URMC / Labs / Waugh Lab / Publications Recent Publications Huang YSDelgadillo LFCyr KHKingsley PDAn XMcGrath KEMohandas NConboy JGWaugh REWan JPalis J (2017 Jul 12). Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating. Scientific reports. Vats KMarsh GHarding KZampetakis IWaugh REBenoit DS (2017 Apr). Nanoscale physicochemical properties of chain- and step-growth polymerized PEG hydrogels affect cell-material interactions. Journal of biomedical materials research. Part A. Svetina SKokot GKebe TŠŽekš BWaugh RE (2016 Jun). A novel strain energy relationship for red blood cell membrane skeleton based on spectrin stiffness and its application to micropipette deformation. Biomechanics and modeling in mechanobiology. Marsh GWaugh RE (2016 Jun). A simple approach for bioactive surface calibration using evanescent waves. Journal of microscopy. Hughes ADMarsh GWaugh REFoster DGKing MR (2015 Dec 22). Halloysite Nanotube Coatings Suppress Leukocyte Spreading. Langmuir : the ACS journal of surfaces and colloids. Cinar EZhou SDeCourcey JWang YWaugh REWan J (2015 Sep 22). Piezo1 regulates mechanotransductive release of ATP from human RBCs. Proceedings of the National Academy of Sciences of the United States of America. Beste MTLomakina EBHammer DAWaugh RE (2015 Sep). Immobilized IL-8 Triggers Phagocytosis and Dynamic Changes in Membrane Microtopology in Human Neutrophils. Annals of biomedical engineering. Kim AROlsen JLEngland SJHuang YSFegan KHDelgadillo LFMcGrath KEKingsley PDWaugh REPalis J (2015 Jun 9). Bmi-1 Regulates Extensive Erythroid Self-Renewal. Stem cell reports. Lomakina EBMarsh GWaugh RE (2014 Sep 16). Cell surface topography is a regulator of molecular interactions during chemokine-induced neutrophil spreading. Biophysical journal. Chung HHChan CKKhire TSMarsh GAClark AWaugh REMcGrath JL (2014 Jul 21). Highly permeable silicon membranes for shear free chemotaxis and rapid cell labeling. Lab on a chip. Waugh RE (2014 Apr 15). Forty-percent area strain in red cell membranes?-Doubtful. Biophysical journal. Sanchez-Lockhart MRojas AVFettis MMBauserman RHiga TRMiao HWaugh REMiller J (2014). T cell receptor signaling can directly enhance the avidity of CD28 ligand binding. PloS one. Gaborski TRSealander MNWaugh REMcGrath JL (2013 Dec). Dynamics of adhesion molecule domains on neutrophil membranes: surfing the dynamic cell topography. European biophysics journal : EBJ. Waugh REHuang YSArif BJBauserman RPalis J (2013 Apr). Development of membrane mechanical function during terminal stages of primitive erythropoiesis in mice. Experimental hematology. Marsh GWaugh RE (2013 Feb 21). Quantifying the mechanical properties of the endothelial glycocalyx with atomic force microscopy. Journal of visualized experiments : JoVE. Hyun YMSumagin RSarangi PPLomakina EOverstreet MGBaker CMFowell DJWaugh RESarelius IHKim M (2012 Jul 2). Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. The Journal of experimental medicine. Baker CMComrie WAHyun YMChung HLFedorchuk CALim KBrakebusch CMcGrath JLWaugh REMeier-Schellersheim MKim M (2012 Jun 26). Opposing roles for RhoH GTPase during T-cell migration and activation. Proceedings of the National Academy of Sciences of the United States of America. Gregoire SXiao JSilva BBGonzalez IAgidi PSKlein MIAmbatipudi KSRosalen PLBauserman RWaugh REKoo H (2011 Sep). Role of glucosyltransferase B in interactions of Candida albicans with Streptococcus mutans and with an experimental pellicle on hydroxyapatite surfaces. Applied and environmental microbiology. Sumagin RPrizant HLomakina EWaugh RESarelius IH (2010 Dec 1). LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ. Journal of immunology (Baltimore, Md. : 1950). Lomakina EBWaugh RE (2010 Jun 1). Signaling and Dynamics of Activation of LFA-1 and Mac-1 by Immobilized IL-8. Cellular and molecular bioengineering. Gaborski TRSealander MNEhrenberg MWaugh REMcGrath JL (2010 Jan). Image correlation microscopy for uniform illumination. Journal of microscopy. Lefort CTHyun YMSchultz JBLaw FYWaugh REKnauf PAKim M (2009 Nov 15). Outside-in signal transmission by conformational changes in integrin Mac-1. Journal of immunology (Baltimore, Md. : 1950). Hocdé SAHyrien OWaugh RE (2009 Jul 8). Molecular accessibility in relation to cell surface topography and compression against a flat substrate. Biophysical journal. Hocdé SAHyrien OWaugh RE (2009 Jul 8). Cell adhesion molecule distribution relative to neutrophil surface topography assessed by TIRFM. Biophysical journal. Hyun YMChung HLMcGrath JLWaugh REKim M (2009 Jul 1). Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1. Journal of immunology (Baltimore, Md. : 1950). Lomakina EKnauf PASchultz JBLaw FYMcGraw MDWaugh RE (2009 May). Activation of human neutrophil Mac-1 by anion substitution. Blood cells, molecules & diseases. Waugh RELomakina EB (2009 Jan). Active site formation, not bond kinetics, limits adhesion rate between human neutrophils and immobilized vascular cell adhesion molecule 1. Biophysical journal. Lomakina EBWaugh RE (2009 Jan). Adhesion between human neutrophils and immobilized endothelial ligand vascular cell adhesion molecule 1: divalent ion effects. Biophysical journal. Gaborski TRClark AWaugh REMcGrath JL (2008 Nov 15). Membrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophils. Biophysical journal. Kaba NKSchultz JLaw FYLefort CTMartel-Gallegos GKim MWaugh REArreola JKnauf PA (2008 Nov). Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils. American journal of physiology. Cell physiology. Butler JMohandas NWaugh RE (2008 Aug). Integral protein linkage and the bilayer-skeletal separation energy in red blood cells. Biophysical journal. Lomakina EBWaugh RE (2006 Oct). Dynamics of increased neutrophil adhesion to ICAM-1 after contacting immobilized IL-8. Annals of biomedical engineering. Hammer DAWaugh RE (2006 Feb). Teaching cellular engineering. Annals of biomedical engineering. Lomakina EBSpillmann CMKing MRWaugh RE (2004 Dec). Rheological analysis and measurement of neutrophil indentation. Biophysical journal. Spillmann CMLomakina EWaugh RE (2004 Dec). Neutrophil adhesive contact dependence on impingement force. Biophysical journal. Svetina SKuzman DWaugh REZiherl PZeks B (2004 May). The cooperative role of membrane skeleton and bilayer in the mechanical behaviour of red blood cells. Bioelectrochemistry (Amsterdam, Netherlands). Lomakina EBWaugh RE (2004 Feb). Micromechanical tests of adhesion dynamics between neutrophils and immobilized ICAM-1. Biophysical journal. Kuzman DSvetina SWaugh REZeks B (2004 Feb). Elastic properties of the red blood cell membrane that determine echinocyte deformability. European biophysics journal : EBJ. Spillmann COsorio DWaugh R (2002 Sep). Integrin activation by divalent ions affects neutrophil homotypic adhesion. Annals of biomedical engineering. Raphael RMWaugh RESvetina SZeks B (2001 Nov). Fractional occurrence of defects in membranes and mechanically driven interleaflet phospholipid transport. Physical review. E, Statistical, nonlinear, and soft matter physics. Waugh REMantalaris ABauserman RGHwang WCWu JH (2001 Mar 15). Membrane instability in late-stage erythropoiesis. Blood. Tees DFWaugh REHammer DA (2001 Feb). A microcantilever device to assess the effect of force on the lifetime of selectin-carbohydrate bonds. Biophysical journal. Murdock RCReynolds CSarelius IHWaugh RE (2000 Oct). Adaptation and survival of surface-deprived red blood cells in mice. American journal of physiology. Cell physiology. Tsai MAWaugh REKeng PC (1998 Jun). Passive mechanical behavior of human neutrophils: effects of colchicine and paclitaxel. Biophysical journal. Svetina SZeks BWaugh RERaphael RM (1998). Theoretical analysis of the effect of the transbilayer movement of phospholipid molecules on the dynamic behavior of a microtube pulled out of an aspirated vesicle. European biophysics journal : EBJ. Hwang WCWaugh RE (1997 Jun). Energy of dissociation of lipid bilayer from the membrane skeleton of red blood cells. Biophysical journal. Waugh REMcKenney JBBauserman RGBrooks DMValeri CRSnyder LM (1997 May). Surface area and volume changes during maturation of reticulocytes in the circulation of the baboon. The Journal of laboratory and clinical medicine. Waugh RESarelius IH (1996 Dec). Effects of lost surface area on red blood cells and red blood cell survival in mice. The American journal of physiology. Raphael RMWaugh RE (1996 Sep). Accelerated interleaflet transport of phosphatidylcholine molecules in membranes under deformation. Biophysical journal. Heinrich VWaugh RE (1996 Sep). A piconewton force transducer and its application to measurement of the bending stiffness of phospholipid membranes. Annals of biomedical engineering. Tsai MAWaugh REKeng PC (1996 Apr). Cell cycle-dependence of HL-60 cell deformability. Biophysical journal. Waugh RE (1996 Feb). Elastic energy of curvature-driven bump formation on red blood cell membrane. Biophysical journal. Khodadad JKWaugh REPodolski JLJosephs RSteck TL (1996 Feb). Remodeling the shape of the skeleton in the intact red cell. Biophysical journal. Waugh REHwang WCSarelius IH (1996). Combined use of fluorescence microscopy and micromechanical measurement to assess cell and membrane properties. Pflügers Archiv : European journal of physiology. Ostberg JRDragone LLWaugh RERyan DFrelinger JGBarth RK (1996 Jan 01). Disregulated expression of leukosialin (CD43) in the erythroid lineage of transgenic mice results in microcytosis Transgenics. Tsai MAWaugh REKeng PC (1996 Jan). Changes in HL-60 cell deformability during differentiation induced by DMSO. Biorheology. Waugh REBauserman RG (1995 May). Physical measurements of bilayer-skeletal separation forces. Annals of biomedical engineering. Tsai MAFrank RSWaugh RE (1994 Jun). Passive mechanical behavior of human neutrophils: effect of cytochalasin B. Biophysical journal. Tsai MAFrank RSWaugh RE (1993 Nov). Passive mechanical behavior of human neutrophils: power-law fluid. Biophysical journal. Song JWaugh RE (1993 Jun). Bending rigidity of SOPC membranes containing cholesterol. Biophysical journal. Bozic BSvetina SZeks BWaugh RE (1992 Apr). Role of lamellar membrane structure in tether formation from bilayer vesicles. Biophysical journal. Waugh RESong JSvetina SZeks B (1992 Apr). Local and nonlocal curvature elasticity in bilayer membranes by tether formation from lecithin vesicles. Biophysical journal. Waugh RENarla MJackson CWMueller TJSuzuki TDale GL (1992 Mar 1). Rheologic properties of senescent erythrocytes: loss of surface area and volume with red blood cell age. Blood. Waugh RE (1992 Jan 01). Red cell deformability in different vertebrate animals Clin. Hemorheol. Waugh RE (1991 Dec 1). Reticulocyte rigidity and passage through endothelial-like pores. Blood. Waugh RESong J (1991 Jan 01). Measurements of membrane bending stiffness: contributions from intrinsic monolayer stiffness and monolayer coupling Periodicum Biologorum. Song JWaugh RE (1990 Aug). Bilayer membrane bending stiffness by tether formation from mixed PC-PS lipid vesicles. Journal of biomechanical engineering. Katnik CWaugh R (1990 Apr). Electric fields induce reversible changes in the surface to volume ratio of micropipette-aspirated erythrocytes. Biophysical journal. Katnik CWaugh R (1990 Apr). Alterations of the apparent area expansivity modulus of red blood cell membrane by electric fields. Biophysical journal. Waugh REErwin G (1989 May). Flexural rigidity of marginal bands isolated from erythrocytes of the newt. The Journal of cell biology. Bo LWaugh RE (1989 Mar). Determination of bilayer membrane bending stiffness by tether formation from giant, thin-walled vesicles. Biophysical journal. Waugh RE (1989 Jan 01). Structural alterations affect the mechanical behavior of erythrocyte membranes Stud. Biophys.. Waugh REAgre P (1988 Jan). Reductions of erythrocyte membrane viscoelastic coefficients reflect spectrin deficiencies in hereditary spherocytosis. The Journal of clinical investigation. Shields MLa Celle PWaugh REScholz MPeters RPassow H (1987 Nov 27). Effects of intracellular Ca2+ and proteolytic digestion of the membrane skeleton on the mechanical properties of the red blood cell membrane. Biochimica et biophysica acta. Waugh REHochmuth RM (1987 Sep). Mechanical equilibrium of thick, hollow, liquid membrane cylinders. Biophysical journal. Waugh RE (1987 Mar). Effects of inherited membrane abnormalities on the viscoelastic properties of erythrocyte membrane. Biophysical journal. Hochmuth RMWaugh RE (1987). Erythrocyte membrane elasticity and viscosity. Annual review of physiology. Waugh REErwin GBouzid A (1986 Aug). Measurement of the extensional and flexural rigidities of a subcellular structure: marginal bands isolated from erythrocytes of the newt. Journal of biomechanical engineering. Waugh RE (1986 Jul). Effects of 2,3-diphosphoglycerate on the mechanical properties of erythrocyte membrane. Blood. Waugh RESassi M (1986 Jul). An in vitro model of erythroid egress in bone marrow. Blood. Waugh REHsu LLClark PClark A (1984). Analysis of cell egress in bone marrow. Kroc Foundation series. Waugh RE (1983). Effects of abnormal cytoskeletal structure on erythrocyte membrane mechanical properties. Cell motility. Waugh RE (1982 Sep). Temperature dependence of the yield shear resultant and the plastic viscosity coefficient of erythrocyte membrane. Implications about molecular events during membrane failure. Biophysical journal. Waugh RE (1982 Apr). Surface viscosity measurements from large bilayer vesicle tether formation. I. Analysis. Biophysical journal. Waugh RE (1982 Apr). Surface viscosity measurements from large bilayer vesicle tether formation. II. Experiments. Biophysical journal. Waugh REvans EA (1979 Apr). Thermoelasticity of red blood cell membrane. Biophysical journal. Lloyd JRMeuller TJWaugh RE (1978 Jan 01). Experimental observations on the thermal fragility of erythrocytes including the effects of storage and anticoagulant J. Biomechan. Engr.. Evans EAWaugh R (1977 Dec). Osmotic correction to elastic area compressibility measurements on red cell membrane. Biophysical journal. Evans EAWaugh R (1977 Jan 01). Mechano chemistry of closed vesicular membrane systems J. Coll. Int. Sci.. Evans EAWaugh RMelnik L (1976 Jun). Elastic area compressibility modulus of red cell membrane. Biophysical journal. Waugh REvans EA (1976 Jan 01). Viscoelastic properties of erythrocyte membranes of different vertebrate animals Microvascular Res..