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February 2018

Catch URMC at the USCAP 2018 Meeting

2/23/2018

USCAP-2017Members of the University of Rochester Medical Center’s Department of Pathology & Laboratory Medicine will join thousands of pathologists from across the globe to present abstracts at the 2018 meeting of the United States and Canadian Academy of Pathology (USCAP).

The meeting, which is the largest of its kind in the world, will be held March 17-23 in Vancouver, BC, Canada. Below is a schedule of events that include URMC faculty and residents. In addition to presenting research, we are pleased to again host a cocktail reception for alumni and friends at the conference on Monday, March 19 (details below). All are welcome!

For general USCAP meeting information, please visit their website

Location Legend

PP – Pan Pacific Vancouver
FW – Fairmont Waterfront
FPR – Fairmont Pacific Rim
PH – Pinnacle Hotel Harbourfront

SUNDAY, MARCH 18, 2018

University of Rochester Fellowship Fair

5:30 - 7:30 PM
Table #4, VCC West Ballroom D

MONDAY, MARCH 19, 2018

Platform Sessions

8:00 AM - 12:00 PM

Cytopathology

8:30 AM
Real Time Cytopathology Feedback (RTCF) versus traditional Rapid On-Site Evaluation (ROSE) for Endobronchial Ultrasound Guided Fine-Needle Aspiration (EBUS-FNA) of mediastinal lymph nodes (MLN). Alexandra Danakas, Carolyn E Jones, John Plavnicky, Christian G Peyre, Sierra Kovar, Joseph J Wizorek, Mary Beth Kearns, Donna Russell, Shawn Evans, Luis De Las Casas. 

Gastrointestinal Pathology

HIV Enteropathy: Real or Myth? A Histologic Review. ILKe Nalbantoglu1, Raul S Gonzalez.

Poster Session I  

9:30 AM - 12:00 PM

74 Significance of Clinicopathologic Parameters, Including Margin Distance and Tumor Budding, on Local Disease Recurrence Following Esophageal Endoscopic Mucosal Resection. Phoenix Bell, ILKe Nalbantoglu, Justin Cates, Raul S Gonzalez. 

85 Perineal Carcinoma Cuniculatum: Histology Review of 38 Cases. Dongwei Zhang, Raul S Gonzalez, Michael Feely, Hwajeong Lee, Kavita Umrau, Daniela Allende, Dipti Karamchandani, Michael P Zaleski, Jingmei Lin, Maria Westerhoff, Xuchen Zhang, Lindsay Alpert, Jinping Lai, Xiuli Liu.

171 NKX3.1 Expression in Salivary Gland Neoplasms: A Marker for Mucinous Differentiation and a Potential Diagnostic Pitfall. Anna-Karoline Israel, Abberly Lott Limbach.

273 Extent of Lesional Cell Spread in Hepatic Epithelioid Hemangioendothelioma: Implications for the Diagnosis in Minimal Samples. Diana Agostini-Vulaj, Burcin Pehlivanoglu, Sharon Weiss, Alyssa Krasinskas, Michael Feely, Jason L Hornick5, Justin Cates, N. Volkan Adsay, Raul S Gonzalez.

Platform Sessions  

1:00 PM - 3:00 PM

Breast Pathology

Moderators:Timothy D'Alfonso and Megan Troxell
Room: VCC West 211

2:45 PM
A Novel Detection Methodology for HER2 Protein Quantitation in Clinical Samples: Correlation with Pathologic Response to Trastuzumab-Based Neoadjuvant Therapy. Bradley M. Turner, Brandon Buscaglia, Hideki Goda, Loralee Mcmahon, Takako Natori, Hisatake Okada, Armen Soukiazian, Yasushi Nakano, David Hicks.

Hematopathology

Moderators:Tracy George and Annette Kim
Room: VCC West 208 - 209

1:15 PM
Microarray CGH-SNP Analysis Detects Frequent Chromosomal Abnormalities Indicating Clonal Cytopenia(s) in Patients With Indeterminate Bone Marrow Dysplasia - An Institutional Study Of 94 Cases. Nisha Patel, Michelle Pitch, Andrew G Evans, M. Anwar Iqbal. 

Liver Pathology

Moderators: Dhanpat Jain and Lei Zhao
Room: VCC West 224

1:45 PM 
Does ASS1 Immunohistochemistry Predict an Increased Risk of Hemorrhage in Hepatocellular Adenomas? Heidi Lehrke, Taofic Mounajjed, Raul S Gonzalez, Riyam T Zreik, Laura J Denham, Rory Smoot, Daniela Allende, Bita V Naini, Roger K Moreira, Rondell Graham.

Poster Session II

1:00 PM - 4:30 PM

123 Immunohistochemistry of Androgen Receptor and Related Signaling Pathways in Bladder Cancer as Prognosticators. Satoshi Inoue, Taichi Mizushima, Hiroki Ide, Takashi Kawahara, Guiyang Jiang, George J Netto, Hiroshi Miyamoto. 

191 Acinic Cell Carcinoma of Salivary Gland Expresses Low Levels of PD-L1 with Retained MMR Proteins: A Potential Biomarker for Therapy. Abberly Lott Limbach.

1:00-5:00 PM
How to Get Started and Succeed in Academics: Mistakes We Made and What We Wish We’d Known on Day One
Room: VCC WEST 302-304
Course Directors: 

  • Raul S. Gonzalez, MD, University of Rochester Medical Center, Rochester, NY
  • Rondell P. Graham, MBBS, Mayo Clinic, Rochester, MN
  • Laura W. Lamps, MD, University of Michigan Hospitals, Ann Arbor, MI
  • Rhonda K. Yantiss, MD, Weill Cornell Medical College, New York, NY

Description: Making the leap from training to a career in academic medicine is daunting for many pathology residents and fellows. As there are few resources specifically devoted to transitioning from pathology training to academic practice, this Special Course would offer trainees and new academic attendings an in-depth look at the first 1-5 years of academic practice. Through the experience of the faculty, participants will hear about mistakes made along the way, lessons learned in areas where there is little formal training, and strategie that have led to successes. The program will discuss useful approaches to securing an academic position, tips, and pitfalls for the first year, and positioning oneself for academic promotion. The program will also discuss how to develop an early career research program, balancing academic activity and clinical work, and avoiding burnout.

University of Rochester Medical Center Alumni Reception
5:30 - 7:30 PM
Room: Fairmont Waterfront, MacKenzie Rm. II
No RSVP required, all are welcome!

TUESDAY, MARCH 20

Poster Session III

9:30 AM - 12:00 PM

101 Should Ki67 Immunohistochemistry Be Performed on All Lesions in Multifocal Small Intestinal Neuroendocrine Tumors? Numbereye Numbere, Aaron Huber, Chanjuan Shi, Justin Cates, Raul S Gonzalez

104 Mesenteric Tumor Deposits Arising from Small Intestinal Neuroendocrine Tumors are Frequently Associated with Sclerosis and IgG4-Expressing Plasma Cells. Jordan Andrew Roberts, Raul S Gonzalez, Frank Revetta, Chanjuan Shi. 

117 Clinical Outcome of Perineal Carcinoma Cuniculatum in a Cohort of 38 Cases. Dongwei Zhang, Raul S Gonzalez, Michael Feely, Kavita Umrau, Hwajeong Lee, Daniela Allende, Dipti Karamchandani, Michael P Zaleski, Jingmei Lin, Maria Westerhoff, Xuchen Zhang, Lindsay Alpert, Jinping Lai, Xiuli Liu.

154 Liver Histology in Septic Patients: Is It All About Ductular Cholestasis? Caroline Bsirini, Raul S Gonzalez.

Platform Sessions

1:00 PM - 2:45 PM

Gastrointestinal Pathology

Moderators: Deepti Dhall and Laura Lamps
Room: Vancouver Convention Centre West 224

2:15 PM
Mesenteric Tumor Deposit Number, But Not Size, Affects Prognosis of Patients with Small Intestinal Well- Differentiated Neuroendocrine Tumors. Raul S Gonzalez, Justin Cates, Chanjuan Shi.

Poster Session IV

1:00 PM - 4:30 PM

40 Quantitative Measurement of Human Epidermal Growth Factor Receptor-2 (HER2) Protein Expression in ‘Classical’ and ‘Non-Classical’ FISH Categories: A Comparative Study. Jian Shen, Brandon Buscaglia, Hideki Goda, Bradley M. Turner, Hisatake Okada, Loralee Mcmahon, Jill Henry, Yasushi Nakano, David Hicks.

102 Lymphocytic Esophagitis in Adult Crohn’s Disease is Characterized by Younger Age, Lower Incidence of Reflux Symptoms, and a CD4 Predominant Infiltrate. Elizabeth Yiru Wu, Deepa T Patil, Michael Drage, Amitabh Srivastava.

116 What Remains of Appendiceal Adenocarcinoma After LAMN and Goblet Cell Neoplasms are Excluded? Raul S Gonzalez, Joseph Misdraji, Rhonda Yantiss

132 Clinicopathologic Analysis of Benign Lipomatous Lesions of the Colon. Sam L Barron, Raul S Gonzalez 

136 Interobserver agreement in the diagnosis of anal dysplasiaSohaib Abu-Farsakh, Michael Drage, Aaron Huber, Bradley M. Turner, Sharlin Varghese, Xi Wang, Christa Whitney- Miller, Raul S Gonzalez.

150 Significance of Method of Lymph Node Involvement in Pancreatic Ductal Adenocarcinoma. Diana Agostini-Vulaj, Justin Cates, Richard Dunne, Raul S Gonzalez.

151 Low Union (Lower Insertion of Cystic Duct into Common Hepatic Duct) as a Major Etiologic Factor in the Development of Pancreatic, Distal Bile Duct and Ampullary Cancers: An analysis of 860 pancreatobiliary resections. Takashi Muraki, Michelle Reid, Raul S Gonzalez, Aarti Sekhar, Bahar Memis, Burcin Pehlivanoglu, Yue Xue, Pardeep Mittal, Juan M Sarmiento, David Kooby, Shishir Maithel, Ken Cardona, Bassel El-Rayes, Alyssa Krasinskas, Gwen Lomberk, Raul Urrutia, Kathleen K Christians, Susan Tsai, Douglas Evans, N. Volkan Adsay, Alpharetta.

162 Loss of ARID1A Expression Predicts Worse Overall Survival in Patients with Resected Pancreatic Adenocarcinoma and Is Associated with Inactivating Mutations of the ARID1A Gene. Annacarolina da Silva, Vicente Morales-Oyarvide, Douglas A Rubinson, Margaret M Kozak, Wenjia Wang, Diana Agostini-Vulaj, Aaron Huber, Daniel T Chang, Thomas E Clancy, Aram F Hezel, Shuji Ogino, Brian M Wolpin, Jonathan A Nowak.

202 Clinical Significance of Perivesical Lymph Node Metastasis in Radical Cystectomy for Bladder Cancer. Meenal Sharma, Jerome Jean-Gilles, Hiroshi Miyamoto.

261 AID-Generated Acquired IGH Glycosylation Sites but Not Somatic Hypermutation Rate Differentiate Low-grade versus High-grade Follicular Lymphoma. Chad Hudson, Janice Spence, Diana G Adlowitz, Richard Burack.

262 Increased AID-Generated Acquired Glycosylation Sites in Diffuse Large B-cell Lymphomas with IGH-BCL2 and CD10 Expression. Chad Hudson, Janice Spence, Diana G Adlowitz, Madalynn Bryant, Richard Burack.

277 Unexpectedly High Prevalence of Cystoisospora belli in Acalculous Gallbladders of Younger Patients. Mushal Noor, Christa Whitney-Miller, Laura W Lamps, Raul S Gonzalez, Aaron Huber, Jennifer J Findeis-Hosey, Zhongren (David) Zhou, Lawrence J Saubermann, Rebecca L Abell, Philip J Katzman, Michael Drage.

WEDNESDAY, MARCH 21

Poster Session V

9:30 AM - 12:00 PM

103 Relationships Among Histologic Characteristics, Molecular Phenotypes, and Patient Outcomes in Mucinous Colorectal Carcinoma. Raul S Gonzalez, Justin Cates, Mary Kay Washington.

149 Evaluation of Histologic Changes in the Livers of Patients With Early and Late Hepatic Artery Thrombosis. Michael J Lee, Raul S Gonzalez.

243 Autoimmune Disease and Lymphoma: A Method for Large Scale Search of the Electronic Medical Record Enables Correlation of Clinical Parameters with Type and Risk of Lymphoproliferative Disease. Genevieve M Crane, Amy Duffield.

265 Next Generation Sequencing-Assays Detect B-Lymphocyte Clonality in Formalin-Fixed Paraffin Embedded Specimens of Classical Hodgkin Lymphoma without Microdissection. Cynthia Reyes Barron, Andrew Campbell, Paul G Rothberg, Richard Burack, Yi Ding DING4 1University of Rochester Medical Center, Victor, NY, 2University of Rochester Medical Center, 3University of Rochester, Rochester, NY, 4University of Rochester Medical Center, Rochester, NY

350 Is the Rate of Frozen Section Discordance Affected by Subspecialty Sign Out? Joseph H Blitman, Brandon Buscaglia, Christa Whitney- Miller, David Hicks, Aaron Huber.

Poster Session VI

1:00 PM - 4:00 PM

162 MCM7 Expression Correlates With Tumor Size and Ki67 Index in Well-Differentiated Small Intestinal Neuroendocrine Tumors. Zhongren (David) Zhou, Numbereye Numbere, Aaron Huber, Chanjuan Shi, Raul S Gonzalez.

167 Expression of TIM3 (CD366) and LAG3 (CD223) in Colorectal Carcinoma-associated Inflammatory Infiltrate Suggest Novel Therapeutic Targets for Immune Checkpoint Blockade. Michael Drage, Max Klapholz, Ana C Anderson, Amitabh Srivastava.

280 L1 CAM – A Potential Biomarker for Recurrent and Aggressive Endometrial Carcinoma. Ioana Moisini, James R Richter, Tanya Pulver, Raphael Hellwegg, Boris Winterhoff, Molly Klein. 

318 Lack of MUM1 Expression Characterizes B-Lymphoblastic Leukemia/Lymphoma. Chad Hudson, Roula Katerji, Richard Burack.

THURSDAY, MARCH 22

Liver Pathology

7:30 PM – 9:30 PM
Secrets from the Consult Files: Puzzling Cases Solved Piece by Piece
Room: VCC WEST 301-305
Moderator: Michael Torbenson, MD, Mayo Clinic, Rochester, MN

Faculty

  • Maria Westerhoff, MD, University of Michigan, Ann Arbor, MI
  • Tom Smyrk, MD, Mayo Clinic Rochester, MN
  • ILKe Nalbantoglu, MD, Yale University, New Haven, CT
  • Raul Gonzalez, MD, University of Rochester Medical Center, Rochester, NY
  • Oyedele (Dele) Adeyi, MD, University of Toronto, ON, Canada

 

 

After Maria: Rebuilding Continues in Dominica

2/6/2018

PolidoresNearly five months have passed since Hurricane Maria struck the island of Dominica, yet most of its residents still can’t turn their lights on.

Joan Polidore, who lives on the island in the Eastern Caribbean, recently visited Rochester. Her daughter, Julia Polidore, is a URMC Pathology employee who coordinated a collection drive to send food and supplies to their home country.

Joan and her husband are pastors who have opened the doors of their churches to provide shelter and resources to their neighbors. Dominica, which already had widespread poverty, was set back even further by the devastation.

“The people are very stressed,” she said. “Some have lost everything and some have lost family members. Many still don’t have housing.”  

Schools have not reopened since the storm, forcing some students to relocate to neighboring islands or the United Kingdom to attend school. To help local children, Joan hosts some group activities like arts and crafts at church during the week. 

The country's infrastructure remains in a state of crisis. Clean water is available, but crews are still working to restore power to residential areas. This is complicated by the fact that most people live inland in mountainous regions inland, and government buildings, hospitals, and businesses take priority when it comes to having the electricity turned back on.

These struggles were more widely publicized after the storm hit, but awareness has diminished in the months since. Julia Polidore is continuing to collect funds and non-perishables to help in the rebuilding effort. 

The initial outpouring of support from Rochester (13 shipping barrels full of food and supplies) was extremely appreciated, but the goods were used up almost as soon as they arrived. That’s why Julia says the effort to support Dominica must continue.

“It’s not in the headlines anymore, but the aftermath is the challenging piece,” she said. “There is not as much attention given to how they’re picking up the pieces. We have to give them hope that people care and won’t leave them hanging." 

Joan agrees. The roof of her home was torn off by the hurricane (which has since been repaired) yet she sees others with greater needs, and continues to look for ways to help. She regularly uses her experience as a retired counselor to listen to those who are struggling and encourage them during this difficult time. 

“Brighter days are coming, so we live in hope,” she said.

How to Give

Financial gifts can be made online via the following link: Hurricane Relief Effort for Dominica W.I. (YouCaring). Donated items may also be brought in person to either of the following locations: 

  • Center for Community Health & Prevention
    46 Prince St., Rochester, NY
  • 1199 Service Employees International Union
    259 Monroe Ave., Rochester, NY
     

Needed Items

  • Canned Goods (chicken, tuna, beef)
  • Rice/Macaroni Products
  • Dry Milk/Juice Mix
  • Dry cereal/Oatmeal
  • Flour, Sugar, Salt
  • Oil, Lemon Juice
  • Bottled Water
  • Flashlights/Batteries
  • Water Filters
  • Tarps
  • Generators/Commercial Tents
  • School Supplies
  • Bedding (sheets, mattresses, etc.)

 

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