URMC / Labs / Xing Lab / Publications Publications Lawal RAZhou XBatey KHoffman CMGeorger MARadtke FHilton MJXing LFrisch BJCalvi LM (2017 Jun). The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Xing LHiguma TWang ZAguirre ADMizuno KTakano MDauerman HLPark SJJang YKim CJKim SJChoi SYItoh TUemura SLowe HWalters DLBarlis PLee SLerman AToma CTan JWCYamamoto EBryniarski KDai JZanchin TZhang SYu BLee HFujimoto JFuster VJang IK (2017 May 23). Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study. Journal of the American College of Cardiology. Huang QQBirkett RDoyle REHaines GKPerlman HShi BHoman PXing LPope RM (2017 May 16). Association of Increased F4/80(high) Macrophages With Suppression of Serum-Transfer Arthritis in Mice With Reduced FLIP in Myeloid Cells. Arthritis & rheumatology (Hoboken, N.J.). Sun WZhang HWang HChiu YGRitchlin CTKiernan ABoyce BFXing L (2017 Mar 03). Targeting Notch-activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Liu JLi XZhang HGu RWang ZGao ZXing L (2017 Mar). Ubiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins. Bone & joint research. Li XSun WLi JWang MZhang HPei LBoyce BFWang ZXing L (2017 Feb 01). Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid. Scientific reports. Bouta EMKuzin Ide Mesy Bentley KWood RWRahimi HJi RCRitchlin CTBottaro AXing LSchwarz EM (2017 Jan 24). Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress. Arthritis & rheumatology (Hoboken, N.J.). Wang WWang HZhou XLi XSun WDellinger MBoyce BFXing L (2017 Jan 04). Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Xu HBouta EMWood RWSchwarz EMWang YXing L (2017). Utilization of longitudinal ultrasound to quantify joint soft-tissue changes in a mouse model of posttraumatic osteoarthritis. Bone research. Li JChen YZhang LXing LXu HWang YShi QLiang Q (2016 Dec 04). Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells. Journal of ethnopharmacology. Huang QQHossain MMSun WXing LPope RMJin JP (2016 Oct 01). Deletion of calponin 2 in macrophages attenuates the severity of inflammatory arthritis in mice. American journal of physiology. Cell physiology. Zhang HSun WLi XWang MBoyce BFHilton MJXing L (2016 Sep). Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation. Bone. Meednu NZhang HOwen TSun WWang VCistrone CRangel-Moreno JXing LAnolik JH (2016 Apr). Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis. Arthritis & rheumatology (Hoboken, N.J.). Liang QJu YChen YWang WLi JZhang LXu HWood RWSchwarz EMBoyce BFWang YXing L (2016 Mar 12). Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice. Arthritis research & therapy. Rahimi HBell RBouta EMWood RWXing LRitchlin CTSchwarz EM (2016). Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential. Arthritis research & therapy. Chen YLi JLi QWang TXing LXu HWang YShi QZhou QLiang Q (2016). Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function. Evidence-based complementary and alternative medicine : eCAM. Liang QQShi QWood RWXing LPWang YJ (2015 Sep). Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis. Chinese journal of integrative medicine. Shu LBeier ESheu TZhang HZuscik MJPuzas EJBoyce BFMooney RAXing L (2015 Apr). High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment. Calcified tissue international. Boyce BFXiu YLi JXing LYao Z (2015 Mar 27). NF-κB-Mediated Regulation of Osteoclastogenesis. Endocrinology and metabolism (Seoul, Korea). Bouta EMLi JJu YBrown EBRitchlin CTXing LSchwarz EM (2015 Jan 15). The Role of the Lymphatic System in Inflammatory-Erosive Arthritis. Seminars in cell & developmental biology. Wang ZWang JLi XXing LDing YShi PZhang YGuo SShu XShan B (2014 Oct). Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2. International journal of oncology. Cui HBGe HEBai XYZhang WZhang YYWang JLi XXing LPGuo SHWang ZY (2014 May). Effect of neoadjuvant chemotherapy combined with hyperthermic intraperitoneal perfusion chemotherapy on advanced gastric cancer. Experimental and therapeutic medicine. Yao ZLi YYin XDong YXing LBoyce BF (2014 Apr). NF-κB RelB negatively regulates osteoblast differentiation and bone formation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Juneja SCVonica AZeiss CLezon-Geyda KYatsula BSell DRMonnier VMLin SArdito TEyre DReynolds DYao ZAwad HAYu HWilson MHonnons SBoyce BFXing LZhang YPerkins AS (2014 Mar). Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia. Bone. Shi JLiang QZuscik MShen JChen DXu HWang YJChen YWood RWLi JBoyce BFXing L (2014 Mar). Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice. Arthritis & rheumatology (Hoboken, N.J.). Brown MLYukata KFarnsworth CWChen DGAwad HHilton MJO'Keefe RJXing LMooney RAZuscik MJ (2014). Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. PloS one. Xing LBoyce BF (2014). RANKL-based osteoclastogenic assays from murine bone marrow cells. Methods in molecular biology (Clifton, N.J.). Wang BJin HZhu MLi JZhao LZhang YTang DXiao GXing LBoyce BFChen D (2014 Jan). Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of osteoclast formation in a murine model. Arthritis & rheumatology (Hoboken, N.J.). Xing LChen DBoyce BF (2013 Dec). Mice Deficient in NF-κB p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism. Bone research. Inzana JAKung MShu LHamada DXing LPZuscik MJAwad HAMooney RA (2013 Nov). Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur. Bone. Shu LZhang HBoyce BFXing L (2013 Sep). Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migration. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Ju YLi JXie CRitchlin CTXing LHilton MJSchwarz EM (2013 Sep). Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice. Genesis (New York, N.Y. : 2000). Zhang HWu CMatesic LELi XWang ZBoyce BFXing L (2013 Aug 2). Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6. The Journal of biological chemistry. Zhang HXing L (2013 Aug). Ubiquitin e3 ligase itch negatively regulates osteoblast differentiation from mesenchymal progenitor cells. Stem cells (Dayton, Ohio). Li JJu YBouta EMXing LWood RWKuzin IBottaro ARitchlin CTSchwarz EM (2013 Jan). Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow. Arthritis and rheumatism. Bouta EMJu YRahimi Hde Mesy-Bentley KLWood RWXing LSchwarz EM (2013). Power Doppler ultrasound phenotyping of expanding versus collapsed popliteal lymph nodes in murine inflammatory arthritis. PloS one. Xing LXiu YBoyce BF (2012 Dec 18). Osteoclast fusion and regulation by RANKL-dependent and independent factors. World journal of orthopedics. Takahata MMaher JRJuneja SCInzana JXing LSchwarz EMBerger AJAwad HA (2012 Nov). Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk. Arthritis and rheumatism. Ju YRahimi HLi JWood RWXing LSchwarz EM (2012 Jun). Validation of 3-dimensional ultrasound versus magnetic resonance imaging quantification of popliteal lymph node volume as a biomarker of erosive inflammatory arthritis in mice. Arthritis and rheumatism. Zhao CXiu YAshton JXing LMorita YJordan CTBoyce BF (2012 Apr). Noncanonical NF-κB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions. Stem cells (Dayton, Ohio). Subik KShu LWu CLiang QHicks DBoyce BSchiffhauer LChen DChen CTang PXing L (2012 Apr). The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis. Bone. Frisch BJAshton JMXing LBecker MWJordan CTCalvi LM (2012 Jan 12). Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia. Blood. Bouta EMWood RWPerry SWBrown EBRitchlin CTXing LSchwarz EM (2011 Dec). Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes. Annals of the New York Academy of Sciences. Boyce BXing L (2011 Dec 1). Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data. Clinical investigation. Zhao LHuang JZhang HWang YMatesic LETakahata MAwad HChen DXing L (2011 Oct). Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1. Stem cells (Dayton, Ohio). Zhou QGuo RWood RBoyce BFLiang QWang YJSchwarz EMXing L (2011 Aug). Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice. Arthritis and rheumatism. Li JZhou QWood RWKuzin IBottaro ARitchlin CTXing LSchwarz EM (2011). CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice. Arthritis research & therapy. Li JKuzin IMoshkani SProulx STXing LSkrombolas DDunn RSanz ISchwarz EMBottaro A (2010 Jun 1). Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy. Journal of immunology (Baltimore, Md. : 1950). Zhao LHuang JGuo RWang YChen DXing L (2010 Jun). Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Xing LZhang MChen D (2010 Jun 1). Smurf control in bone cells. Journal of cellular biochemistry.