URochester Medicine / Labs / Rand Lab / Publications

Recent Publications from the Rand Lab

1. Beamish CR
2. Becker J
3. Tam LM
4. Love T
5. Rand MD
Transcriptomic analysis identifies muscle-specific mitochondrial and vesicular transport genes as methylmercury toxicity targets in a Drosophila model of Congenital Minamata Disease.; Toxicological sciences : an official journal of the Society of Toxicology. 2025 Feb 14.
1. Tam LM
2. Rand MD
Review: myogenic and muscle toxicity targets of environmental methylmercury exposure.; Archives of toxicology. 2024 Mar 28.
1. Rand MD
2. Tennessen JM
3. Mackay TFC
4. Anholt RRH
Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science.; Current protocols; Vol 3(8), pp. e870. 2023 Aug.
1. Coe GL
2. Krout IN
3. Munro-Ehrlich M
4. Beamish CR
5. Vorojeikina D
6. Colman DR
7. Boyd EJ
8. Walk ST
9. Rand MD
Assessing the role of the gut microbiome in methylmercury demethylation and elimination in humans and gnotobiotic mice.; Archives of toxicology. 2023 Jul 01.
1. de Paula HK
2. Love TM
3. Pineda D
4. Watson GE
5. Thurston SW
6. Yeates AJ
7. Mulhern MS
8. McSorley EM
9. Strain JJ
10. Shamlaye CF
11. Myers GJ
12. Rand MD
13. van Wijngaarden E
14. Broberg K
KEAP1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal MeHg from the Seychelles Child Development Study Nutrition Cohort 2.; Neurotoxicology. 2023 Jan 17.
1. Klus JK
2. Thurston SW
3. Myers GJ
4. Watson GE
5. Rand MD
6. Love TM
7. Yeates AJ
8. Mulhern MS
9. McSorley EM
10. Strain JJ
11. Shamlaye CF
12. van Wijngaarden E
Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2.; Neurotoxicology; Vol 99, pp. 115-119. 2023 Jan 11.
1. Krout IN
2. Scrimale T
3. Vorojekina D
4. Boyd ES
5. Rand MD
Organomercurial lyase (MerB)-mediated demethylation decreases bacterial methylmercury resistance in the absence of mercuric reductase (MerA).; Applied and environmental microbiology. 2022 Feb 09.
1. Krout IN
2. Scrimale T
3. Rand MD
Targeted Intracellular Demethylation of Methylmercury Enhances Elimination Kinetics and Reduces Developmental Toxicity in Transgenic Drosophila.; Toxicological sciences : an official journal of the Society of Toxicology. 2022 Jan 06.
1. Beamish CR
2. Love TM
3. Rand MD
Developmental Toxicology of Metal Mixtures in Drosophila: Unique Properties of Potency and Interactions of Mercury Isoforms.; International journal of molecular sciences; Vol 22(22). 2021 Nov 09.
1. Peppriell AE
2. Gunderson JT
3. Krout IN
4. Vorojeikina D
5. Rand MD
Latent effects of early-life methylmercury exposure on motor function in Drosophila.; Neurotoxicology and teratology. 2021 Oct 14.
1. Zavez A
2. Thurston SW
3. Rand MD
4. Mruzek DW
5. Love T
6. Smith T
7. Shamlaye CF
8. van Wijngaarden E
Delivery Mode and Child Development at 20 Months of Age and 7 Years of Age in the Republic of Seychelles.; Maternal and child health journal. 2021 Oct 05.
1. Gunderson JT
2. Peppriell AE
3. Krout IN
4. Vorojeikina D
5. Rand MD
Neuroligin-1 is a mediator of methylmercury neuromuscular toxicity.; Toxicological sciences : an official journal of the Society of Toxicology. 2021 Sep 21.
1. Strain JJ
2. Love TM
3. Yeates AJ
4. Weller D
5. Mulhern MS
6. McSorley EM
7. Thurston SW
8. Watson GE
9. Mruzek D
10. Broberg K
11. Rand MD
12. Henderson J
13. Shamlaye CF
14. Myers GJ
15. Davidson PW
16. van Wijngaarden E
Associations of prenatal methylmercury exposure and maternal polyunsaturated fatty acid status with neurodevelopmental outcomes at 7 years of age: results from the Seychelles Child Development Study Nutrition Cohort 2.; The American journal of clinical nutrition; Vol 113(2), pp. 304-313. 2021 Feb.
1. Pope Q
2. Rand MD
Variation in Methylmercury Metabolism and Elimination in Humans: Physiological Pharmacokinetic Modeling highlights the role of gut biotransformation, skeletal muscle and hair.; Toxicological sciences : an official journal of the Society of Toxicology. 2021 Jan 22.
1. Strain JJ
2. Love TM
3. Yeates AJ
4. Weller D
5. Mulhern MS
6. McSorley EM
7. Thurston SW
8. Watson GE
9. Mruzek D
10. Broberg K
11. Rand MD
12. Henderson J
13. Shamlaye CF
14. Myers GJ
15. Davidson PW
16. van Wijngaarden E
Associations of prenatal methylmercury exposure and maternal polyunsaturated fatty acid status with neurodevelopmental outcomes at 7 years of age: results from the Seychelles Child Development Study Nutrition Cohort 2.; The American journal of clinical nutrition. 2020 Dec 17.
1. Gunderson JT
2. Peppriell AE
3. Vorojeikina D
4. Rand MD
Tissue-specific Nrf2 signaling protects against methylmercury toxicity in Drosophila neuromuscular development.; Archives of toxicology. 2020 Aug 20.
1. Peppriell AE
2. Gunderson JT
3. Vorojeikina D
4. Rand MD
Methylmercury myotoxicity targets formation of the myotendinous junction.; Toxicology. 2020 Aug 12.
1. Rand MD
2. Conrad K
3. Marvin E
4. Harvey K
5. Henderson D
6. Tawil R
7. Sobolewski M
8. Cory-Slechta DA
Developmental exposure to methylmercury and resultant muscle mercury accumulation and adult motor deficits in mice.; Neurotoxicology. 2020 Jul 28.
1. Haraguchi K
2. Sakamoto M
3. Matsuyama A
4. Yamamoto M
5. Hung DT
6. Nagasaka H
7. Uchida K
8. Ito Y
9. Kodamatani H
10. Horvat M
11. Chan HM
12. Rand M
13. Cirtiu CM
14. Kim BG
15. Nielsen F
16. Yamakawa A
17. Mashyanov N
18. Panichev N
19. Panova E
20. Watanabe T
21. Kaneko N
22. Yoshinaga J
23. Herwati RF
24. Suoth AE
25. Akagi H
Development of Human Hair Reference Material Supporting the Biomonitoring of Methylmercury.; Analytical sciences : the international journal of the Japan Society for Analytical Chemistry; Vol 36(5). 2020 May 10.
1. Culbreth M
2. Rand MD
Methylmercury modifies temporally expressed myogenic regulatory factors to inhibit myoblast differentiation.; Toxicology in vitro : an international journal published in association with BIBRA; Vol 63. 2020 Mar.
1. Rand MD
2. Vorojeikina D
3. Peppriell A
4. Gunderson J
5. Prince LM
Drosophotoxicology: Elucidating Kinetic and Dynamic Pathways of Methylmercury Toxicity in a Drosophila Model; Front. Genet. 2019 Jan 01.
1. Rand MD
2. Caito SW
Variation in the biological half-life of methylmercury in humans: Methods, measurements and meaning.; Biochimica et biophysica acta. General subjects. 2019 Feb 08.
1. Xu Y
2. Wahlberg K
3. Love TM
4. Watson GE
5. Yeates AJ
6. Mulhern MS
7. McSorley EM
8. Strain JJ
9. Davidson PW
10. Shamlaye CF
11. Rand MD
12. Myers GJ
13. van Wijngaarden E
14. Broberg K
Associations of blood mercury and fatty acid concentrations with blood mitochondrial DNA copy number in the Seychelles Child Development Nutrition Study.; Environment international; Vol 124. 2019 Jan 17.
1. Rand MD
2. Vorojeikina D
3. Peppriell A
4. Gunderson J
5. Prince LM
Drosophotoxicology: Elucidating Kinetic and Dynamic Pathways of Methylmercury Toxicity in a Drosophila Model.; Frontiers in genetics; Vol 10. 2019.
1. Wahlberg K
2. Love TM
3. Pineda D
4. Engström K
5. Watson GE
6. Thurston SW
7. Yeates AJ
8. Mulhern MS
9. McSorley EM
10. Strain JJ
11. Smith TH
12. Davidson PW
13. Shamlaye CF
14. Myers GJ
15. Rand MD
16. van Wijngaarden E
17. Broberg K
Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet.; Environment international; Vol 115. 2018 Mar 21.
1. Caito SW
2. Jackson BP
3. Punshon T
4. Scrimale T
5. Grier A
6. Gill SR
7. Love TM
8. Watson GE
9. van Wijngaarden E
10. Rand MD
Variation in Methylmercury Metabolism and Elimination Status (MerMES) in Humans Following Fish Consumption.; Toxicological sciences : an official journal of the Society of Toxicology. 2017 Nov 14.
1. Prince LM
2. Rand MD
Methylmercury exposure causes a persistent inhibition of myogenin expression and C2C12 myoblast differentiation.; Toxicology. 2017 Nov 02.
1. Llop S
2. Tran V
3. Ballester F
4. Barbone F
5. Sofianou-Katsoulis A
6. Sunyer J
7. Engström K
8. Alhamdow A
9. Love TM
10. Watson GE
11. Bustamante M
12. Murcia M
13. Iñiguez C
14. Shamlaye CF
15. Rosolen V
16. Mariuz M
17. Horvat M
18. Tratnik JS
19. Mazej D
20. van Wijngaarden E
21. Davidson PW
22. Myers GJ
23. Rand MD
24. Broberg K
CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment.; Environment international; Vol 105. 2017 May 09.
1. Vorojeikina D
2. Broberg K
3. Love TM
4. Davidson PW
5. van Wijngaarden E
6. Rand MD
Glutathione S-Transferase Activity Moderates Methylmercury Toxicity During Development in Drosophila.; Toxicological sciences : an official journal of the Society of Toxicology. 2017 Feb 10.
1. Prince LM
2. Rand MD
Notch Target Gene E(spl)mδ Is a Mediator of Methylmercury-Induced Myotoxicity in Drosophila.; Frontiers in genetics; Vol 8. 2017.
1. Engström K
2. Love TM
3. Watson GE
4. Zareba G
5. Yeates A
6. Wahlberg K
7. Alhamdow A
8. Thurston SW
9. Mulhern M
10. McSorley EM
11. Strain JJ
12. Davidson PW
13. Shamlaye CF
14. Myers GJ
15. Rand MD
16. van Wijngaarden E
17. Broberg K
Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study.; Environment international; Vol 94. 2016 Jun 2.
1. Rand MD
2. Vorojeikina D
3. van Wijngaarden E
4. Jackson BP
5. Scrimale T
6. Zareba G
7. Love TM
8. Myers GJ
9. Watson G
Methods for individualized determination of methylmercury elimination rate and de-methylation status in humans following fish consumption.; Toxicological sciences : an official journal of the Society of Toxicology. 2015 Nov 15.
1. Prince L
2. Korbas M
3. Davidson P
4. Broberg K
5. Rand MD
Target organ specific activity of drosophila MRP (ABCC1) moderates developmental toxicity of methylmercury.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 140(2). 2014 Aug 1.
1. Engel GL
2. Rand MD
The Notch target E(spl)mδ is a muscle-specific gene involved in methylmercury toxicity in motor neuron development.; Neurotoxicology and teratology; Vol 43. 2014 May.
1. Rand MD
A method of permeabilization of Drosophila embryos for assays of small molecule activity.; Journal of visualized experiments : JoVE. 2014.
1. Montgomery SL
2. Vorojeikina D
3. Huang W
4. Mackay TF
5. Anholt RR
6. Rand MD
Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways.; PloS one; Vol 9(10). 2014.
1. Rand MD
2. Montgomery SL
3. Prince L
4. Vorojeikina D
Developmental toxicity assays using the Drosophila model.; Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]; Vol 59. 2014.
1. Jebbett NJ
2. Hamilton JW
3. Rand MD
4. Eckenstein F
Low level methylmercury enhances CNTF-evoked STAT3 signaling and glial differentiation in cultured cortical progenitor cells.; Neurotoxicology; Vol 38. 2013 Sep.
1. Rand MD
2. Lowe JA
3. Mahapatra CT
Drosophila CYP6g1 and its human homolog CYP3A4 confer tolerance to methylmercury during development.; Toxicology; Vol 300(1-2). 2012 Oct 9.
1. Mahapatra CT
2. Rand MD
Methylmercury tolerance is associated with the humoral stress factor gene Turandot A.; Neurotoxicology and teratology; Vol 34(4). 2012 Jul.
1. Engel GL
2. Delwig A
3. Rand MD
The effects of methylmercury on Notch signaling during embryonic neural development in Drosophila melanogaster.; Toxicology in vitro : an international journal published in association with BIBRA; Vol 26(3). 2012 Apr.
1. Rand MD
2. Kearney AL
3. Dao J
4. Clason T
Permeabilization of Drosophila embryos for introduction of small molecules.; Insect biochemistry and molecular biology; Vol 40(11). 2010 Nov.
1. Mahapatra CT
2. Bond J
3. Rand DM
4. Rand MD
Identification of methylmercury tolerance gene candidates in Drosophila.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 116(1). 2010 Jul.
1. Rand MD
Drosophotoxicology: the growing potential for Drosophila in neurotoxicology.; Neurotoxicology and teratology; Vol 32(1). 2010 Jan.
1. Rand MD
2. Dao JC
3. Clason TA
Methylmercury disruption of embryonic neural development in Drosophila.; Neurotoxicology; Vol 30(5). 2009 Sep.
1. Delwig A
2. Rand MD
Kuz and TACE can activate Notch independent of ligand.; Cellular and molecular life sciences : CMLS; Vol 65(14). 2008 Jul.
1. Rand MD
2. Bland CE
3. Bond J
Methylmercury activates enhancer-of-split and bearded complex genes independent of the notch receptor.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 104(1). 2008 Jul.
1. Cornbrooks C
2. Bland C
3. Williams DW
4. Truman JW
5. Rand MD
Delta expression in post-mitotic neurons identifies distinct subsets of adult-specific lineages in Drosophila.; Developmental neurobiology; Vol 67(1). 2007 Jan.
1. Bland C
2. Rand MD
Methylmercury induces activation of Notch signaling.; Neurotoxicology; Vol 27(6). 2006 Dec.
1. Delwig A
2. Bland C
3. Beem-Miller M
4. Kimberly P
5. Rand MD
Endocytosis-independent mechanisms of Delta ligand proteolysis.; Experimental cell research; Vol 312(8). 2006 May 1.