URMC / Labs / Nedergaard Lab / Publications Recent Publications Lohela TJLilius TONedergaard M The glymphatic system: implications for drugs for central nervous system diseases.; Nature reviews. Drug discovery. 2022 Aug 10. Wostyn PMader THGibson CRNedergaard M The effect of long-duration spaceflight on perivascular spaces within the brain.; Proceedings of the National Academy of Sciences of the United States of America; Vol 119(32), pp. e2207724119. 2022 Jul 18. Kjaerby CAndersen MHauglund NUntiet VDall CSigurdsson BDing FFeng JLi YWeikop PHirase HNedergaard M Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine.; Nature neuroscience. 2022 Jul 07. Mestre HVerma NGreene TDLin LALadron-de-Guevara ASweeney AMLiu GThomas VKGalloway CAde Mesy Bentley KLNedergaard MMehta RI Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease.; Nature communications; Vol 13(1). 2022 Jul 06. Tithof JBoster KASBork PARNedergaard MThomas JHKelley DH A network model of glymphatic flow under different experimentally-motivated parametric scenarios.; iScience; Vol 25(5). 2022 May 20. Kananen JJärvelä MKorhonen VTuovinen THuotari NRaitamaa LHelakari HVäyrynen TRaatikainen VNedergaard MAnsakorpi HJacobs JLeVan PKiviniemi V Increased interictal synchronicity of respiratory related brain pulsations in epilepsy.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2022 May 14. Ladrón-de-Guevara AShang JKNedergaard MKelley DH Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment.; Journal of theoretical biology. 2022 Mar 23. Monai HKoketsu SShinohara YUeki TKusk PHauglund NLSamson AJNedergaard MHirase H Author Correction: Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.; Scientific reports; Vol 12(1). 2022 Mar 18. Beaman EEBonde ANUlv Larsen SMOzenne BLohela TJNedergaard MGíslason GHKnudsen GMHolst SC Blood-brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension.; Brain : a journal of neurology. 2022 Feb 23. Helakari HKorhonen VHolst SCPiispala JKallio MVäyrynen THuotari NRaitamaa LTuunanen JKananen JJärvelä MTuovinen TRaatikainen VBorchardt VKinnunen HNedergaard MKiviniemi V Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations.; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 Feb 07. Newell DWNedergaard MAaslid R Physiological Mechanisms and Significance of Intracranial B Waves.; Frontiers in neurology; Vol 13. 2022. Wostyn PMader THGibson CRNedergaard M Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?; Eye and brain; Vol 14. 2022. Martikainen MVAakko-Saksa Pvan den Broek LCassee FRCarare ROChew SDinnyes AGiugno RKanninen KMMalm TMuala ANedergaard MOudin AOyola PPfeiffer TVRönkkö TSaarikoski SSandström TSchins RPFTopinka JYang MZeng XWesterink RHSJalava PI TUBE Project: Transport-Derived Ultrafines and the Brain Effects.; International journal of environmental research and public health; Vol 19(1). 2021 Dec 28. Battistella RKritsilis MMatuskova HHaswell DCheng AXMeissner ANedergaard MLundgaard I Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature.; International journal of molecular sciences; Vol 22(21). 2021 Oct 26. Hablitz LMNedergaard M The glymphatic system.; Current biology : CB; Vol 31(20). 2021 Oct 25. Du TMestre HKress BTLiu GSweeney AMSamson AJRasmussen MKMortensen KNBork PARPeng WOlveda GEBashford LToro ERTithof JKelley DHThomas JHHjorth PGMartens EAMehta RIHirase HMori YNedergaard M Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.; Brain : a journal of neurology. 2021 Sep 28. Hablitz LMNedergaard M The Glymphatic System: A Novel Component of Fundamental Neurobiology.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 41(37). 2021 Sep 15. Pavan CL R Xavier ARamos MFisher JKritsilis MLinder ABentzer PNedergaard MLundgaard I DNase Treatment Prevents Cerebrospinal Fluid Block in Early Experimental Pneumococcal Meningitis.; Annals of neurology. 2021 Aug 16. Benveniste HNedergaard M Cerebral small vessel disease: A glymphopathy?; Current opinion in neurobiology; Vol 72. 2021 Aug 15. Mogensen FLDelle CNedergaard M The Glymphatic System (En)during Inflammation.; International journal of molecular sciences; Vol 22(14). 2021 Jul 13. Wardlaw JMBenveniste HNedergaard MZlokovic BVCharpak SSmith KJBlack SE Reply to: Rethink the classical view of cerebrospinal fluid production.; Nature reviews. Neurology. 2021 Jul 12. Rasmussen MKMestre HNedergaard M Fluid Transport in the Brain.; Physiological reviews. 2021 May 05. Monai HKoketsu SShinohara YUeki TKusk PHauglund NLSamson AJNedergaard MHirase H Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.; Scientific reports; Vol 11(1). 2021 Apr 14. Rajna ZMattila HHuotari NTuovinen TKrüger JHolst SCKorhonen VRemes AMSeppänen THennig JNedergaard MKiviniemi V Cardiovascular brain impulses in Alzheimer's disease.; Brain : a journal of neurology. 2021 Mar 31. Yuste RHawrylycz MAalling NAguilar-Valles AArendt DArmañanzas RAscoli GABielza CBokharaie VBergmann TBBystron ICapogna MChang YClemens Ade Kock CPJDeFelipe JDos Santos SEDunville KFeldmeyer DFiáth RFishell GJFoggetti AGao XGhaderi PGoriounova NAGüntürkün OHagihara KHall VJHelmstaedter MHerculano-Houzel SHilscher MMHirase HHjerling-Leffler JHodge RHuang JHuda RKhodosevich KKiehn OKoch HKuebler ESKühnemund MLarrañaga PLelieveldt BLouth ELLui JHMansvelder HDMarin OMartinez-Trujillo JChameh HMMohapatra ANMunguba HNedergaard MNěmec POfer NPfisterer UGPontes SRedmond WRossier JSanes JRScheuermann RHSerrano-Saiz EStaiger JFSomogyi PTamás GTolias ASTosches MAGarcía MTWozny CWuttke TVLiu YYuan JZeng HLein E Author Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types.; Nature neuroscience. 2021 Mar 19. Raghunandan ALadron-de-Guevara ATithof JMestre HDu TNedergaard MThomas JHKelley DH Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection.; eLife; Vol 10. 2021 Mar 09. Stanton EHPersson NDÅGomolka RSLilius TSigurðsson BLee HXavier ALRBenveniste HNedergaard MMori Y Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia.; Magnetic resonance in medicine. 2021 Jan 11. Liu GMestre HSweeney AMSun QWeikop PDu TNedergaard M Direct Measurement of Cerebrospinal Fluid Production in Mice.; Cell reports; Vol 33(12). 2020 Dec 22. Tuovinen TKananen JRajna ZLieslehto JKorhonen VRytty RMattila HHuotari NRaitamaa LHelakari HElseoud AAKrüger JLeVan PTervonen OHennig JRemes AMNedergaard MKiviniemi V The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies.; Scientific reports; Vol 10(1). 2020 Dec 09. Yuste RHawrylycz MAalling NAguilar-Valles AArendt DArnedillo RAAscoli GABielza CBokharaie VBergmann TBBystron ICapogna MChang YClemens Ade Kock CPJDeFelipe JDos Santos SEDunville KFeldmeyer DFiáth RFishell GJFoggetti AGao XGhaderi PGoriounova NAGüntürkün OHagihara KHall VJHelmstaedter MHerculano SHilscher MMHirase HHjerling-Leffler JHodge RHuang JHuda RKhodosevich KKiehn OKoch HKuebler ESKühnemund MLarrañaga PLelieveldt BLouth ELLui JHMansvelder HDMarin OMartinez-Trujillo JMoradi Chameh HNath ANedergaard MNěmec POfer NPfisterer UGPontes SRedmond WRossier JSanes JRScheuermann RSerrano-Saiz ESteiger JFSomogyi PTamás GTolias ASTosches MAGarcía MTVieira HMWozny CWuttke TVYong LYuan JZeng HLein E Publisher Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types.; Nature neuroscience. 2020 Dec 04. Goldman NHablitz LMMori YNedergaard M The Glymphatic System and Pain.; Medical acupuncture; Vol 32(6). 2020 Dec 01. Min Rivas FLiu JMartell BCDu TMestre HNedergaard MTithof JThomas JHKelley DH Surface periarterial spaces of the mouse brain are open, not porous.; Journal of the Royal Society, Interface; Vol 17(172). 2020 Nov. Nedergaard MGoldman SA Glymphatic failure as a final common pathway to dementia.; Science (New York, N.Y.); Vol 370(6512). 2020 Oct 02. Giannetto MXia MStæger FFMetcalfe TVinitsky HSDang JAMLXavier ALRKress BTNedergaard MHablitz LM Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice.; Scientific reports; Vol 10(1). 2020 Sep 30. Hablitz LMPlá VGiannetto MVinitsky HSStæger FFMetcalfe TNguyen RBenrais ANedergaard M Circadian control of brain glymphatic and lymphatic fluid flow.; Nature communications; Vol 11(1). 2020 Sep 02. Yuste RHawrylycz MAalling NAguilar-Valles AArendt DArnedillo RAAscoli GABielza CBokharaie VBergmann TBBystron ICapogna MChang YClemens Ade Kock CPJDeFelipe JDos Santos SEDunville KFeldmeyer DFiáth RFishell GJFoggetti AGao XGhaderi PGoriounova NAGüntürkün OHagihara KHall VJHelmstaedter MHerculano SHilscher MMHirase HHjerling-Leffler JHodge RHuang JHuda RKhodosevich KKiehn OKoch HKuebler ESKühnemund MLarrañaga PLelieveldt BLouth ELLui JHMansvelder HDMarin OMartinez-Trujillo JMoradi Chameh HNath ANedergaard MNěmec POfer NPfisterer UGPontes SRedmond WRossier JSanes JRScheuermann RSerrano-Saiz ESteiger JFSomogyi PTamás GTolias ASTosches MAGarcía MTVieira HMWozny CWuttke TVYong LYuan JZeng HLein E A community-based transcriptomics classification and nomenclature of neocortical cell types.; Nature neuroscience. 2020 Aug 24. Ng Kee Kwong KCMehta ARNedergaard MChandran S Defining novel functions for cerebrospinal fluid in ALS pathophysiology.; Acta neuropathologica communications; Vol 8(1). 2020 Aug 20. Rangroo Thrane VHynnekleiv LWang XThrane ASKrohn JNedergaard M Twists and turns of ocular glymphatic clearance - new study reveals surprising findings in glaucoma.; Acta ophthalmologica. 2020 Jul 24. Stæger FFMortensen KNNielsen MSNSigurdsson BKaufmann LKHirase HNedergaard M A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices.; Scientific data; Vol 7(1). 2020 Jul 13. Windrem MSSchanz SJZou LChandler-Militello DKuypers NJNedergaard MLu YMariani JNGoldman SA Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.; Cell reports; Vol 31(7). 2020 May 19. Mestre HMori YNedergaard M The Brain's Glymphatic System: Current Controversies.; Trends in neurosciences. 2020 May 15. Rasmussen RO'Donnell JDing FNedergaard M Interstitial ions: A key regulator of state-dependent neural activity?; Progress in neurobiology. 2020 May 12. Ulv Larsen SMLandolt HPBerger WNedergaard MKnudsen GMHolst SC Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep.; PLoS biology; Vol 18(5). 2020 May. Viggiano DWagner CAMartino GNedergaard MZoccali CUnwin RCapasso G Mechanisms of cognitive dysfunction in CKD.; Nature reviews. Nephrology. 2020 Mar 31. Wang XLou NEberhardt AYang YKusk PXu QFörstera BPeng SShi MLadrón-de-Guevara ADelle CSigurdsson BXavier ALRErtürk ALibby RTChen LThrane ASNedergaard M An ocular glymphatic clearance system removes β-amyloid from the rodent eye.; Science translational medicine; Vol 12(536). 2020 Mar 25. Hauglund NLKusk PKornum BRNedergaard M Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 40(11). 2020 Mar 11. Karimy JKReeves BCDamisah EDuy PQAntwi PDavid WWang KSchiff SJLimbrick DDAlper SLWarf BCNedergaard MSimard JMKahle KT Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.; Nature reviews. Neurology. 2020 Mar 09. Koundal SElkin RNadeem SXue YConstantinou SSanggaard SLiu XMonte BXu FNostrand WVNedergaard MLee HWardlaw JBenveniste HTannenbaum A Publisher Correction: Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.; Scientific reports; Vol 10(1). 2020 Feb 27. Wardlaw JMBenveniste HNedergaard MZlokovic BVMestre HLee HDoubal FNBrown RRamirez JMacIntosh BJTannenbaum ABallerini LRungta RLBoido DSweeney MMontagne ACharpak SJoutel ASmith KJBlack SE Perivascular spaces in the brain: anatomy, physiology and pathology.; Nature reviews. Neurology. 2020 Feb 24. Li QAalling NNFörstera BErtürk ANedergaard MMøllgård KXavier ALR Aquaporin 1 and the Na+/K+/2Cl- cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system.; Fluids and barriers of the CNS; Vol 17(1). 2020 Feb 11.