URMC / Labs / Yule Lab / Publications Publications Ivanova HRitane AWagner LLuyten TShapovalov GWelkenhuyzen KSeitaj BMonaco GDe Smedt HPrevarskaya NYule DIParys JBBultynck G (2016 Aug 2). The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition. Oncotarget. Wang LAlzayady KJYule DI (2016 Jun 1). Proteolytic fragmentation of inositol 1,4,5-trisphosphate receptors: a novel mechanism regulating channel activity? The Journal of physiology. Gerber SAlzayady KJBurglen LBrémond-Gignac DMarchesin VRoche ORio MFunalot BCalmon RDurr AGil-da-Silva-Lopes VLRibeiro Bittar MFOrssaud CHéron BAyoub EBerquin PBahi-Buisson NBole CMasson CMunnich ASimons MDelous MDollfus HBoddaert NLyonnet SKaplan JCalvas PYule DIRozet JMFares Taie L (2016 May 5). Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome. American journal of human genetics. Sneyd JMeans SZhu DRugis JWon JHYule DI (2016 May 4). Modeling Calcium Waves in an Anatomically Accurate Three-Dimensional Parotid Acinar Cell. Journal of theoretical biology. Chandrasekhar RAlzayady KJWagner LEYule DI (2016 Mar 4). Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs. The Journal of biological chemistry. Alzayady KJWang LChandrasekhar RWagner LEVan Petegem FYule DI (2016). Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release. Science signaling. Teos LYZhang YCotrim APSwaim WWon JHAmbrus JShen LBebris LGrisius MJang SIYule DIAmbudkar ISAlevizos I (2015 Sep 14). IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome. Scientific reports. Vervloessem TYule DIBultynck GParys JB (2015 Sep). The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel. Biochimica et biophysica acta. Alzayady KJSebé-Pedrós AChandrasekhar RWang LRuiz-Trillo IYule DI (2015 Sep). Tracing the Evolutionary History of Inositol, 1, 4, 5-Trisphosphate Receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs. Molecular biology and evolution. Chandrasekhar RAlzayady KJYule DI (2015 Jun). Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors. Biochemical Society transactions. Hedgepeth SCGarcia MIWagner LERodriguez AMChintapalli SVSnyder RRHankins GDHenderson BRBrodie KMYule DIvan Rossum DBBoehning D (2015 Mar 13). The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release. The Journal of biological chemistry. Wagner LEGroom LADirksen RTYule DI (2014 Aug). Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp. Cell calcium. Yule DI (2014 Jun). Cell Calcium. Special issue: Ca²⁺ signaling and secretory function. Preface. Cell calcium. Bánsághi SGolenár TMadesh MCsordás GRamachandraRao SSharma KYule DIJoseph SKHajnóczky G (2014 Mar 21). Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species. The Journal of biological chemistry. Kemény LVSchnúr ACzepán MRakonczay ZGál ELonovics JLázár GSimonka ZVenglovecz VMaléth JJudák LNémeth IBSzabó KAlmássy JVirág LGeisz ATiszlavicz LYule DIWittmann TVarró AHegyi P (2013 Oct 15). Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts. American journal of physiology. Gastrointestinal and liver physiology. Alzayady KJWagner LEChandrasekhar RMonteagudo AGodiska RTall GGJoseph SKYule DI (2013 Oct 11). Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits. The Journal of biological chemistry. Alzayady KJChandrasekhar RYule DI (2013 Apr 19). Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels. The Journal of biological chemistry. Wei-LaPierre LGong GGerstner BJDucreux SYule DIPouvreau SWang XSheu SSCheng HDirksen RTWang W (2013 Apr 12). Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity. The Journal of biological chemistry. Zhang LMalik SPang JWang HPark KMYule DIBlaxall BCSmrcka AV (2013 Mar 28). Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. Gunter TEGerstner BGunter KKMalecki JGelein RValentine WMAschner MYule DI (2013 Jan). Manganese transport via the transferrin mechanism. Neurotoxicology. Almassy JYule DI (2013 Jan). Photolysis of caged compounds: studying Ca(2+) signaling and activation of Ca(2+)-dependent ion channels. Cold Spring Harbor protocols. Almassy JYule DI (2013 Jan). Studying the activation of epithelial ion channels using global whole-field photolysis. Cold Spring Harbor protocols. Almassy JYule DI (2013 Jan). Investigating ion channel distribution using a combination of spatially limited photolysis, Ca(2+) imaging, and patch clamp recording. Cold Spring Harbor protocols. Almassy JYule DI (2013 Jan). Analyzing Ca(2+) dynamics in intact epithelial cells using spatially limited flash photolysis. Cold Spring Harbor protocols. Monaco GDecrock ENuyts KWagner LELuyten TStrelkov SVMissiaen LDe Borggraeve WMLeybaert LYule DIDe Smedt HParys JBBultynck G (2013). Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor. PloS one. Patterson KCatalán MAMelvin JEYule DICrampin EJSneyd J (2012 Nov 15). A quantitative analysis of electrolyte exchange in the salivary duct. American journal of physiology. Gastrointestinal and liver physiology. Palk LSneyd JPatterson KShuttleworth TJYule DIMaclaren OCrampin EJ (2012 Jul 21). Modelling the effects of calcium waves and oscillations on saliva secretion. Journal of theoretical biology. Wagner LEYule DI (2012 Jul 15). Differential regulation of the InsP₃ receptor type-1 and -2 single channel properties by InsP₃, Ca²⁺ and ATP. The Journal of physiology. Bhattacharya SVerrill DSCarbone KMBrown SYule DIGiovannucci DR (2012 Jun 1). Distinct contributions by ionotropic purinoceptor subtypes to ATP-evoked calcium signals in mouse parotid acinar cells. The Journal of physiology. Almassy JWon JHBegenisich TBYule DI (2012 Feb). Apical Ca2+-activated potassium channels in mouse parotid acinar cells. The Journal of general physiology. Park HSBetzenhauser MJZhang YYule DI (2012 Jan 01). Regulation of Ca²⁺ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells. American journal of physiology. Gastrointestinal and liver physiology. Won JHZhang YJi BLogsdon CDYule DI (2011 Feb 01). Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis. Molecular biology of the cell. Masuda WBetzenhauser MJYule DI (2010 Nov 26). InsP3R-associated cGMP kinase substrate determines inositol 1,4,5-trisphosphate receptor susceptibility to phosphoregulation by cyclic nucleotide-dependent kinases. The Journal of biological chemistry. Yule DI (2010 Nov). Pancreatic acinar cells: molecular insight from studies of signal-transduction using transgenic animals. The international journal of biochemistry & cell biology. Palk LSneyd JShuttleworth TJYule DICrampin EJ (2010 Oct 21). A dynamic model of saliva secretion. Journal of theoretical biology. Yule DIBetzenhauser MJJoseph SK (2010 Jun). Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis. Cell calcium. Park KMYule DIBowers WJ (2010 Mar). Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons. Cellular signalling. Brown DAYule DI (2010 Feb). Protein kinase A regulation of P2X(4) receptors: requirement for a specific motif in the C-terminus. Biochimica et biophysica acta. Ryu SYPeixoto PMWon JHYule DIKinnally KW (2010 Jan). Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry. Cell calcium. Betzenhauser MJYule DI (2010). Regulation of inositol 1,4,5-trisphosphate receptors by phosphorylation and adenine nucleotides. Current topics in membranes. Park KMYule DIBowers WJ (2009 Oct 2). Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter. The Journal of biological chemistry. Betzenhauser MJFike JLWagner LEYule DI (2009 Sep 11). Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937. The Journal of biological chemistry. Gin EWagner LEYule DISneyd J (2009 Sep). Inositol trisphosphate receptor and ion channel models based on single-channel data. Chaos (Woodbury, N.Y.). Betzenhauser MJWagner LEPark HSYule DI (2009 Jun 12). ATP regulation of type-1 inositol 1,4,5-trisphosphate receptor activity does not require walker A-type ATP-binding motifs. The Journal of biological chemistry. Gin EFalcke MWagner LEYule DISneyd J (2009 May 20). A kinetic model of the inositol trisphosphate receptor based on single-channel data. Biophysical journal. Gin EFalcke MWagner LEYule DISneyd J (2009 Apr 7). Markov chain Monte Carlo fitting of single-channel data from inositol trisphosphate receptors. Journal of theoretical biology. Park KMYule DIBowers WJ (2008 Nov 28). Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor. The Journal of biological chemistry. Betzenhauser MJWagner LEWon JHYule DI (2008 Nov). Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation. Methods (San Diego, Calif.). Park HSBetzenhauser MJWon JHChen JYule DI (2008 Sep 19). The type 2 inositol (1,4,5)-trisphosphate (InsP3) receptor determines the sensitivity of InsP3-induced Ca2+ release to ATP in pancreatic acinar cells. The Journal of biological chemistry. Warner JDPeters CGSaunders RWon JHBetzenhauser MJGunning WTYule DIGiovannucci DR (2008 Sep). Visualizing form and function in organotypic slices of the adult mouse parotid gland. American journal of physiology. Gastrointestinal and liver physiology.