BME 265/465 PHP 465 – Intro to Cell Mechanics and Mechanobiology
Fall Semester, 4 Cr.
Course Description: This course will examine the mechanical properties of cells and the mechanotransduction processes of clinical and technological importance. Topics covered include the role of mechanotransducing biomolecules, models of cell mechanics, and the methods to measure mechanical properties of cells. This course will also introduce students to effects of internal / external mechanical stimuli on cellular processes which may lead to various human diseases. Students will learn basic terminology and concepts of mechanics at the molecular and cellular level with an emphasis on quantitative analysis, modeling, and applications to clinical medicine. Two additional laboratory modules will provide hands-on experience to measure cellular mechanical properties and mechanotransduction signaling using FRET-based force sensors and Calcium dye.
BME/PHP 468 – Intro to Structure and Analysis of Biomolecules
Spring Semester, 2 Cr.
Course Description: This course is designed to provide beginning to intermediate level training for students to learn the basic principles of protein & DNA structure, function and associated human disease. The course will be taught using multiple instructional methods, including lectures, labs using the open source program Visual Molecular Dynamics (VMD), and oral presentations with an associated critical discussion. After class, students will be able to (1) understand the principles of protein & DNA structure-dynamics-function relationships, (2) learn how to visualize and manipulate protein structures from the Protein Data Bank (PDB) using the VMD software, and (3) gain experience reading and critically discussing original literature in this field.
IND 464 Musculoskeletal Basic Science
Course Description: This course provides an overview of key basic science concepts relating to musculoskeletal tissues including bone, bone marrow, cartilage, muscle and tendon. Lectures address a range of topics, including developmental biology, musculoskeletal tissue homeostasis and pathologies. Lectures are designed for real time interaction, and student/fellows are encouraged to contribute to the discussion.
IND 532 –Current Techniques in Musculoskeletal Research
IND 501/506 – Ethics and Professional Integrity in Research
Fall 2018, Fall 2019
Course Description: This course is required of all graduate students in the biomedical sciences in the School of Medicine and Dentistry. The course features 10 sessions consisting of lecture/case study presentations followed by small group discussions that provide information on the various topics that the National Institutes for Health consider essential for the responsible conduct of research. Specific topics include the ethical issues underlying human experimentation and related conflicts of interest, animal experimentation, the mentor-mentee relationship, scientific misconduct and plagiarism, collaborative and team science, and publication/authorship. The course also provides an introduction to approaches for improving rigor and transparency with the goal of enhancing research reproducibility. 1 credit hour. (Fall)