URochester Medicine / Labs / Yao-Z Lab / Publications

Publications

1. Tang C
2. Sittplangkoon C
3. Xiang C
4. Schnur L
5. Duan R
6. Lin X
7. Li D
8. Yao Z
Evaluating Osteoarthritis Severity in Mice Using μCT-Derived Geometric Indices.; Biology; Vol 15(3). 2026 Jan 31.
1. Yao Z
2. Sittplangkoon C
Chimeric antigen receptor cells as a tool for localized delivery of TNFα in solid cancer treatment.; Human vaccines & immunotherapeutics; Vol 21(1), pp. 2576262. 2025 Oct 21.
1. Yao Z
2. Ayoub A
3. Srinivasan V
4. Wu J
5. Tang C
6. Duan R
7. Milosavljevic A
8. Xing L
9. Ebetino FH
10. Frontier AJ
11. Boyce BF
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects.; Bone research; Vol 12(1), pp. 52. 2024 Sep 05.
1. Duan R
2. Milton P
3. Sittplangkoon C
4. Liu X
5. Sui Z
6. Boyce BF
7. Yao Z
Chimeric antigen receptor dendritic cells targeted delivery of a single tumoricidal factor for cancer immunotherapy.; Cancer immunology, immunotherapy : CII; Vol 73(10), pp. 203. 2024 Aug 06.
1. Yao Z
2. Ayoub A
3. Srinivasan V
4. Wu J
5. Tang C
6. Duan R
7. Milosavljevic A
8. Ebetino F
9. Frontier A
10. Boyce B
Hydroxychloroquine and a low activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects.; Research square. 2024 May 03.
1. Boyce BF
2. Li J
3. Yao Z
4. Xing L
Nuclear Factor-Kappa B Regulation of Osteoclastogenesis and Osteoblastogenesis.; Endocrinology and metabolism (Seoul, Korea). 2023 Sep 26.
1. Li J
2. Yao Z
3. Liu X
4. Duan R
5. Yi X
6. Ayoub A
7. Sanders JO
8. Mesfin A
9. Xing L
10. Boyce BF
TGFβ1+CCR5+ neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice.; Nature communications; Vol 14(1), pp. 159. 2023 Jan 11.
1. Yao Z
2. Boyce BF
TGFβ priming promotes TNF-induced bone erosion: a promising new target in RA?; Nature reviews. Rheumatology. 2022 Sep 16.
1. Liu X
2. Yao JJ
3. Chen Z
4. Lei W
5. Duan R
6. Yao Z
Lipopolysaccharide sensitizes the therapeutic response of breast cancer to IAP antagonist.; Frontiers in immunology; Vol 13, pp. 906357. 2022 Aug 31.
1. Shen G
2. Liu X
3. Lei W
4. Duan R
5. Yao Z
Plumbagin is a NF-κB-Inducing Kinase Inhibitor with Dual Anabolic and Anti-Resorptive Effects that Prevents Menopausal-Related Osteoporosis in Mice.; The Journal of biological chemistry. 2022 Feb 27.
1. Yao Z
2. Getting SJ
3. Locke IC
Regulation of TNF-Induced Osteoclast Differentiation.; Cells; Vol 11(1). 2021 Dec 31.
1. Yi X
2. Liu X
3. Kenney HM
4. Duan R
5. Lin X
6. Schwarz E
7. Yao Z
TNF-polarized macrophages produce insulin like 6 peptide to stimulate bone formation in rheumatoid arthritis in mice.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021 Sep 29.
1. Sun S
2. Tao J
3. Sedghizadeh PP
4. Cherian P
5. Junka AF
6. Sodagar E
7. Xing L
8. Boeckman RK
9. Srinivasan V
10. Yao Z
11. Boyce BF
12. Lipe B
13. Neighbors JD
14. Russell G
15. McKenna CE
16. Ebetino FH
Bisphosphonates for delivering drugs to bone.; British journal of pharmacology. 2020 Sep 02.
1. Xing L
2. Ebetino FH
3. Boeckman RK
4. Srinivasan V
5. Tao J
6. Sawyer TK
7. Li J
8. Yao Z
9. Boyce BF
Targeting anti-cancer agents to bone using bisphosphonates.; Bone. 2020 Jun 22.
1. Lei W
2. Duan R
3. Li J
4. Liu X
5. Huston A
6. Boyce BF
7. Yao Z
The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice.; Scientific reports; Vol 10(1). 2020 Apr 24.
1. Li J
2. Yi X
3. Yao Z
4. Chakkalakal JV
5. Xing L
6. Boyce BF
TNF receptor-associated factor 6 mediates TNFα-induced skeletal muscle atrophy in mice during aging.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2020 Apr 08.
1. Li J
2. Ayoub A
3. Xiu Y
4. Yin X
5. Sanders JO
6. Mesfin A
7. Xing L
8. Yao Z
9. Boyce BF
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.; Nature communications; Vol 10(1). 2019 Jun 26.
1. Boyce BF
2. Li J
3. Xing L
4. Yao Z
Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption.; Frontiers in immunology; Vol 9. 2018.
1. Yao Z
2. Lei W
3. Duan R
4. Li Y
5. Luo L
6. Boyce BF
RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors.; The Journal of biological chemistry; Vol 292(24). 2017 Jun 16.
1. Krieger NS
2. Yao Z
3. Kyker-Snowman K
4. Kim MH
5. Boyce BF
6. Bushinsky DA
Increased bone density in mice lacking the proton receptor OGR1.; Kidney international; Vol 89(3). 2016 Mar.
1. Boyce BF
2. Xiu Y
3. Li J
4. Xing L
5. Yao Z
NF-κB-Mediated Regulation of Osteoclastogenesis.; Endocrinology and metabolism (Seoul, Korea); Vol 30(1). 2015 Mar 27.
1. Bhardwaj R
2. Yester JW
3. Singh SK
4. Biswas DD
5. Surace MJ
6. Waters MR
7. Hauser KF
8. Yao Z
9. Boyce BF
10. Kordula T
RelB/p50 complexes regulate cytokine-induced YKL-40 expression.; Journal of immunology (Baltimore, Md. : 1950); Vol 194(6). 2015 Mar 15.
1. Zhao Z
2. Hou X
3. Yin X
4. Li Y
5. Duan R
6. Boyce BF
7. Yao Z
TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression.; PloS one; Vol 10(8). 2015.
1. Zhang H
2. Hilton MJ
3. Anolik JH
4. Welle SL
5. Zhao C
6. Yao Z
7. Li X
8. Wang Z
9. Boyce BF
10. Xing L
NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.; The Journal of clinical investigation; Vol 124(7). 2014 Jul.
1. Yao Z
2. Li Y
3. Yin X
4. Dong Y
5. Xing L
6. Boyce BF
NF-κB RelB negatively regulates osteoblast differentiation and bone formation.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 29(4). 2014 Apr.
1. Juneja SC
2. Vonica A
3. Zeiss C
4. Lezon-Geyda K
5. Yatsula B
6. Sell DR
7. Monnier VM
8. Lin S
9. Ardito T
10. Eyre D
11. Reynolds D
12. Yao Z
13. Awad HA
14. Yu H
15. Wilson M
16. Honnons S
17. Boyce BF
18. Xing L
19. Zhang Y
20. Perkins AS
Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.; Bone; Vol 60. 2014 Mar.
1. Xiu Y
2. Xu H
3. Zhao C
4. Li J
5. Morita Y
6. Yao Z
7. Xing L
8. Boyce BF
Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation.; The Journal of clinical investigation; Vol 124(1). 2014 Jan.
1. Boyce BF
2. Yao Z
3. Xing L
Functions of nuclear factor kappaB in bone.; Annals of the New York Academy of Sciences; Vol 1192. 2010 Mar.
1. Kiebala M
2. Polesskaya O
3. Yao Z
4. Perry SW
5. Maggirwar SB
Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production.; PloS one; Vol 5(7). 2010.
1. Yao Z
2. Xing L
3. Boyce BF
NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.; The Journal of clinical investigation; Vol 119(10). 2009 Oct.
1. Boyce BF
2. Yao Z
3. Xing L
Osteoclasts have multiple roles in bone in addition to bone resorption.; Critical reviews in eukaryotic gene expression; Vol 19(3). 2009.
1. Yao Z
2. Li P
3. Zhang Q
4. Guo R
5. Schwarz EM
6. Boyce BF
7. Xing L
Disruption of Rankl/Rank Signaling Reduces TNF-Induced Joint Inflammation In Vivo. The Open Arthritis Journal, 2009, 2, 7-13.; The Open Arthritis Journal; Vol 2, pp. 7-9. 2009 Jan 01.
1. Yao Z
2. Xing L
3. Qin C
4. Schwarz EM
5. Boyce BF
Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism.; The Journal of biological chemistry; Vol 283(15). 2008 Apr 11.
1. Engin F
2. Yao Z
3. Yang T
4. Zhou G
5. Bertin T
6. Jiang MM
7. Chen Y
8. Wang L
9. Zheng H
10. Sutton RE
11. Boyce BF
12. Lee B
Dimorphic effects of Notch signaling in bone homeostasis.; Nature medicine; Vol 14(3). 2008 Mar.
1. Boyce BF
2. Yao Z
3. Zhang Q
4. Guo R
5. Lu Y
6. Schwarz EM
7. Xing L
New roles for osteoclasts in bone.; Annals of the New York Academy of Sciences; Vol 1116. 2007 Nov.
1. Yamashita T
2. Yao Z
3. Li F
4. Zhang Q
5. Badell IR
6. Schwarz EM
7. Takeshita S
8. Wagner EF
9. Noda M
10. Matsuo K
11. Xing L
12. Boyce BF
NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.; The Journal of biological chemistry; Vol 282(25). 2007 Jun 22.
1. Zhang Q
2. Lu Y
3. Proulx ST
4. Guo R
5. Yao Z
6. Schwarz EM
7. Boyce BF
8. Xing L
Increased lymphangiogenesis in joints of mice with inflammatory arthritis.; Arthritis research & therapy; Vol 9(6). 2007.
1. Morello R
2. Bertin TK
3. Chen Y
4. Hicks J
5. Tonachini L
6. Monticone M
7. Castagnola P
8. Rauch F
9. Glorieux FH
10. Vranka J
11. Bächinger HP
12. Pace JM
13. Schwarze U
14. Byers PH
15. Weis M
16. Fernandes RJ
17. Eyre DR
18. Yao Z
19. Boyce BF
20. Lee B
CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta.; Cell; Vol 127(2). 2006 Oct 20.
1. Boyce BF
2. Xing L
3. Yao Z
4. Yamashita T
5. Shakespeare WC
6. Wang Y
7. Metcalf CA
8. Sundaramoorthi R
9. Dalgarno DC
10. Iuliucci JD
11. Sawyer TK
SRC inhibitors in metastatic bone disease.; Clinical cancer research : an official journal of the American Association for Cancer Research; Vol 12(20 Pt 2). 2006 Oct 15.
1. Yao Z
2. Li P
3. Zhang Q
4. Schwarz EM
5. Keng P
6. Arbini A
7. Boyce BF
8. Xing L
Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression.; The Journal of biological chemistry; Vol 281(17). 2006 Apr 28.
1. Boyce BF
2. Xing L
3. Yao Z
4. Shakespeare WC
5. Wang Y
6. Metcalf CA
7. Sundaramoorthi R
8. Dalgarno DC
9. Iuliucci JD
10. Sawyer TK
Future anti-catabolic therapeutic targets in bone disease.; Annals of the New York Academy of Sciences; Vol 1068. 2006 Apr.
1. Kaneki H
2. Guo R
3. Chen D
4. Yao Z
5. Schwarz EM
6. Zhang YE
7. Boyce BF
8. Xing L
Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.; The Journal of biological chemistry; Vol 281(7). 2006 Feb 17.
1. Zhang Q
2. Badell IR
3. Schwarz EM
4. Boulukos KE
5. Yao Z
6. Boyce BF
7. Xing L
Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2.; Arthritis and rheumatism; Vol 52(9). 2005 Sep.
1. Boyce BF
2. Li P
3. Yao Z
4. Zhang Q
5. Badell IR
6. Schwarz EM
7. O'Keefe RJ
8. Xing L
TNF-alpha and pathologic bone resorption.; The Keio journal of medicine; Vol 54(3). 2005 Sep.
1. Boyce BF
2. Yamashita T
3. Yao Z
4. Zhang Q
5. Li F
6. Xing L
Roles for NF-kappaB and c-Fos in osteoclasts.; Journal of bone and mineral metabolism; Vol 23 Suppl. 2005.
1. Kapur RP
2. Yao Z
3. Iida MH
4. Clarke CM
5. Doggett B
6. Xing L
7. Boyce BF
Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 19(10). 2004 Oct.
1. Yao Z
2. Lafage-Proust MH
3. Plouët J
4. Bloomfield S
5. Alexandre C
6. Vico L
Increase of both angiogenesis and bone mass in response to exercise depends on VEGF.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 19(9). 2004 Sep.