  6. Du T
  7. Thomas JH
  8. Nedergaard M
  9. Karniadakis GE
  10. Kelley DH
  Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(14), pp. e2217744120. 2023 Mar 29.
• 1. Delle C
  2. Cankar N
  3. Digebjerg Holgersson C
  4. Hvorup Knudsen H
  5. Schiøler Nielsen E
  6. Kjaerby C
  7. Mori Y
  8. Nedergaard M
  9. Weikop P
  Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice.; Scientific reports; Vol 13(1), pp. 4137. 2023 Mar 13.
• 1. Sigurdsson B
  2. Hauglund NL
  3. Lilius TO
  4. Mogensen FL
  5. Mortensen KN
  6. Beschorner N
  7. Klinger L
  8. Bærentzen SL
  9. Rosenholm MP
  10. Shalgunov V
  11. Herth M
  12. Mori Y
  13. Nedergaard M
  A SPECT-based method for dynamic imaging of the glymphatic system in rats.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023 Feb 21.
• 1. Raicevic N
  2. Forer JM
  3. Ladron-de-Guevara A
  4. Du T
  5. Nedergaard M
  6. Kelley DH
  7. Boster KAS
  Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries.; Research square. 2023 Feb 17.
• 1. Gomolka RS
  2. Hablitz LM
  3. Mestre H
  4. Giannetto M
  5. Du T
  6. Hauglund NL
  7. Xie L
  8. Peng W
  9. Martinez PM
  10. Nedergaard M
  11. Mori Y
  Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.; eLife; Vol 12. 2023 Feb 09.
• 1. Lilius TO
  2. Mortensen KN
  3. Deville C
  4. Lohela TJ
  5. Stæger FF
  6. Sigurdsson B
  7. Fiordaliso EM
  8. Rosenholm M
  9. Kamphuis C
  10. Beekman FJ
  11. Jensen AI
  12. Nedergaard M
  Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles.; Journal of controlled release : official journal of the Controlled Release Society. 2023 Jan 30.
• 1. Parka A
  2. Degel C
  3. Dreyer J
  4. Richter U
  5. Hall B
  6. Bastlund JF
  7. Laursen B
  8. Nedergaard M
  9. Sotty F
  10. Botta P
  Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model.; Neurobiology of disease; Vol 178, pp. 106012. 2023 Jan 23.
• 1. Møllgård K
  2. Beinlich FRM
  3. Kusk P
  4. Miyakoshi LM
  5. Delle C
  6. Plá V
  7. Hauglund NL
  8. Esmail T
  9. Rasmussen MK
  10. Gomolka RS
  11. Mori Y
  12. Nedergaard M
  A mesothelium divides the subarachnoid space into functional compartments.; Science (New York, N.Y.); Vol 379(6627), pp. 84-88. 2023 Jan 05.
• 1. Lilius TO
  2. Rosenholm M
  3. Klinger L
  4. Mortensen KN
  5. Sigurdsson B
  6. Mogensen FL
  7. Hauglund NL
  8. Nielsen MSN
  9. Rantamäki T
  10. Nedergaard M
  SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline.; iScience; Vol 25(10), pp. 105250. 2022 Sep 29.
• 1. Lopes van den Broek S
  2. Shalgunov V
  3. García Vázquez R
  4. Beschorner N
  5. Bidesi NSR
  6. Nedergaard M
  7. Knudsen GM
  8. Sehlin D
  9. Syvänen S
  10. Herth MM
  Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?; Pharmaceuticals (Basel, Switzerland); Vol 15(10). 2022 Sep 27.
• 1. Wang X
  2. Delle C
  3. Asiminas A
  4. Akther S
  5. Vittani M
  6. Brøgger P
  7. Kusk P
  8. Vo CT
  9. Radovanovic T
  10. Konno A
  11. Hirai H
  12. Fukuda M
  13. Weikop P
  14. Goldman SA
  15. Nedergaard M
  16. Hirase H
  Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation.; Cell reports methods; Vol 2(10), pp. 100302. 2022 Sep 21.
• 1. Carlsen EMM
  2. Nedergaard M
  3. Rasmussen RN
  Versatile treadmill system for measuring locomotion and neural activity in head-fixed mice.; STAR protocols; Vol 3(4), pp. 101701. 2022 Sep 14.
• 1. Wu SY
  2. Wen Y
  3. Serre NBC
  4. Laursen CCH
  5. Dietz AG
  6. Taylor BR
  7. Drobizhev M
  8. Molina RS
  9. Aggarwal A
  10. Rancic V
  11. Becker M
  12. Ballanyi K
  13. Podgorski K
  14. Hirase H
  15. Nedergaard M
  16. Fendrych M
  17. Lemieux MJ
  18. Eberl DF
  19. Kay AR
  20. Campbell RE
  21. Shen Y
  A sensitive and specific genetically encoded potassium ion biosensor for in vivo applications across the tree of life.; PLoS biology; Vol 20(9), pp. e3001772. 2022 Sep 06.
• 1. Bohr T
  2. Hjorth PG
  3. Holst SC
  4. Hrabětová S
  5. Kiviniemi V
  6. Lilius T
  7. Lundgaard I
  8. Mardal KA
  9. Martens EA
  10. Mori Y
  11. Nägerl UV
  12. Nicholson C
  13. Tannenbaum A
  14. Thomas JH
  15. Tithof J
  16. Benveniste H
  17. Iliff JJ
  18. Kelley DH
  19. Nedergaard M
  The glymphatic system: Current understanding and modeling.; iScience; Vol 25(9), pp. 104987. 2022 Aug 20.
• 1. Lohela TJ
  2. Lilius TO
  3. Nedergaard M
  The glymphatic system: implications for drugs for central nervous system diseases.; Nature reviews. Drug discovery. 2022 Aug 10.
• 1. Wostyn P
  2. Mader TH
  3. Gibson CR
  4. Nedergaard M
  The effect of long-duration spaceflight on perivascular spaces within the brain.; Proceedings of the National Academy of Sciences of the United States of America; Vol 119(32), pp. e2207724119. 2022 Jul 18.
• 1. Kjaerby C
  2. Andersen M
  3. Hauglund N
  4. Untiet V
  5. Dall C
  6. Sigurdsson B
  7. Ding F
  8. Feng J
  9. Li Y
  10. Weikop P
  11. Hirase H
  12. Nedergaard M
  Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine.; Nature neuroscience. 2022 Jul 07.
• 1. Mestre H
  2. Verma N
  3. Greene TD
  4. Lin LA
  5. Ladron-de-Guevara A
  6. Sweeney AM
  7. Liu G
  8. Thomas VK
  9. Galloway CA
  10. de Mesy Bentley KL
  11. Nedergaard M
  12. Mehta RI
  Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease.; Nature communications; Vol 13(1). 2022 Jul 06.
• 1. Tithof J
  2. Boster KAS
  3. Bork PAR
  4. Nedergaard M
  5. Thomas JH
  6. Kelley DH
  A network model of glymphatic flow under different experimentally-motivated parametric scenarios.; iScience; Vol 25(5). 2022 May 20.
• 1. Kananen J
  2. Järvelä M
  3. Korhonen V
  4. Tuovinen T
  5. Huotari N
  6. Raitamaa L
  7. Helakari H
  8. Väyrynen T
  9. Raatikainen V
  10. Nedergaard M
  11. Ansakorpi H
  12. Jacobs J
  13. LeVan P
  14. Kiviniemi V
  Increased interictal synchronicity of respiratory related brain pulsations in epilepsy.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2022 May 14.
• 1. Ladrón-de-Guevara A
  2. Shang JK
  3. Nedergaard M
  4. Kelley DH
  Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment.; Journal of theoretical biology. 2022 Mar 23.
• 1. Monai H
  2. Koketsu S
  3. Shinohara Y
  4. Ueki T
  5. Kusk P
  6. Hauglund NL
  7. Samson AJ
  8. Nedergaard M
  9. Hirase H
  Author Correction: Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.; Scientific reports; Vol 12(1). 2022 Mar 18.
• 1. Beaman EE
  2. Bonde AN
  3. Ulv Larsen SM
  4. Ozenne B
  5. Lohela TJ
  6. Nedergaard M
  7. Gíslason GH
  8. Knudsen GM
  9. Holst SC
  Blood-brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension.; Brain : a journal of neurology. 2022 Feb 23.
• 1. Helakari H
  2. Korhonen V
  3. Holst SC
  4. Piispala J
  5. Kallio M
  6. Väyrynen T
  7. Huotari N
  8. Raitamaa L
  9. Tuunanen J
  10. Kananen J
  11. Järvelä M
  12. Tuovinen T
  13. Raatikainen V
  14. Borchardt V
  15. Kinnunen H
  16. Nedergaard M
  17. Kiviniemi V
  Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations.; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 Feb 07.
• 1. Ge GR
  2. Song W
  3. Nedergaard M
  4. Rolland JP
  5. Parker KJ
  Theory of sleep/wake cycles affecting brain elastography.; Physics in medicine and biology. 2022 Jan 27.
• 1. Feng W
  2. Zhang Y
  3. Ding S
  4. Chen S
  5. Wang T
  6. Wang Z
  7. Zou Y
  8. Sheng C
  9. Chen Y
  10. Pang Y
  11. Marshall C
  12. Shi J
  13. Nedergaard M
  14. Li Q
  15. Xiao M
  B lymphocytes ameliorate Alzheimer's disease-like neuropathology via interleukin-35.; Brain, behavior, and immunity; Vol 108, pp. 16-31. 2022 Jan 24.
• 1. Persson NDÅ
  2. Uusalo P
  3. Nedergaard M
  4. Lohela TJ
  5. Lilius TO
  Could dexmedetomidine be repurposed as a glymphatic enhancer?; Trends in pharmacological sciences. 2022 Jan 21.
• 1. Liu G
  2. Ladrón-de-Guevara A
  3. Izhiman Y
  4. Nedergaard M
  5. Du T
  Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.; Fluids and barriers of the CNS; Vol 19(1), pp. 101. 2022 Jan 15.
• 1. Shalgunov V
  2. Lopes van den Broek S
  3. Vang Andersen I
  4. García Vázquez R
  5. Raval NR
  6. Palner M
  7. Mori Y
  8. Schäfer G
  9. Herrmann B
  10. Mikula H
  11. Beschorner N
  12. Nedergaard M
  13. Syvänen S
  14. Barz M
  15. Moos Knudsen G
  16. Battisti UM
  17. Herth MM
  Pretargeted imaging beyond the blood-brain barrier.; RSC medicinal chemistry; Vol 14(3), pp. 444-453. 2022 Jan 02.
• 1. Newell DW
  2. Nedergaard M
  3. Aaslid R
  Physiological Mechanisms and Significance of Intracranial B Waves.; Frontiers in neurology; Vol 13. 2022.
• 1. Wostyn P
  2. Mader TH
  3. Gibson CR
  4. Nedergaard M
  Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?; Eye and brain; Vol 14. 2022.