URMC / Labs / Rangel-Moreno Lab / Projects / Evaluation of Experimental Therapies in a Preclinical Model of Lupus
Evaluation of Experimental Therapies in a Preclinical Model of Lupus
In collaboration with Dr. Allan Smrcka, we previously demonstrated that inhibition of G protein bgsignaling prevents lupus nephritis by targeting the migration of immune cells and impairing auto-reactive germinal centers (Arthritis Rheumatol 68(9): 2244-2256: 2016). In a similar fashion, experimental treatment with inhibitors of nuclear disrupts splenic germinal centers and the niche for auto-reactive and inflammatory cells in the inflamed kidney of lupus prone mice. Picture from plasma cells after treatment with selective inhibitors of nuclear export.
![Spleen of mice treated with SINE drugs (PCNA in red and IgG in green)](/MediaLibraries/URMCMedia/labs/rangel-moreno-lab/images/lupus-large.jpg)
Spleen of mice treated with SINE drugs (PCNA in red and IgG in green).