URMC / Labs / Nedergaard Lab / Publications Recent Publications Gan YHolstein-Rønsbo SNedergaard MBoster KASThomas JHKelley DH Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism.; Journal of the Royal Society, Interface; Vol 20(206), pp. 20230288. 2023 Sep 20. Holstein-Rønsbo SGan YGiannetto MJRasmussen MKSigurdsson BBeinlich FRMRose LUntiet VHablitz LMKelley DHNedergaard M Publisher Correction: Glymphatic influx and clearance are accelerated by neurovascular coupling.; Nature neuroscience. 2023 Sep 04. Ozawa KNagao MKonno AIwai YVittani MKusk PMishima THirai HNedergaard MHirase H Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes.; International journal of molecular sciences; Vol 24(17). 2023 Sep 02. Staudt MShalgunov VNedergaard MHerth MM Development of 11 C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species.; Journal of labelled compounds & radiopharmaceuticals. 2023 Aug 31. Andersen MTsopanidou ARadovanovic TCompere VNHauglund NNedergaard MKjaerby C Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep.; Bio-protocol; Vol 13(15), pp. e4734. 2023 Aug 05. Kim DGan YNedergaard MKelley DHTithof J Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow.; bioRxiv : the preprint server for biology. 2023 Jul 24. Miyakoshi LMStæger FFLi QPan CXie LKang HPavan CDang JSun QErtürk ANedergaard M The state of brain activity modulates cerebrospinal fluid transport.; Progress in neurobiology. 2023 Jul 21. Raicevic NForer JMLadrón-de-Guevara ADu TNedergaard MKelley DHBoster K Sizes and shapes of perivascular spaces surrounding murine pial arteries.; Fluids and barriers of the CNS; Vol 20(1), pp. 56. 2023 Jul 17. Bork PARLadrón-de-Guevara AChristensen AHJensen KHNedergaard MBohr T Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow.; Journal of the Royal Society, Interface; Vol 20(204), pp. 20230050. 2023 Jul 12. Vittani MKnak PAGFukuda MNagao MWang XKjaerby CKonno AHirai HNedergaard MHirase H Virally induced CRISPR/Cas9-based knock-in of fluorescent albumin allows long-term visualization of cerebral circulation in infant and adult mice.; bioRxiv : the preprint server for biology. 2023 Jul 10. Mathiesen BKMiyakoshi LMCederroth CRTserga EVersteegh CBork PARHauglund NLGomolka RSMori YEdvall NKRouse SMøllgård KHolt JRNedergaard MCanlon B Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice.; Science translational medicine; Vol 15(702), pp. eabq3916. 2023 Jun 28. Hirase HNedergaard M Locomotion Induces Fundamentally Different Patterns of Ca2+ Signaling in Astrocytes and Neurons.; Function (Oxford, England); Vol 4(4), pp. zqad028. 2023 Jun 05. Holstein-Rønsbo SGan YGiannetto MJRasmussen MKSigurdsson BBeinlich FRMRose LUntiet VHablitz LMKelley DHNedergaard M Glymphatic influx and clearance are accelerated by neurovascular coupling.; Nature neuroscience. 2023 Jun 01. Raizen DMMullington JAnaclet CClarke GCritchley HDantzer RDavis RDrew KLFessel JFuller PMGibson EMHarrington MLipkin WIKlerman EBKlimas NKomaroff ALKoroshetz WKrupp LKuppuswamy ALasselin JLewis LDMagistretti PJMatos HYMiaskowski CMiller AHNath ANedergaard MOpp MRRitchie MDRogulja DRolls ASalamone JDSaper CWhittemore VWylie GYounger JZee PCHeller HC Beyond the Symptom: The Biology of Fatigue.; Sleep. 2023 May 24. Agarwal NLewis LDHirschler LRivera LRNaganawa SLevendovszky SRRingstad GKlarica MWardlaw JIadecola CHawkes CCarare ROWells JBakker ENTPKurtcuoglu VBilston LNedergaard MMori YStoodley MAlperin Nde Leon Mvan Osch MJP Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome.; Journal of magnetic resonance imaging : JMRI. 2023 May 04. Kjaerby CAndersen MHauglund NUntiet VDall CDing FHirase HNedergaard M Reply to: 'Do all norepinephrine surges disrupt sleep?'.; Nature neuroscience. 2023 Apr 20. Untiet VBeinlich FRMKusk PKang NLadrón-de-Guevara ASong WKjaerby CAndersen MHauglund NBojarowska ZSigurdsson BDeng SHirase HPetersen NCVerkhratsky ANedergaard M Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice.; Nature communications; Vol 14(1), pp. 1871. 2023 Apr 04. Parka AVolbracht CHall BBastlund JFNedergaard MLaursen BBotta PSotty F Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model.; Journal of Alzheimer's disease : JAD. 2023 Mar 31. Ge GRRolland JPSong WNedergaard MParker KJ Fluid compartments influence elastography of the aging mouse brain.; Physics in medicine and biology. 2023 Mar 30. Boster KASCai SLadrón-de-Guevara ASun JZheng XDu TThomas JHNedergaard MKarniadakis GEKelley DH Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(14), pp. e2217744120. 2023 Mar 29. Delle CCankar NDigebjerg Holgersson CHvorup Knudsen HSchiøler Nielsen EKjaerby CMori YNedergaard MWeikop P Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice.; Scientific reports; Vol 13(1), pp. 4137. 2023 Mar 13. Sigurdsson BHauglund NLLilius TOMogensen FLMortensen KNBeschorner NKlinger LBærentzen SLRosenholm MPShalgunov VHerth MMori YNedergaard M A SPECT-based method for dynamic imaging of the glymphatic system in rats.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023 Feb 21. Raicevic NForer JMLadron-de-Guevara ADu TNedergaard MKelley DHBoster KAS Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries.; Research square. 2023 Feb 17. Gomolka RSHablitz LMMestre HGiannetto MDu THauglund NLXie LPeng WMartinez PMNedergaard MMori Y Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.; eLife; Vol 12. 2023 Feb 09. Lilius TOMortensen KNDeville CLohela TJStæger FFSigurdsson BFiordaliso EMRosenholm MKamphuis CBeekman FJJensen AINedergaard M Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles.; Journal of controlled release : official journal of the Controlled Release Society. 2023 Jan 30. Parka ADegel CDreyer JRichter UHall BBastlund JFLaursen BNedergaard MSotty FBotta P Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model.; Neurobiology of disease; Vol 178, pp. 106012. 2023 Jan 23. Møllgård KBeinlich FRMKusk PMiyakoshi LMDelle CPlá VHauglund NLEsmail TRasmussen MKGomolka RSMori YNedergaard M A mesothelium divides the subarachnoid space into functional compartments.; Science (New York, N.Y.); Vol 379(6627), pp. 84-88. 2023 Jan 05. Lilius TORosenholm MKlinger LMortensen KNSigurdsson BMogensen FLHauglund NLNielsen MSNRantamäki TNedergaard M SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline.; iScience; Vol 25(10), pp. 105250. 2022 Sep 29. Lopes van den Broek SShalgunov VGarcía Vázquez RBeschorner NBidesi NSRNedergaard MKnudsen GMSehlin DSyvänen SHerth MM Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?; Pharmaceuticals (Basel, Switzerland); Vol 15(10). 2022 Sep 27. Wang XDelle CAsiminas AAkther SVittani MBrøgger PKusk PVo CTRadovanovic TKonno AHirai HFukuda MWeikop PGoldman SANedergaard MHirase H Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation.; Cell reports methods; Vol 2(10), pp. 100302. 2022 Sep 21. Carlsen EMMNedergaard MRasmussen RN Versatile treadmill system for measuring locomotion and neural activity in head-fixed mice.; STAR protocols; Vol 3(4), pp. 101701. 2022 Sep 14. Wu SYWen YSerre NBCLaursen CCHDietz AGTaylor BRDrobizhev MMolina RSAggarwal ARancic VBecker MBallanyi KPodgorski KHirase HNedergaard MFendrych MLemieux MJEberl DFKay ARCampbell REShen Y A sensitive and specific genetically encoded potassium ion biosensor for in vivo applications across the tree of life.; PLoS biology; Vol 20(9), pp. e3001772. 2022 Sep 06. Bohr THjorth PGHolst SCHrabětová SKiviniemi VLilius TLundgaard IMardal KAMartens EAMori YNägerl UVNicholson CTannenbaum AThomas JHTithof JBenveniste HIliff JJKelley DHNedergaard M The glymphatic system: Current understanding and modeling.; iScience; Vol 25(9), pp. 104987. 2022 Aug 20. Lohela TJLilius TONedergaard M The glymphatic system: implications for drugs for central nervous system diseases.; Nature reviews. Drug discovery. 2022 Aug 10. Wostyn PMader THGibson CRNedergaard M The effect of long-duration spaceflight on perivascular spaces within the brain.; Proceedings of the National Academy of Sciences of the United States of America; Vol 119(32), pp. e2207724119. 2022 Jul 18. Kjaerby CAndersen MHauglund NUntiet VDall CSigurdsson BDing FFeng JLi YWeikop PHirase HNedergaard M Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine.; Nature neuroscience. 2022 Jul 07. Mestre HVerma NGreene TDLin LALadron-de-Guevara ASweeney AMLiu GThomas VKGalloway CAde Mesy Bentley KLNedergaard MMehta RI Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease.; Nature communications; Vol 13(1). 2022 Jul 06. Tithof JBoster KASBork PARNedergaard MThomas JHKelley DH A network model of glymphatic flow under different experimentally-motivated parametric scenarios.; iScience; Vol 25(5). 2022 May 20. Kananen JJärvelä MKorhonen VTuovinen THuotari NRaitamaa LHelakari HVäyrynen TRaatikainen VNedergaard MAnsakorpi HJacobs JLeVan PKiviniemi V Increased interictal synchronicity of respiratory related brain pulsations in epilepsy.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2022 May 14. Ladrón-de-Guevara AShang JKNedergaard MKelley DH Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment.; Journal of theoretical biology. 2022 Mar 23. Monai HKoketsu SShinohara YUeki TKusk PHauglund NLSamson AJNedergaard MHirase H Author Correction: Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.; Scientific reports; Vol 12(1). 2022 Mar 18. Beaman EEBonde ANUlv Larsen SMOzenne BLohela TJNedergaard MGíslason GHKnudsen GMHolst SC Blood-brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension.; Brain : a journal of neurology. 2022 Feb 23. Helakari HKorhonen VHolst SCPiispala JKallio MVäyrynen THuotari NRaitamaa LTuunanen JKananen JJärvelä MTuovinen TRaatikainen VBorchardt VKinnunen HNedergaard MKiviniemi V Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations.; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 Feb 07. Ge GRSong WNedergaard MRolland JPParker KJ Theory of sleep/wake cycles affecting brain elastography.; Physics in medicine and biology. 2022 Jan 27. Feng WZhang YDing SChen SWang TWang ZZou YSheng CChen YPang YMarshall CShi JNedergaard MLi QXiao M B lymphocytes ameliorate Alzheimer's disease-like neuropathology via interleukin-35.; Brain, behavior, and immunity; Vol 108, pp. 16-31. 2022 Jan 24. Persson NDÅUusalo PNedergaard MLohela TJLilius TO Could dexmedetomidine be repurposed as a glymphatic enhancer?; Trends in pharmacological sciences. 2022 Jan 21. Liu GLadrón-de-Guevara AIzhiman YNedergaard MDu T Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.; Fluids and barriers of the CNS; Vol 19(1), pp. 101. 2022 Jan 15. Shalgunov VLopes van den Broek SVang Andersen IGarcía Vázquez RRaval NRPalner MMori YSchäfer GHerrmann BMikula HBeschorner NNedergaard MSyvänen SBarz MMoos Knudsen GBattisti UMHerth MM Pretargeted imaging beyond the blood-brain barrier.; RSC medicinal chemistry; Vol 14(3), pp. 444-453. 2022 Jan 02. Newell DWNedergaard MAaslid R Physiological Mechanisms and Significance of Intracranial B Waves.; Frontiers in neurology; Vol 13. 2022. Wostyn PMader THGibson CRNedergaard M Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?; Eye and brain; Vol 14. 2022.