URMC / Labs / Yi-Fen Lee Lab / Publications Publications Silvers CRMiyamoto HMessing EMNetto GJLee YF Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.; Oncotarget; Vol 8(53). 2017 Oct 31. Silvers CRLiu YRWu CHMiyamoto HMessing EMLee YF Identification of extracellular vesicle-borne periostin as a feature of muscle-invasive bladder cancer.; Oncotarget. 2016 Mar 10. Yasmin-Karim SKing MRMessing EMLee YF E-selectin ligand-1 controls circulating prostate cancer cell rolling/adhesion and metastasis.; Oncotarget; Vol 5(23). 2014 Dec 15. Beckham CJOlsen JYin PNWu CHTing HJHagen FKScosyrev EMessing EMLee YF Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression.; The Journal of urology; Vol 192(2). 2014 Aug. Lin SJLee SOLee YFMiyamoto HYang DRLi GChang C TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system.; Carcinogenesis; Vol 35(6). 2014 Jun. Hsu JWYin PNWood RMessing JMessing ELee YF 1 alpha, 25-dihydroxylvitamin D3 promotes Bacillus Calmette-Guérin immunotherapy of bladder cancer.; Oncotarget; Vol 4(12). 2013 Dec. Ting HJMessing JYasmin-Karim SLee YF Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin D.; The Journal of biological chemistry; Vol 288(1). 2013 Jan 4. Yan SJLee YFTing HJLiu NCLiu SLin SJYeh SDLi GChang C Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation.; Cellular & molecular biology letters; Vol 17(2). 2012 Jun. Ting HJYasmin-Karim SYan SJHsu JWLin THZeng WMessing JSheu TJBao BYLi WXMessing ELee YF A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D.; Cancer research; Vol 72(4). 2012 Feb 15. Lin SJHo HCLee YFLiu NCLiu SLi GShyr CRChang C Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis.; Reproductive biology and endocrinology : RB&E; Vol 10. 2012. Liu SYan SJLee YFLiu NCTing HJLi GWu QChen LMChang C Testicular nuclear receptor 4 (TR4) regulates UV light-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair.; The Journal of biological chemistry; Vol 286(44). 2011 Nov 4. Liu SLee YFChou SUno HLi GBrookes PMassett MPWu QChen LMChang C Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I.; Molecular endocrinology (Baltimore, Md.); Vol 25(8). 2011 Aug. Lee YFLiu SLiu NCWang RSChen LMLin WJTing HJHo HCLi GPuzas EJWu QChang C Premature aging with impaired oxidative stress defense in mice lacking TR4.; American journal of physiology. Endocrinology and metabolism; Vol 301(1). 2011 Jul. Xie SNi JLee YFLiu SLi GShyr CRChang C Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation.; The Journal of biological chemistry; Vol 286(24). 2011 Jun 17. Kim ELiu NCYu ICLin HYLee YFSparks JDChen LMChang C Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity.; Diabetes; Vol 60(5). 2011 May. Hsu JWYasmin-Karim SKing MRWojciechowski JCMickelsen DBlair MLTing HJMa WLLee YF Suppression of prostate cancer cell rolling and adhesion to endothelium by 1α,25-dihydroxyvitamin D3.; The American journal of pathology; Vol 178(2). 2011 Feb. Collins LLLee YFTing HJLin WJLiu NCMeshul CKUno HBao BYChen YTChang C The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice.; Reproductive biology and endocrinology : RB&E; Vol 9. 2011. Bao BYTing HJHsu JWYasmin-Karim SMessing ELee YF Down-regulation of NF-kappaB signals is involved in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness.; The Journal of steroid biochemistry and molecular biology; Vol 120(1). 2010 May. Liu NCLin WJYu ICLin HYLiu SLee YFChang C Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling.; Endocrine; Vol 36(2). 2009 Oct. Xie SLee YFKim EChen LMNi JFang LYLiu SLin SJAbe JBerk BHo FMChang C TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation.; Proceedings of the National Academy of Sciences of the United States of America; Vol 106(32). 2009 Aug 11. Cai YLee YFLi GLiu SBao BYHuang JHsu CLChang C A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor.; International journal of cancer; Vol 123(1). 2008 Jul 1. Li GLee YFLiu SCai YXie SLiu NCBao BYChen ZChang C Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a.; Endocrinology; Vol 149(7). 2008 Jul. Bao BYTing HJHsu JWLee YF Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells.; International journal of cancer; Vol 122(12). 2008 Jun 15. Chen LMWang RSLee YFLiu NCChang YJWu CCXie SHung YCChang C Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4.; Molecular endocrinology (Baltimore, Md.); Vol 22(4). 2008 Apr. Liu NCLin WJKim ECollins LLLin HYYu ICSparks JDChen LMLee YFChang C Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis.; Diabetes; Vol 56(12). 2007 Dec. Ting HJBao BYReeder JEMessing EMLee YF Increased expression of corepressors in aggressive androgen-independent prostate cancer cells results in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness.; Molecular cancer research : MCR; Vol 5(9). 2007 Sep. Zhang YChen YTXie SWang LLee YFChang SSChang C Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain.; Molecular endocrinology (Baltimore, Md.); Vol 21(4). 2007 Apr. Ting HJHsu JBao BYLee YF Docetaxel-induced growth inhibition and apoptosis in androgen independent prostate cancer cells are enhanced by 1alpha,25-dihydroxyvitamin D3.; Cancer letters; Vol 247(1). 2007 Mar 8. Chen TCPersons KSZheng SMathieu JHolick MFLee YFBao BArai MAKittaka A Evaluation of C-2-substituted 19-nor-1alpha,25-dihydroxyvitamin D3 analogs as therapeutic agents for prostate cancer.; The Journal of steroid biochemistry and molecular biology; Vol 103(3-5). 2007 Mar. Wang CPLee YFChang CLee HJ Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor.; Biochemical and biophysical research communications; Vol 351(1). 2006 Dec 8. Bao BYYao JLee YF 1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis.; Carcinogenesis; Vol 27(9). 2006 Sep. Bao BYYeh SDLee YF 1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases.; Carcinogenesis; Vol 27(1). 2006 Jan. Chuang KHLee YFLin WJChu CYAltuwaijri SWan YJChang C 9-cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor.; Molecular endocrinology (Baltimore, Md.); Vol 19(5). 2005 May. Ting HJBao BYHsu CLLee YF Androgen-receptor coregulators mediate the suppressive effect of androgen signals on vitamin D receptor activity.; Endocrine; Vol 26(1). 2005 Feb. Lee YFBao BYChang C Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor.; Biochemical and biophysical research communications; Vol 323(3). 2004 Oct 22. Collins LLLee YFHeinlein CALiu NCChen YTShyr CRMeshul CKUno HPlatt KAChang C Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4.; Proceedings of the National Academy of Sciences of the United States of America; Vol 101(42). 2004 Oct 19. Lee YFJohn MFalconer AEdwards SClark JFlohr PRoe TWang RShipley JGrimer RJMangham DCThomas JMFisher CJudson ICooper CS A gene expression signature associated with metastatic outcome in human leiomyosarcomas.; Cancer research; Vol 64(20). 2004 Oct 15. Chen HHLee YFChan MHLo PS The role of N-methyl-D-aspartate receptors in neurobehavioral changes induced by toluene exposure during synaptogenesis.; Annals of the New York Academy of Sciences; Vol 1025. 2004 Oct. Mu XLee YFLiu NCChen YTKim EShyr CRChang C Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis.; Molecular and cellular biology; Vol 24(13). 2004 Jul. Bao BYHu YCTing HJLee YF Androgen signaling is required for the vitamin D-mediated growth inhibition in human prostate cancer cells.; Oncogene; Vol 23(19). 2004 Apr 22. Kim EXie SYeh SDLee YFCollins LLHu YCShyr CRMu XMLiu NCChen YTWang PHChang C Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster.; The Journal of biological chemistry; Vol 278(47). 2003 Nov 21. Lin WJLi JLee YFYeh SDAltuwaijri SOu JHChang C Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4.; The Journal of biological chemistry; Vol 278(11). 2003 Mar 14. Inui SLee YFChang EShyr CRChang C Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.; Journal of dermatological science; Vol 31(1). 2003 Feb. Lee YFLin WJHuang JMessing EMChan FLWilding GChang C Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.; Cancer research; Vol 62(21). 2002 Nov 1. Lee YFLee HJChang C Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily.; The Journal of steroid biochemistry and molecular biology; Vol 81(4-5). 2002 Aug. Lee HJLee YFChang C TR4 orphan receptor represses the human steroid 21-hydroxylase gene expression through the monomeric AGGTCA motif.; Biochemical and biophysical research communications; Vol 285(5). 2001 Aug 3. Lee YFShyr CRThin THLin WJChang C Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily.; Proceedings of the National Academy of Sciences of the United States of America; Vol 96(26). 1999 Dec 21. Lee YFYoung WJLin WJShyr CRChang C Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor.; The Journal of biological chemistry; Vol 274(23). 1999 Jun 4. Inui SLee YFHaake ARGoldsmith LAChang C Induction of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytes.; The Journal of investigative dermatology; Vol 112(4). 1999 Apr. Lee HJLee YFChang C Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor.; Molecular and cellular biochemistry; Vol 194(1-2). 1999 Apr.