Publications

• 1. Sarkar S
  Microglial ion channels: Key players in non-cell autonomous neurodegeneration.; Neurobiology of disease; Vol 174, pp. 105861. 2022 Sep 14.
• 1. Langley MR
  2. Rangaraju S
  3. Dey A
  4. Sarkar S
  Editorial: Environmental Effect on Neuroinflammation and Neurodegeneration.; Frontiers in cellular neuroscience; Vol 16, pp. 935190. 2022 Jun 21.
• 1. Hallacli E
  2. Kayatekin C
  3. Nazeen S
  4. Wang XH
  5. Sheinkopf Z
  6. Sathyakumar S
  7. Sarkar S
  8. Jiang X
  9. Dong X
  10. Di Maio R
  11. Wang W
  12. Keeney MT
  13. Felsky D
  14. Sandoe J
  15. Vahdatshoar A
  16. Udeshi ND
  17. Mani DR
  18. Carr SA
  19. Lindquist S
  20. De Jager PL
  21. Bartel DP
  22. Myers CL
  23. Greenamyre JT
  24. Feany MB
  25. Sunyaev SR
  26. Chung CY
  27. Khurana V
  The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.; Cell; Vol 185(12), pp. 2035-2056.e33. 2022 Jun 09.
• 1. Palanisamy BN
  2. Sarkar S
  3. Malovic E
  4. Samidurai M
  5. Charli A
  6. Zenitsky G
  7. Jin H
  8. Anantharam V
  9. Kanthasamy A
  10. Kanthasamy AG
  Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson's disease: Potential relevance to gut-brain axis inflammation in Parkinson's disease pathogenesis.; The international journal of biochemistry & cell biology; Vol 147, pp. 106225. 2022 May 12.
• 1. Ghaisas S
  2. Harischandra DS
  3. Palanisamy B
  4. Proctor A
  5. Jin H
  6. Dutta S
  7. Sarkar S
  8. Langley M
  9. Zenitsky G
  10. Anantharam V
  11. Kanthasamy A
  12. Phillips GJ
  13. Kanthasamy A
  Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study.; Environmental health perspectives; Vol 129(8), pp. 87005. 2021 Aug 19.
• 1. Sarkar S
  2. Feany MB
  Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson's Disease.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 182(2), pp. 159-167. 2021 Aug 03.
• 1. Sarkar S
  Mechanism of Gene-Environment Interactions Driving Glial Activation in Parkinson's Diseases.; Current environmental health reports; Vol 8(3), pp. 203-211. 2021 May 27.
• 1. Sarkar S
  2. Bardai F
  3. Olsen AL
  4. Lohr KM
  5. Zhang YY
  6. Feany MB
  Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.; Molecular neurodegeneration; Vol 16(1), pp. 33. 2021 May 24.
• 1. Sarkar S
  2. Olsen AL
  3. Sygnecka K
  4. Lohr KM
  5. Feany MB
  α-synuclein impairs autophagosome maturation through abnormal actin stabilization.; PLoS genetics; Vol 17(2), pp. e1009359. 2021 Feb 08.
• 1. Sarkar S
  2. Nguyen HM
  3. Malovic E
  4. Luo J
  5. Langley M
  6. Palanisamy BN
  7. Singh N
  8. Manne S
  9. Neal M
  10. Gabrielle M
  11. Abdalla A
  12. Anantharam P
  13. Rokad D
  14. Panicker N
  15. Singh V
  16. Ay M
  17. Charli A
  18. Harischandra D
  19. Jin LW
  20. Jin H
  21. Rangaraju S
  22. Anantharam V
  23. Wulff H
  24. Kanthasamy AG
  Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.; The Journal of clinical investigation; Vol 130(8), pp. 4195-4212. 2020 Aug 03.
• 1. Sarkar S
  2. Dammer EB
  3. Malovic E
  4. Olsen AL
  5. Raza SA
  6. Gao T
  7. Xiao H
  8. Oliver DL
  9. Duong D
  10. Joers V
  11. Seyfried N
  12. Huang M
  13. Kukar T
  14. Tansey MG
  15. Kanthasamy AG
  16. Rangaraju S
  Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.; Frontiers in immunology; Vol 11, pp. 33. 2020 Jan 31.
• 1. Sarkar S
  2. Murphy MA
  3. Dammer EB
  4. Olsen AL
  5. Rangaraju S
  6. Fraenkel E
  7. Feany MB
  Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy.; NPJ Parkinson's disease; Vol 6(1), pp. 40. 2020 Jan 11.
• 1. Ghaisas S
  2. Langley MR
  3. Palanisamy BN
  4. Dutta S
  5. Narayanaswamy K
  6. Plummer PJ
  7. Sarkar S
  8. Ay M
  9. Jin H
  10. Anantharam V
  11. Kanthasamy A
  12. Kanthasamy AG
  MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson's disease.; Neurotoxicology; Vol 75, pp. 186-199. 2019 Sep 07.
• 1. Panicker N
  2. Sarkar S
  3. Harischandra DS
  4. Neal M
  5. Kam TI
  6. Jin H
  7. Saminathan H
  8. Langley M
  9. Charli A
  10. Samidurai M
  11. Rokad D
  12. Ghaisas S
  13. Pletnikova O
  14. Dawson VL
  15. Dawson TM
  16. Anantharam V
  17. Kanthasamy AG
  18. Kanthasamy A
  Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.; The Journal of experimental medicine; Vol 216(6), pp. 1411-1430. 2019 Apr 29.
• 1. Harischandra DS
  2. Rokad D
  3. Neal ML
  4. Ghaisas S
  5. Manne S
  6. Sarkar S
  7. Panicker N
  8. Zenitsky G
  9. Jin H
  10. Lewis M
  11. Huang X
  12. Anantharam V
  13. Kanthasamy A
  14. Kanthasamy AG
  Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.; Science signaling; Vol 12(572). 2019 Mar 12.
• 1. Sarkar S
  2. Rokad D
  3. Malovic E
  4. Luo J
  5. Harischandra DS
  6. Jin H
  7. Anantharam V
  8. Huang X
  9. Lewis M
  10. Kanthasamy A
  11. Kanthasamy AG
  Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.; Science signaling; Vol 12(563). 2019 Jan 08.
• 1. Neal M
  2. Luo J
  3. Harischandra DS
  4. Gordon R
  5. Sarkar S
  6. Jin H
  7. Anantharam V
  8. Désaubry L
  9. Kanthasamy A
  10. Kanthasamy A
  Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes.; Glia; Vol 66(10), pp. 2137-2157. 2018 Sep 12.
• 1. Singh N
  2. Lawana V
  3. Luo J
  4. Phong P
  5. Abdalla A
  6. Palanisamy B
  7. Rokad D
  8. Sarkar S
  9. Jin H
  10. Anantharam V
  11. Kanthasamy AG
  12. Kanthasamy A
  Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events.; Neurobiology of disease; Vol 117, pp. 82-113. 2018 May 31.
• 1. Sarkar S
  2. Malovic E
  3. Sarda D
  4. Lawana V
  5. Rokad D
  6. Jin H
  7. Anantharam V
  8. Kanthasamy A
  9. Kanthasamy AG
  Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults.; Neurotoxicology; Vol 67, pp. 129-140. 2018 May 30.
• 1. Anantharam P
  2. Whitley EM
  3. Mahama B
  4. Kim DS
  5. Sarkar S
  6. Santana C
  7. Chan A
  8. Kanthasamy AG
  9. Kanthasamy A
  10. Boss GR
  11. Rumbeiha WK
  Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model.; Annals of the New York Academy of Sciences; Vol 1408(1), pp. 61-78. 2017 Nov.
• 1. Sarkar S
  2. Malovic E
  3. Harischandra DS
  4. Ngwa HA
  5. Ghosh A
  6. Hogan C
  7. Rokad D
  8. Zenitsky G
  9. Jin H
  10. Anantharam V
  11. Kanthasamy AG
  12. Kanthasamy A
  Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.; Neurotoxicology; Vol 64, pp. 204-218. 2017 May 21.
• 1. Lawana V
  2. Singh N
  3. Sarkar S
  4. Charli A
  5. Jin H
  6. Anantharam V
  7. Kanthasamy AG
  8. Kanthasamy A
  Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System.; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology; Vol 12(4), pp. 624-660. 2017 May 02.
• 1. Sarkar S
  2. Malovic E
  3. Plante B
  4. Zenitsky G
  5. Jin H
  6. Anantharam V
  7. Kanthasamy A
  8. Kanthasamy AG
  Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility.; Journal of visualized experiments : JoVE. 2017 Apr 13.
• 1. Langley M
  2. Ghosh A
  3. Charli A
  4. Sarkar S
  5. Ay M
  6. Luo J
  7. Zielonka J
  8. Brenza T
  9. Bennett B
  10. Jin H
  11. Ghaisas S
  12. Schlichtmann B
  13. Kim D
  14. Anantharam V
  15. Kanthasamy A
  16. Narasimhan B
  17. Kalyanaraman B
  18. Kanthasamy AG
  Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.; Antioxidants & redox signaling; Vol 27(14), pp. 1048-1066. 2017 Apr 04.
• 1. Sharma S
  2. Carlson S
  3. Puttachary S
  4. Sarkar S
  5. Showman L
  6. Putra M
  7. Kanthasamy AG
  8. Thippeswamy T
  Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy.; Neurobiology of disease; Vol 110, pp. 102-121. 2017 Jan 29.
• 1. Sarkar S
  2. Malovic E
  3. Harishchandra DS
  4. Ghaisas S
  5. Panicker N
  6. Charli A
  7. Palanisamy BN
  8. Rokad D
  9. Jin H
  10. Anantharam V
  11. Kanthasamy A
  12. Kanthasamy AG
  Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.; NPJ Parkinson's disease; Vol 3, pp. 30. 2017 Jan 17.
• 1. Gordon R
  2. Singh N
  3. Lawana V
  4. Ghosh A
  5. Harischandra DS
  6. Jin H
  7. Hogan C
  8. Sarkar S
  9. Rokad D
  10. Panicker N
  11. Anantharam V
  12. Kanthasamy AG
  13. Kanthasamy A
  Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.; Neurobiology of disease; Vol 93, pp. 96-114. 2016 May 02.
• 1. Panicker N
  2. Saminathan H
  3. Jin H
  4. Neal M
  5. Harischandra DS
  6. Gordon R
  7. Kanthasamy K
  8. Lawana V
  9. Sarkar S
  10. Luo J
  11. Anantharam V
  12. Kanthasamy AG
  13. Kanthasamy A
  Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(27), pp. 10058-77. 2015 Jul 08.